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AU2001230864A1 - Inhibitors of prenyl-protein transferase - Google Patents

Inhibitors of prenyl-protein transferase

Info

Publication number
AU2001230864A1
AU2001230864A1 AU2001230864A AU3086401A AU2001230864A1 AU 2001230864 A1 AU2001230864 A1 AU 2001230864A1 AU 2001230864 A AU2001230864 A AU 2001230864A AU 3086401 A AU3086401 A AU 3086401A AU 2001230864 A1 AU2001230864 A1 AU 2001230864A1
Authority
AU
Australia
Prior art keywords
prenyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001230864A
Inventor
Christopher J. Dinsmore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2001230864A1 publication Critical patent/AU2001230864A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001230864A 2000-01-12 2001-01-08 Inhibitors of prenyl-protein transferase Abandoned AU2001230864A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17570600P 2000-01-12 2000-01-12
US60175706 2000-01-12
PCT/US2001/000433 WO2001051494A1 (en) 2000-01-12 2001-01-08 Inhibitors of prenyl-protein transferase

Publications (1)

Publication Number Publication Date
AU2001230864A1 true AU2001230864A1 (en) 2001-07-24

Family

ID=22641302

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001230864A Abandoned AU2001230864A1 (en) 2000-01-12 2001-01-08 Inhibitors of prenyl-protein transferase

Country Status (3)

Country Link
US (1) US6632818B2 (en)
AU (1) AU2001230864A1 (en)
WO (1) WO2001051494A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210612B1 (en) 2003-06-18 2016-10-05 Ocera Therapeutics, Inc. Macrocyclic antagonists of the motilin receptor
WO2006006610A1 (en) * 2004-07-09 2006-01-19 Banyu Pharmaceutical Co., Ltd Oxopiperazine derivative
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
WO2007136746A2 (en) * 2006-05-19 2007-11-29 Xenon Pharmaceuticals Inc. Macrocyclic compounds and their uses as stearoyl-coa desaturase
US20100056555A1 (en) * 2008-08-29 2010-03-04 Enzon Pharmaceuticals, Inc. Method of treating ras associated cancer
CA2738807A1 (en) * 2008-10-21 2010-04-29 Enzon Pharmaceuticals, Inc. Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
BRPI1010086A2 (en) * 2009-06-22 2018-02-06 Dmi Acquisition Corp disease treatment method and products
DE202010017530U1 (en) 2009-06-22 2012-03-28 Dmi Acquisition Corp. Danazol compound for the treatment of diseases
EA201500752A1 (en) 2012-12-19 2016-05-31 Ампио Фармасьютикалс, Инк. METHOD OF TREATMENT OF DISEASES

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE40911B1 (en) 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
DE3811574A1 (en) 1988-03-31 1989-10-19 Schering Ag N-SUBSTITUTED IMIDAZOLES, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
JPH09504277A (en) * 1993-09-30 1997-04-28 メルク エンド カンパニー インコーポレーテッド Farnesyl-protein transferase inhibitors
US5756528A (en) 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997017070A1 (en) 1995-11-06 1997-05-15 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US5780488A (en) 1996-04-03 1998-07-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
GEP20012500B (en) 1996-05-22 2001-07-25 Warner Lambert Co Inhibitors of Protein Farnesyl Transferase
US6414145B1 (en) 1997-01-29 2002-07-02 Zeneca Limited Imidazolyl compounds as inhibitors of farnesyl-protein tranferase
JP2001520222A (en) 1997-10-22 2001-10-30 ゼネカ・リミテッド Imidazole derivatives and their use as farnesyl protein transferase inhibitors
EP1090012A4 (en) 1998-07-02 2005-04-06 Merck & Co Inc INHIBITORS OF PRENYL PROTEIN TRANSFERASE
CA2336054A1 (en) 1998-07-02 2000-01-13 Merck And Co., Inc. Inhibitors of prenyl-protein transferase
WO2000001701A1 (en) 1998-07-02 2000-01-13 Merck & Co., Inc. Inhibitors of prenyl-protein transferase

Also Published As

Publication number Publication date
US6632818B2 (en) 2003-10-14
US20030134860A1 (en) 2003-07-17
WO2001051494A1 (en) 2001-07-19

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