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AR053237A1 - Proceso para la preparacion de quetiapina y fumarato de quetiapina - Google Patents

Proceso para la preparacion de quetiapina y fumarato de quetiapina

Info

Publication number
AR053237A1
AR053237A1 ARP060101584A ARP060101584A AR053237A1 AR 053237 A1 AR053237 A1 AR 053237A1 AR P060101584 A ARP060101584 A AR P060101584A AR P060101584 A ARP060101584 A AR P060101584A AR 053237 A1 AR053237 A1 AR 053237A1
Authority
AR
Argentina
Prior art keywords
quetiapine
dibenzo
fumarate
thiazepine
chloro
Prior art date
Application number
ARP060101584A
Other languages
English (en)
Inventor
I Llado Jordi Bosch
Montero Carmen Burgarolas
Gutierrez Iolanda Chamorro
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR053237A1 publication Critical patent/AR053237A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Proceso para preparar quetiapina y/o sus sales, incluyendo fumarato de quetiapina. En general, el proceso comprende hacer reaccionar dibenzotiazepinona (dibenzo [b,f][1,4]tiazepin-11(10H)-ona) con oxicloruro fosforoso en presencia de trietilamina en un solvente orgánico aromático tal como tolueno o preferentemente, xileno a temperatura de reflujo para obtener una solucion de hidrocarburo aromático de 11-cloro-dibenzo[b,f][1,4]tiazepina. Luego de eso, la 11-cloro-dibenzo[b,f][1,4]tiazepina se hace reaccionar con 2-(2-piperazin-1-iletoxi)etanol para producir quetiapina luego de seguir varios pasos de tratamiento. Entonces, el compuesto 1 se puede hacer seguir reaccionando con ácido fumárico a una temperatura elevada para producir fumarato de quetiapina. El fumarato de quetiapina resultante obtenido es apropiado para utilizar en reparados farmacéuticos.
ARP060101584A 2005-04-21 2006-04-21 Proceso para la preparacion de quetiapina y fumarato de quetiapina AR053237A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67337305P 2005-04-21 2005-04-21
US73086405P 2005-10-28 2005-10-28

Publications (1)

Publication Number Publication Date
AR053237A1 true AR053237A1 (es) 2007-04-25

Family

ID=37308368

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060101584A AR053237A1 (es) 2005-04-21 2006-04-21 Proceso para la preparacion de quetiapina y fumarato de quetiapina

Country Status (5)

Country Link
US (1) US8048876B2 (es)
EP (1) EP1879874A2 (es)
AR (1) AR053237A1 (es)
CA (1) CA2605473C (es)
WO (1) WO2006117700A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006113425A1 (en) 2005-04-14 2006-10-26 Teva Pharmaceutical Industries Ltd. Process for preparing quetiapine fumarate
HU230144B1 (hu) * 2007-06-12 2015-09-28 Richter Gedeon Nyrt. Eljárás quetiapin előállítására
JP5343362B2 (ja) * 2008-01-23 2013-11-13 住友化学株式会社 ビス｛２−〔２−（４−ジベンゾ〔ｂ，ｆ〕〔１，４〕チアゼピン−１１−イル−１−ピペラジニル）エトキシ〕エタノール｝モノフマレートの製造方法
EP2245021B1 (en) 2008-01-31 2012-09-12 Fermion Oy A process for the preparation of quetiapine
US20110052648A1 (en) * 2008-03-12 2011-03-03 Avi Avramoff Oral modified-release formulations containing thiazepines
EP2153834A3 (en) * 2008-08-07 2010-02-24 Farmaprojects, S.A. Extended release pharmaceutical compositions comprising quetiapine salts
JP2010053044A (ja) * 2008-08-26 2010-03-11 Sumitomo Chemical Co Ltd １１−クロロジベンゾ〔ｂ，ｆ〕〔１，４〕チアゼピンの製造方法
EP2370432A2 (en) * 2008-12-15 2011-10-05 Alembic Limited A process for preparing quetiapine fumarate
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
CN101940561A (zh) * 2010-09-14 2011-01-12 浙江华海药业股份有限公司 喹硫平片及其制备方法
CN108586385B (zh) * 2017-12-26 2020-03-20 山东安信制药有限公司 一种制备大粒度富马酸喹硫平的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US5286722A (en) 1990-07-24 1994-02-15 Akzo N.V. Tetrahydropyridinyldibenzazepine derivatives
GB9922271D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Formulation
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
WO2003039516A1 (en) * 2001-11-07 2003-05-15 Fujisawa Pharmaceuticla Co., Ltd. Method for improving dissolution of poorly dispersible medicaments
AU2003235435A1 (en) 2002-03-20 2003-10-08 Teva Pharmaceutical Industries Ltd. Crystalline forms of quetiapine hemifumarate
US7238686B2 (en) 2003-03-03 2007-07-03 Hetero Drugs Limited Polymorphs of quetiapine fumarate
KR101038389B1 (ko) 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
US20060063927A1 (en) * 2004-09-22 2006-03-23 Olga Etlin Processes for preparing quetiapine and salts thereof

Also Published As

Publication number Publication date
WO2006117700A2 (en) 2006-11-09
EP1879874A2 (en) 2008-01-23
CA2605473A1 (en) 2006-11-09
CA2605473C (en) 2013-10-29
US8048876B2 (en) 2011-11-01
WO2006117700A3 (en) 2007-03-01
US20090076262A1 (en) 2009-03-19

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