AR061103A1 - 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion - Google Patents
2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacionInfo
- Publication number
- AR061103A1 AR061103A1 ARP070102222A ARP070102222A AR061103A1 AR 061103 A1 AR061103 A1 AR 061103A1 AR P070102222 A ARP070102222 A AR P070102222A AR P070102222 A ARP070102222 A AR P070102222A AR 061103 A1 AR061103 A1 AR 061103A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- alkynyl
- cycloalkyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000005015 aryl alkynyl group Chemical group 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 abstract 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 heteroaryl-C1-4alkyl Chemical group 0.000 abstract 1
- 125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005312 heteroarylalkynyl group Chemical group 0.000 abstract 1
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Su preparacion, composiciones que las contienen y su utilizacion como medicamento, en particular como agentes anticancerígenos. Reivindicacion 1: Producto de formula general (1) en la que: a) R1 se selecciona independientemente del grupo constituido por alquilo C1-12, alquenilo C2-12, alquinilo C2-12, cicloalquilo, heterociclilo, arilo, heteroarilo, cicloalquil-alquilo C1-12, cicloalquil-alquenilo C2-12, cicloalquil-alquinilo C2-12, heterociclil-alquilo C1-12, heterociclil-alquenilo C2-12, heterociclil-alquinilo C2-12, aril-aIquilo C1-12, aril-alquenilo C2-12, aril-alquinilo C2-12, heteroaril-alquilo C1-12, heteroaril-alquenilo C2-12, heteroaril-alquinilo C2-12, estando opcionalmente sustituido con uno o varios halogenos el grupo arilo de cada R1; b) R2 se selecciona del grupo constituido por alquilo C1-6, aril-alquilo C1-6, heteroaril-alquilo C1-6, arilo, heteroarilo, alquiltio C1-6-alquilo C1-6, dialquilamino C1-6-alquilo C1-6, ariloxi-alquilo C1-6, alcoxi C1-6- alquilo C1-6, c) R3 se selecciona del grupo constituido por H, COO(R5), CONH(R5), CO(R5), O(R5), R5; d) R4 se selecciona independientemente del grupo constituido por H, F, CI, Br, N(R5)2, NO2, CN, COO(R5), CON(R5)2, NHCO(R5), NHCOO(R5), OCONH(R5), O(R5), R5 o bien, dos sustituyentes R4, unidos a 2 carbonos adyacentes al fenilo, forman juntos un ciclo elegido entre cicloalquilo, heterociclilo, arilo o heteroarilo, opcionalmente sustituido con uno o varios R4; e) m tiene por valor 0, 1, 2, 3, o 4; f) R5 se elige independientemente entre un par de electrones no enlazantes, H, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, halogeno-alquilo C1-12, aril-alquilo C1-12, heteroaril-alquilo C1-12, heteroarilaril-alquilo C1-12, arilo, heteroarilo, cicloalquilo, en el que cada R5 está opcionalmente sustituido con al menos un sustituyente elegido entre OH, halogeno, alquilo C1-4, alcoxi C1-4, aril-alquilo C1-4, arilo, heteroaril-alquilo C1-4, heteroarilo, -N(CH3)2, -NH2, CONH2, o los grupos de formulas (2) donde cada uno de los Rz se selecciona independientemente del grupo constituido por H, COO(R5), CONH(R5), CON(R5)2, CO(R5), R5, en el que cada R5 se selecciona independientemente entre alquilo C1-4, halogeno-alquilo C1-4, aril-alquilo C1-4, heteroaril-alquilo C1-4, en el que cada R5 está opcionalmente sustituido con un sustituyente elegido entre OH, halogeno, alquilo C1-4, alcoxi C1-4, aril-alquilo C1-4, arilo, heteroaril-alquilo C1-4, heteroarilo; con la condicion de que cuando R1 es (E) -CH=CH-C(CH3)3, R2 es metilo y R3 es H, cuando m es diferente de 0.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0604733A FR2901554B1 (fr) | 2006-05-24 | 2006-05-24 | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061103A1 true AR061103A1 (es) | 2008-08-06 |
Family
ID=37487536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102222A AR061103A1 (es) | 2006-05-24 | 2007-05-23 | 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7994162B2 (es) |
| EP (1) | EP2035387A2 (es) |
| JP (1) | JP2009537614A (es) |
| KR (1) | KR20090010071A (es) |
| CN (1) | CN101454290A (es) |
| AR (1) | AR061103A1 (es) |
| AU (1) | AU2007253196A1 (es) |
| BR (1) | BRPI0712925A2 (es) |
| CA (1) | CA2649336A1 (es) |
| CR (1) | CR10382A (es) |
| DO (1) | DOP2007000104A (es) |
| EA (1) | EA200870565A1 (es) |
| EC (1) | ECSP088893A (es) |
| FR (1) | FR2901554B1 (es) |
| GT (1) | GT200800249A (es) |
| IL (2) | IL194972A0 (es) |
| MA (1) | MA30561B1 (es) |
| MX (1) | MX2008014844A (es) |
| NO (1) | NO20085285L (es) |
| PE (1) | PE20080705A1 (es) |
| TN (1) | TNSN08402A1 (es) |
| TW (1) | TW200812971A (es) |
| UY (1) | UY30368A1 (es) |
| WO (1) | WO2007135293A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2878528B1 (fr) | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
| CN102924462B (zh) * | 2012-10-24 | 2015-01-14 | 华东师范大学 | 1,2,3,4,5,9-取代苯并吖庚因类化合物的合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692522A (en) * | 1985-04-01 | 1987-09-08 | Merck & Co., Inc. | Benzofused lactams useful as cholecystokinin antagonists |
| US4831135A (en) * | 1986-06-18 | 1989-05-16 | The Regents Of The University Of California | Bengamide anthelmintics |
| US5283241A (en) * | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| GB9411841D0 (en) | 1994-06-14 | 1994-08-03 | Pharma Mar Sa | New antitumoral compounds from jaspis sponge |
| JP2002241368A (ja) | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| US6239127B1 (en) * | 1999-11-17 | 2001-05-29 | Novartis Ag | Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation |
| CO5140099A1 (es) | 1998-11-17 | 2002-03-22 | Novartis Ag | Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores |
| ES2299515T3 (es) * | 2000-05-11 | 2008-06-01 | Novartis Ag | Carbonatos y eteres de caprolactama sustituidos y su uso como agentes antitumorales. |
| JP2004514122A (ja) | 2000-11-14 | 2004-05-13 | ノバルティス アクチエンゲゼルシャフト | 抗増殖性化合物をスクリーニングしかつ腫瘍増殖を阻害する方法 |
| US6545148B2 (en) * | 2001-03-12 | 2003-04-08 | Novartis Ag | Process for preparing certain substituted caprolactams |
| JP2004262793A (ja) | 2003-02-28 | 2004-09-24 | Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai | 化合物ｎ−９０１１、その製造法及び用途 |
| CA2533335A1 (en) * | 2003-07-25 | 2005-02-17 | Novartis Ag | Substituted lactams and their use as anti-cancer agents |
| US7153846B2 (en) * | 2003-10-24 | 2006-12-26 | Sanofi-Aventis Deutschland Gmbh | Bengamide derivatives, process for preparing them, and their use |
| DE10349669B3 (de) | 2003-10-24 | 2005-05-25 | Aventis Pharma Deutschland Gmbh | Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FR2878525B1 (fr) * | 2004-11-29 | 2007-02-23 | Aventis Pharma Sa | Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation |
| FR2878528B1 (fr) * | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
-
2006
- 2006-05-24 FR FR0604733A patent/FR2901554B1/fr not_active Expired - Fee Related
-
2007
- 2007-05-17 TW TW096117596A patent/TW200812971A/zh unknown
- 2007-05-21 PE PE2007000622A patent/PE20080705A1/es not_active Application Discontinuation
- 2007-05-23 MX MX2008014844A patent/MX2008014844A/es not_active Application Discontinuation
- 2007-05-23 CN CNA2007800189967A patent/CN101454290A/zh active Pending
- 2007-05-23 BR BRPI0712925-4A patent/BRPI0712925A2/pt not_active Application Discontinuation
- 2007-05-23 CA CA002649336A patent/CA2649336A1/fr not_active Abandoned
- 2007-05-23 JP JP2009511545A patent/JP2009537614A/ja not_active Withdrawn
- 2007-05-23 AU AU2007253196A patent/AU2007253196A1/en not_active Abandoned
- 2007-05-23 KR KR1020087028521A patent/KR20090010071A/ko not_active Withdrawn
- 2007-05-23 WO PCT/FR2007/000866 patent/WO2007135293A2/fr not_active Ceased
- 2007-05-23 AR ARP070102222A patent/AR061103A1/es unknown
- 2007-05-23 EA EA200870565A patent/EA200870565A1/ru unknown
- 2007-05-23 EP EP07765942A patent/EP2035387A2/fr not_active Withdrawn
- 2007-05-24 UY UY30368A patent/UY30368A1/es not_active Application Discontinuation
- 2007-05-24 DO DO2007000104A patent/DOP2007000104A/es unknown
-
2008
- 2008-10-15 TN TNP2008000402A patent/TNSN08402A1/en unknown
- 2008-10-20 CR CR10382A patent/CR10382A/es unknown
- 2008-10-28 IL IL194972A patent/IL194972A0/en unknown
- 2008-11-06 IL IL195148A patent/IL195148A0/en unknown
- 2008-11-10 US US12/267,689 patent/US7994162B2/en not_active Expired - Fee Related
- 2008-11-17 EC EC2008008893A patent/ECSP088893A/es unknown
- 2008-11-19 GT GT200800249A patent/GT200800249A/es unknown
- 2008-12-05 MA MA31458A patent/MA30561B1/fr unknown
- 2008-12-17 NO NO20085285A patent/NO20085285L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP088893A (es) | 2008-12-30 |
| UY30368A1 (es) | 2008-01-02 |
| TW200812971A (en) | 2008-03-16 |
| EP2035387A2 (fr) | 2009-03-18 |
| EA200870565A1 (ru) | 2009-06-30 |
| WO2007135293A2 (fr) | 2007-11-29 |
| MA30561B1 (fr) | 2009-07-01 |
| IL194972A0 (en) | 2009-08-03 |
| CA2649336A1 (fr) | 2007-11-29 |
| MX2008014844A (es) | 2009-02-17 |
| IL195148A0 (en) | 2009-09-22 |
| JP2009537614A (ja) | 2009-10-29 |
| DOP2007000104A (es) | 2007-11-15 |
| CN101454290A (zh) | 2009-06-10 |
| AU2007253196A1 (en) | 2007-11-29 |
| WO2007135293A3 (fr) | 2008-05-02 |
| TNSN08402A1 (en) | 2010-04-14 |
| PE20080705A1 (es) | 2008-07-30 |
| US7994162B2 (en) | 2011-08-09 |
| NO20085285L (no) | 2008-12-17 |
| FR2901554B1 (fr) | 2011-04-01 |
| US20090099152A1 (en) | 2009-04-16 |
| FR2901554A1 (fr) | 2007-11-30 |
| CR10382A (es) | 2009-02-26 |
| KR20090010071A (ko) | 2009-01-28 |
| BRPI0712925A2 (pt) | 2013-01-08 |
| GT200800249A (es) | 2009-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |