DK1610787T3 - Synergistisk kombination der omfatter roflumilast og et antikolinergt middel der er valgt blandt tiotropiumsalte til behandling af respiratoriske sygdomme - Google Patents
Synergistisk kombination der omfatter roflumilast og et antikolinergt middel der er valgt blandt tiotropiumsalte til behandling af respiratoriske sygdommeInfo
- Publication number
- DK1610787T3 DK1610787T3 DK04723608T DK04723608T DK1610787T3 DK 1610787 T3 DK1610787 T3 DK 1610787T3 DK 04723608 T DK04723608 T DK 04723608T DK 04723608 T DK04723608 T DK 04723608T DK 1610787 T3 DK1610787 T3 DK 1610787T3
- Authority
- DK
- Denmark
- Prior art keywords
- roflumilast
- treatment
- agent selected
- respiratory diseases
- anticholinergic agent
- Prior art date
Links
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title abstract 2
- 239000000812 cholinergic antagonist Substances 0.000 title abstract 2
- 208000023504 respiratory system disease Diseases 0.000 title abstract 2
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002586 roflumilast Drugs 0.000 title abstract 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title abstract 2
- 239000011885 synergistic combination Substances 0.000 title 1
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 abstract 1
- 229960001888 ipratropium Drugs 0.000 abstract 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 abstract 1
- 229960000797 oxitropium Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03007104 | 2003-03-28 | ||
| PCT/EP2004/050376 WO2004084896A1 (en) | 2003-03-28 | 2004-03-26 | Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1610787T3 true DK1610787T3 (da) | 2008-06-02 |
Family
ID=33040925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04723608T DK1610787T3 (da) | 2003-03-28 | 2004-03-26 | Synergistisk kombination der omfatter roflumilast og et antikolinergt middel der er valgt blandt tiotropiumsalte til behandling af respiratoriske sygdomme |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060147382A1 (da) |
| EP (1) | EP1610787B1 (da) |
| AT (1) | ATE384529T1 (da) |
| CA (1) | CA2519679C (da) |
| CY (1) | CY1110373T1 (da) |
| DE (1) | DE602004011494T2 (da) |
| DK (1) | DK1610787T3 (da) |
| ES (1) | ES2300755T3 (da) |
| MX (1) | MXPA05010160A (da) |
| PL (1) | PL1610787T3 (da) |
| PT (1) | PT1610787E (da) |
| SI (1) | SI1610787T1 (da) |
| WO (1) | WO2004084896A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| PL1606261T3 (pl) | 2003-03-10 | 2010-04-30 | Astrazeneca Ab | Nowy sposób przygotowania roflumilastu |
| US20050026887A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a steroid |
| PT1713473E (pt) * | 2004-02-06 | 2013-05-13 | Meda Pharma Gmbh & Co Kg | Combinação de anticolinérgicos e glucocorticóides para o tratamento a longo prazo de asma e copd |
| CN101518532A (zh) * | 2004-02-06 | 2009-09-02 | Meda制药有限及两合公司 | 用于呼吸道疾病治疗的抗胆碱能药和4型磷酸二酯酶抑制剂的组合 |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| AU2005247106B2 (en) * | 2004-05-31 | 2010-11-11 | Laboratorios Almirall, S.A. | Combinations comprising antimuscarinic agents and PDE4 inhibitors |
| CN101128196B (zh) * | 2005-03-16 | 2013-01-02 | Meda制药有限及两合公司 | 用于治疗呼吸系统疾病的抗胆碱能药和白三烯受体拮抗剂的组合 |
| WO2006097456A1 (en) * | 2005-03-16 | 2006-09-21 | Nycomed Gmbh | Taste masked dosage form containing roflumilast |
| US20060219242A1 (en) * | 2005-03-30 | 2006-10-05 | Boehringer Ingelheim International | Method for the Administration of an Anticholinergic by Inhalation |
| JP2009509980A (ja) * | 2005-09-28 | 2009-03-12 | メルク フロスト カナダ リミテツド | 篩分けされたラクトースを含むエアゾール粉末製剤 |
| NZ568349A (en) | 2005-12-21 | 2011-05-27 | Meda Pharma Gmbh & Co Kg | Combination of anticholinergics, glucocorticoids, beta2-agonists, PDE 4 inhibitor and antileukotriene for the treatment of inflammatory diseases |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59911149D1 (de) * | 1998-07-24 | 2004-12-30 | Jago Res Ag Muttenz | Medizinische aerosolformulierungen |
| US20020052312A1 (en) * | 2000-05-30 | 2002-05-02 | Reiss Theodore F. | Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists |
| DE10110772A1 (de) * | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| US20020193393A1 (en) * | 2001-03-07 | 2002-12-19 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| AU2002314102A1 (en) * | 2001-05-25 | 2002-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Combination of a pde4 inhibitor and tiotropium or derivate thereof for treating obstructive airways |
| EE200300585A (et) * | 2001-05-25 | 2004-04-15 | Pfizer Inc. | PDE4 inhibiitori ja antikolinergilise vahendi kombinatsioon obstruktiivsete hingamisteede haiguste raviks |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| US20050107420A1 (en) * | 2002-05-23 | 2005-05-19 | Boehringe Ingelheim Pharma Gmbh & Co. Kg | Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases |
-
2004
- 2004-03-26 EP EP04723608A patent/EP1610787B1/en not_active Expired - Lifetime
- 2004-03-26 ES ES04723608T patent/ES2300755T3/es not_active Expired - Lifetime
- 2004-03-26 WO PCT/EP2004/050376 patent/WO2004084896A1/en not_active Ceased
- 2004-03-26 PL PL04723608T patent/PL1610787T3/pl unknown
- 2004-03-26 AT AT04723608T patent/ATE384529T1/de active
- 2004-03-26 CA CA2519679A patent/CA2519679C/en not_active Expired - Fee Related
- 2004-03-26 MX MXPA05010160A patent/MXPA05010160A/es active IP Right Grant
- 2004-03-26 PT PT04723608T patent/PT1610787E/pt unknown
- 2004-03-26 US US10/550,192 patent/US20060147382A1/en not_active Abandoned
- 2004-03-26 DK DK04723608T patent/DK1610787T3/da active
- 2004-03-26 SI SI200430665T patent/SI1610787T1/sl unknown
- 2004-03-26 DE DE602004011494T patent/DE602004011494T2/de not_active Expired - Lifetime
-
2008
- 2008-03-27 CY CY20081100350T patent/CY1110373T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1610787T3 (pl) | 2008-07-31 |
| ATE384529T1 (de) | 2008-02-15 |
| US20060147382A1 (en) | 2006-07-06 |
| EP1610787B1 (en) | 2008-01-23 |
| CY1110373T1 (el) | 2015-04-29 |
| DE602004011494D1 (de) | 2008-03-13 |
| EP1610787A1 (en) | 2006-01-04 |
| CA2519679C (en) | 2012-08-28 |
| PT1610787E (pt) | 2008-04-23 |
| WO2004084896A1 (en) | 2004-10-07 |
| SI1610787T1 (sl) | 2008-06-30 |
| ES2300755T3 (es) | 2008-06-16 |
| CA2519679A1 (en) | 2004-10-07 |
| DE602004011494T2 (de) | 2009-01-22 |
| MXPA05010160A (es) | 2005-11-16 |
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