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AU2001237041A1 - Kinase inhibitors - Google Patents

Kinase inhibitors

Info

Publication number
AU2001237041A1
AU2001237041A1 AU2001237041A AU2001237041A AU2001237041A1 AU 2001237041 A1 AU2001237041 A1 AU 2001237041A1 AU 2001237041 A AU2001237041 A AU 2001237041A AU 2001237041 A AU2001237041 A AU 2001237041A AU 2001237041 A1 AU2001237041 A1 AU 2001237041A1
Authority
AU
Australia
Prior art keywords
kinase inhibitors
kinase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2001237041A
Other versions
AU2001237041B9 (en
AU2001237041B2 (en
Inventor
David M. Armistead
Jean E. Bemis
Lucian V. Di Pietro
Stephanie D. Geuns-Meyer
Gregory J. Habgood
Joseph L. Kim
Joseph J. Nunes
Vinod F. Patel
Leticia M. Toledo-Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority claimed from PCT/US2001/004983 external-priority patent/WO2001060816A1/en
Publication of AU2001237041A1 publication Critical patent/AU2001237041A1/en
Application granted granted Critical
Publication of AU2001237041B2 publication Critical patent/AU2001237041B2/en
Publication of AU2001237041B9 publication Critical patent/AU2001237041B9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

AU2001237041A 2000-02-17 2001-02-16 Kinase inhibitors Ceased AU2001237041B9 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18325600P 2000-02-17 2000-02-17
US60/183,256 2000-02-17
USNOTGIVEN 2000-05-23
PCT/US2001/004983 WO2001060816A1 (en) 2000-02-17 2001-02-16 Kinase inhibitors
US09/785,599 US20030004174A9 (en) 2000-02-17 2001-02-16 Kinase inhibitors

Publications (3)

Publication Number Publication Date
AU2001237041A1 true AU2001237041A1 (en) 2001-11-08
AU2001237041B2 AU2001237041B2 (en) 2005-07-21
AU2001237041B9 AU2001237041B9 (en) 2005-07-28

Family

ID=22672081

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001237041A Ceased AU2001237041B9 (en) 2000-02-17 2001-02-16 Kinase inhibitors
AU3704101A Pending AU3704101A (en) 2000-02-17 2001-02-16 Kinase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU3704101A Pending AU3704101A (en) 2000-02-17 2001-02-16 Kinase inhibitors

Country Status (12)

Country Link
US (3) US20030004174A9 (en)
EP (1) EP1257546A1 (en)
JP (1) JP2003532635A (en)
KR (1) KR20030024659A (en)
CN (1) CN1429222A (en)
AU (2) AU2001237041B9 (en)
CA (1) CA2400447C (en)
HU (1) HUP0301117A3 (en)
IL (1) IL151104A0 (en)
MX (1) MXPA02007957A (en)
WO (1) WO2001060816A1 (en)
ZA (1) ZA200206386B (en)

Families Citing this family (271)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
IL150388A0 (en) 1999-12-24 2002-12-01 Aventis Pharma Ltd Azaindoles
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
AU2001277621A1 (en) * 2000-08-09 2002-03-04 Astrazeneca Ab Antiangiogenic bicyclic derivatives
GB0021726D0 (en) 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
CN1926132B (en) * 2000-09-15 2010-12-29 沃泰克斯药物股份有限公司 Pyrazole compounds useful as protein kinase inhibitors
SI1318997T1 (en) * 2000-09-15 2006-12-31 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
RU2340611C2 (en) * 2000-09-15 2008-12-10 Вертекс Фармасьютикалз Инкорпорейтед Pyrazole derivatives applied as protein kinase inhibitors
AU2001296871A1 (en) * 2000-09-15 2002-03-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
AU2006201228B2 (en) * 2000-12-21 2010-01-28 Vertex Pharmaceuticals Incorporated Pyrazole Compounds Useful as Protein Kinase Inhibitors
EP1343782B1 (en) 2000-12-21 2009-05-06 SmithKline Beecham Corporation Pyrimidineamines as angiogenesis modulators
HUP0400639A3 (en) * 2000-12-21 2010-03-29 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
US7081454B2 (en) 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
GB0113041D0 (en) 2001-05-30 2001-07-18 Astrazeneca Ab Chemical compounds
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
EP1401412A2 (en) * 2001-06-29 2004-03-31 AB Science Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
CA2452368A1 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
EP1401415B1 (en) * 2001-06-29 2006-06-21 AB Science Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases
WO2003004007A2 (en) * 2001-06-29 2003-01-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd)
DK1401413T3 (en) 2001-06-29 2007-03-26 Ab Science Use of tyrosine kinase inhibitors for the treatment of allergic diseases
ATE401079T1 (en) * 2001-06-29 2008-08-15 Ab Science THE USE OF C-KITE INHIBITORS TO TREAT AUTOIMMUNE DISEASES
JO3429B1 (en) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv Hiv inhibiting pyrimidines derivatives
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
ATE401078T1 (en) * 2001-09-20 2008-08-15 Ab Science THE USE OF C-KIT INHIBITORS TO PROMOTE HAIR GROWTH
US20040242601A1 (en) * 2001-09-20 2004-12-02 Alain Moussy Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
WO2003026666A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors
NZ532593A (en) * 2001-10-25 2007-11-30 Wisconsin Alumni Res Found Vascular stent or graft coated or impregnated with protein tyrosine kinase inhibitors and method of using same
CA2463822A1 (en) * 2001-11-01 2003-05-08 Janssen Pharmaceutica N.V. Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
SE0104140D0 (en) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
GB0129476D0 (en) * 2001-12-10 2002-01-30 Syngenta Participations Ag Organic compounds
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
JP4656838B2 (en) * 2002-02-06 2011-03-23 バーテックス ファーマシューティカルズ インコーポレイテッド Heteroaryl compounds useful as inhibitors of GSK-3
WO2003066601A1 (en) 2002-02-08 2003-08-14 Smithkline Beecham Corporation Pyrimidine compounds
WO2003072090A2 (en) * 2002-02-27 2003-09-04 Ab Science Use of tyrosine kinase inhibitors for treating cns disorders
JP2005524672A (en) 2002-03-09 2005-08-18 アストラゼネカ アクチボラグ Imidazolyl-substituted pyrimidine derivatives having CDK inhibitory activity
GB0205688D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205690D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
EP1485100B1 (en) * 2002-03-15 2010-05-05 Vertex Pharmaceuticals Incorporated Azinylaminoazoles as inhibitors of protein kinases
WO2003078426A1 (en) 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azolylaminoazine as inhibitors of protein kinases
EP1485380B1 (en) * 2002-03-15 2010-05-19 Vertex Pharmaceuticals Incorporated Azolylaminoazines as inhibitors of protein kinases
IL165286A0 (en) * 2002-06-17 2005-12-18 Smithkline Beecham Corp Chemical process
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
GB0215844D0 (en) 2002-07-09 2002-08-14 Novartis Ag Organic compounds
RU2491071C2 (en) * 2002-07-29 2013-08-27 Райджел Фармасьютикалз, Инк. Method of treating or preventing autoimmune diseases by 2,4-pyrimidinediamine compounds
CN103169708B (en) 2002-07-29 2018-02-02 里格尔药品股份有限公司 The method that autoimmune disease is treated or prevented with 2,4 pyrimidinediamine compounds
EP2130541A3 (en) * 2002-07-29 2013-12-18 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
PL374967A1 (en) 2002-08-02 2005-11-14 Vertex Pharmaceuticals Incorporated Pyrazole compositions useful as inhibitors of gsk-3
AU2003266413B2 (en) 2002-08-09 2009-04-02 Janssen Pharmaceutica N.V. Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
WO2004039796A1 (en) * 2002-10-28 2004-05-13 Bayer Healthcare Ag Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors
US7109337B2 (en) 2002-12-20 2006-09-19 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
MXPA06002608A (en) 2002-12-20 2007-01-23 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth.
US20040121968A1 (en) * 2002-12-23 2004-06-24 Alexander Ljubimov Antiangiogenesis by inhibiting protein kinase CK2 activity
WO2004072029A2 (en) * 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
DE602004021472D1 (en) 2003-02-20 2009-07-23 Smithkline Beecham Corp Pyrimiidinverbindungen
RU2400477C2 (en) * 2003-03-14 2010-09-27 Новартис Аг 2,4-di(phenylamino)pyrimidines, applied in treatment of neoplastic diseases, inflammatory disorders and immune system disorders
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
GB0311276D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
GB0311274D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
JP2007516196A (en) * 2003-07-02 2007-06-21 ガラパゴス エヌブイ Pyrazine and pyralidine derivatives as Rho kinase inhibitors
US7312215B2 (en) 2003-07-29 2007-12-25 Bristol-Myers Squibb Company Benzimidazole C-2 heterocycles as kinase inhibitors
BRPI0412351A (en) * 2003-07-30 2006-09-05 Cyclacel Ltd pyridylamino pyrimidine derivatives as protein kinase inhibitors
US7122542B2 (en) 2003-07-30 2006-10-17 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
JP4607879B2 (en) 2003-08-15 2011-01-05 ノバルティス アーゲー 2,4-Pyrimidinediamine useful for the treatment of neoplastic diseases, inflammation and immune disorders
GB0321710D0 (en) * 2003-09-16 2003-10-15 Novartis Ag Organic compounds
JP2007507531A (en) * 2003-09-30 2007-03-29 アイアールエム・リミテッド・ライアビリティ・カンパニー Compounds and compositions as protein kinase inhibitors
CA2542522A1 (en) 2003-10-17 2005-05-06 Astrazeneca Ab 4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer
US20050107374A1 (en) * 2003-10-21 2005-05-19 Amgen Inc. Substituted heterocyclic compounds and methods of use
MY141220A (en) * 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
CA2548172A1 (en) * 2003-12-04 2005-06-23 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
CA2551948A1 (en) * 2004-01-09 2005-07-28 Novartis Ag Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives as igf-ir inhibitors
US20050209231A1 (en) * 2004-01-16 2005-09-22 Xu Wu Compositions and methods for inducing cardiomyogenesis
TW200528101A (en) 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
US20050267060A1 (en) * 2004-03-19 2005-12-01 The Penn State Research Foundation Combinatorial methods and compositions for treatment of melanoma
WO2005095400A1 (en) 2004-03-30 2005-10-13 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
JP2007537235A (en) 2004-05-14 2007-12-20 ファイザー・プロダクツ・インク Pyrimidine derivatives for the treatment of abnormal cell proliferation
WO2005111016A1 (en) 2004-05-14 2005-11-24 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
CA2566332A1 (en) 2004-05-14 2005-11-24 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
JP4812763B2 (en) 2004-05-18 2011-11-09 ライジェル ファーマシューティカルズ， インコーポレイテッド Cycloalkyl-substituted pyrimidinediamine compounds and uses thereof
US7521457B2 (en) * 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
PE20060664A1 (en) 2004-09-15 2006-08-04 Novartis Ag BICYCLE AMIDAS AS KINASE INHIBITORS
AU2005289426A1 (en) * 2004-09-27 2006-04-06 Amgen Inc. Substituted heterocyclic compounds and methods of use
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
GB2420559B (en) 2004-11-15 2008-08-06 Rigel Pharmaceuticals Inc Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
WO2006055831A2 (en) 2004-11-17 2006-05-26 Miikana Therapeutics, Inc. Kinase inhibitors
ATE540035T1 (en) 2004-11-24 2012-01-15 Rigel Pharmaceuticals Inc SPIRO-2,4-PYRIMIDINEDIAMINE COMPOUNDS AND USES THEREOF
US8211929B2 (en) 2004-12-30 2012-07-03 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
US7449458B2 (en) 2005-01-19 2008-11-11 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
PT1846394E (en) 2005-02-04 2012-01-05 Astrazeneca Ab Pyrazolylaminopyridine derivatives useful as kinase inhibitors
ES2308731T3 (en) 2005-02-16 2008-12-01 Astrazeneca Ab CHEMICAL COMPOUNDS.
WO2006091737A1 (en) * 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity
RU2418788C2 (en) * 2005-03-10 2011-05-20 Сги Фармасьютиклз, Инк. Some substituted amides, method of their obtaining and method of their application
CA2601628C (en) 2005-03-10 2014-05-13 Cgi Pharmaceuticals, Inc. Certain substituted amides, method of making, and method of use thereof
AU2006248780B2 (en) 2005-05-16 2010-06-03 Astrazeneca Ab Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
WO2006129100A1 (en) * 2005-06-03 2006-12-07 Glaxo Group Limited Novel compounds
RU2485106C2 (en) 2005-06-08 2013-06-20 Райджел Фамэсьютикэлз, Инк. Compounds exhibiting jak-kinase activity (versions), method of treating jak-kinase mediated diseases, method of inhibiting jak-kinase activity (versions), pharmaceutical composition of said compounds
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
JP5054004B2 (en) * 2005-07-01 2012-10-24 アイアールエム・リミテッド・ライアビリティ・カンパニー Pyrimidine substituted benzimidazole derivatives as protein kinase inhibitors
WO2007009681A1 (en) * 2005-07-15 2007-01-25 Glaxo Group Limited 1 , 1-DIOXID0-2 , 3-DIHYDRO-l , 2-BENZISOTHIAZ0L-6-YL-1H-INDAZOL-4-YL-2 , 4-PYRIMIDINEDI AMINE DERIVATIVES
WO2007028445A1 (en) * 2005-07-15 2007-03-15 Glaxo Group Limited 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
JP5255438B2 (en) 2005-07-26 2013-08-07 バーテックス ファーマシューティカルズ インコーポレイテッド Benzimidazoles useful as protein kinase inhibitors
EP1917259B1 (en) * 2005-08-18 2012-01-25 Vertex Pharmaceuticals Incorporated Pyrazine kinase inhibitors
EP1919456A2 (en) 2005-08-24 2008-05-14 Wyeth a Corporation of the State of Delaware Bazedoxifene acetate formulations and manufacturing process thereof
US7745428B2 (en) 2005-09-30 2010-06-29 Astrazeneca Ab Imidazo[1,2-A]pyridine having anti-cell-proliferation activity
ES2535854T3 (en) * 2005-09-30 2015-05-18 Miikana Therapeutics, Inc. Substituted Pyrazole Compounds
GB0520958D0 (en) 2005-10-14 2005-11-23 Cyclacel Ltd Compound
WO2007049041A1 (en) 2005-10-28 2007-05-03 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
US8604042B2 (en) * 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) * 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
MY167260A (en) * 2005-11-01 2018-08-14 Targegen Inc Bi-aryl meta-pyrimidine inhibitors of kinases
CN101316597B (en) * 2005-11-03 2013-04-17 顶点医药品公司 Aminopyrimidines useful as kinase inhibitors
US7705009B2 (en) 2005-11-22 2010-04-27 Hoffman-La Roche Inc. 4-aminopyrimidine-5-thione derivatives
NZ601687A (en) 2006-01-17 2014-03-28 Vertex Pharma Azaindoles useful as inhibitors of janus kinases
TW200736232A (en) * 2006-01-26 2007-10-01 Astrazeneca Ab Pyrimidine derivatives
WO2007085540A1 (en) * 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
RU2008140382A (en) * 2006-03-16 2010-04-27 Новартис АГ (CH) HETEROCYCLIC ORGANIC COMPOUNDS, FOR example, FOR THE TREATMENT OF MELANOMA
WO2007146981A2 (en) * 2006-06-15 2007-12-21 Boehringer Ingelheim International Gmbh 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha
CA2656290A1 (en) 2006-07-05 2008-01-10 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
EP2066319B1 (en) 2006-09-08 2012-02-01 F. Hoffmann-La Roche AG Benzotriazole kinase modulators
US20100048657A1 (en) * 2006-09-12 2010-02-25 Cleveland State University Control of malignant cells proliferation through the inhibition of casein kinase 2
US20090054507A1 (en) * 2006-09-12 2009-02-26 Cleveland State University Control of malignant cells by kinase inhibition
EP2086965B1 (en) * 2006-11-02 2010-02-10 Vertex Pharmaceuticals, Inc. Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases
EP2433635A1 (en) 2006-11-10 2012-03-28 Massachusetts Institute Of Technology PAK Modulators
BRPI0720264B1 (en) * 2006-12-08 2022-03-03 Novartis Ag COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
WO2008068171A1 (en) * 2006-12-08 2008-06-12 F. Hoffmann-La Roche Ag Substituted pyrimidines and their use as jnk modulators
RS53588B1 (en) 2006-12-08 2015-02-27 Irm Llc COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
AU2007333650A1 (en) * 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
MX2009009590A (en) * 2007-03-09 2009-11-10 Vertex Pharma Aminopyrimidines useful as inhibitors of protein kinases.
JP2010520887A (en) 2007-03-09 2010-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド Aminopyridines useful as inhibitors of protein kinases
JP5393489B2 (en) * 2007-03-09 2014-01-22 バーテックス ファーマシューティカルズ インコーポレイテッド Aminopyrimidines useful as inhibitors of protein kinases
AU2008231304B2 (en) * 2007-03-23 2011-05-12 Amgen Inc. Heterocyclic compounds and their uses
CA2683785A1 (en) 2007-04-13 2008-10-23 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
MX2009011199A (en) * 2007-04-16 2010-03-17 Hutchison Medipharma Entpr Ltd Pyrimidine derivatives.
CA2694381A1 (en) * 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
MX2009011811A (en) * 2007-05-02 2010-01-14 Vertex Pharma Aminopyrimidines useful as kinase inhibitors.
JP5389785B2 (en) * 2007-05-02 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド Thiazoles and pyrazoles useful as kinase inhibitors
UA99459C2 (en) 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
CN101687852A (en) * 2007-05-24 2010-03-31 沃泰克斯药物股份有限公司 Thiazoles and pyrazoles useful as kinase inhibitors
CA2683152A1 (en) * 2007-06-11 2008-12-18 Miikana Therapeutics, Inc. Substituted pyrazole compounds
EA201000101A1 (en) * 2007-07-16 2010-08-30 Астразенека Аб DERIVATIVES OF PYRIMIDINE 934
CN101790532B (en) 2007-07-31 2013-11-20 沃泰克斯药物股份有限公司 Preparation method of 5-fluoro-1H-pyrazolo [3,4-b ] pyridine-3-amine and derivatives thereof
EP2190826A2 (en) * 2007-08-28 2010-06-02 Irm Llc 2-biphenylamino-4-aminopyrimidine derivatives as kinase inhibitors
US8008013B2 (en) * 2007-11-16 2011-08-30 Oklahoma Medical Research Foundation Predicting and diagnosing patients with autoimmune disease
JP2011032169A (en) * 2007-12-11 2011-02-17 Genecare Research Institute Co Ltd 4-aminopyrimidine derivative and medicinal composition containing the compound
WO2009111644A2 (en) * 2008-03-05 2009-09-11 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating pancreatic cancer
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
PT2300013T (en) * 2008-05-21 2017-10-31 Ariad Pharma Inc Phosphorous derivatives as kinase inhibitors
AU2013205506B2 (en) * 2008-05-21 2016-04-21 Takeda Pharmaceutical Company Limited Phosphorous derivatives as kinase inhibitors
KR20110039278A (en) 2008-06-23 2011-04-15 버텍스 파마슈티칼스 인코포레이티드 Protein kinase inhibitors
UY31929A (en) 2008-06-25 2010-01-05 Irm Llc COMPOUNDS AND COMPOSITIONS AS CINASE INHIBITORS
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
EP2361248B1 (en) 2008-06-27 2018-09-19 Celgene CAR LLC Heteroaryl compounds and uses thereof
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
US20100016247A1 (en) * 2008-07-21 2010-01-21 Florida State University Research Foundation Using budding yeast to screen for inhibitors of aurora kinases
WO2010027921A1 (en) * 2008-09-03 2010-03-11 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical formulations comprising the same
WO2010031056A2 (en) 2008-09-15 2010-03-18 The Regents Of The University Of California Methods and compositions for modulating ire1, src, and abl activity
WO2010044103A1 (en) * 2008-10-13 2010-04-22 National Institute Of Immunology Pharmaceutical composition for therapeutic or prophylactic treatment of bacterial infections and associated diseases
WO2010049731A1 (en) * 2008-10-29 2010-05-06 Astrazeneca Ab Pyrazolo- and imidazopyridinylpyrimidineamines as igf-1r tyrosine kinase inhibitors
PA8852901A1 (en) 2008-12-22 2010-07-27 Lilly Co Eli PROTEIN CINASE INHIBITORS
JP5918693B2 (en) 2009-05-05 2016-05-18 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド EGFR inhibitor and disease treatment method
US8536180B2 (en) * 2009-05-27 2013-09-17 Abbvie Inc. Pyrimidine inhibitors of kinase activity
TW201100441A (en) 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
AU2010262905B2 (en) 2009-06-17 2015-04-16 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
KR101246911B1 (en) 2009-11-02 2013-03-25 한국화학연구원 Novel 2,4-pyrimidine derivatives and use thereof
WO2011060295A1 (en) * 2009-11-13 2011-05-19 Genosco Kinase inhibitors
JP2013523658A (en) * 2010-03-26 2013-06-17 グラクソ グループ リミテッド Pyrazolyl-pyrimidines as kinase inhibitors
US20130023532A1 (en) * 2010-03-26 2013-01-24 Casillas Linda N Indazolyl-pyrimidines as kinase inhibitors
NZ607845A (en) 2010-08-10 2015-03-27 Celgene Avilomics Res Inc Besylate salt of a btk inhibitor
UY33549A (en) * 2010-08-10 2012-01-31 Glaxo Group Ltd QUINOLIL AMINAS AS INHIBITING AGENTS OF KINASES
EP2635285B1 (en) 2010-11-01 2017-05-03 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
WO2012061299A1 (en) 2010-11-01 2012-05-10 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
US8796255B2 (en) 2010-11-10 2014-08-05 Celgene Avilomics Research, Inc Mutant-selective EGFR inhibitors and uses thereof
PT2646448T (en) 2010-11-29 2017-10-04 Osi Pharmaceuticals Llc Macrocyclic kinase inhibitors
KR20140014110A (en) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 Inhibitors of influenza viruses replication
CN103857288B (en) 2011-03-04 2016-09-21 葛兰素史密斯克莱知识产权发展有限公司 Amino-quinolines as kinase inhibitors
JP2014511391A (en) * 2011-03-07 2014-05-15 フォンダッツィオーネ・テレソン TFEB phosphorylation inhibitors and uses thereof
EP2704572B1 (en) 2011-05-04 2015-12-30 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
WO2013006634A2 (en) 2011-07-05 2013-01-10 Vertex Pharmaceuticals Incorporated Processes and intermediates for producing azaindoles
US8673269B2 (en) 2011-07-14 2014-03-18 Keith R. Latham Halogenated phenols for diagnostics, antioxidant protection and drug delivery
US9416132B2 (en) 2011-07-21 2016-08-16 Tolero Pharmaceuticals, Inc. Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
UA118010C2 (en) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед INFLUENCES OF INFLUENZA VIRUS REPLICATION
TWI547494B (en) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 Aminoquinazolines as kinase inhibitors
CN103781779B (en) * 2011-09-05 2016-06-08 浙江海正药业股份有限公司 4-substituted-(3-substituted-1H-pyrazole-5-amino)-pyrimidine derivatives having protein kinase inhibitory activity and uses thereof
JP6026544B2 (en) * 2011-09-27 2016-11-16 ノバルティス アーゲー 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
EP2770830A4 (en) 2011-10-28 2015-05-27 Celgene Avilomics Res Inc Methods of treating a bruton's tyrosine kinase disease or disorder
KR101401664B1 (en) * 2011-11-15 2014-06-11 중앙대학교 산학협력단 Novel pyrimidine-2,4-diamine derivatives for differentiation of neural stem cells and medical use thereof
UY34632A (en) 2012-02-24 2013-05-31 Novartis Ag OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME
PT2825042T (en) 2012-03-15 2018-11-16 Celgene Car Llc Salts of an epidermal growth factor receptor kinase inhibitor
MX356753B (en) 2012-03-15 2018-06-12 Celgene Avilomics Res Inc Solid forms of an epidermal growth factor receptor kinase inhibitor.
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
WO2013192128A1 (en) * 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Imidazolyl analogs as syk inhibitors
EP2863914B1 (en) * 2012-06-20 2018-10-03 Merck Sharp & Dohme Corp. Pyrazolyl derivatives as syk inhibitors
AR092529A1 (en) 2012-09-13 2015-04-22 Glaxosmithkline Llc AMINOQUINAZOLINE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND USE OF THIS COMPOSITE FOR THE PREPARATION OF A MEDICINAL PRODUCT
AR092530A1 (en) 2012-09-13 2015-04-22 Glaxosmithkline Llc AMINO-QUINOLINE COMPOSITE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND USE OF THIS COMPOUND FOR THE PREPARATION OF A MEDICINAL PRODUCT
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
US9073875B2 (en) 2012-11-20 2015-07-07 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
KR20220143164A (en) * 2012-11-21 2022-10-24 피티씨 테라퓨틱스, 인크. Substituted reverse pyrimidine bmi-1 inhibitors
US9512136B2 (en) * 2012-11-26 2016-12-06 Universal Display Corporation Organic electroluminescent materials and devices
US9126950B2 (en) 2012-12-21 2015-09-08 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
WO2014124230A2 (en) 2013-02-08 2014-08-14 Celgene Avilomics Research, Inc. Erk inhibitors and uses thereof
EP2958911B1 (en) 2013-02-21 2017-10-18 GlaxoSmithKline Intellectual Property Development Limited Quinazolines as kinase inhibitors
DK2970205T3 (en) * 2013-03-14 2019-07-29 Tolero Pharmaceuticals Inc JAK2 and ALK2 inhibitors and methods for their use
HK1213251A1 (en) 2013-03-14 2016-06-30 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
KR20150127197A (en) * 2013-03-14 2015-11-16 노파르티스 아게 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
WO2014181813A1 (en) * 2013-05-10 2014-11-13 武田薬品工業株式会社 Heterocyclic compound
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
CA2922657C (en) 2013-08-30 2022-04-12 Ptc Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
ES2741444T3 (en) 2013-11-13 2020-02-11 Vertex Pharma Inhibitors of influenza virus replication
EP3068782B1 (en) 2013-11-13 2018-05-23 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
US10584115B2 (en) 2013-11-21 2020-03-10 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine BMI-1 inhibitors
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
ES2741785T3 (en) 2014-08-13 2020-02-12 Celgene Car Llc Forms and compositions of an ERK inhibitor
TWI730331B (en) 2014-10-13 2021-06-11 南韓商柳韓洋行股份有限公司 Compounds and compositions for modulating egfr mutant kinase activities
CN105085489B (en) 2014-11-05 2019-03-01 益方生物科技（上海）有限公司 Pyrimidine or pyridine compound, its preparation method and medical use
US10202365B2 (en) 2015-02-06 2019-02-12 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
EP4591936A3 (en) * 2015-03-23 2025-10-15 Tianli Biotech Pty Ltd Treatment of respiratory diseases
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
US10329277B2 (en) 2015-07-16 2019-06-25 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(3-methyl-2-OXO-2,3-dihydro-1h-benzo[d]imidazol-1-yl)pyrimidin-2-yl)amino)phenyl)acrylamide hydrochloride as an inhibitor of epidermal growth factor receptor activity
CN105061506B (en) * 2015-07-27 2017-08-29 苏州明锐医药科技有限公司 Antineoplastic AP26113 preparation method
EA038890B1 (en) 2015-11-02 2021-11-03 Блюпринт Медсинс Корпорейшн Inhibitors of ret
CN106699810A (en) * 2015-11-17 2017-05-24 清华大学 Nitrogen-containing heterogeneous ring compound, preparation method thereof and application of nitrogen-containing heterogeneous ring compound in inhibition of kinase activity
CA3012031C (en) 2016-01-22 2024-03-26 Janssen Pharmaceutica Nv 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors
US11180487B2 (en) 2016-01-22 2021-11-23 Janssen Pharmaceutica Nv Substituted cyanoindoline derivatives as NIK inhibitors
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
AR107912A1 (en) 2016-03-17 2018-06-28 Blueprint Medicines Corp RET INHIBITORS
WO2018002219A1 (en) 2016-06-30 2018-01-04 Janssen Pharmaceutica Nv Cyanoindoline derivatives as nik inhibitors
JP6936815B2 (en) 2016-06-30 2021-09-22 ヤンセン ファーマシューティカ エヌ．ベー． Heteroaromatic derivatives as NIK inhibitors
WO2018017983A1 (en) * 2016-07-22 2018-01-25 Blueprint Medicines Corporation Compounds useful for treating disorders related to ret
WO2018022761A1 (en) 2016-07-27 2018-02-01 Blueprint Medicines Corporation Substituted cyclopentane-amides for treating disorders related to ret
AU2017379796B2 (en) * 2016-12-19 2021-10-21 Isocure Biosciences Inc. Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof
CA3096043A1 (en) 2018-04-03 2019-10-10 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
WO2019195753A1 (en) 2018-04-05 2019-10-10 Tolero Pharmaceuticals, Inc. Axl kinase inhibitors and use of the same
EP3773560A4 (en) 2018-04-13 2022-01-19 Sumitomo Dainippon Pharma Oncology, Inc. PIM-KINASE INHIBITORS FOR THE TREATMENT OF CANCER-ASSOCIATED MYELOPROLIFERATIVE NEOPLASMA AND FIBROSIS
CN108864052A (en) * 2018-06-07 2018-11-23 福建医科大学 A kind of synthesis and application of the fluorescence probe for GC33-3-1 antibody with specific recognition
CN112512597A (en) 2018-07-26 2021-03-16 大日本住友制药肿瘤公司 Methods for treating diseases associated with aberrant ACVR1 expression and ACVR1 inhibitors useful therefor
BR112021002630A2 (en) 2018-08-17 2021-05-11 Ptc Therapeutics, Inc. method to treat pancreatic cancer
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CA3127502A1 (en) 2019-02-12 2020-08-20 Sumitomo Dainippon Pharma Oncology, Inc. Formulations comprising heterocyclic protein kinase inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
PH12022550361A1 (en) 2019-08-14 2023-02-27 Incyte Corp Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
CN110746402B (en) * 2019-09-21 2021-01-15 温州医科大学 A kind of 2-N-aryl-4-N-aryl-5-fluoropyrimidine compound and its preparation method and application
CN110669038B (en) * 2019-09-21 2020-10-30 温州医科大学 Pyrimidine FGFR4V550LInhibitor, preparation method and application thereof
PE20221905A1 (en) 2019-10-11 2022-12-23 Incyte Corp BICYCLIC AMINES AS INHIBITORS OF CDK2
KR20230017234A (en) 2020-05-29 2023-02-03 블루프린트 메디신즈 코포레이션 Solid forms of pralcetinib
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
AU2023372386A1 (en) 2022-10-31 2025-05-08 Sumitomo Pharma America, Inc. Pim1 inhibitor for treating myeloproliferative neoplasms

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2861560D1 (en) * 1977-11-28 1982-03-04 Barry Boettcher Complexes of bivalent copper, methods of preparation thereof and compositions containing said complexes
ES2087056T3 (en) * 1986-01-13 1996-07-16 American Cyanamid Co 2-PIRIMIDINAMINES SUBSTITUTED IN POSITIONS 4, 5 AND 6.
HU206337B (en) 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
US5043317A (en) * 1990-12-14 1991-08-27 Eastman Kodak Company Yellow dye mixture for thermal color proofing
TW225528B (en) * 1992-04-03 1994-06-21 Ciba Geigy Ag
GB9309573D0 (en) 1993-05-10 1993-06-23 Merck Sharp & Dohme Therapeutic agents
ATE325113T1 (en) * 1993-10-01 2006-06-15 Novartis Pharma Gmbh PHARMACOLOGICALLY ACTIVE PYRIMIDINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
HUT74464A (en) * 1993-10-12 1996-12-30 Du Pont Merck Pharma 1n-alkyl-n-arylpyrimidinamines and derivatives thereof, and pharmaceutical compositions containing them
TW574214B (en) 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
JP2896532B2 (en) * 1994-08-13 1999-05-31 ユーハン コーポレーション Novel pyrimidine derivative and method for producing the same
US5935966A (en) * 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) * 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
DE19750701A1 (en) * 1997-11-15 1999-05-20 Dystar Textilfarben Gmbh & Co Reaction of F-substituted triazine and pyrimidine compounds with amino compounds
JP4135318B2 (en) 1997-12-15 2008-08-20 アステラス製薬株式会社 Novel pyrimidine-5-carboxamide derivatives
CA2321153A1 (en) * 1998-02-17 1999-08-19 Timothy D. Cushing Anti-viral pyrimidine derivatives
DK0945443T3 (en) 1998-03-27 2003-06-02 Janssen Pharmaceutica Nv HIV inhibitory pyrimidine derivatives
AU5438299A (en) * 1998-08-29 2000-03-21 Astrazeneca Ab Pyrimidine compounds
AU762523C (en) 1998-11-10 2004-02-12 Janssen Pharmaceutica N.V. HIV replication inhibiting pyrimidines
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
CA2359680A1 (en) * 1999-01-22 2000-07-27 David M. Armistead Kinase inhibitors
GB9905075D0 (en) * 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
EP1040831A3 (en) 1999-04-02 2003-05-02 Pfizer Products Inc. Use of corticotropin releasing factor (CRF) antagonists to prevent sudden death
GB9907658D0 (en) 1999-04-06 1999-05-26 Zeneca Ltd Chemical compounds
CO5170501A1 (en) * 1999-04-14 2002-06-27 Novartis Ag USEFUL REPLACED BLUES FOR THE TREATMENT OF DISEASES MEDIATED BY TNFa eIL-1 AND DISEASES OF THE OSEO METABOLISM
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
EP1206265B1 (en) * 1999-06-30 2003-11-12 Merck & Co., Inc. Src kinase inhibitor compounds
GB9919778D0 (en) * 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
KR100820605B1 (en) 1999-09-24 2008-04-08 얀센 파마슈티카 엔.브이. Antiviral composition
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
IL149402A0 (en) 1999-11-29 2002-11-10 Aventis Pharma Sa Arylamine derivatives and their use as anti-telomerase agent
TR200201431T2 (en) * 1999-11-30 2002-09-23 Pfizer Products Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
EP1343782B1 (en) * 2000-12-21 2009-05-06 SmithKline Beecham Corporation Pyrimidineamines as angiogenesis modulators
US20040171630A1 (en) * 2001-06-19 2004-09-02 Yuntae Kim Tyrosine kinase inhibitors

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