AR054816A1 - Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos - Google Patents
Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidosInfo
- Publication number
- AR054816A1 AR054816A1 ARP060102875A ARP060102875A AR054816A1 AR 054816 A1 AR054816 A1 AR 054816A1 AR P060102875 A ARP060102875 A AR P060102875A AR P060102875 A ARP060102875 A AR P060102875A AR 054816 A1 AR054816 A1 AR 054816A1
- Authority
- AR
- Argentina
- Prior art keywords
- agents
- substituted
- prophylaxis
- treatment
- remedy
- Prior art date
Links
- WZELXJBMMZFDDU-UHFFFAOYSA-N Imidazol-2-one Chemical group O=C1N=CC=N1 WZELXJBMMZFDDU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 6
- 238000011282 treatment Methods 0.000 abstract 4
- 238000011321 prophylaxis Methods 0.000 abstract 3
- 229940035676 analgesics Drugs 0.000 abstract 2
- 239000000730 antalgic agent Substances 0.000 abstract 2
- 230000001149 cognitive effect Effects 0.000 abstract 2
- 230000003533 narcotic effect Effects 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical class 0.000 abstract 1
- 208000017194 Affective disease Diseases 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000004880 Polyuria Diseases 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 229940124377 agent for diabetes insipidus Drugs 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 229940124330 analgesic enhancer Drugs 0.000 abstract 1
- 239000000883 anti-obesity agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229940125710 antiobesity agent Drugs 0.000 abstract 1
- 239000002830 appetite depressant Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000002764 nociceptin receptor antagonist Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Proporciona derivados de 2-oxoimidazol sustituidos con dihidroxialquilo en N que son utiles como medicinas, representados por la formula (1) [en los que R representa alquilo C1-6 sustituido con dihidroxi, y Cy representa un grupo carbocíclico alifático bicíclico o tricíclico C6-10 opcionalmente sustituido]. Estos compuestos actuan como antagonistas del receptor de nociceptina, y son utiles, como agentes para aliviar la tolerancia a analgésicos narcoticos, dependencia o adiccion a analgésicos narcoticos, potenciadores de la analgesia; agentes contra la obesidad o supresores del apetito; agentes de tratamiento o profilaxis para deficiencia cognitiva y demencia / amnesia; agentes para tratar anormalidad cognitivas del desarrollo remedio para la esquizofrenia; agentes para tratar enfermedades neurodegenerativas; antidepresivos o agentes d tratamiento para trastorno afectivo; agente de tratamiento o profilaxis para diabetes insípida; agentes de tratamiento o profilaxis para poliuria; y remedio para la hipotension y similares.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005204264 | 2005-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054816A1 true AR054816A1 (es) | 2007-07-18 |
Family
ID=37637260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102875A AR054816A1 (es) | 2005-07-13 | 2006-07-04 | Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1914232B1 (es) |
| JP (1) | JP4748162B2 (es) |
| KR (1) | KR20080033262A (es) |
| CN (1) | CN101223158B (es) |
| AR (1) | AR054816A1 (es) |
| AU (1) | AU2006267391B2 (es) |
| BR (1) | BRPI0613109A2 (es) |
| CA (1) | CA2614688A1 (es) |
| CR (1) | CR9692A (es) |
| DE (1) | DE602006018950D1 (es) |
| DO (1) | DOP2006000165A (es) |
| EC (1) | ECSP088096A (es) |
| ES (1) | ES2355580T3 (es) |
| IL (1) | IL188418A0 (es) |
| MA (1) | MA29738B1 (es) |
| NI (1) | NI200800003A (es) |
| NO (1) | NO20080770L (es) |
| NZ (1) | NZ565026A (es) |
| PE (1) | PE20070176A1 (es) |
| RU (1) | RU2414456C2 (es) |
| TW (1) | TW200740436A (es) |
| WO (1) | WO2007007890A1 (es) |
| ZA (1) | ZA200711025B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009033780A2 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of growth hormone-releasing factor and/or k237 as a therapeutic agents |
| JP2010539024A (ja) * | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | ガストリン−１およびＧ−Ｐｅｎ−ＧＲＧＤＳＰＣＡの治療学的な使用 |
| MX337106B (es) | 2010-05-27 | 2016-02-12 | Targacept Inc | Antagonistas no competitivos de receptores nicotinicos. |
| DK3345907T3 (da) * | 2015-09-01 | 2020-06-22 | Taiho Pharmaceutical Co Ltd | Pyrazolo[3,4-d]pyrimidinforbindelser eller salte deraf |
| CA3224323A1 (en) * | 2021-07-14 | 2023-01-19 | Jian Wang | Piperidine derivative, and pharmaceutical composition thereof, preparation method therefor, and use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2200468A1 (en) * | 1994-10-27 | 1996-05-09 | Wayne J. Thompson | Muscarine antagonists |
| WO1997040035A1 (en) * | 1996-04-19 | 1997-10-30 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
| AU732329B2 (en) * | 1997-05-30 | 2001-04-12 | Banyu Pharmaceutical Co., Ltd. | 2-oxoimidazole derivative |
| DK1049689T3 (da) * | 1998-01-19 | 2002-07-22 | Pfizer | 4-(2-keto-1-benzimidazolinyl)piperidinderivater som ORL1-receptoragonister |
| ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| US7456198B2 (en) * | 1999-12-06 | 2008-11-25 | Purdue Pharma L.P. | Benzimidazole compounds having nociceptin receptor affinity |
| RU2265018C2 (ru) * | 2001-04-18 | 2005-11-27 | Эро-Селтик, С.А. | Производные бензимидазола и фармацевтические композиции на их основе |
-
2006
- 2006-07-04 AR ARP060102875A patent/AR054816A1/es not_active Application Discontinuation
- 2006-07-05 TW TW095124503A patent/TW200740436A/zh unknown
- 2006-07-10 PE PE2006000816A patent/PE20070176A1/es not_active Application Discontinuation
- 2006-07-11 AU AU2006267391A patent/AU2006267391B2/en not_active Ceased
- 2006-07-11 CN CN2006800256149A patent/CN101223158B/zh not_active Expired - Fee Related
- 2006-07-11 RU RU2008105396/04A patent/RU2414456C2/ru not_active IP Right Cessation
- 2006-07-11 BR BRPI0613109-3A patent/BRPI0613109A2/pt not_active IP Right Cessation
- 2006-07-11 ES ES06781147T patent/ES2355580T3/es active Active
- 2006-07-11 NZ NZ565026A patent/NZ565026A/en not_active IP Right Cessation
- 2006-07-11 WO PCT/JP2006/314122 patent/WO2007007890A1/ja not_active Ceased
- 2006-07-11 DE DE602006018950T patent/DE602006018950D1/de active Active
- 2006-07-11 EP EP06781147A patent/EP1914232B1/en active Active
- 2006-07-11 CA CA002614688A patent/CA2614688A1/en not_active Abandoned
- 2006-07-11 JP JP2007524723A patent/JP4748162B2/ja not_active Expired - Fee Related
- 2006-07-11 KR KR1020087000923A patent/KR20080033262A/ko not_active Ceased
- 2006-07-12 DO DO2006000165A patent/DOP2006000165A/es unknown
-
2007
- 2007-12-19 ZA ZA200711025A patent/ZA200711025B/xx unknown
- 2007-12-25 IL IL188418A patent/IL188418A0/en unknown
-
2008
- 2008-01-04 NI NI200800003A patent/NI200800003A/es unknown
- 2008-01-10 EC EC2008008096A patent/ECSP088096A/es unknown
- 2008-01-25 CR CR9692A patent/CR9692A/es unknown
- 2008-02-11 MA MA30637A patent/MA29738B1/fr unknown
- 2008-02-12 NO NO20080770A patent/NO20080770L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101223158B (zh) | 2013-01-09 |
| JPWO2007007890A1 (ja) | 2009-01-29 |
| TW200740436A (en) | 2007-11-01 |
| AU2006267391B2 (en) | 2011-12-08 |
| NZ565026A (en) | 2010-09-30 |
| PE20070176A1 (es) | 2007-03-09 |
| RU2414456C2 (ru) | 2011-03-20 |
| RU2008105396A (ru) | 2009-08-20 |
| EP1914232A1 (en) | 2008-04-23 |
| MA29738B1 (fr) | 2008-09-01 |
| KR20080033262A (ko) | 2008-04-16 |
| DE602006018950D1 (de) | 2011-01-27 |
| EP1914232A4 (en) | 2009-10-28 |
| EP1914232B1 (en) | 2010-12-15 |
| CR9692A (es) | 2008-02-21 |
| WO2007007890A1 (ja) | 2007-01-18 |
| ECSP088096A (es) | 2008-02-20 |
| ES2355580T3 (es) | 2011-03-29 |
| CN101223158A (zh) | 2008-07-16 |
| ZA200711025B (en) | 2008-12-31 |
| CA2614688A1 (en) | 2007-01-18 |
| DOP2006000165A (es) | 2007-02-28 |
| NO20080770L (no) | 2008-04-11 |
| JP4748162B2 (ja) | 2011-08-17 |
| NI200800003A (es) | 2008-07-21 |
| AU2006267391A1 (en) | 2007-01-18 |
| BRPI0613109A2 (pt) | 2012-12-04 |
| IL188418A0 (en) | 2008-11-03 |
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