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CN106166159A - 一种复方注射麻醉剂 - Google Patents

一种复方注射麻醉剂 Download PDF

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Publication number
CN106166159A
CN106166159A CN201610539604.2A CN201610539604A CN106166159A CN 106166159 A CN106166159 A CN 106166159A CN 201610539604 A CN201610539604 A CN 201610539604A CN 106166159 A CN106166159 A CN 106166159A
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China
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component
compound injection
anesthetis
injection anesthetis
etomidate
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孙剑
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种复方注射麻醉剂，其包括：组分A:

Description

一种复方注射麻醉剂
技术领域
本发明涉及一种复方注射麻醉剂。
背景技术
麻醉药是医学手术中必不可少的药物，通常分为全身麻醉药和局部麻醉药，而全身麻醉药深入抑制大脑皮层，使人神志消失。传统使用的全身麻醉药由乙醚和含氟化合物，但该类药物储存要求较高，易发生光解、热解，稳定性差，存放不当即存在杂质，影响麻醉效果，甚至导致麻醉安全事故。因此迫切需要开发一种用于稳定麻醉剂高效、无毒副作用、无杂质、存放。
发明内容
本发明的目的是提供一种存放稳定，无杂质产生，使用安全、高效、无毒副作用的复方注射麻醉剂。
本发明的技术方案是：一种复方注射麻醉剂，其包括：
组分A:;
式中：R1为2至5个由3至6元环缩合而成的缩合的多环烃基团；
组分B：山梨糖醇酐脂肪酸酯；
组分C：依托咪酯;
组分D：甲哌卡因;
组分E：[2-(8，9-二氧代-2，6-二氮杂双环[5.2.0]壬-1-(7)-烯-2-基)乙基]膦酸。
2、根据权利要求1所述的一种复方注射麻醉剂，其特征是：所述组分A:B:C:D:E质量比=2：1：5：30：3。
采用该化合物制备麻醉药，可避免在生产、储存、运输中分解产生杂质，影响麻醉安全，提高使用安全性。
具体实施方式
1、一种复方注射麻醉剂，其包括：
组分A:;
式中：R1为2至5个由3至6元环缩合而成的缩合的多环烃基团；
组分B：山梨糖醇酐脂肪酸酯；
组分C：依托咪酯;
组分D：甲哌卡因;
组分E：[2-(8，9-二氧代-2，6-二氮杂双环[5.2.0]壬-1-(7)-烯-2-基)乙基]膦酸。
组分A:B:C:D:E质量比=2：1：5：30：3。

Claims (2)

1.一种复方注射麻醉剂，其包括：
组分A:;
式中：R1为2至5个由3至6元环缩合而成的缩合的多环烃基团；
组分B：山梨糖醇酐脂肪酸酯；
组分C：依托咪酯;
组分D：甲哌卡因;
组分E：[2-(8，9-二氧代-2，6-二氮杂双环[5.2.0]壬-1-(7)-烯-2-基)乙基]膦酸。
2.根据权利要求1所述的一种复方注射麻醉剂，其特征是：所述组分A:B:C:D:E质量比=2：1：5：30：3。
CN201610539604.2A 2016-07-11 2016-07-11 一种复方注射麻醉剂 Pending CN106166159A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610539604.2A CN106166159A (zh) 2016-07-11 2016-07-11 一种复方注射麻醉剂

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610539604.2A CN106166159A (zh) 2016-07-11 2016-07-11 一种复方注射麻醉剂

Publications (1)

Publication Number Publication Date
CN106166159A true CN106166159A (zh) 2016-11-30

Family

ID=58064690

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610539604.2A Pending CN106166159A (zh) 2016-07-11 2016-07-11 一种复方注射麻醉剂

Country Status (1)

Country Link
CN (1) CN106166159A (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050077497A1 (en) * 2003-10-08 2005-04-14 David Anderson Stabilized uncoated particles of reversed liquid crystalline phase materials
CN101765582A (zh) * 2007-04-26 2010-06-30 奥斯拜客斯制药有限公司 氘标记的氯胺酮
CN101896205A (zh) * 2007-08-27 2010-11-24 惠氏有限责任公司 使用nmda拮抗剂用于获得麻醉剂节约效果的组合物和方法
CN102844022A (zh) * 2010-04-21 2012-12-26 帝国制药美国公司 局部麻醉剂乳液组合物及其制造和使用方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050077497A1 (en) * 2003-10-08 2005-04-14 David Anderson Stabilized uncoated particles of reversed liquid crystalline phase materials
CN101765582A (zh) * 2007-04-26 2010-06-30 奥斯拜客斯制药有限公司 氘标记的氯胺酮
CN101896205A (zh) * 2007-08-27 2010-11-24 惠氏有限责任公司 使用nmda拮抗剂用于获得麻醉剂节约效果的组合物和方法
CN102844022A (zh) * 2010-04-21 2012-12-26 帝国制药美国公司 局部麻醉剂乳液组合物及其制造和使用方法

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