AR061066A1 - Coterapeutica para el tratamiento de epilepsia y trastornos relacionados - Google Patents
Coterapeutica para el tratamiento de epilepsia y trastornos relacionadosInfo
- Publication number
- AR061066A1 AR061066A1 ARP070102201A ARP070102201A AR061066A1 AR 061066 A1 AR061066 A1 AR 061066A1 AR P070102201 A ARP070102201 A AR P070102201A AR P070102201 A ARP070102201 A AR P070102201A AR 061066 A1 AR061066 A1 AR 061066A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydrogen
- epilepsy
- effective amount
- therapeutically effective
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 206010015037 epilepsy Diseases 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 239000001961 anticonvulsive agent Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000011262 co‐therapy Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxy, methoxy Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Un método para tratar epilepsia o un trastorno relacionado, que comprende la administracion a un sujeto que lo necesita de una coterapéutica con una cantidad terapéuticamente efectiva de uno o varios agentes antiepilépticos o anticonvulsivantes y una cantidad terapéuticamente efectiva de un compuesto de la formula (1) en donde R1 está seleccionado del grupo que consiste en hidrogeno, halogeno, hidroxi, metoxi, trifluorometilo, nitro y ciano; X-Y está seleccionado del grupo que consiste en -S-CH-, -S-C(CH3)-, -O-CH-, -O-C(CH3)-, -N(CH3)-CH- y -CH=CH-CH-; A está seleccionado del grupo que consiste en -CH2- y -CH(CH3)-; R2 está seleccionado del grupo que consiste en hidrogeno y metilo; R3 y R4 están seleccionados cada uno, de modo independiente entre sí, del grupo que consiste en hidrogeno y alquilo C1-4; de modo alternativo, R3 y R4 se toman juntos con el átomo de nitrogeno al que están unidos para formar una estructura de anillo saturada, parcialmente insaturada o aromática de 5 a 7 miembros, que opcionalmente contiene uno a dos heteroátomos adicionales seleccionados, de modo independiente, del grupo que consiste en O, N y S; o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80200106P | 2006-05-19 | 2006-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061066A1 true AR061066A1 (es) | 2008-07-30 |
Family
ID=38510389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102201A AR061066A1 (es) | 2006-05-19 | 2007-05-21 | Coterapeutica para el tratamiento de epilepsia y trastornos relacionados |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070293476A1 (es) |
| AR (1) | AR061066A1 (es) |
| CL (1) | CL2007001468A1 (es) |
| PE (1) | PE20080234A1 (es) |
| TW (1) | TW200812574A (es) |
| UY (1) | UY30360A1 (es) |
| WO (1) | WO2007137164A2 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| AR049646A1 (es) * | 2004-06-16 | 2006-08-23 | Janssen Pharmaceutica Nv | Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados |
| JP2008545650A (ja) * | 2005-05-20 | 2008-12-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | スルファミド誘導体の製造方法 |
| US8497298B2 (en) * | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US20070155823A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
| US8691867B2 (en) * | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| US20070155827A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression |
| US8716231B2 (en) * | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US8492431B2 (en) * | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
| US8937096B2 (en) * | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| US20070191474A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine |
| AU2007253814A1 (en) * | 2006-05-19 | 2007-11-29 | Janssen Pharmaceutica N.V. | Co-therapy for the treatment of epilepsy |
| CN102846601B (zh) | 2006-06-15 | 2015-04-29 | 优时比制药有限公司 | 具有协同抗惊厥作用的药物组合物 |
| US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
| US20090247616A1 (en) * | 2008-03-26 | 2009-10-01 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety |
| EP2340246A2 (en) | 2008-06-23 | 2011-07-06 | Janssen Pharmaceutica, N.V. | Crystalline form of (2s)-(-)-n-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide |
| US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10117891B2 (en) | 2014-09-16 | 2018-11-06 | India Globalization Capital, Inc. | Cannabinoid composition for treating pain |
| EP3247359A4 (en) | 2015-01-25 | 2018-08-08 | India Globalization Capital, Inc. | Composition and method for treating seizure disorders |
| US10596159B2 (en) | 2015-08-12 | 2020-03-24 | India Globalization Capital, Inc. | Method and composition for treating cachexia and eating disorders |
| EP3471746A4 (en) | 2016-06-15 | 2020-02-26 | India Globalization Capital, Inc. | METHOD AND COMPOSITION FOR TREATING CRAMPING SEASONS |
| RU2020128731A (ru) | 2018-03-20 | 2022-04-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Средство для лечения эпилепсии |
| WO2024054807A1 (en) * | 2022-09-06 | 2024-03-14 | Biohaven Therapeutics Ltd. | Combination therapies including metal channel activators and tdp-43 modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| AU1328197A (en) * | 1995-12-01 | 1997-06-19 | Synaptic Pharmaceutical Corporation | Aryl sulfonamide and sulfamide derivatives and uses thereof |
| EA006598B1 (ru) * | 1999-08-20 | 2006-02-24 | Орто-Макнейл Фармасьютикал, Инк. | Композиция, содержащая трамадол и противосудорожное лекарственное средство |
| CN1897950A (zh) * | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| EP1727538A2 (en) * | 2004-02-13 | 2006-12-06 | Neuromolecular Inc. | Combination of an nmda receptor antagonist and an anti-epileptic drug for the treatment of epilepsy and other cns disorders |
| MX2007002309A (es) * | 2004-08-24 | 2007-10-08 | Johnson & Johnson | Novedosos derivados de heteroarilsulfamida benzofusionados utiles como agentes anticonvulsivos. |
| US20070191460A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Disease Modification / Epileptogenesis |
-
2007
- 2007-05-18 US US11/750,579 patent/US20070293476A1/en not_active Abandoned
- 2007-05-18 TW TW096117855A patent/TW200812574A/zh unknown
- 2007-05-18 WO PCT/US2007/069250 patent/WO2007137164A2/en not_active Ceased
- 2007-05-21 PE PE2007000616A patent/PE20080234A1/es not_active Application Discontinuation
- 2007-05-21 AR ARP070102201A patent/AR061066A1/es not_active Application Discontinuation
- 2007-05-22 CL CL200701468A patent/CL2007001468A1/es unknown
- 2007-05-22 UY UY30360A patent/UY30360A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY30360A1 (es) | 2007-08-31 |
| WO2007137164A3 (en) | 2008-01-17 |
| TW200812574A (en) | 2008-03-16 |
| CL2007001468A1 (es) | 2008-04-04 |
| WO2007137164A2 (en) | 2007-11-29 |
| PE20080234A1 (es) | 2008-04-25 |
| US20070293476A1 (en) | 2007-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |