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AU2001277536A1 - 2-(1h-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity - Google Patents

2-(1h-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity

Info

Publication number
AU2001277536A1
AU2001277536A1 AU2001277536A AU7753601A AU2001277536A1 AU 2001277536 A1 AU2001277536 A1 AU 2001277536A1 AU 2001277536 A AU2001277536 A AU 2001277536A AU 7753601 A AU7753601 A AU 7753601A AU 2001277536 A1 AU2001277536 A1 AU 2001277536A1
Authority
AU
Australia
Prior art keywords
indol
oxo
acetic acid
acid amides
antitumor activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001277536A
Other languages
English (en)
Inventor
Ernesto Menta
Nicoletta Pescalli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novuspharma SpA
Original Assignee
Novuspharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma SpA filed Critical Novuspharma SpA
Publication of AU2001277536A1 publication Critical patent/AU2001277536A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2001277536A 2000-07-25 2001-07-12 2-(1h-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity Abandoned AU2001277536A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI200A001697 2000-07-25
IT2000MI001697A IT1318641B1 (it) 2000-07-25 2000-07-25 Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
PCT/EP2001/008075 WO2002008225A1 (fr) 2000-07-25 2001-07-12 Amides d'acide acetique 2-(1h-indol-3-yl)-2-oxo a activite antitumorale

Publications (1)

Publication Number Publication Date
AU2001277536A1 true AU2001277536A1 (en) 2002-02-05

Family

ID=11445559

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001277536A Abandoned AU2001277536A1 (en) 2000-07-25 2001-07-12 2-(1h-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity

Country Status (7)

Country Link
US (1) US6987122B2 (fr)
EP (1) EP1322646A1 (fr)
JP (1) JP2004504398A (fr)
AU (1) AU2001277536A1 (fr)
CA (1) CA2417189A1 (fr)
IT (1) IT1318641B1 (fr)
WO (1) WO2002008225A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
AU2002323474B2 (en) 2001-09-13 2006-10-05 Synta Pharmaceuticals Corp 3-glyoxlylamideindoles for treating cancer
US6903104B2 (en) 2001-12-06 2005-06-07 National Health Research Institutes Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
US20050049214A1 (en) * 2003-01-15 2005-03-03 Chiron Corporation Inhibition of E3-ubiquitin ligase HAKAI for treatment of proliferative disorders
US7205299B2 (en) * 2003-06-05 2007-04-17 Zentaris Gmbh Indole derivatives having an apoptosis-inducing effect
EP1484329A1 (fr) * 2003-06-06 2004-12-08 Zentaris GmbH Dérivés d'indole déstinés à l'induction d'apoptose
JP4878285B2 (ja) * 2003-06-05 2012-02-15 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング アポトーシス誘発作用を有するインドール誘導体
US7211588B2 (en) 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
WO2005023761A2 (fr) 2003-09-11 2005-03-17 Kemia, Inc. Inhibiteurs des cytokines
WO2008019357A2 (fr) 2006-08-07 2008-02-14 Ironwood Pharmaceuticals, Inc. Composés d'indole
CA2670778A1 (fr) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Utilisation de derives d'acide indolyl-3-glyoxylique comprenant de l'indibuline, seuls ou combines a d'autres agents, pour traiter le cancer
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
WO2013159095A1 (fr) * 2012-04-20 2013-10-24 Anderson Gaweco Modulateurs de ror et leurs utilisations
CN107021959A (zh) * 2017-05-02 2017-08-08 青岛科技大学 一类新型吲哚衍生物及其体外抗肿瘤活性

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192770A (en) * 1990-12-07 1993-03-09 Syntex (U.S.A.) Inc. Serotonergic alpha-oxoacetamides
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
AU4834200A (en) 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
IT1315267B1 (it) * 1999-12-23 2003-02-03 Novuspharma Spa Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale

Also Published As

Publication number Publication date
WO2002008225A1 (fr) 2002-01-31
US6987122B2 (en) 2006-01-17
US20040029858A1 (en) 2004-02-12
CA2417189A1 (fr) 2002-01-31
ITMI20001697A1 (it) 2002-01-25
ITMI20001697A0 (it) 2000-07-25
EP1322646A1 (fr) 2003-07-02
IT1318641B1 (it) 2003-08-27
JP2004504398A (ja) 2004-02-12

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