[go: up one dir, main page]

AR078856A1 - Composiciones locales de emulsion anestesica y metodos para la fabricacion y utilizacion de las mismas - Google Patents

Composiciones locales de emulsion anestesica y metodos para la fabricacion y utilizacion de las mismas

Info

Publication number
AR078856A1
AR078856A1 ARP100104027A ARP100104027A AR078856A1 AR 078856 A1 AR078856 A1 AR 078856A1 AR P100104027 A ARP100104027 A AR P100104027A AR P100104027 A ARP100104027 A AR P100104027A AR 078856 A1 AR078856 A1 AR 078856A1
Authority
AR
Argentina
Prior art keywords
local anesthetic
anesthetic emulsion
manufacture
methods
composition according
Prior art date
Application number
ARP100104027A
Other languages
English (en)
Original Assignee
Teikoku Pharma Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Pharma Usa Inc filed Critical Teikoku Pharma Usa Inc
Publication of AR078856A1 publication Critical patent/AR078856A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan composiciones locales de emulsion anestésica. Las composiciones locales de emulsion anestésica pueden incluir: una fase oleosa que comprende una mezcla eutéctica de un anestésico local y una amida acíclica; un surfactante; y una fase acuosa. También se proporcionan métodos para la fabricacion y utilizacion de las emulsiones. Reivindicacion 2: La composicion de emulsion anestésica local de acuerdo con la reivindicacion 1, en donde el anestésico local se selecciona del grupo que consta de: benzocaína, bupivacaína, butanilicaína, dibucaína, etidocaína, lidocaína, mepivacaína y, prilocaína, tetracaína y trimecaína, y sus mezclas. Reivindicacion 4: La composicion de emulsion anestésica local de acuerdo con la reivindicacion 1, en donde la amida acíclica se describe mediante la formula: R2-C*(R1)(R2)(CONHR') en donde: R1, R2 y R3 son cada uno alquilo C1-5; y R' es alquilo C1-5, hidroxialquilo C1-8 o alquilcarboxialquilo de hasta 8 átomos de carbono. Reivindicacion 14: Uso de una composicion de emulsion anestésica local de acuerdo con cualquiera de las reivindicaciones 1 a 13, para la preparacion de un medicamento para el tratamiento de neuralgia post-herpética.
ARP100104027A 2010-04-21 2010-11-01 Composiciones locales de emulsion anestesica y metodos para la fabricacion y utilizacion de las mismas AR078856A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32661310P 2010-04-21 2010-04-21

Publications (1)

Publication Number Publication Date
AR078856A1 true AR078856A1 (es) 2011-12-07

Family

ID=44816318

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104027A AR078856A1 (es) 2010-04-21 2010-11-01 Composiciones locales de emulsion anestesica y metodos para la fabricacion y utilizacion de las mismas

Country Status (9)

Country Link
US (1) US8535692B2 (es)
EP (1) EP2560626A4 (es)
JP (1) JP2013532119A (es)
KR (1) KR20120118495A (es)
CN (1) CN102844022A (es)
AR (1) AR078856A1 (es)
AU (1) AU2010351562B2 (es)
TW (1) TW201136615A (es)
WO (1) WO2011133177A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9642912B2 (en) 2006-03-06 2017-05-09 Crescita Therapeutics Inc. Topical formulations for treating skin conditions
US9308181B2 (en) 2006-03-06 2016-04-12 Nuvo Research Inc. Topical formulations, systems and methods
US8637577B2 (en) 2009-01-22 2014-01-28 Absorption Pharmaceuticals, LLC Desensitizing drug product
CN106166159A (zh) * 2016-07-11 2016-11-30 孙剑 一种复方注射麻醉剂
CN106109468A (zh) * 2016-07-11 2016-11-16 孙剑 一种女性发育期注射麻醉剂
CN106038487A (zh) * 2016-07-11 2016-10-26 孙剑 一种孕妇静脉注射乳液麻醉剂
CN107789628B (zh) * 2016-12-29 2021-07-23 天津键凯科技有限公司 一种聚乙二醇和局部麻醉药的结合物在非麻醉镇痛中的应用
FR3085848B1 (fr) * 2018-09-17 2020-09-18 Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic Composition pharmaceutique a usage topique comprenant au moins une substance anesthesiante locale

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338779C (en) 1989-03-17 1996-12-10 Harry Hind Method for treating pain associated with herpes-zoster and post-herpetic neuralgia by topical application of local anesthetics
US6113921A (en) * 1993-03-23 2000-09-05 Pharmos Corp. Topical and transdermal delivery system utilizing submicron oil spheres
US5658583A (en) 1995-07-28 1997-08-19 Zhang; Jie Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
SE9601421D0 (sv) * 1996-04-12 1996-04-12 Astra Ab New composition
DK0981330T3 (da) * 1997-05-14 2002-12-02 Galen Chemicals Ltd Topiske præparater
US5993836A (en) 1998-04-28 1999-11-30 Castillo; James G. Topical anesthetic formulation
WO2000049994A1 (en) * 1999-02-23 2000-08-31 Den-Mat Corporation An aqueous non-alcoholic oral rinse containing benzocaine and carbomer
US6299902B1 (en) * 1999-05-19 2001-10-09 The University Of Georgia Research Foundation, Inc. Enhanced transdermal anesthesia of local anesthetic agents
US6528086B2 (en) 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US20020006435A1 (en) * 2000-01-27 2002-01-17 Samuels Paul J. Transdermal anesthetic and vasodilator composition and methods for topical administration
US6391886B1 (en) * 2000-12-04 2002-05-21 The Procter & Gamble Company Oral compositions having improved consumer aesthetics
AU2003212962A1 (en) * 2002-02-07 2003-09-02 Massachusetts Institute Of Technology Transdermal drug delivery systems
IL152486A0 (en) * 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
ES2541488T3 (es) * 2003-08-25 2015-07-21 Foamix Pharmaceuticals Ltd. Espuma farmacéutica penetrante
CN101102748A (zh) * 2004-12-23 2008-01-09 麦克内尔-Ppc股份有限公司 具有感觉提示剂的在口中分裂的药物组合物
JP5117196B2 (ja) * 2005-01-04 2013-01-09 テイコク ファーマ ユーエスエー インコーポレーテッド 冷却局所用貼付製剤
MX2008000486A (es) * 2005-10-24 2008-03-07 Teikoku Pharma Usa Inc Composiciones topicas para el alivio del dolor de n-2,3-trimetil-2-isopropilbutamida y metodos para usar las mismas.

Also Published As

Publication number Publication date
EP2560626A1 (en) 2013-02-27
JP2013532119A (ja) 2013-08-15
KR20120118495A (ko) 2012-10-26
TW201136615A (en) 2011-11-01
US20110263715A1 (en) 2011-10-27
AU2010351562B2 (en) 2013-10-10
WO2011133177A1 (en) 2011-10-27
US8535692B2 (en) 2013-09-17
AU2010351562A1 (en) 2012-09-20
EP2560626A4 (en) 2013-09-18
CN102844022A (zh) 2012-12-26

Similar Documents

Publication Publication Date Title
AR078856A1 (es) Composiciones locales de emulsion anestesica y metodos para la fabricacion y utilizacion de las mismas
PE20160608A1 (es) Compuestos de quinolina selectivamente sustituida
PE20080611A1 (es) Compuestos de azabenzofuranil y metodos de uso
CO6680699A2 (es) Derivados de amina para el control de plagas
MX382569B (es) Compuesto de carboxamida, sulfonamida y amina para trastornos metabolicos.
PE20091561A1 (es) Compuestos inhibidores de raf y metodos para su uso
PE20151794A1 (es) Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y metodos de uso
AR068512A1 (es) Derivados de 4-aril-1h-piridin-2-onas disustituidas, composiciones farmaceuticas que las contienen y usos de las mismas para tratar o prevenir trastornos del sistema nervioso central
EA201591429A1 (ru) 2,3-дизамещенные производные 1-ацил-4-амино-1,2,3,4-тетрагидрохинолинов и их применение в качестве ингибиторов бромодомена
AR085128A1 (es) Composicion de acido hialuronico
AR081385A1 (es) Composiciones metodo y uso
RU2014122033A (ru) Соединения с нематоцидной активностью
EA201690019A1 (ru) Производное аминотриазина и содержащая его фармацевтическая композиция
EP2797881A4 (en) PHENYL ALKYL CARBAMATE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREWITH
CL2012000999A1 (es) Compuestos derivados de pirazoloespirocetona sustituida, inhibidores de acetil-coa carboxilasa; composicion farmaceutica que los comprende; uso para tratar o retrasar la progresion o el inicio de diabetes tipo 2, higado graso no alcoholico (hgna) o la resistencia hepatica a la insulina.
PE20140011A1 (es) Compuestos y composiciones novedosos para la inhibicion de nampt
AR078201A1 (es) Compuestos de 2-piridona y su uso en el tratamiento de enfermedades mediadas por la elastasa de neutrofilos
PE20142081A1 (es) Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodo de uso de los mismos
PE20081395A1 (es) Derivados de aril sulfamida y metodos para su uso
CO6580196A1 (es) Nuevos co- cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
EA201690135A1 (ru) Трициклические соединения бензоксаборола и их применение
AR065464A1 (es) Derivados de nicotinamida. composiciones farmaceuticas
MY194004A (en) 4 -substituted benzoxaborole compounds and uses thereof
RU2010115337A (ru) Трициклические гетероциклические производные
AR091687A1 (es) Formas solidas de inhibidores de fosfodiesterasa tipo 5

Legal Events

Date Code Title Description
FB Suspension of granting procedure