EP2170313A2 - Aqueous formulations of acetaminophen for injection - Google Patents
Aqueous formulations of acetaminophen for injectionInfo
- Publication number
- EP2170313A2 EP2170313A2 EP08837144A EP08837144A EP2170313A2 EP 2170313 A2 EP2170313 A2 EP 2170313A2 EP 08837144 A EP08837144 A EP 08837144A EP 08837144 A EP08837144 A EP 08837144A EP 2170313 A2 EP2170313 A2 EP 2170313A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- approximately
- acetaminophen
- injection
- aqueous formulation
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims abstract description 74
- 229960005489 paracetamol Drugs 0.000 title claims abstract description 37
- 239000013011 aqueous formulation Substances 0.000 title claims abstract description 28
- 238000002347 injection Methods 0.000 title claims abstract description 15
- 239000007924 injection Substances 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000008215 water for injection Substances 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims description 7
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 7
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 7
- 229940069328 povidone Drugs 0.000 claims description 7
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 7
- 208000002193 Pain Diseases 0.000 claims description 6
- 230000036407 pain Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000012298 atmosphere Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000011261 inert gas Substances 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003635 deoxygenating effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000006207 intravenous dosage form Substances 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- the invention relates to novel stable aqueous formulations of acetaminophen for injection as well as processes for preparing and using the same.
- Acetaminophen also known as paracetamol, is a common analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics.
- U.S. Pat. No. 6,028,222 describes aqueous formulations of acetaminophen containing a buffering agent and a free radical antagonist and/or a free radical scavenger which need to be bubbled with an inert gas through the aqueous solvent in order to remove oxygen from the medium and maintain the stability of acetaminophen.
- U.S. Pat. No. 6,992,218 B2 relates to aqueous formulations with an active principle susceptible to oxidation, for example acetaminophen, wherein the essential means for stabilizing them is deoxygenating by bubbling with an inert gas and/or placing under vacuum until the oxygen content is below 2 ppm.
- the invention relates to novel stable aqueous formulations of acetaminophen for injection as well as processes for preparing and using the same.
- the invention provides new, stable, aqueous acetaminophen formulations.
- the invention relates to a new stable, aqueous acetaminophen formulation that includes: a. approximately 200.0 mg to approximately 1,400.0 mg of acetaminophen; b. approximately 200.0 mg to approximately 10,000.0 mg of mannitol for injection; c. approximately 0.0 mg to approximately 30.0 mg of monobasic sodium phosphate; d. approximately 0.0 mg to approximately 300.0 mg of povidone; e. a sufficient amount of sodium hydroxide (as needed) is added to adjust the pH between approximately 4.0 and approximately 8.0; f. a sufficient amount of hydrochloric acid (as needed) is added to adjust the pH between approximately 4.0 and approximately 8.0; and g. an injection volume of water for injection up to a volume of approximately 100 mL.
- the invention includes a new stable, aqueous composition that includes acetaminophen having the following composition: a. approximately 1,000.0 mg of acetaminophen; b. approximately 3,750.0 mg of mannitol for injection; c. approximately 13.0 mg of monobasic sodium phosphate; d. approximately 100.0 mg of povidone; e. a sufficient amount of sodium hydroxide is added to adjust the pH until approximately 5.5; f. a sufficient amount of hydrochloric acid is added to adjust the pH until approximately 5.5; and g. an injection volume of water for injection up to a volume of approximately 10O mL.
- acetaminophen having the following composition: a. approximately 1,000.0 mg of acetaminophen; b. approximately 3,750.0 mg of mannitol for injection; c. approximately 13.0 mg of monobasic sodium phosphate; d. approximately 100.0 mg of povidone; e. a sufficient amount of sodium hydroxide is added to adjust the pH
- Another embodiment of the invention provides a process for preparing the above- described aqueous composition that includes the following steps: a. adding monobasic sodium phosphate, povidone, mannitol for injection and acetaminophen in a volume of water for injection to form the aqueous formulation; b. if necessary, adding sodium hydroxide or hydrochloric acid to adjust the pH of the aqueous formulation between approximately 4.0 and approximately
- bottles is meant to convey glass or plastic containers or any other materials suitable for containing the aqueous formulations of acetaminophen described herein.
- the invention further includes the use of the aqueous pharmaceutical formulations of acetaminophen according to the invention for the treatment of pain.
- the invention further includes the use of the aqueous pharmaceutical formulations of acetaminophen for the treatment of pain after surgery and treatment of short period of fever when intravenous administration is justified or when others routes of administration are not possible.
- EXAMPLE 1 Aqueous solution of acetaminophen
- Table 1 illustrates a formulation of an aqueous acetaminophen solution with the following constituents:
- the aqueous acetaminophen formulation of Table 1 was prepared by dissolving 13.0 mg of monobasic sodium phosphate, 100.0 mg of povidone, 3,750.0 mg of mannitol for injection and 1,000.0 mg of acetaminophen in 80 mL of water for injection. Then, the pH is checked, and if necessary was adjusted until 5.5 by adding sodium hydroxide or hydrochloric acid. The solution was adjusted to 100 mL by the addition of water for injection. Next, he solution was filtered and filled into a 100 mL bottle. The bottle was then closed under a nitrogen atmosphere and sterilized.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to novel stable aqueous formulations of acetaminophen for injection as well as processes for preparing and using the same.
Description
AQUEOUS FORMULATIONS OF ACETAMINOPHEN FOR INJECTION CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority to United States Provisional Application
No. 60/929, 192, filed June 18, 2007, which application is expressly incorporated herein by reference in its entirety.
BACKGROUNP OF THE INVENTION
1. Field of the Invention
[0002] The invention relates to novel stable aqueous formulations of acetaminophen for injection as well as processes for preparing and using the same.
2. Discussion of the Related Art
[0003] Acetaminophen, also known as paracetamol, is a common analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics.
[0004] It has been known for many years the poor stability of acetaminophen in aqueous solutions and its inadequate solubility. Acetaminophen forms undesired degradation products by reaction with the oxygen in the air or with the oxygen dissolved in the aqueous solution. The rate of decomposition is accelerated as the temperature is increased and upon exposure to light. The stability is also a function of the solution's pH.
[0005] The instability of acetaminophen in aqueous solutions and the specific regulatory requirements to assure the safety, efficacy and quality of pharmaceutical drugs have prevented the development of intravenous dosage forms in comparison with tablet and suppository forms.
[0006] U.S. Pat. No. 6,028,222 describes aqueous formulations of acetaminophen containing a buffering agent and a free radical antagonist and/or a free radical scavenger which need to be bubbled with an inert gas through the aqueous solvent in order to remove oxygen from the medium and maintain the stability of acetaminophen.
[0007J U.S. Pat. No. 6,992,218 B2 relates to aqueous formulations with an active principle susceptible to oxidation, for example acetaminophen, wherein the essential means for stabilizing them is deoxygenating by bubbling with an inert gas and/or placing under vacuum until the oxygen content is below 2 ppm.
[0008] Thus, there is thus still a need for acetaminophen aqueous formulations, free of any organic solvent, which are stable at ambient and room temperature and avoids removing the dissolved oxygen by bubbling an inert gas and/or placing under vacuum. The fact of not having to bubble an inert gas and/or to applying vacuum is traduced to an improved manufacturing process that requires less steps and therefore less cost.
SUMMARY OF THE INVENTION
[0009] The invention relates to novel stable aqueous formulations of acetaminophen for injection as well as processes for preparing and using the same.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0010] Reference will now be made in detail to the preferred embodiments of the invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In addition, and as will be appreciated by one of skill in the art, the invention may be embodied as a method, system or process.
[0011] The invention provides new, stable, aqueous acetaminophen formulations.
[0012] In one aspect, the invention relates to a new stable, aqueous acetaminophen formulation that includes: a. approximately 200.0 mg to approximately 1,400.0 mg of acetaminophen; b. approximately 200.0 mg to approximately 10,000.0 mg of mannitol for injection; c. approximately 0.0 mg to approximately 30.0 mg of monobasic sodium phosphate; d. approximately 0.0 mg to approximately 300.0 mg of povidone;
e. a sufficient amount of sodium hydroxide (as needed) is added to adjust the pH between approximately 4.0 and approximately 8.0; f. a sufficient amount of hydrochloric acid (as needed) is added to adjust the pH between approximately 4.0 and approximately 8.0; and g. an injection volume of water for injection up to a volume of approximately 100 mL.
[0013] In another aspect, the invention includes a new stable, aqueous composition that includes acetaminophen having the following composition: a. approximately 1,000.0 mg of acetaminophen; b. approximately 3,750.0 mg of mannitol for injection; c. approximately 13.0 mg of monobasic sodium phosphate; d. approximately 100.0 mg of povidone; e. a sufficient amount of sodium hydroxide is added to adjust the pH until approximately 5.5; f. a sufficient amount of hydrochloric acid is added to adjust the pH until approximately 5.5; and g. an injection volume of water for injection up to a volume of approximately 10O mL.
[0014] Another embodiment of the invention provides a process for preparing the above- described aqueous composition that includes the following steps: a. adding monobasic sodium phosphate, povidone, mannitol for injection and acetaminophen in a volume of water for injection to form the aqueous formulation; b. if necessary, adding sodium hydroxide or hydrochloric acid to adjust the pH of the aqueous formulation between approximately 4.0 and approximately
8.0; c. adjusting the final volume of he aqueous formulation by adding additional water for injection;
d. filtering the aqueous formulation; e. filling the aqueous formulation into bottles; f. closing the bottles containing the aqueous formulation under an inert (e.g., nitrogen) atmosphere; and g. sterilizing the bottle containing the aqueous formulation.
[0015] It should be understood that the word "bottles" is meant to convey glass or plastic containers or any other materials suitable for containing the aqueous formulations of acetaminophen described herein.
[0016] The invention further includes the use of the aqueous pharmaceutical formulations of acetaminophen according to the invention for the treatment of pain. In particular, the invention further includes the use of the aqueous pharmaceutical formulations of acetaminophen for the treatment of pain after surgery and treatment of short period of fever when intravenous administration is justified or when others routes of administration are not possible.
[0017] It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention and specific examples provided herein without departing from the spirit or scope of the invention. Thus, it is intended that the present invention covers the modifications and variations of this invention that come within the scope of any claims and their equivalents.
[0018] The following example is for illustrative purposes only and is not intended, nor should it be interpreted, to limit the scope of the invention.
[0019] EXAMPLE 1: Aqueous solution of acetaminophen
[0020] Table 1 illustrates a formulation of an aqueous acetaminophen solution with the following constituents:
Table 1
[0021] The aqueous acetaminophen formulation of Table 1 was prepared by dissolving 13.0 mg of monobasic sodium phosphate, 100.0 mg of povidone, 3,750.0 mg of mannitol for injection and 1,000.0 mg of acetaminophen in 80 mL of water for injection. Then, the pH is checked, and if necessary was adjusted until 5.5 by adding sodium hydroxide or hydrochloric acid. The solution was adjusted to 100 mL by the addition of water for injection. Next, he solution was filtered and filled into a 100 mL bottle. The bottle was then closed under a nitrogen atmosphere and sterilized.
[0022] The stability of acetaminophen solution was evaluated until 6 weeks. The solution was stored at 25° C/60% HR and 40° C/75% HR. During the stability period time, relative substances, color and pH were studied and we can conclude that acetaminophen solution is stable and no acetaminophen degradation occurred and none of its physicochemical characteristics has changed significantly.
[0023] Although the invention has been described and illustrated with a certain degree of particularity, it is understood that the disclosure has been made only by way of example, and that numerous changes in the conditions and order of steps can be resorted to by those skilled in the art without departing from the spirit and scope of the invention.
Claims
1. A stable aqueous formulation of acetaminophen for injection comprising: a. approximately 200.0 mg to approximately 1,400.0 mg of acetaminophen; b. approximately 200.0 mg to approximately 10,000.0 mg of mannitol for injection; c. approximately 0.0 mg to approximately 30.0 mg of monobasic sodium phosphate; d. approximately 0.0 mg to approximately 300.0 mg of povidone; e. a sufficient amount of sodium hydroxide and hydrochloric acid as needed in order to adjust the pH to between approximately 4.0 and approximately 8.0; and f. a volume of water for injection up to a volume of approximately 100 mL.
2. The aqueous formulation of acetaminophen of claim 1 comprising approximately 1,000.0 mg of said acetaminophen; approximately 3,750.0 mg of said mannitol for injection; approximately 13.0 mg of said monobasic sodium phosphate; and approximately 100.0 mg of said povidone.
3. A process for preparing the aqueous formulation of acetaminophen of any of claims 1 and 2 comprising: a. adding said monobasic sodium phosphate, said povidone, said mannitol for injection and said acetaminophen in a volume of water for injection to form the aqueous formulation; b. if necessary, adding sodium hydroxide or hydrochloric acid to adjust the pH of the aqueous formulation to between approximately 4.0 and approximately 8.0; and c. adjusting the final volume of the aqueous formulation by adding additional water for injection.
4. The process of claim 3, further comprising at least one of: a. filtering the aqueous formulation; b. filling the aqueous formulation into a bottle; c. closing a bottle containing the aqueous formulation under an inert atmosphere; and d. sterilizing a bottle containing the aqueous formulation.
5. Use of the aqueous formulation of acetaminophen according to any of claims 1 and 2 or made by any of the methods of claims 3 and 4 comprising administering a sufficient amount of the aqueous formulation of acetaminophen to a patient in need thereof to eliminate pain.
6. The use of claim 5, wherein the pain occurs following surgery.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92919207P | 2007-06-18 | 2007-06-18 | |
| PCT/IB2008/003217 WO2009047634A2 (en) | 2007-06-18 | 2008-06-18 | Aqueous formulations of acetaminophen for injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP2170313A2 true EP2170313A2 (en) | 2010-04-07 |
Family
ID=40429866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP08837144A Withdrawn EP2170313A2 (en) | 2007-06-18 | 2008-06-18 | Aqueous formulations of acetaminophen for injection |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2170313A2 (en) |
| AR (1) | AR067048A1 (en) |
| WO (1) | WO2009047634A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2243477A1 (en) * | 2009-04-22 | 2010-10-27 | Fresenius Kabi Deutschland GmbH | Paracetamol for parenteral application |
| WO2011071400A1 (en) * | 2009-12-10 | 2011-06-16 | Tecnimede - Sociedade Técnico-Medicinal, S.A. | Method and composition for preparing stable liquid formulations of paracetamol |
| PT2377516E (en) | 2010-04-14 | 2012-07-02 | Braun Melsungen Ag | Acetaminophen composition |
| AU2011273064B2 (en) * | 2010-06-30 | 2014-01-09 | Troikaa Pharmaceuticals Limited | Pharmaceutical compositions comprising paracetamol and process for preparing the same |
| ZA201300398B (en) * | 2012-11-27 | 2013-09-25 | Genfarma Laboratories S L | Injectable liquid formulation of the combination of tramadol and paracetamol |
| TN2017000232A1 (en) | 2014-12-20 | 2018-10-19 | Troikaa Pharmaceuticals Ltd | Injectable formulations of paracetamol |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751875B1 (en) * | 1996-08-05 | 1998-12-24 | Scr Newpharm | NOVEL STABLE LIQUID FORMULATIONS BASED ON PARACETAMOL AND THEIR METHOD OF PREPARATION |
| FR2809619B1 (en) * | 2000-06-06 | 2004-09-24 | Pharmatop | NOVEL AQUEOUS FORMULATIONS OF OXIDATION-SENSITIVE ACTIVE INGREDIENTS AND PROCESS FOR OBTAINING THEM |
| FR2851164B1 (en) * | 2003-02-14 | 2005-04-22 | Xuan Tho Nguyen | INFLATABLE LIQUID FORMULATION OF PARACETAMOL |
| GB0613925D0 (en) * | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
-
2008
- 2008-06-18 EP EP08837144A patent/EP2170313A2/en not_active Withdrawn
- 2008-06-18 AR ARP080102597A patent/AR067048A1/en unknown
- 2008-06-18 WO PCT/IB2008/003217 patent/WO2009047634A2/en not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2009047634A3 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AR067048A1 (en) | 2009-09-30 |
| WO2009047634A2 (en) | 2009-04-16 |
| WO2009047634A3 (en) | 2009-06-04 |
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