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AU2006289921B2 - Substituted cycloalkene derivative - Google Patents

Substituted cycloalkene derivative Download PDF

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Publication number
AU2006289921B2
AU2006289921B2 AU2006289921A AU2006289921A AU2006289921B2 AU 2006289921 B2 AU2006289921 B2 AU 2006289921B2 AU 2006289921 A AU2006289921 A AU 2006289921A AU 2006289921 A AU2006289921 A AU 2006289921A AU 2006289921 B2 AU2006289921 B2 AU 2006289921B2
Authority
AU
Australia
Prior art keywords
group
ring
dioxo
ethyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006289921A
Other languages
English (en)
Other versions
AU2006289921A1 (en
Inventor
Osamu Ando
Tomio Kimura
Takayoshi Nagasaki
Nobuyuki Ohkawa
Atsuhiro Sugidachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of AU2006289921A1 publication Critical patent/AU2006289921A1/en
Application granted granted Critical
Publication of AU2006289921B2 publication Critical patent/AU2006289921B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/50—Spiro compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
AU2006289921A 2005-09-14 2006-09-13 Substituted cycloalkene derivative Ceased AU2006289921B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005-267504 2005-09-14
JP2005267504 2005-09-14
PCT/JP2006/318103 WO2007032362A1 (ja) 2005-09-14 2006-09-13 置換シクロアルケン誘導体

Publications (2)

Publication Number Publication Date
AU2006289921A1 AU2006289921A1 (en) 2007-03-22
AU2006289921B2 true AU2006289921B2 (en) 2010-11-18

Family

ID=37864954

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006289921A Ceased AU2006289921B2 (en) 2005-09-14 2006-09-13 Substituted cycloalkene derivative

Country Status (17)

Country Link
US (2) USRE43858E1 (zh)
EP (1) EP1935879B1 (zh)
JP (1) JP4195074B2 (zh)
KR (1) KR101327610B1 (zh)
CN (1) CN101309900B (zh)
AU (1) AU2006289921B2 (zh)
BR (1) BRPI0615932A2 (zh)
CA (1) CA2622694C (zh)
IL (1) IL190063A (zh)
MX (1) MX2008003759A (zh)
MY (1) MY146284A (zh)
NO (1) NO20081789L (zh)
NZ (1) NZ567269A (zh)
RU (1) RU2386613C2 (zh)
TW (1) TWI387453B (zh)
WO (1) WO2007032362A1 (zh)
ZA (1) ZA200802382B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2435767C1 (ru) * 2010-07-05 2011-12-10 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" (е)-5-(4-хлорфенил)-3-[2-(4-хлорфенил)этенил]-2-оксаспиро[5,6]додец-3-ен-1-он, проявляющий анальгетическую активность
WO2012039447A1 (ja) 2010-09-24 2012-03-29 第一三共株式会社 置換シクロアルケン誘導体の結晶
WO2016181894A1 (ja) * 2015-05-08 2016-11-17 武田薬品工業株式会社 環状化合物
CA2985325C (en) 2015-05-08 2023-09-26 Takeda Pharmaceutical Company Limited Cyclic compounds for inhibition of toll-like receptor 4
US10738004B2 (en) 2016-09-09 2020-08-11 Takeda Pharmaceutical Company Limited Cyclic compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497954A (en) * 1983-11-15 1985-02-05 Riker Laboratories, Inc. Cyclopentanone derivatives
US5001144A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
HRP940124A2 (en) * 1994-02-21 1997-10-31 Pliva Pharm & Chem Works Novel sulfonamidodioxepanes, methods of preparation, intermediates, salts and the use thereof
RU2214398C2 (ru) * 1998-03-09 2003-10-20 Такеда Кемикал Индастриз, Лтд. Производное циклоалкена, способ его получения (варианты), фармацевтическая композиция, способ ингибирования, способ профилактики или лечения
JP2002534468A (ja) 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
CA2380990A1 (en) * 1999-08-06 2001-02-15 Takeda Chemical Industries, Ltd. Substituted aromatic-ring compounds, process for producing the same, and use
JP4108260B2 (ja) 1999-08-06 2008-06-25 武田薬品工業株式会社 置換芳香環化合物、その製造法および用途
WO2001040498A1 (en) * 1999-11-29 2001-06-07 Takeda Chemical Industries, Ltd. Process for the production of optically active cyclohexene derivatives and intermediates therefor
US6951885B2 (en) * 2000-08-10 2005-10-04 Takeda Pharmaceutical Company Limited Pharmaceutical composition
JP2004002370A (ja) 2002-04-08 2004-01-08 Takeda Chem Ind Ltd 重症セプシス予防治療剤
JPWO2008004673A1 (ja) * 2006-07-07 2009-12-10 武田薬品工業株式会社 シクロアルケン誘導体、その製造法および用途

Also Published As

Publication number Publication date
MX2008003759A (es) 2008-09-12
NO20081789L (no) 2008-06-12
RU2386613C2 (ru) 2010-04-20
KR101327610B1 (ko) 2013-11-12
IL190063A0 (en) 2008-08-07
JPWO2007032362A1 (ja) 2009-03-19
US7935835B2 (en) 2011-05-03
BRPI0615932A2 (pt) 2011-05-31
KR20080043846A (ko) 2008-05-19
NZ567269A (en) 2010-06-25
CA2622694A1 (en) 2007-03-22
EP1935879B1 (en) 2016-05-11
AU2006289921A1 (en) 2007-03-22
JP4195074B2 (ja) 2008-12-10
MY146284A (en) 2012-07-31
US20090233952A1 (en) 2009-09-17
RU2008114340A (ru) 2009-10-20
TWI387453B (zh) 2013-03-01
IL190063A (en) 2015-10-29
ZA200802382B (en) 2009-06-24
WO2007032362A1 (ja) 2007-03-22
EP1935879A1 (en) 2008-06-25
EP1935879A4 (en) 2011-07-06
CN101309900A (zh) 2008-11-19
USRE43858E1 (en) 2012-12-11
TW200745002A (en) 2007-12-16
CA2622694C (en) 2011-02-08
CN101309900B (zh) 2015-04-22

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired