AU2002211226A1 - New treatments for restless legs syndrome - Google Patents

New treatments for restless legs syndrome

Info

Publication number: AU2002211226A1
Authority: AU; Australia
Prior art keywords: compound; rls; alkyl; cycloalkyl; phenyl
Prior art date: 2000-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2002211226A

Other languages

English (en)

Inventor

Richard W. Anderson

Sylvia Mcbrinn

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co LLC

Original Assignee

Pharmacia and Upjohn Co

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-31

Filing date

2001-10-29

Publication date

2002-05-15

2001-10-29 Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co

2002-05-15 Publication of AU2002211226A1 publication Critical patent/AU2002211226A1/en

Status Abandoned legal-status Critical Current

Links

208000005793 Restless legs syndrome Diseases 0.000 title claims description 83
238000011282 treatment Methods 0.000 title claims description 32
150000001875 compounds Chemical class 0.000 claims description 93
-1 heterocyclic amine Chemical class 0.000 claims description 51
238000000034 method Methods 0.000 claims description 45
239000003814 drug Substances 0.000 claims description 33
150000003839 salts Chemical class 0.000 claims description 27
229910052739 hydrogen Inorganic materials 0.000 claims description 18
239000001257 hydrogen Substances 0.000 claims description 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
125000000217 alkyl group Chemical group 0.000 claims description 17
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 15
229910052736 halogen Inorganic materials 0.000 claims description 15
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 14
229910052757 nitrogen Inorganic materials 0.000 claims description 14
229910052760 oxygen Inorganic materials 0.000 claims description 14
IRFHMTUHTBSEBK-QGZVFWFLSA-N tert-butyl n-[(2s)-2-(2,5-difluorophenyl)-3-quinolin-3-ylpropyl]carbamate Chemical compound C1([C@H](CC=2C=C3C=CC=CC3=NC=2)CNC(=O)OC(C)(C)C)=CC(F)=CC=C1F IRFHMTUHTBSEBK-QGZVFWFLSA-N 0.000 claims description 14
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 12
125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 12
125000004981 cycloalkylmethyl group Chemical group 0.000 claims description 12
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 11
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 10
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 6
229910052799 carbon Inorganic materials 0.000 claims description 6
125000004093 cyano group Chemical group *C#N 0.000 claims description 6
150000002367 halogens Chemical class 0.000 claims description 6
UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 claims description 5
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims description 5
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 5
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 4
229910052717 sulfur Inorganic materials 0.000 claims description 4
GTSVNRNOMOFNEY-PFEQFJNWSA-N (3s)-3-(3-methylsulfonylphenyl)-1-propylpiperidine;hydrobromide Chemical compound Br.C1N(CCC)CCC[C@H]1C1=CC=CC(S(C)(=O)=O)=C1 GTSVNRNOMOFNEY-PFEQFJNWSA-N 0.000 claims description 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 3
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 3
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims description 3
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 3
125000003342 alkenyl group Chemical group 0.000 claims description 3
125000003545 alkoxy group Chemical group 0.000 claims description 3
125000000304 alkynyl group Chemical group 0.000 claims description 3
125000004432 carbon atom Chemical group C* 0.000 claims description 3
150000003857 carboxamides Chemical class 0.000 claims description 3
125000004122 cyclic group Chemical group 0.000 claims description 3
125000002541 furyl group Chemical group 0.000 claims description 3
125000005842 heteroatom Chemical group 0.000 claims description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 claims description 3
XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 claims description 3
150000003536 tetrazoles Chemical class 0.000 claims description 3
125000001544 thienyl group Chemical group 0.000 claims description 3
150000003852 triazoles Chemical class 0.000 claims description 3
125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 claims description 3
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 3
150000001412 amines Chemical class 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 claims description 2
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
150000002431 hydrogen Chemical class 0.000 claims 4
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
239000000203 mixture Substances 0.000 description 26
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OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
238000006243 chemical reaction Methods 0.000 description 15
208000024891 symptom Diseases 0.000 description 15
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 13
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WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 12
230000000694 effects Effects 0.000 description 12
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230000003416 augmentation Effects 0.000 description 10
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239000003136 dopamine receptor stimulating agent Substances 0.000 description 9
125000004435 hydrogen atom Chemical class [H]* 0.000 description 9
239000002002 slurry Substances 0.000 description 8
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 7
229960004502 levodopa Drugs 0.000 description 7
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 7
208000035824 paresthesia Diseases 0.000 description 7
230000035807 sensation Effects 0.000 description 7
239000013078 crystal Substances 0.000 description 6
229960003638 dopamine Drugs 0.000 description 6
229940005501 dopaminergic agent Drugs 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
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UWCVGPLTGZWHGS-ZORIOUSZSA-N pergolide mesylate Chemical compound CS(O)(=O)=O.C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 UWCVGPLTGZWHGS-ZORIOUSZSA-N 0.000 description 6
239000002904 solvent Substances 0.000 description 6
239000000126 substance Substances 0.000 description 6
UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 5
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230000001965 increasing effect Effects 0.000 description 5
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239000000047 product Substances 0.000 description 5
OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 4
MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 4
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229960002802 bromocriptine Drugs 0.000 description 4
DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 4
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CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Anesthesiology (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)
Fats And Perfumes (AREA)

AU2002211226A 2000-10-31 2001-10-29 New treatments for restless legs syndrome Abandoned AU2002211226A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24466600P	2000-10-31	2000-10-31
US60/244,666		2000-10-31
PCT/US2001/027785 WO2002036123A2 (en)	2000-10-31	2001-10-29	New treatments for restless legs syndrome

Publications (1)

Publication Number	Publication Date
AU2002211226A1 true AU2002211226A1 (en)	2002-05-15

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ID=22923642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2002211226A Abandoned AU2002211226A1 (en)	2000-10-31	2001-10-29	New treatments for restless legs syndrome

Country Status (18)

Country	Link
US (2)	US6602868B2 (es)
EP (1)	EP1330248A2 (es)
JP (1)	JP2004512367A (es)
KR (1)	KR20030042037A (es)
CN (1)	CN1606442A (es)
AR (1)	AR031152A1 (es)
AU (1)	AU2002211226A1 (es)
BR (1)	BR0115071A (es)
CA (1)	CA2421705A1 (es)
EA (1)	EA200300527A1 (es)
IL (1)	IL155591A0 (es)
MX (1)	MXPA03003912A (es)
NO (1)	NO20031923L (es)
NZ (1)	NZ525574A (es)
PE (1)	PE20020514A1 (es)
PL (1)	PL360904A1 (es)
WO (1)	WO2002036123A2 (es)
ZA (1)	ZA200301865B (es)

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USRE46117E1 (en)	1999-12-22	2016-08-23	Teva Pharmaceuticals International Gmbh	Modulators of dopamine neurotransmission
DE10066158B4 (de) *	2000-08-24	2007-08-09	Neurobiotec Gmbh	Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms
DE10053397A1 (de) *	2000-10-20	2002-05-02	Schering Ag	Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10064453A1 (de) *	2000-12-16	2002-07-04	Schering Ag	Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
US20030065002A1 (en)	2001-05-11	2003-04-03	Endo Pharmaceuticals, Inc.	Abuse-resistant controlled-release opioid dosage form
EP1492505B1 (en)	2002-04-05	2015-06-03	Euro-Celtique S.A.	Pharmaceutical preparation containing oxycodone and naloxone
AR040683A1 (es) *	2002-07-25	2005-04-13	Pharmacia Corp	Composicion de tabletas de liberacion sostenida que comprende un agonista de los receptores de la dopamina
CA2500919A1 (en) *	2002-10-04	2004-04-22	Pharmacia Corporation	Compositions and methods for treating sexual dysfunction
AU2003267769A1 (en) *	2002-10-25	2004-05-13	Pharmacia & Upjohn Company Llc	Use of heterocyclic amine-type compounds as neuroprotective agents
CA2538802C (en)	2003-09-17	2015-01-27	Xenoport, Inc.	Treating or preventing restless legs syndrome using prodrugs of gaba analogs
EP1604667A1 (en) *	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioids for the treatment of the restless leg syndrome
EP1604666A1 (en)	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
GEP20105052B (en) *	2005-01-28	2010-07-26	Euro Celtique Sa	Alcohol resistant dosage forms
EP1702558A1 (en)	2005-02-28	2006-09-20	Euro-Celtique S.A.	Method and device for the assessment of bowel function
EP1695700A1 (en) *	2005-02-28	2006-08-30	Euro-Celtique S.A.	Dosage form containing oxycodone and naloxone
CN101263136A (zh)	2005-07-13	2008-09-10	弗·哈夫曼-拉罗切有限公司	作为5-ht6、5-ht24的苯并咪唑衍生物
US20100168119A1 (en) *	2008-11-05	2010-07-01	Pharmorx, Inc.	Compositions and methods for minimizing or reducing agonist-induced desensitization
BRPI1006186A2 (pt)	2009-03-10	2016-08-23	Euro Celtique Sa	composições farmaceuticas de liberação imediata compreedendo oxicodona e naloxona
US8690933B2 (en) *	2009-08-31	2014-04-08	Brigham Young University	System and method for treating symptoms of restless legs syndrome
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2001
- 2001-10-23 AR ARP010104960A patent/AR031152A1/es unknown
- 2001-10-24 PE PE2001001052A patent/PE20020514A1/es not_active Application Discontinuation
- 2001-10-29 BR BR0115071-5A patent/BR0115071A/pt not_active IP Right Cessation
- 2001-10-29 JP JP2002538934A patent/JP2004512367A/ja not_active Withdrawn
- 2001-10-29 KR KR10-2003-7005874A patent/KR20030042037A/ko not_active Withdrawn
- 2001-10-29 EA EA200300527A patent/EA200300527A1/ru unknown
- 2001-10-29 CA CA002421705A patent/CA2421705A1/en not_active Abandoned
- 2001-10-29 AU AU2002211226A patent/AU2002211226A1/en not_active Abandoned
- 2001-10-29 MX MXPA03003912A patent/MXPA03003912A/es not_active Application Discontinuation
- 2001-10-29 NZ NZ52557401A patent/NZ525574A/xx unknown
- 2001-10-29 EP EP01979241A patent/EP1330248A2/en not_active Withdrawn
- 2001-10-29 WO PCT/US2001/027785 patent/WO2002036123A2/en not_active Ceased
- 2001-10-29 IL IL15559101A patent/IL155591A0/xx unknown
- 2001-10-29 PL PL36090401A patent/PL360904A1/xx not_active Application Discontinuation
- 2001-10-29 US US10/039,446 patent/US6602868B2/en not_active Expired - Fee Related
- 2001-10-29 CN CNA018156134A patent/CN1606442A/zh active Pending
2003
- 2003-03-06 ZA ZA200301865A patent/ZA200301865B/en unknown
- 2003-04-25 US US10/423,078 patent/US6716854B2/en not_active Expired - Fee Related
- 2003-04-29 NO NO20031923A patent/NO20031923L/no unknown

Also Published As

Publication number	Publication date
EP1330248A2 (en)	2003-07-30
CA2421705A1 (en)	2002-05-10
US6716854B2 (en)	2004-04-06
NZ525574A (en)	2004-12-24
AR031152A1 (es)	2003-09-10
ZA200301865B (en)	2004-06-25
BR0115071A (pt)	2003-07-29
US20020107257A1 (en)	2002-08-08
MXPA03003912A (es)	2004-09-10
WO2002036123A2 (en)	2002-05-10
PE20020514A1 (es)	2002-06-12
US20030212065A1 (en)	2003-11-13
JP2004512367A (ja)	2004-04-22
IL155591A0 (en)	2003-11-23
KR20030042037A (ko)	2003-05-27
PL360904A1 (en)	2004-09-20
EA200300527A1 (ru)	2003-08-28
NO20031923D0 (no)	2003-04-29
WO2002036123A3 (en)	2002-09-19
US6602868B2 (en)	2003-08-05
CN1606442A (zh)	2005-04-13
NO20031923L (no)	2003-06-27

Publication	Publication Date	Title
US6716854B2 (en)	2004-04-06	Treatments for restless legs syndrome
AU2001253114B2 (en)	2005-08-25	Compounds for treating fibromyalgia and chronic fatigue syndrome
AU2001253114A1 (en)	2002-01-24	Compounds for treating fibromyalgia and chronic fatigue syndrome
EP1066038B1 (en)	2005-12-21	Use of cabergoline in the treatment of restless legs syndrome
CN1332628A (zh)	2002-01-23	治疗性功能障碍的方法
JP2004506621A (ja)	2004-03-04	嗜癖障害治療用の化合物
JP2015515982A (ja)	2015-06-04	経口メチルナルトレキソンのバイオアベイラビリティはホスファチジルコリンベースの製剤で増加する
US20110124600A1 (en)	2011-05-26	Use of Dopamine partial agonists for treament of the restless leg syndrome and corresponding pharmaceutical preparation
ZA200208273B (en)	2004-01-30	Compounds for treating fibromyalgia and chronic fatigue syndrome.
EP1569649A2 (en)	2005-09-07	Use of heterocyclic amine-type compounds as neuroprotective agents
HK1072893A (en)	2005-09-16	New treatments for restless legs syndrome
HK1056680A (en)	2004-02-27	Compounds for treating fibromyalgia and chronic fatigue syndrome
EP1477168A1 (en)	2004-11-17	Use of cabergoline in the treatment of restless leg syndrome
HK1068255A (zh)	2005-04-29	用於治疗纤维肌痛和慢性疲劳综合症的化合物

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