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AR240825A2 - Procedimiento para obtener compuestos de 7-(2-aminotiazol-4-il-acetamido-3(((1-(2-dimetil aminoetil)-1h-tetrazol-5-il)tio)metil)-cef-3-em-4-carboxilato y sus sales - Google Patents

Procedimiento para obtener compuestos de 7-(2-aminotiazol-4-il-acetamido-3(((1-(2-dimetil aminoetil)-1h-tetrazol-5-il)tio)metil)-cef-3-em-4-carboxilato y sus sales

Info

Publication number
AR240825A2
AR240825A2 AR29679484A AR29679484A AR240825A2 AR 240825 A2 AR240825 A2 AR 240825A2 AR 29679484 A AR29679484 A AR 29679484A AR 29679484 A AR29679484 A AR 29679484A AR 240825 A2 AR240825 A2 AR 240825A2
Authority
AR
Argentina
Prior art keywords
formula
production
trialquilo
ester derivatives
mono
Prior art date
Application number
AR29679484A
Other languages
English (en)
Other versions
AR240825A1 (es
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58099212A external-priority patent/JPS59225192A/ja
Priority claimed from JP59076834A external-priority patent/JPS60218394A/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of AR240825A2 publication Critical patent/AR240825A2/es
Publication of AR240825A1 publication Critical patent/AR240825A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE 7(2-AMINO-TIAZOL-4-IL)-ACETAMIDO-3-(((1-(2-DIMETILAMINO-ETIL)-1H-TETRAZOL-5-IL)TIO)-METIL)-CEF-3-EM-4-CARBOXILATO DE ALQUILO DE FORMULA (I), DONDE R1 ES UN ATOMO DE H O UN GRUPO ALQUILO; R2 ES UN GRUPO ALICLICO ELEGIDO ENTRE: CICLOALQUILO, METILO, BORNILO, ADAMANTILO, ENDO-3-NOR-BORNILO, FENCHILO, EXO-NOR-BORNILO, CICLOALQUILO, ALQUILO O MONO, DI O TRIALQUIL CICLOALQUILO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, QUE COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) O SUS SALES, CON UN COMPUESTO DE FORMULA (III), DONDE R1 Y R2 POSEEN LOS SIGNIFICADOS DADOS ANTERIORMENTE Y X ES HALOGENO.
AR296794A 1983-06-02 1984-05-30 Procedimiento para obtener compuestos de 7-(2-aminotiazol-4-il-acetamido-3(((1-(2-dimetil aminoetil)-1h-tetrazol-5-il)tio)metil)-cef-3-em-4-carboxilato y sus sales AR240825A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58099212A JPS59225192A (ja) 1983-06-02 1983-06-02 セフアロスポリンエステル誘導体
JP59076834A JPS60218394A (ja) 1984-04-16 1984-04-16 セフアロスポリンエステル誘導体

Publications (2)

Publication Number Publication Date
AR240825A2 true AR240825A2 (es) 1991-02-28
AR240825A1 AR240825A1 (es) 1991-02-28

Family

ID=26417948

Family Applications (2)

Application Number Title Priority Date Filing Date
AR296794A AR240825A1 (es) 1983-06-02 1984-05-30 Procedimiento para obtener compuestos de 7-(2-aminotiazol-4-il-acetamido-3(((1-(2-dimetil aminoetil)-1h-tetrazol-5-il)tio)metil)-cef-3-em-4-carboxilato y sus sales
AR87308151A AR245132A1 (es) 1983-06-02 1987-07-15 Un procedimiento para la produccion de compuestos de 7-(2-aminotiazol-4-il) acetamido-3-(((1-(2-dimetilaminoetil-1h-tetrazol-5-il)tio )metil)-cef-3-em-4-carboxilico

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR87308151A AR245132A1 (es) 1983-06-02 1987-07-15 Un procedimiento para la produccion de compuestos de 7-(2-aminotiazol-4-il) acetamido-3-(((1-(2-dimetilaminoetil-1h-tetrazol-5-il)tio )metil)-cef-3-em-4-carboxilico

Country Status (22)

Country Link
US (1) US5120841A (es)
EP (1) EP0128029B1 (es)
KR (1) KR910008350B1 (es)
AR (2) AR240825A1 (es)
AT (1) ATE40691T1 (es)
AU (1) AU566096B2 (es)
BG (1) BG60500B2 (es)
CA (1) CA1216285A (es)
DE (1) DE3476662D1 (es)
DK (1) DK273784A (es)
ES (4) ES8506577A1 (es)
FI (1) FI75574C (es)
GR (1) GR79941B (es)
HK (1) HK9492A (es)
HU (1) HU192028B (es)
IN (1) IN158586B (es)
MY (1) MY101993A (es)
NO (1) NO162470C (es)
NZ (1) NZ208281A (es)
PH (1) PH19575A (es)
PT (1) PT78684B (es)
SG (1) SG392G (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0010475D0 (en) * 2000-04-28 2000-06-14 Biochemie Gmbh Organic compounds
CN101993449B (zh) * 2009-08-13 2012-10-31 丽珠医药集团股份有限公司 高纯度头孢替安酯及其二盐酸盐的制备方法
CN102241692A (zh) * 2010-05-14 2011-11-16 广州白云山制药股份有限公司广州白云山制药总厂 溶媒结晶法制备头孢替安酯盐酸盐的方法
CN101948476B (zh) * 2010-09-19 2012-07-25 苏州致君万庆药业有限公司 一种头孢替安酯盐酸盐的制备方法
CN102424687A (zh) * 2011-11-01 2012-04-25 湖南方盛制药股份有限公司 盐酸头孢替安酯的制备方法
CN102898441A (zh) * 2012-10-11 2013-01-30 南通康鑫药业有限公司 一种头孢替安的合成方法
CN103012436B (zh) * 2012-12-04 2015-07-01 山东鑫泉医药有限公司 头孢替安盐酸盐的制备方法
CN104031068A (zh) * 2014-06-11 2014-09-10 济南诚汇双达化工有限公司 一锅法制备盐酸头孢替安酯的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
US4189479A (en) * 1977-12-22 1980-02-19 Takeda Chemical Industries, Ltd. Cephalosporin esters
DE2805794A1 (de) * 1978-02-11 1979-08-16 Hoechst Ag Vorrichtung zum biologischen reinigen von abwasser
JPS6042766B2 (ja) * 1978-12-09 1985-09-25 日本化薬株式会社 基剤
JPS5759894A (en) * 1980-09-30 1982-04-10 Sankyo Co Ltd Cephalosporin for oral administration
JPS58189186A (ja) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd セフアロスポリン誘導体
JPS5989691A (ja) * 1982-11-15 1984-05-23 Takeda Chem Ind Ltd セフアロスポリンエステル
US4616008A (en) * 1984-05-02 1986-10-07 Takeda Chemical Industries, Ltd. Antibacterial solid composition for oral administration

Also Published As

Publication number Publication date
IN158586B (es) 1986-12-13
HUT34505A (en) 1985-03-28
US5120841A (en) 1992-06-09
PT78684A (en) 1984-07-01
NZ208281A (en) 1986-11-12
AR245132A1 (es) 1993-12-30
KR850000455A (ko) 1985-02-27
NO162470C (no) 1990-01-10
FI75574B (fi) 1988-03-31
EP0128029A2 (en) 1984-12-12
CA1216285A (en) 1987-01-06
FI842210A0 (fi) 1984-06-01
AU2874884A (en) 1984-12-06
DE3476662D1 (en) 1989-03-16
EP0128029A3 (en) 1985-12-18
PT78684B (en) 1986-10-21
ES540839A0 (es) 1986-05-16
BG60500B2 (bg) 1995-05-31
GR79941B (es) 1984-10-31
EP0128029B1 (en) 1989-02-08
FI842210L (fi) 1984-12-03
ES8703480A1 (es) 1987-02-16
MY101993A (en) 1992-02-29
ES533051A0 (es) 1985-08-01
ATE40691T1 (de) 1989-02-15
ES549761A0 (es) 1987-02-16
ES8607317A1 (es) 1986-05-16
FI75574C (fi) 1988-07-11
ES8506577A1 (es) 1985-08-01
ES556838A0 (es) 1988-01-01
DK273784A (da) 1984-12-03
AU566096B2 (en) 1987-10-08
ES8801287A1 (es) 1988-01-01
PH19575A (en) 1986-05-26
NO162470B (no) 1989-09-25
KR910008350B1 (ko) 1991-10-12
SG392G (en) 1992-03-20
DK273784D0 (da) 1984-06-01
HU192028B (en) 1987-04-28
NO842224L (no) 1984-12-03
HK9492A (en) 1992-01-31
AR240825A1 (es) 1991-02-28

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