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AR072086A1 - Compuestos triciclicos, metodos para su preparacion, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de las proteinas quinasas. - Google Patents

Compuestos triciclicos, metodos para su preparacion, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de las proteinas quinasas.

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Publication number
AR072086A1
AR072086A1 ARP090102084A ARP090102084A AR072086A1 AR 072086 A1 AR072086 A1 AR 072086A1 AR P090102084 A ARP090102084 A AR P090102084A AR P090102084 A ARP090102084 A AR P090102084A AR 072086 A1 AR072086 A1 AR 072086A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
heterocyclyl
heteroaryl
cycloalkyl
Prior art date
Application number
ARP090102084A
Other languages
English (en)
Inventor
Bryan A Fiamengo
Neil Wishart
David J Calderwood
Michael Friedman
Kent D Stewart
Dawn M George
Biqin C Li
Lu Wang
Eric R Goedken
Grier A Wallace
Kevin R Woller
Maria A Argiriadi
Kristine E Frank
Michael J Morytko
Anna M Ericsson
Nathan S Josephsohn
Jeffrey W Voss
Original Assignee
Abbott Lab
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41415363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR072086(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR072086A1 publication Critical patent/AR072086A1/es

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Abstract

Los compuestos de la presente son de utilidad para el tratamiento de condiciones inmunologicas, y oncologica. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1) sales farmaceuticamente aceptables, prodrogas, metabolitos biologicamente activos, estereoisomeros e isomeros del mismo donde T es N, U es N, X es CR3 e Y es N; o T es CR6, U es N, X es CR3 e Y es N; o T es N, U es CR4, X es CR3 e Y es N; o T es CR6, U es CR4, X es CR3 e Y es N; o T es CR6, U es N, X es NR3 e Y es C; o T es O, U es N, X es CR3 e Y es C; o T es NR6, U es N, X es CR3 e Y es C; o T es CR6, U es CR4, X es NR3 e Y es C; o T es S, U es N, X es CR3 e Y es C; R1 R2 y R5 son en forma independiente entre s¡ hidrogeno, deuterio, -N(Ra)(Rb), halogeno, -ORa, -SRa, -S(O)Ra, S(O)2Ra, -NO2, -C(O)ORa, -CN, -C(O)N(Ra)(Rb), -N(Ra)C(O)(Rb), -C(O)Ra, -C(OH)RaRb, -N(Ra)S(O)2-Rb, -S(O)2N(Ra)(Rb), -CF3, -OCF3, alquilo C1-6 opcionalmente sustituido, alquenilo C2-6 opcionalmente sustituido, alquinilo C2-6 opcionalmente sustituido, cicloalquilo C3-10 opcionalmente sustituido, heteroarilo C1-10 opcionalmente sustituido, heterociclilo C1-10 opcionalmente sustituido, o arilo C6-10 opcionalmente sustituido; donde en una unidad que contiene N(Ra)(Rb), el nitrogeno, Ra y Rb pueden formar un anillo de manera que -N(Ra)(Rb) representa un heterociclilo C2-10 opcionalmente sustituido o heteroarilo C1-10 opcionalmente sustituido unido a traves de un nitrogeno; R3 es hidrogeno, un cicloalquilo C5-12 en puente opcionalmente sustituido, heterociclilo C2-10 en puente opcionalmente sustituido, alquilo C1-8 opcionalmente sustituido, cicloalquilo C3-10 opcionalmente sustituido, cicloalquenilo C3-8 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, heteroarilo C1-10 opcionalmente sustituido, heterociclilo C2-10 opcionalmente sustituido; o R3 es -A-D-E-G, donde: A es un enlace, -C(O)-, alquileno C1-6 opcionalmente sustituido, alquenileno C2-6 opcionalmente sustituido, alquinileno C2-6 opcionalmente sustituido, cicloalquileno C3-12 opcionalmente sustituido, heterociclileno C2-6 opcionalmente sustituido, -C(O)N(Ra)Re-, N(Ra)C(O)-Re-, -O-Re-, N(Ra)-Re, -S-Re, -S(O)2-Re-, -S(O)Re, -C(O-Ra)(Rb)-Re-, -S(O)2N(Ra)-Re-, -N(Ra)S(O)2-Re o -N(Ra)C(O)N(Rb)-Re-; D es un alquileno C1-8 opcionalmente sustituido, cicloalquileno C5-12 en puente opcionalmente sustituido, cicloalquileno C3-10 opcionalmente sustituido, cicloalquenileno C5-10 en puente opcionalmente sustituido, cicloalquenileno C3-10 opcionalmente sustituido, arileno C6-10 opcionalmente sustituido, heteroarileno C1-10 opcionalmente sustituido, heterociclileno C2-10 en puente opcionalmente sustituido o un heterociclileno C2-10 opcionalmente sustituido; E es un enlace, -Re-, -Re-C(O)-Re-, -Re-C(O)C(O)-Re, -Re-C(O)O-Re-, -Re-C(O)C(O)N(Ra)-Re, -Re-N(Ra)-C(O)C(O)-Re-, -Re-O-Re-, -Re-S(O)2-Re-, -Re-S(O)-Re-, -Re-S-Re-, -Re-N(Ra)-Re-, -Re-N(Ra)C(O)-Re-, -ReC(O)N(Ra)Re-, -Re-OC(O)N(Ra)-Re, -Re-N(Ra)C(O)ORe-, -Re-OC(O)-Re, -Re-N(Ra)C(O)N(Rb)-Re-, -Re-N(Ra)S(O)2-Re-, o -Re-S(O)2N(Ra)-Re-; o E es como en formula 2, donde en todos los casos, E est  unido a un  tomo de carbono o nitrogeno en D; G es hidrogeno, deuterio, -N(Ra)(Rb), halogeno, -ORa, -SRa, -S(O)Ra, -S(O)2Ra, -NO2, -C(O)ORa, -CN, -C(O)N(Ra)(Rb), -N(Ra)C(O)Rb, - N(Ra)C(O)ORb, -OC(O)N(Ra), -N(Ra)C(O)N(Rb)2, -C(O-Ra)(Rb)2, -C(O)Ra; -CF3, -OCF3, -N(Ra)S(O)2Rb, -S(O)2N(Ra)(Rb), -S(O)2N(Ra)C(O)Rb, un alquilo C1-6 opcionalmente sustituido, alquenilo C2-6 opcionalmente sustituido, alquinilo C2-6 opcionalmente sustituido, cicloalquilo C3-10 opcionalmente sustituido, heteroarilo C1-10 opcionalmente sustituido, heterociclilo C1-10 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, alquil C1-6-cicloalquilo C3-10 opcionalmente sustituido, alquil C1-6-arilo C6-10 opcionalmente sustituido, alquil C1-6-heteroarilo C1-10 opcionalmente sustituido, o un alquil C1-6-heterociclilo C1-10opcionalmente sustituido; donde en una unidad que contiene N(Ra)(Rb), el nitrogeno, Ra y Rb pueden formar un anillo de manera que -N(Ra)(Rb) representa un heterociclilo C2-10 opcionalmente sustituido o un heteroarilo C1-10opcionalmente sustituido unido a traves de un nitrogeno; R4 y R6 son en forma independiente entre si un hidrogeno, halogeno, deuterio, un grupo cicloalquilo C5-12 en puente opcionalmente sustituido, heterociclilo C2-10 en puente opcionalmente sustituido, alquilo C1-8 opcionalmente sustituido, cicloalquilo C3-10 opcionalmente sustituido, cicloalquenilo C3-8 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, heteroarilo C1-10 opcionalmente sustituido, heterociclilo C2-10 opcionalmente sustituido o -J-L-M-Q; donde: J es un enlace, -C(O)-, alquileno C1-6 opcionalmente sustituido, alquenileno C2-6 opcionalmente sustituido, alquinileno C2-6 opcionalmente sustituido, cicloalquileno C3-12 opcionalmente sustituido, heterociclileno C2-6 opcionalmente sustituido, -C(O)N(Ra)-Re-, -N(Ra)C(O)-Re-, -O-Re, N(Ra)-Re, -S-Re-, -S(O)2-Re-, -S(O)Re-, -C(O-Ra)(Rb)-Re-, -S(O)2N(Ra)- Re-, -N(Ra)S(O)2-Re o -N(Ra)C(O)N(Rb)-Re-; L es un enlace, un alquileno C1-8 opcionalmente sustituido, cicloalquileno C5-12 en puente opcionalmente sustituido, cicloalquileno C3-10 opcionalmente sustituido, cicloalquenileno C5-10 en puente opcionalmente sustituido, cicloalquenileno C3-10 opcionalmente sustituido, arileno C6-10 opcionalmente sustituido, heteroarileno C1-10 opcionalmente sustituido, heterociclileno C2-10 en puente opcionalmente sustituido o un heterociclileno C2-10 opcionalmente sustituido; M es un enlace, -Re-, -Re-C(O)-Re-, -Re-C(O)C(O)-Re, -Re-C(O)O-Re-, -Re-OC(O)-Re-, -Re-C(O)C(O)N(Ra)-Re, -Re-N(Ra)-C(O)C(O)-Re-, -Re-O-Re-, -Re-S(O)2-Re-, -Re-S(O)-Re-, -Re-S-Re-, -Re-N(Ra)-Re-, -Re-N(Ra)C(O)-Re-, -Re-C(O)N(Ra)Re-, -Re-OC(O)N(Ra)-Re, -Re-N(Ra)C(O)ORe-, -Re-N(Ra)C(O)n(Rb)-Re, -Re-N(Ra)S(O)2-Re-, o -Re-S(O)2N(Ra)-Re-; o M es como en formula 2, donde en todos los casos, M est  unido a un  tomo de carbono o nitrogeno en L; Q es hidrogeno, deuterio, -N(Ra)(Rb), halogeno, -ORa, -SRa, -S(O)Ra, -S(O)2Ra, -NO2, -C(O)ORa, -CN, -C(O)N(Ra)(Rb), -N(Ra)C(O)Rb, -N(Ra)C(O)ORb, -N(Ra)C(O)N(Rb)2, -C(O-Ra)(Rb)2, -C(O)Ra; -CF3, -OCF3, -N(Ra)S(O)2Rb, -S(O)2N(Ra)(Rb), -S(O)2N(Ra)C(O)Rb, un alquilo C1-6 opcionalmente sustituido, alquenilo C2-6 opcionalmente sustituido, alquinilo C2-6 opcionalmente sustituido, cicloalquilo C3-10 opcionalmente sustituido, heteroarilo C1-10 opcionalmente sustituido, heterociclilo C1-10 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, alquil C1-6-cicloalquilo C3-10 opcionalmente sustituido, alquil C1-6-arilo C6-10 opcionalmente sustituido, alquil C1-6-heteroarilo C1-10 opcionalmente sustituido, o un alquil C1-6-heterociclilo C1-10 opcionalmente sustituido; donde en una unidad que contiene -N(Ra)(Rb), el nitrogeno, Ra y Rb pueden formar un anillo de manera que -N(Ra)(Rb) representa un heterociclilo C2-10 opcionalmente sustituido o un heteroarilo C1-10 opcionalmente sustituido unido a traves de un nitrogeno; Ra y Rb son en forma independiente entre s¡ hidrogeno, deuterio, un alquilo C1-10 opcionalmente sustituido, alquenilo C2-10 opcionalmente sustituido, un alquinilo C2-10 opcionalmente sustituido, alquil C1-10-O-alquilo C1-10 opcionalmente sustituido, cicloalquilo C3-10 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, heteroarilo C1-10 opcionalmente sustituido, heterociclilo C1-10 opcionalmente sustituido, un alquilen C1-6-cicloalquilo C3-10 opcionalmente sustituido, alquilen C1-6-arilo C6-10 opcionalmente sustituido, alquilen C1-6-heteroarilo C1-10 opcionalmente sustituido, o alquilen C1-6-heterociclilo C1-10 opcionalmente sustituido; y Re en cada instancia es en forma independiente un enlace, un alquileno C1-10 opcionalmente sustituido, alquenileno C2-10 opcionalmente sustituido, alquinileno C2-10 opcionalmente sustituido, un grupo alquilen C1-10-O-alquileno C1-10 opcionalmente sustituido, cicloalquileno C3-10 opcionalmente sustituido, arileno C6-10 opcionalmente sustituido, heteroarileno C1-10 opcionalmente sustituido, o un heterociclileno C1-10 opcionalmente sustituido; con la condicion de que cuando el compuesto es como en formula (4), R3 es como se ha definido y R6 no est  unido al anillo pirazol por medio de un  tomo de nitrogeno u ox¡geno; y con la condicion de que cuando el compuesto es como en formula (5) cuando R3 es H, CH3 o -C(O)OH entonces R4 no es H, -C(O)OCH2CH3, -C(O)NH-fenilo opcionalmente sustituido, -NHC(O)-fenilo opcionalmente sustituido o -S(O)2-fenilo.
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