AR071653A1 - Derivados 2-fenil-4-ciclopropil-pirimidina - Google Patents
Derivados 2-fenil-4-ciclopropil-pirimidinaInfo
- Publication number
- AR071653A1 AR071653A1 ARP090101256A ARP090101256A AR071653A1 AR 071653 A1 AR071653 A1 AR 071653A1 AR P090101256 A ARP090101256 A AR P090101256A AR P090101256 A ARP090101256 A AR P090101256A AR 071653 A1 AR071653 A1 AR 071653A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyrimidine
- compound
- derivatives
- conditions
- ciclopropil
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- VVSVMCMSJARUID-UHFFFAOYSA-N 4-cyclopropyl-2-phenylpyrimidine Chemical class C1CC1C1=CC=NC(C=2C=CC=CC=2)=N1 VVSVMCMSJARUID-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se relaciona con derivados 2-fenil-4-ciclopropil-pirimidina y su uso como antagonistas del receptor P2Y12 en el tratamiento y/o en la prevencion de enfermedades o afecciones vasculares perifericas, de enfermedades o afecciones vasculares -viscerales, -hep ticas y -renales, cardiovasculares y cerebrovasculares asociadas con la agregacion de plaquetas, incluyendo trombosis en humanos y en otros mam¡feros. Reivindicacion 1: Un compuesto de formula (1) en el cual R1 representa fenilo opcionalmente substituido una vez con halogeno, metilo, metoxilo, trifluorometilo o trifluorometoxilo; y R2 representa hidrogeno, hidroximetilo o alcoximetilo; o una sal de un tal compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008051389 | 2008-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071653A1 true AR071653A1 (es) | 2010-07-07 |
Family
ID=40790423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101256A AR071653A1 (es) | 2008-04-11 | 2009-04-08 | Derivados 2-fenil-4-ciclopropil-pirimidina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8466156B2 (es) |
| EP (1) | EP2283011B1 (es) |
| JP (1) | JP5374578B2 (es) |
| KR (1) | KR101610417B1 (es) |
| CN (1) | CN101998953B (es) |
| AR (1) | AR071653A1 (es) |
| AT (1) | ATE534634T1 (es) |
| AU (1) | AU2009235123A1 (es) |
| CA (1) | CA2719569C (es) |
| ES (1) | ES2376820T3 (es) |
| IL (1) | IL208548A0 (es) |
| MA (1) | MA32277B1 (es) |
| MX (1) | MX2010010932A (es) |
| NZ (1) | NZ589169A (es) |
| TW (1) | TW200944516A (es) |
| WO (1) | WO2009125365A1 (es) |
| ZA (1) | ZA201008052B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
| CN101868469B (zh) * | 2007-11-29 | 2014-04-02 | 埃科特莱茵药品有限公司 | 膦酸衍生物及其作为p2y12受体拮抗剂 |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| MA33260B1 (fr) | 2009-04-08 | 2012-05-02 | Actelion Pharmaceuticals Ltd | 6-(3-azabicyclo[3.1.0.]hex-3-yl)-2-phenylpyrimidines |
| SG175297A1 (en) | 2009-04-22 | 2011-12-29 | Actelion Pharmaceuticals Ltd | Thiazole derivatives and their use as p2y12 receptor antagonists |
| WO2013033178A1 (en) | 2011-08-30 | 2013-03-07 | University Of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
| PT3515924T (pt) | 2016-09-22 | 2022-03-11 | Idorsia Pharmaceuticals Ltd | Formas cristalinas |
| US11179390B2 (en) | 2017-03-15 | 2021-11-23 | Idorsia Pharmaceuticals Ltd | Subcutaneous administration of a P2Y12 receptor antagonist |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2020437A1 (en) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Cinnamamide derivative |
| JPH05303586A (ja) | 1992-04-07 | 1993-11-16 | Nec Corp | 高精度連立一次方程式解析装置 |
| DE60022508T2 (de) | 1999-06-14 | 2006-06-08 | Eli Lilly And Co., Indianapolis | Inhibitoren von serin proteasen |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| ES2348942T3 (es) | 2002-12-11 | 2010-12-17 | Bayer Schering Pharma Aktiengesellschaft | Compuestos de 2-aminocarbonil-quinolina como antagonistas del receptor plaquetario de adenosin difosfato. |
| CA2521313A1 (en) | 2003-04-09 | 2004-10-28 | Wyeth | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists |
| TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| WO2007046075A1 (en) | 2005-10-21 | 2007-04-26 | Actelion Pharmaceuticals Ltd | Piperazine derivatives as antimalarial agents |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
| MX2009011089A (es) | 2007-04-23 | 2009-10-30 | Sanofi Aventis | Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12. |
| CN101868469B (zh) | 2007-11-29 | 2014-04-02 | 埃科特莱茵药品有限公司 | 膦酸衍生物及其作为p2y12受体拮抗剂 |
| WO2009080226A2 (en) | 2007-12-26 | 2009-07-02 | Sanofis-Aventis | Heterocyclic pyrazole-carboxamides as p2y12 antagonists |
| WO2009080227A2 (en) | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Pyrazole-carboxamide derivatives as p2y12 antagonists |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| MA33260B1 (fr) | 2009-04-08 | 2012-05-02 | Actelion Pharmaceuticals Ltd | 6-(3-azabicyclo[3.1.0.]hex-3-yl)-2-phenylpyrimidines |
| SG175297A1 (en) | 2009-04-22 | 2011-12-29 | Actelion Pharmaceuticals Ltd | Thiazole derivatives and their use as p2y12 receptor antagonists |
-
2009
- 2009-04-08 AR ARP090101256A patent/AR071653A1/es unknown
- 2009-04-09 WO PCT/IB2009/051498 patent/WO2009125365A1/en not_active Ceased
- 2009-04-09 NZ NZ589169A patent/NZ589169A/en not_active IP Right Cessation
- 2009-04-09 AT AT09730987T patent/ATE534634T1/de active
- 2009-04-09 AU AU2009235123A patent/AU2009235123A1/en not_active Abandoned
- 2009-04-09 ES ES09730987T patent/ES2376820T3/es active Active
- 2009-04-09 CA CA2719569A patent/CA2719569C/en active Active
- 2009-04-09 KR KR1020107024690A patent/KR101610417B1/ko not_active Expired - Fee Related
- 2009-04-09 EP EP09730987A patent/EP2283011B1/en active Active
- 2009-04-09 JP JP2011503537A patent/JP5374578B2/ja not_active Expired - Fee Related
- 2009-04-09 US US12/936,664 patent/US8466156B2/en not_active Expired - Fee Related
- 2009-04-09 CN CN200980112591.9A patent/CN101998953B/zh not_active Expired - Fee Related
- 2009-04-09 MX MX2010010932A patent/MX2010010932A/es unknown
- 2009-04-10 TW TW098112082A patent/TW200944516A/zh unknown
-
2010
- 2010-10-07 IL IL208548A patent/IL208548A0/en unknown
- 2010-11-01 MA MA33296A patent/MA32277B1/fr unknown
- 2010-11-10 ZA ZA2010/08052A patent/ZA201008052B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101610417B1 (ko) | 2016-04-07 |
| CN101998953B (zh) | 2014-12-17 |
| MX2010010932A (es) | 2010-11-05 |
| CA2719569C (en) | 2016-06-07 |
| TW200944516A (en) | 2009-11-01 |
| NZ589169A (en) | 2012-06-29 |
| EP2283011A1 (en) | 2011-02-16 |
| CA2719569A1 (en) | 2009-10-15 |
| IL208548A0 (en) | 2010-12-30 |
| ES2376820T3 (es) | 2012-03-20 |
| EP2283011B1 (en) | 2011-11-23 |
| KR20100132541A (ko) | 2010-12-17 |
| CN101998953A (zh) | 2011-03-30 |
| AU2009235123A1 (en) | 2009-10-15 |
| US8466156B2 (en) | 2013-06-18 |
| WO2009125365A1 (en) | 2009-10-15 |
| JP5374578B2 (ja) | 2013-12-25 |
| ZA201008052B (en) | 2012-04-25 |
| MA32277B1 (fr) | 2011-05-02 |
| JP2011516539A (ja) | 2011-05-26 |
| US20110028484A1 (en) | 2011-02-03 |
| ATE534634T1 (de) | 2011-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |