AR053409A1 - 4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-((5-(amino-sustituido)metil)-3-furil)-3-quinolincarbonitrilos como inhibidores de quinasa. procesos de obtencion y composiciones farmaceuticas. - Google Patents
4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-((5-(amino-sustituido)metil)-3-furil)-3-quinolincarbonitrilos como inhibidores de quinasa. procesos de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR053409A1 AR053409A1 ARP050103414A ARP050103414A AR053409A1 AR 053409 A1 AR053409 A1 AR 053409A1 AR P050103414 A ARP050103414 A AR P050103414A AR P050103414 A ARP050103414 A AR P050103414A AR 053409 A1 AR053409 A1 AR 053409A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- heteroaryl
- aryl
- alkyl
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- -1 -OH Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procesos de obtencion y composiciones farmacéuticas que los contienen. Reivindicacion 1: un compuesto de formula (1) donde: R1 y R2 pueden ser iguales o diferentes, y se seleccionan de H, alquilo C1-6, (CH2)nXR4, (CH2)nNZZ', alquenilo C2-6, alquinilo C2-6, arilo o heteroarilo; R1 y R2 se pueden tomar junto con el N al cual están unidos para formar un anillo heterocíclico que, en forma opcional, tiene un heteroátomo adicional seleccionado de N, O y S, donde el S puede estar mono- o di- oxidado, opcionalmente sustituido con por lo menos un -R3 en un C o N, o en N con un grupo -(CH2)nXR4, -(CH2) nNZZ', o en C con un grupo -(CH2)qXR4, -(CH2)qNZZ', halogeno; Z y Z' se seleccionan de H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo o heteroarilo; y Z y Z' se pueden tomar junto con el N al cual están unidos para formar un anillo heterocíclico que, en forma opcional, contiene un heteroátomo adicional seleccionado de N, O y S; R3 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, O, alquilarilo, alquilheteroarilo, cicloalquilo, arilo o heteroarilo; donde el arilo o el heteroarilo está opcionalmente sustituid con uno o más alquilo C1-6, alcoxi C1-6, halogeno, -OH, alquilhidroxi o trifluormetilo; R4 es H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo o heteroarilo; X es O, S, NR4; n es 2-5; q es 0-5; y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60182504P | 2004-08-16 | 2004-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053409A1 true AR053409A1 (es) | 2007-05-09 |
Family
ID=35395715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103414A AR053409A1 (es) | 2004-08-16 | 2005-08-12 | 4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-((5-(amino-sustituido)metil)-3-furil)-3-quinolincarbonitrilos como inhibidores de quinasa. procesos de obtencion y composiciones farmaceuticas. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7479561B2 (es) |
| AR (1) | AR053409A1 (es) |
| GT (1) | GT200500219A (es) |
| PE (1) | PE20060495A1 (es) |
| TW (1) | TW200612944A (es) |
| WO (1) | WO2006023395A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200829555A (en) * | 2006-11-10 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| WO2008064004A2 (en) * | 2006-11-16 | 2008-05-29 | Wyeth | 4-anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (aml) |
| US20080119463A1 (en) * | 2006-11-16 | 2008-05-22 | Wyeth | 4-Anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (AML) |
| AU2013280644B2 (en) | 2012-06-26 | 2018-08-02 | Jeffrey A. BACHA | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| CN103848785B (zh) * | 2012-12-04 | 2016-07-13 | 上海医药集团股份有限公司 | 一类氘代3-氰基喹啉类化合物、其药用组合物、制备方法及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521618B2 (en) * | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
| AR035851A1 (es) * | 2000-03-28 | 2004-07-21 | Wyeth Corp | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas |
| US6961765B2 (en) * | 2000-04-06 | 2005-11-01 | Bbx Technologies, Inc. | System and method for real time monitoring and control of networked computers |
| MXPA06001590A (es) | 2003-08-19 | 2006-05-19 | Wyeth Corp | Proceso para la preparacion de 4-amino-3-quinolincarbonitrilos. |
-
2005
- 2005-08-11 US US11/201,705 patent/US7479561B2/en not_active Expired - Fee Related
- 2005-08-12 WO PCT/US2005/028758 patent/WO2006023395A2/en not_active Ceased
- 2005-08-12 PE PE2005000938A patent/PE20060495A1/es not_active Application Discontinuation
- 2005-08-12 GT GT200500219A patent/GT200500219A/es unknown
- 2005-08-12 AR ARP050103414A patent/AR053409A1/es unknown
- 2005-08-12 TW TW094127419A patent/TW200612944A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060035930A1 (en) | 2006-02-16 |
| PE20060495A1 (es) | 2006-07-14 |
| TW200612944A (en) | 2006-05-01 |
| WO2006023395A2 (en) | 2006-03-02 |
| US7479561B2 (en) | 2009-01-20 |
| WO2006023395A3 (en) | 2006-06-08 |
| GT200500219A (es) | 2006-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |