AR111786A1 - Composiciones de gemcabeno y su uso - Google Patents
Composiciones de gemcabeno y su usoInfo
- Publication number
- AR111786A1 AR111786A1 ARP180101242A ARP180101242A AR111786A1 AR 111786 A1 AR111786 A1 AR 111786A1 AR P180101242 A ARP180101242 A AR P180101242A AR P180101242 A ARP180101242 A AR P180101242A AR 111786 A1 AR111786 A1 AR 111786A1
- Authority
- AR
- Argentina
- Prior art keywords
- copolymer
- tablet
- core
- gemcabeno
- approximately
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 6
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical group COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 239000006186 oral dosage form Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical group CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical group CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical group COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract 1
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 abstract 1
- 229960000815 ezetimibe Drugs 0.000 abstract 1
- 125000005395 methacrylic acid group Chemical group 0.000 abstract 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Chemical group CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Un comprimido, caracterizado porque comprende: un núcleo, donde el núcleo comprende una estatina o una sal farmacéuticamente aceptable de la misma; y un recubrimiento externo, donde dicho recubrimiento externo comprende un primer copolímero o un segundo copolímero, el primer copolímero comprende unidades repetidas de acrilato de metilo, metacrilato de metilo y ácido metacrílico a una relación de (aproximadamente 7):(aproximadamente 3):(aproximadamente 1), y el segundo copolímero comprende unidades repetidas de ácido metacrílico y etilo acrilato a una relación de (aproximadamente 1):(aproximadamente 1), en donde el núcleo tiene una superficie exterior y en donde el recubrimiento externo está dispuesto sobre toda la superficie externa; y en donde la cantidad total del primer copolímero y el segundo copolímero varía en un rango entre aproximadamente 2% y aproximadamente 3% p/p del comprimido. Reivindicación 31: Una forma de dosificación oral, caracterizada porque comprende el comprimido de la reivindicación 1 y una composición que comprende otro agente farmacéuticamente activo. Reivindicación 32: La forma de dosificación oral de la reivindicación 31, caracterizada porque el otro agente farmacéuticamente activo es ezetimibe, gemcabeno o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762505085P | 2017-05-11 | 2017-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111786A1 true AR111786A1 (es) | 2019-08-21 |
Family
ID=64105018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180101242A AR111786A1 (es) | 2017-05-11 | 2018-05-11 | Composiciones de gemcabeno y su uso |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20190008779A1 (es) |
| AR (1) | AR111786A1 (es) |
| TW (1) | TW201906599A (es) |
| WO (1) | WO2018209257A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3986860A1 (en) | 2019-06-21 | 2022-04-27 | Esperion Therapeutics, Inc. | Salt forms of bempedoic acid and methods for using the same |
| TWI760067B (zh) * | 2020-08-13 | 2022-04-01 | 友霖生技醫藥股份有限公司 | 固態口服醫藥組成物 |
| WO2024030500A1 (en) * | 2022-08-02 | 2024-02-08 | Anna Gukovskaya | Compositions and methods for treating pancreatitis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500457B1 (en) * | 2000-08-14 | 2002-12-31 | Peirce Management, Llc | Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent |
| JPWO2002026056A1 (ja) * | 2000-09-28 | 2004-09-30 | 日本新薬株式会社 | 運動持久力を増強しうる食肉加工食品 |
| US6634243B1 (en) * | 2002-01-14 | 2003-10-21 | Rapid Medical Diagnostics Corporation | Sample testing device |
| DE10211289A1 (de) * | 2002-03-14 | 2003-09-25 | Basf Ag | Kombination von Polyvinylacetat von wasserunlöslichen, säureunlöslichen oder alkaliunlöslichen Polymeren zur Hestellung von Filmüberzügen mit sehr kontrollierter Freisetzung und hoher Stabilität |
| AU2003225027A1 (en) * | 2002-04-16 | 2003-11-03 | Merck And Co., Inc. | Combination therapy using a ppar alpha/gamma agonist |
| WO2008022932A2 (en) * | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Controlled release system and method for manufacturing the same |
| US9486446B2 (en) * | 2006-12-28 | 2016-11-08 | Takeda Pharmaceutical Company Limited | Orally disintegrating solid preparation |
| US8259984B2 (en) * | 2007-06-29 | 2012-09-04 | Sony Ericsson Mobile Communications Ab | Headset with on-ear detection |
| EP2171745A4 (en) * | 2007-07-19 | 2014-10-15 | California Inst Of Techn | STRUCTURES AND METHOD FOR FORMING VERTICALLY ORIENTED SI-WIRE ARRAYS |
| WO2009024889A2 (en) * | 2007-08-21 | 2009-02-26 | Ranbaxy Laboratories Limited | Pharmaceutical composition comprising a hmg-coa reductase inhibitor and ezetimibe |
| EP2230932B1 (en) * | 2008-01-10 | 2017-03-29 | Evonik Röhm GmbH | Coated pharmaceutical or nutraceutical preparation with enhanced active substance release in the colon |
| TR201005325A2 (tr) * | 2010-06-30 | 2012-01-23 | Bi̇lgi̇ç Mahmut | Atorvastatin ve aspirin içeren farmasötik formülasyonlar |
| PE20141115A1 (es) * | 2010-12-27 | 2014-09-12 | Takeda Pharmaceutical | Comprimido de desintegracion oral |
| DE102011120756B4 (de) * | 2011-12-05 | 2013-06-27 | Arman Emami | Grillgerät |
| CN104136023A (zh) * | 2012-01-06 | 2014-11-05 | 密执安生命治疗有限责任公司 | 降低心血管疾病风险的方法 |
-
2018
- 2018-05-11 US US15/977,226 patent/US20190008779A1/en not_active Abandoned
- 2018-05-11 AR ARP180101242A patent/AR111786A1/es unknown
- 2018-05-11 TW TW107116148A patent/TW201906599A/zh unknown
- 2018-05-11 WO PCT/US2018/032351 patent/WO2018209257A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20190008779A1 (en) | 2019-01-10 |
| WO2018209257A1 (en) | 2018-11-15 |
| TW201906599A (zh) | 2019-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |