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AR061992A1 - Mejoras referidas a nanodispersiones - Google Patents

Mejoras referidas a nanodispersiones

Info

Publication number
AR061992A1
AR061992A1 ARP070103118A ARP070103118A AR061992A1 AR 061992 A1 AR061992 A1 AR 061992A1 AR P070103118 A ARP070103118 A AR P070103118A AR P070103118 A ARP070103118 A AR P070103118A AR 061992 A1 AR061992 A1 AR 061992A1
Authority
AR
Argentina
Prior art keywords
soluble
solvent
carrier material
nanodispersions
mixture
Prior art date
Application number
ARP070103118A
Other languages
English (en)
Inventor
Long James
Jayne Foster Alison
John Duncalf David
Wang Dong
Paul Rannard Steven
Angus Doris
James Elphick Andrew
Original Assignee
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nv filed Critical Unilever Nv
Publication of AR061992A1 publication Critical patent/AR061992A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)

Abstract

Procedimiento para preparar nanodispersiones solubles en forma contraria de materiales a lo sumo levemente solubles en un material portador soluble, que comprende las siguientes etapas: (i) proporcionar una mezcla de una única fase de: d) un solvente o una mezcla de solventes miscibles, e) al menos un material portador soluble en un solvente (a), y dicho material portador también es soluble en forma contraria al material de carga (c) y sólido a temperatura ambiente, f) al menos un material de carga que es soluble en el solvente (a), y (ii) secar la mezcla para remover el solvente (a) y, de este modo, obtener el material portador (b) en forma sólida con la carga (c) allí dispersa como nanopartículas.
ARP070103118A 2006-07-13 2007-07-13 Mejoras referidas a nanodispersiones AR061992A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0613925.7A GB0613925D0 (en) 2006-07-13 2006-07-13 Improvements relating to nanodispersions

Publications (1)

Publication Number Publication Date
AR061992A1 true AR061992A1 (es) 2008-08-10

Family

ID=36955583

Family Applications (4)

Application Number Title Priority Date Filing Date
ARP070103118A AR061992A1 (es) 2006-07-13 2007-07-13 Mejoras referidas a nanodispersiones
ARP070103117A AR061991A1 (es) 2006-07-13 2007-07-13 Mejoras relacionadas a composiciones biocidas
ARP070103116A AR061990A1 (es) 2006-07-13 2007-07-13 Mejoras relacionadas a composiciones antiparasitarias
ARP100102205A AR077195A2 (es) 2006-07-13 2010-06-23 Mejoras relacionadas a composiciones biocidas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ARP070103117A AR061991A1 (es) 2006-07-13 2007-07-13 Mejoras relacionadas a composiciones biocidas
ARP070103116A AR061990A1 (es) 2006-07-13 2007-07-13 Mejoras relacionadas a composiciones antiparasitarias
ARP100102205A AR077195A2 (es) 2006-07-13 2010-06-23 Mejoras relacionadas a composiciones biocidas

Country Status (17)

Country Link
US (10) US9060937B2 (es)
EP (8) EP2040681B1 (es)
JP (9) JP2009542760A (es)
CN (11) CN101489535A (es)
AP (1) AP2008004713A0 (es)
AR (4) AR061992A1 (es)
AU (9) AU2007271829B2 (es)
BR (8) BRPI0714179A2 (es)
CA (8) CA2659666A1 (es)
CL (4) CL2007002031A1 (es)
ES (2) ES2741124T3 (es)
GB (1) GB0613925D0 (es)
IL (2) IL195911A0 (es)
MX (2) MX2009000309A (es)
TW (1) TW200812694A (es)
WO (8) WO2008006716A2 (es)
ZA (7) ZA200900030B (es)

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ZA200900029B (en) 2010-04-28
AU2007271828A1 (en) 2008-01-17
CN101489532A (zh) 2009-07-22
AP2008004713A0 (en) 2008-12-31
US20100015233A1 (en) 2010-01-21
WO2008007152A2 (en) 2008-01-17
AU2010201900A1 (en) 2010-06-03
AU2007271829A1 (en) 2008-01-17
CA2657586A1 (en) 2008-01-17
US20090175953A1 (en) 2009-07-09
AU2007271831A1 (en) 2008-01-17
CN101516342A (zh) 2009-08-26
WO2008006714A3 (en) 2008-02-21
BRPI0714353A2 (pt) 2013-05-07
CA2656233A1 (en) 2008-01-17
CN101489534A (zh) 2009-07-22
WO2008006714A2 (en) 2008-01-17
JP2009542763A (ja) 2009-12-03
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AU2007271828B2 (en) 2010-12-02
CA2656223A1 (en) 2008-01-17
US20100015229A1 (en) 2010-01-21
ZA200900027B (en) 2010-04-28
BRPI0714176A2 (pt) 2012-12-25
CN101489531A (zh) 2009-07-22
CL2010000516A1 (es) 2010-10-15
AR061991A1 (es) 2008-08-10
BRPI0714351A2 (pt) 2013-03-19
EP2269581A1 (en) 2011-01-05
WO2008006716A2 (en) 2008-01-17
US20120135058A1 (en) 2012-05-31
CN101489535A (zh) 2009-07-22
MX2009000307A (es) 2009-01-26
ZA200900028B (en) 2010-04-28
WO2008007150A1 (en) 2008-01-17
WO2008007152A3 (en) 2008-03-06
WO2008006712A2 (en) 2008-01-17
AU2007271830A1 (en) 2008-01-17
AR061990A1 (es) 2008-08-10
US20120134940A1 (en) 2012-05-31
AU2007274039A1 (en) 2008-01-17
EP2040677A2 (en) 2009-04-01
EP2040680B1 (en) 2019-08-07
CL2007002032A1 (es) 2008-01-18
CA2656217A1 (en) 2008-01-17
CN101849911A (zh) 2010-10-06
IL195933A (en) 2013-06-27
WO2008006715A2 (en) 2008-01-17
CN102631874A (zh) 2012-08-15
AU2007271830B2 (en) 2010-11-11
IL195911A0 (en) 2009-09-01
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EP2040681B1 (en) 2017-08-09
WO2008006715A3 (en) 2008-05-08
ZA200900345B (en) 2010-05-26
WO2008006712A3 (en) 2009-02-26
AU2007274040A1 (en) 2008-01-17
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JP2009542760A (ja) 2009-12-03
US20100068282A1 (en) 2010-03-18
AU2007271829B2 (en) 2011-10-27
US8945626B2 (en) 2015-02-03
EP2387992A1 (en) 2011-11-23
BRPI0714177A2 (pt) 2011-05-03
WO2008006716A3 (en) 2008-03-13
CA2659666A1 (en) 2008-01-17
CL2007002031A1 (es) 2008-01-18
BRPI0722376A2 (pt) 2012-05-22
JP2009542761A (ja) 2009-12-03
JP2009542795A (ja) 2009-12-03
JP2009542794A (ja) 2009-12-03
MX2009000309A (es) 2009-01-26
JP2010202665A (ja) 2010-09-16
EP2040678A2 (en) 2009-04-01
JP2009542762A (ja) 2009-12-03
EP2386292A1 (en) 2011-11-16
EP2040680A2 (en) 2009-04-01
EP2040677B1 (en) 2019-05-08
AU2007274041A1 (en) 2008-01-17
US20090304806A1 (en) 2009-12-10
IL195933A0 (en) 2009-09-01
CN101516341A (zh) 2009-08-26
ES2741124T3 (es) 2020-02-10
CA2656229C (en) 2014-05-27
CN102671585A (zh) 2012-09-19
TW200812694A (en) 2008-03-16
WO2008007151A2 (en) 2008-01-17
EP2040679A2 (en) 2009-04-01
ZA200900347B (en) 2010-04-28
ZA200900030B (en) 2010-04-28
US20100008995A1 (en) 2010-01-14
BRPI0714352A2 (pt) 2013-03-19
WO2008006713A3 (en) 2008-07-31
AU2007271827A1 (en) 2008-01-17
AU2007271827B2 (en) 2010-10-14
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US7691873B2 (en) 2010-04-06

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