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AR051172A1 - Compuestos derivados de acido tartarico para el tratamiento de desordenes inflamatorios. composiciones farmaceuticas - Google Patents

Compuestos derivados de acido tartarico para el tratamiento de desordenes inflamatorios. composiciones farmaceuticas

Info

Publication number
AR051172A1
AR051172A1 ARP050102245A ARP050102245A AR051172A1 AR 051172 A1 AR051172 A1 AR 051172A1 AR P050102245 A ARP050102245 A AR P050102245A AR P050102245 A ARP050102245 A AR P050102245A AR 051172 A1 AR051172 A1 AR 051172A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
cycloalkyl
heterocyclyl
heteroaryl
Prior art date
Application number
ARP050102245A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35355800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR051172(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR051172A1 publication Critical patent/AR051172A1/es

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Abstract

La presente se refiere a composiciones farmacéuticas. Reivindicacion 1: Un compuesto de formula (1), o una sal o solvato farmacéuticamente aceptable del mismo, donde: A se selecciona del grupo que consiste de formulas (2); d es 0 a 4; J se selecciona del grupo que consiste en: O, S, y NR5; E se selecciona del grupo que consiste en: O, S y NR5; T es O o S; R1 y R2 son iguales o diferentes, seleccionándose cada uno independientemente del grupo que consiste en H, alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroaralquilo, y heteroarilo; o de manera alternativa R1 y R2, tomados junto con el N al cual R1 y R2 se muestran unidos, representan un anillo heterocíclico de 4-8 miembros que posee 1-3 heteroátomos incluyendo dicho N, estando dicho anillo heterocíclico fusionado opcionalmente con arilo, heteroarilo, cicloalquilo, o heterociclilo, donde cada uno de dichos alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroaralquilo, heteroarilo y anillo heterocíclico de 4-8 miembros puede ser no sustituido u opcionalmente sustituido de manera independiente con uno o más restos que pueden ser iguales o diferentes, seleccionándose cada resto independientemente del grupo de restos R70 indicados más adelante; R10 se selecciona del grupo que consiste en H, alquilo, y fluoroalquilo; R20 se selecciona del grupo que consiste en H, alquilo, y fluoroalquilo; R30 es H o alquilo, o de manera alternativa R30 y R40 tomados juntos con el N al cual R40 se muestra unido en la formula (1), se unen para formar un anillo heterocíclico de 4-7 miembros, donde dicho anillo heterocíclico es no sustituido o sustituido de manera independiente opcionalmente por uno o más restos que pueden ser iguales o diferentes, seleccionándose cada resto independientemente del grupo de restos R70 indicados más adelante; R40 es H o alquilo; R50 es H o alquilo; W es -(CR132)n-, donde n es 0 a 5 o un enlace covalente, o de manera alternativa dos grupos R13 se pueden fusionar para formar un cicloalquilo de 3-8 miembros, donde dicho cicloalquilo de 3-8 miembros puede ser no sustituido u sustituido opcionalmente de manera independiente con uno o más restos que pueden ser iguales o diferentes, seleccionándose cada resto independientemente del grupo de restos R6 siguientes; X está ausente o presente, y si se encuentra presente X se selecciona del grupo que consiste en un enlace covalente, alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo, donde dicho alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo puede ser no sustituido u opcionalmente sustituido de manera independiente con uno o más restos que pueden ser iguales o diferentes, seleccionándose cada resto independientemente del grupo de restos R70 siguientes; Y está ausente o presente, y si se encuentra presente Y se selecciona del grupo que consiste en un enlace covalente, -[C(R6)2]n- donde n es 1 a 2, -O-, - S-, -NR1-, -Sov- donde v es 1 a 2, -Son(CR62)p- donde n es 1 o 2 y p es 1 a 4, -O(CR62)q- o -(CR62)qO- donde q es 1 a 4, -N(R7)S(O)n- o -S(O)nN(R7)- donde n es 1 o 2, y -N(R7)C(O)- o -C(O)N(R7)-; Z se selecciona del grupo que consiste en H, alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo, estando dicho cicloalquilo, heterociclilo, arilo y heteroarilo fusionados opcionalmente con arilo, heterociclilo, heteroarilo o cicloalquilo; donde cada uno de dichos alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo puede ser no sustituido u opcionalmente sustituido de manera independiente con uno o más restos que pueden ser iguales o diferentes, seleccionándose cada resto independientemente del grupo de restos R70 indicados más adelante; R5 se selecciona del grupo que consiste en hidrogeno, alquilo, y alquilarilo; cada R6 es igual o diferente y se selecciona independientemente del grupo que consiste en hidrogeno, halogeno, -SR15, -S(O)qR15 donde q es 1 a 2, alquilo, cicloalquilo, heterociclilo, alcoxilo, hidroxi, nitro, ciano, amino, alquenilo, alquinilo, arilalquilo, aminocarbonilo, alquilcarbonilo, y alcoxicarbonilo; cada R7 es igual o diferente y se selecciona independientemente del grupo que consiste en hidrogeno, alquilo, arilo, cicloalquilo, heteroarilo, heterociclilo, alquenilo, alquinilo, arilalquilo, alquilcarbonilo, y alcoxicarbonilo, donde cada uno del arilo, heteroarilo y heterociclilo puede ser no sustituido u opcionalmente sustituido de manera independiente con uno o más restos que pueden ser iguales o diferentes, seleccionándose cada resto independientemente del grupo de restos R70 indicados más adelante; R13 es igual o diferente y se selecciona independientemente del grupo que consiste en hidrogeno, halogeno, -OH, -OR14, alquilo, cicloalquilo, heterociclilo, alquenilo, alquinilo, alquilarilo, alquilamino, y alquilcarbonilo; R14 es alquilo; cada R70 es un sustituyente para H donde se indico y es igual o diferente y se selecciona independientemente del grupo que consiste en alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, halo, -CN, -CF3, -OCF3, -OR15, -C(O)R15, -C(O)OR15, -C(O)N(R15)(R16), -SR15, -S(O)qN(R15)(R16) donde q es 1 a 2, -C(=NOR15)R16, -N(R15)(R16), -alquil-N(R15)(R16), -N(R15)C(O)R16, -CH2-N(R15)C(O)R16, -N(R15)S(O)R16, -N(R15)S(O)2R16, -CH2- N(R15)S(O)2R16, -N(R17)S(O)2N(R16)C(O)R15, -N(R17)S(O)N(R16)(R15), -N(R17)C(O)N(R16)(R15), -CH2-N(R17)C(O)N(R16)(R15), -N(R15)C(O)OR16, -CH2-N(R15)C(O)OR16 y -S(O)qR15 donde q es 1 a 2; y donde cada uno del alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, alquenilo y alquinilo son no sustituidos o sustituidos de manera independiente por 1 a 5 grupos seleccionados de manera independiente del grupo que consiste en alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, halo, -CF3, -CN, -OR15, -N(R15)(R16), -C(O)OR15, -C(O)N(R15)(R16), y -N(R15)S(O)R16; cada R15, R16 y R17 se seleccionan de manera independiente del grupo que consiste en H, alquilo, cicloalquilo, heterociclilo, arilo, y heteroarilo, o de manera alternativa R15 y R16 tomados junto con el N al cual estos se muestran unidos, se unen para formar un anillo heterocíclico de 4-8 miembros, donde dicho cicloalquilo de 4-8 miembros puede ser no sustituido u opcionalmente sustituido de manera independiente con uno o más restos que pueden ser iguales o diferentes, seleccionándose cada resto independientemente del grupo de abajo restos R75; cada R75 se selecciona independientemente del grupo que consiste en alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, alquenilo y alquinilo, y donde cada uno del alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, alquenilo y alquinilo son no sustituidos o sustituidos de manera independiente por 1 a 5 grupos seleccionados de manera independiente del grupo que consiste en alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, halo, -CF3, -CN, -OR19, -N(R19)2, -C(O)OR19, -C(O)N(R19)2 y - N(R19)S(O)R19; y cada R19 se selecciona independientemente del grupo que consiste en H, alquilo, cicloalquilo, heterociclilo, arilo, y heteroarilo.
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