AR062896A1 - Derivados de pirrolizina, indolizina y quinolizina su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de pirrolizina, indolizina y quinolizina su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR062896A1 AR062896A1 ARP070104135A ARP070104135A AR062896A1 AR 062896 A1 AR062896 A1 AR 062896A1 AR P070104135 A ARP070104135 A AR P070104135A AR P070104135 A ARP070104135 A AR P070104135A AR 062896 A1 AR062896 A1 AR 062896A1
- Authority
- AR
- Argentina
- Prior art keywords
- quinolizina
- pirrolizina
- indolizina
- therapeutics
- derivatives
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- -1 pyridine- 3-yl Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Abstract
Compuesto que responde a la formula general en (1) en la que m y n representan cada uno el numero 1 o 2, Ar representa un grupo elegido entre los grupos fenilo, naftilo-1, naftilo-2, piridin-2-ilo, piridin-3-ilo, piridin-4-ilo, furan-2-ilo, furan-3- ilo, tien-2-ilo, tien-3-ilo, tiazol-2-ilo y oxazol-2-ilo, pudiendo estar este grupo Ar sustituido opcionalmente; R representa bien un átomo de hidrogeno, bien uno o varios sustituyentes idénticos o diferentes el uno del otro elegidos entre los átomos de halogenos y los grupos mono o polifluoroalquilo C1-6 y mono o polifluoroalquiloxi C1-6, alquilos C1-6 lineales, C3-7 ramificados o cíclicos, cicloalquil C3-7-alquilo C1-6-alcoxi C1-6, cicloalquiloxi C3-7, cicloalquil C3-7-alquiloxi C1-6, alquiltio C1-6, ciano, amino, fenilo, acetilo, benzoilo, alquilsulfonilo C1-6, carboxi, alcoxicarbonilo C1-6 y pentafluorosulfanilo. Aplicacion en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0608348A FR2906251B1 (fr) | 2006-09-22 | 2006-09-22 | Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062896A1 true AR062896A1 (es) | 2008-12-10 |
Family
ID=37897398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104135A AR062896A1 (es) | 2006-09-22 | 2007-09-19 | Derivados de pirrolizina, indolizina y quinolizina su preparacion y su aplicacion en terapeutica |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7776880B2 (es) |
| EP (1) | EP2077837A2 (es) |
| JP (1) | JP2010504311A (es) |
| KR (1) | KR20090080947A (es) |
| CN (1) | CN101573113A (es) |
| AR (1) | AR062896A1 (es) |
| AU (1) | AU2007301880A1 (es) |
| BR (1) | BRPI0717100A2 (es) |
| CA (1) | CA2663080A1 (es) |
| CL (1) | CL2007002732A1 (es) |
| CO (1) | CO6160309A2 (es) |
| CR (1) | CR10658A (es) |
| EA (1) | EA015974B1 (es) |
| FR (1) | FR2906251B1 (es) |
| GT (1) | GT200900061A (es) |
| HN (1) | HN2009000504A (es) |
| IL (1) | IL197500A0 (es) |
| MA (1) | MA30790B1 (es) |
| ME (1) | MEP10109A (es) |
| MX (1) | MX2009003083A (es) |
| NO (1) | NO20091351L (es) |
| NZ (1) | NZ575573A (es) |
| PE (1) | PE20081376A1 (es) |
| SV (1) | SV2009003191A (es) |
| TN (1) | TN2009000082A1 (es) |
| TW (1) | TW200819455A (es) |
| UY (1) | UY30604A1 (es) |
| WO (1) | WO2008037881A2 (es) |
| ZA (1) | ZA200901850B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2842804B1 (fr) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861074B1 (fr) * | 2003-10-17 | 2006-04-07 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| CN102405222A (zh) * | 2009-01-28 | 2012-04-04 | 阿斯利康(瑞典)有限公司 | 2-氮杂-二环[2.2.1]庚烷化合物及其用途 |
| AR075182A1 (es) * | 2009-01-28 | 2011-03-16 | Astrazeneca Ab | Compuestos 2-aza-biciclo (2.2.2) octano y sus usos |
| US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| US8143273B2 (en) * | 2010-06-22 | 2012-03-27 | Hoffman-La Roche Inc. | Quinolizidine and indolizidine derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3801636A (en) * | 1971-08-13 | 1974-04-02 | Abbott Lab | 3,4,5-tri-substituted cinnamides |
| US4409225A (en) * | 1981-03-16 | 1983-10-11 | Beecham Group Limited | Substituted benzamides |
| EP0603220A1 (en) * | 1991-09-12 | 1994-06-29 | Smithkline Beecham Plc | Azabicyclic compounds as 5-ht 4? receptor antagonists |
| CZ284456B6 (cs) | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| US20030013733A1 (en) * | 2000-09-22 | 2003-01-16 | Richard Apodaca | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine |
| FR2861073B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
-
2006
- 2006-09-22 FR FR0608348A patent/FR2906251B1/fr not_active Expired - Fee Related
-
2007
- 2007-09-13 TW TW096134256A patent/TW200819455A/zh unknown
- 2007-09-19 AR ARP070104135A patent/AR062896A1/es unknown
- 2007-09-20 PE PE2007001267A patent/PE20081376A1/es not_active Application Discontinuation
- 2007-09-21 MX MX2009003083A patent/MX2009003083A/es active IP Right Grant
- 2007-09-21 CN CNA2007800392487A patent/CN101573113A/zh active Pending
- 2007-09-21 ME MEP-101/09A patent/MEP10109A/xx unknown
- 2007-09-21 EA EA200970312A patent/EA015974B1/ru not_active IP Right Cessation
- 2007-09-21 WO PCT/FR2007/001545 patent/WO2008037881A2/fr not_active Ceased
- 2007-09-21 CA CA002663080A patent/CA2663080A1/fr not_active Abandoned
- 2007-09-21 EP EP07848274A patent/EP2077837A2/fr not_active Withdrawn
- 2007-09-21 NZ NZ575573A patent/NZ575573A/en not_active IP Right Cessation
- 2007-09-21 JP JP2009528756A patent/JP2010504311A/ja not_active Withdrawn
- 2007-09-21 KR KR1020097008124A patent/KR20090080947A/ko not_active Withdrawn
- 2007-09-21 ZA ZA200901850A patent/ZA200901850B/xx unknown
- 2007-09-21 CL CL200702732A patent/CL2007002732A1/es unknown
- 2007-09-21 AU AU2007301880A patent/AU2007301880A1/en not_active Abandoned
- 2007-09-21 UY UY30604A patent/UY30604A1/es not_active Application Discontinuation
- 2007-09-21 BR BRPI0717100-5A patent/BRPI0717100A2/pt not_active IP Right Cessation
-
2009
- 2009-03-09 IL IL197500A patent/IL197500A0/en unknown
- 2009-03-10 TN TN2009000082A patent/TN2009000082A1/fr unknown
- 2009-03-11 CR CR10658A patent/CR10658A/es not_active Application Discontinuation
- 2009-03-16 GT GT200900061A patent/GT200900061A/es unknown
- 2009-03-18 HN HN2009000504A patent/HN2009000504A/es unknown
- 2009-03-19 US US12/407,276 patent/US7776880B2/en not_active Expired - Fee Related
- 2009-03-19 SV SV2009003191A patent/SV2009003191A/es active IP Right Grant
- 2009-03-19 CO CO09028765A patent/CO6160309A2/es unknown
- 2009-04-01 NO NO20091351A patent/NO20091351L/no not_active Application Discontinuation
- 2009-04-16 MA MA31786A patent/MA30790B1/fr unknown
-
2010
- 2010-06-30 US US12/827,614 patent/US20100267766A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TN2009000082A1 (en) | 2010-08-19 |
| US20090258899A1 (en) | 2009-10-15 |
| IL197500A0 (en) | 2009-12-24 |
| EP2077837A2 (fr) | 2009-07-15 |
| MX2009003083A (es) | 2009-04-02 |
| TW200819455A (en) | 2008-05-01 |
| KR20090080947A (ko) | 2009-07-27 |
| CR10658A (es) | 2009-06-24 |
| SV2009003191A (es) | 2009-10-27 |
| NO20091351L (no) | 2009-06-22 |
| NZ575573A (en) | 2011-12-22 |
| FR2906251A1 (fr) | 2008-03-28 |
| WO2008037881A3 (fr) | 2008-05-22 |
| JP2010504311A (ja) | 2010-02-12 |
| US20100267766A1 (en) | 2010-10-21 |
| US7776880B2 (en) | 2010-08-17 |
| ZA200901850B (en) | 2010-06-30 |
| MEP10109A (en) | 2011-12-20 |
| PE20081376A1 (es) | 2008-11-07 |
| CO6160309A2 (es) | 2010-05-20 |
| UY30604A1 (es) | 2008-05-02 |
| AU2007301880A1 (en) | 2008-04-03 |
| EA200970312A1 (ru) | 2009-12-30 |
| CL2007002732A1 (es) | 2008-04-18 |
| CA2663080A1 (fr) | 2008-04-03 |
| GT200900061A (es) | 2010-06-21 |
| WO2008037881A2 (fr) | 2008-04-03 |
| EA015974B1 (ru) | 2012-01-30 |
| CN101573113A (zh) | 2009-11-04 |
| MA30790B1 (fr) | 2009-10-01 |
| HN2009000504A (es) | 2011-10-20 |
| BRPI0717100A2 (pt) | 2013-10-15 |
| FR2906251B1 (fr) | 2008-11-07 |
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