ATE384529T1 - Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen - Google Patents
Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungenInfo
- Publication number
- ATE384529T1 ATE384529T1 AT04723608T AT04723608T ATE384529T1 AT E384529 T1 ATE384529 T1 AT E384529T1 AT 04723608 T AT04723608 T AT 04723608T AT 04723608 T AT04723608 T AT 04723608T AT E384529 T1 ATE384529 T1 AT E384529T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- respiratory diseases
- active ingredients
- synergistic combination
- ingredients selected
- Prior art date
Links
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002586 roflumilast Drugs 0.000 title abstract 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 230000001078 anti-cholinergic effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 title 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 abstract 1
- 229960001888 ipratropium Drugs 0.000 abstract 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 abstract 1
- 229960000797 oxitropium Drugs 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03007104 | 2003-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE384529T1 true ATE384529T1 (de) | 2008-02-15 |
Family
ID=33040925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04723608T ATE384529T1 (de) | 2003-03-28 | 2004-03-26 | Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060147382A1 (de) |
| EP (1) | EP1610787B1 (de) |
| AT (1) | ATE384529T1 (de) |
| CA (1) | CA2519679C (de) |
| CY (1) | CY1110373T1 (de) |
| DE (1) | DE602004011494T2 (de) |
| DK (1) | DK1610787T3 (de) |
| ES (1) | ES2300755T3 (de) |
| MX (1) | MXPA05010160A (de) |
| PL (1) | PL1610787T3 (de) |
| PT (1) | PT1610787E (de) |
| SI (1) | SI1610787T1 (de) |
| WO (1) | WO2004084896A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| ME00524B (me) | 2003-03-10 | 2011-10-10 | Astrazeneca Ab | Novi postupak za dobijanje roflumilasta |
| US20050026887A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a steroid |
| DK1713471T3 (da) * | 2004-02-06 | 2012-05-14 | Meda Pharma Gmbh & Co Kg | Kombination af anticholinergika og inhibitorer af phosphodiesterase type 4 til behandling af respiratoriske sygdomme |
| PL1713473T3 (pl) * | 2004-02-06 | 2013-08-30 | Meda Pharma Gmbh & Co Kg | Kombinacja leków antycholinergicznych i glikokortykoidów do długotrwałego leczenia astmy i POChP |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| NZ551666A (en) * | 2004-05-31 | 2010-07-30 | Almirall Lab | Combinations comprising antimuscarinic agents and beta-adrenergic agonists |
| EP1861074B1 (de) * | 2005-03-16 | 2013-04-24 | Takeda GmbH | Geschmacksmaskierte dosierform von roflumilast |
| HUE027076T2 (en) * | 2005-03-16 | 2016-08-29 | Meda Pharma Gmbh & Co Kg | Combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases |
| US20060219242A1 (en) * | 2005-03-30 | 2006-10-05 | Boehringer Ingelheim International | Method for the Administration of an Anticholinergic by Inhalation |
| AU2006297037A1 (en) * | 2005-09-28 | 2007-04-05 | Merck Frosst Canada Ltd | Aerosol powder formulation comprising sieved lactose |
| ES2389231T3 (es) | 2005-12-21 | 2012-10-24 | Meda Pharma Gmbh & Co. Kg | Combinación de anticolinérgicos, glucocorticoides y agonistas de beta2 para el tratamiento de enfermedades inflamatorias |
| EP2100599A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2100598A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2510928A1 (de) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2234266T3 (es) * | 1998-07-24 | 2005-06-16 | Jago Research Ag | Formulaciones medicas para aerosoles. |
| US20020052312A1 (en) * | 2000-05-30 | 2002-05-02 | Reiss Theodore F. | Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists |
| US20020193393A1 (en) * | 2001-03-07 | 2002-12-19 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| DE10110772A1 (de) * | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| JP2004530705A (ja) * | 2001-05-25 | 2004-10-07 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 閉塞性気道疾患及びその他の炎症性疾患を治療するためのｐｄｅ４インヒビター及びチオトロピウム又はその誘導体の組み合わせ |
| KR20040007605A (ko) * | 2001-05-25 | 2004-01-24 | 화이자 인코포레이티드 | 폐색성 기도 질환을 치료하기 위한 ｐｄｅ4 억제제 및항콜린제의 복합물 |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| US20050107420A1 (en) * | 2002-05-23 | 2005-05-19 | Boehringe Ingelheim Pharma Gmbh & Co. Kg | Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases |
-
2004
- 2004-03-26 EP EP04723608A patent/EP1610787B1/de not_active Expired - Lifetime
- 2004-03-26 MX MXPA05010160A patent/MXPA05010160A/es active IP Right Grant
- 2004-03-26 US US10/550,192 patent/US20060147382A1/en not_active Abandoned
- 2004-03-26 DK DK04723608T patent/DK1610787T3/da active
- 2004-03-26 CA CA2519679A patent/CA2519679C/en not_active Expired - Fee Related
- 2004-03-26 ES ES04723608T patent/ES2300755T3/es not_active Expired - Lifetime
- 2004-03-26 AT AT04723608T patent/ATE384529T1/de active
- 2004-03-26 WO PCT/EP2004/050376 patent/WO2004084896A1/en not_active Ceased
- 2004-03-26 PL PL04723608T patent/PL1610787T3/pl unknown
- 2004-03-26 PT PT04723608T patent/PT1610787E/pt unknown
- 2004-03-26 DE DE602004011494T patent/DE602004011494T2/de not_active Expired - Lifetime
- 2004-03-26 SI SI200430665T patent/SI1610787T1/sl unknown
-
2008
- 2008-03-27 CY CY20081100350T patent/CY1110373T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004084896A1 (en) | 2004-10-07 |
| CA2519679A1 (en) | 2004-10-07 |
| DK1610787T3 (da) | 2008-06-02 |
| EP1610787B1 (de) | 2008-01-23 |
| EP1610787A1 (de) | 2006-01-04 |
| US20060147382A1 (en) | 2006-07-06 |
| DE602004011494T2 (de) | 2009-01-22 |
| ES2300755T3 (es) | 2008-06-16 |
| CY1110373T1 (el) | 2015-04-29 |
| PT1610787E (pt) | 2008-04-23 |
| SI1610787T1 (sl) | 2008-06-30 |
| CA2519679C (en) | 2012-08-28 |
| DE602004011494D1 (de) | 2008-03-13 |
| MXPA05010160A (es) | 2005-11-16 |
| PL1610787T3 (pl) | 2008-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1110373T1 (el) | Συνεργιστικος συνδυασμος που περιλαμβανει ροφλουμιλαστη και εναν αντιχολινεργικο παραγοντα που επιλεγεται απο αλατα τιοτροπιου για την θεραπεια αναπνευστικων ασθενειων | |
| MY140826A (en) | Substituted pyrazoline compounds, their preparation and use as medicaments. | |
| ATE548354T1 (de) | Ureido-substituierte benzoesäureverbindungen und ihre verwendung für die nonsense-suppression und behandlung von erkrankungen | |
| DE602005021770D1 (de) | Indol-1-yl-essigsäurederivate | |
| CY1108794T1 (el) | Σπειροκυκλικα παραγωγα κυκλοεξανιου | |
| UA85708C2 (ru) | Лекарственные комбинации, содержащие бензоксазины, для лечения заболеваний дыхательных путей | |
| GEP20084452B (en) | Sulfonamide derivatives for the treatment of diseases | |
| ATE412646T1 (de) | Zur behandlung von schmerzen geeignete therapeutische mittel | |
| TW200745043A (en) | Substituted pyrazoline compounds, their preparation and use as medicaments | |
| MY145647A (en) | (4-hydroxy-2-oxo-3h-benzothiazol-7-yl)ethylamine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy (for example in the treatment of respiratory disease states) | |
| TW200611695A (en) | Pyrrolopyridine derivatives | |
| DE60326069D1 (de) | 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen | |
| ATE526967T1 (de) | Medikamente für inhalationen enthaltend ein anticholinergikum und ein betamimetikum | |
| DK1651270T3 (da) | Medikamenter til inhalation omfattende betamimetika og et anticholinergikum | |
| MXPA05010161A (es) | Combinacion sinergistica que comprende roflumilast y un agente anticolinergico seleccionado a partir de sales de ipratropio, oxitropio y tiotropio para el tratamiento de enfermedades respiratorias. | |
| TW200738699A (en) | 4-Substituted pyrazoline compounds, their preparation and use as medicaments | |
| SE0002729D0 (sv) | Novel compound form | |
| MX2008008556A (es) | Derivados de triterpenoquinonas y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias. | |
| EA200900269A1 (ru) | Лекарственные комбинации для лечения заболеваний дыхательных путей | |
| MX2009005912A (es) | Derivados de etilamina-fenilo heterociclilo sustituidos, su preparacion y uso como medicamentos. | |
| MY146802A (en) | Novel drugs for treating respiratory diseases | |
| ATE344662T1 (de) | Mittel enthaltend n-chlortaurin sowie dessen verwendung zur behandlung von schleimhautpolypen | |
| TW200745042A (en) | Substituted pyrazoline compounds, their preparation and use as medicaments | |
| DE60310730D1 (de) | Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege | |
| ATE524180T1 (de) | Mittel zur prophylaxe oder behandlung von alkoholabhängigkeit oder drogenabhängigkeit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1610787 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner |