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AR043998A1 - Acidos fenoxiaceticos - Google Patents

Acidos fenoxiaceticos

Info

Publication number
AR043998A1
AR043998A1 ARP040101180A ARP040101180A AR043998A1 AR 043998 A1 AR043998 A1 AR 043998A1 AR P040101180 A ARP040101180 A AR P040101180A AR P040101180 A ARP040101180 A AR P040101180A AR 043998 A1 AR043998 A1 AR 043998A1
Authority
AR
Argentina
Prior art keywords
halogen
alkyl
cycloalkyl
optionally substituted
independently selected
Prior art date
Application number
ARP040101180A
Other languages
English (en)
Inventor
Stephen Tohm
Garry Pairaudeau
Anil Patel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR043998A1 publication Critical patent/AR043998A1/es

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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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Abstract

Se refiere a derivados de ácidos fenoxiacéticos como compuestos farmacéuticos útiles para el tratamiento de trastornos respiratorios, composiciones farmacéuticas que los contienen, procesos para su preparación. Estos compuestos actúan como moduladores del receptor CRTh2 y son útiles en el tratamiento de enfermedades respiratorias. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1) o una sal aceptable para uso farmacéutico del mismo, en el cual: X es halógeno, ciano, nitro, S(O).R6 o alquilo C1-4 el cual se sustituye por uno o más átomos de halógeno; Y se selecciona entre hidrógeno, halógeno, CN, nitro, SO2R3, OR4, SR4, SOR3, SO2NR4R5, CONR4R5, NR4R5, NR6SO2R3, NR6CO2R6, NR6COR3, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 o alquilo C1-6, los últimos cuatro grupos se sustituyen opcionalmente por uno o más sustituyentes seleccionados independientemente entre halógeno, OR6 y NR6R7, S(O)nR6 donde n es 0, 1 ó 2; Z es arilo o un anillo A, donde A es un anillo aromático heterocíclico de 6 miembros que contiene uno o más átomos de nitrógeno o puede ser un biciclo fusionado 6,6 ó 6,5, que contiene uno o más átomos de O, N, S, los anillo arilo o A todos se sustituyen opcionalmente por uno o más sustituyentes seleccionados independientemente entre hidrógeno, halógeno, CN, OH, SH, nitro, COR9, CO2R6, SO2R9, OR9, SR9, SOR9, SO2NR10R11, CONR10R11, NR10R11, NHSO2R9, NR9SO2R9, NR6CO2R6, NHCOR9, NR9COR9, NR6CONR4R5, NR6SO2NR4R5, arilo, heteroarilo, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 o alquilo C1-6, los últimos cuatro grupos se sustituyen opcionalmente por uno o más sustituyentes seleccionados independientemente entre halógeno, cicloalquilo C3-7, o 6, NR6R7, S(O).R6 (donde n es 0, 1 ó 2), CONR6R7, NR6COR7, SO2NR6R7 y NR6SOR7. R1 y R2 representan independientemente un átomo de hidrógeno, halógeno, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 o un grupo alquilo C1-6, los últimos cuatro se sustituyen opcionalmente por uno o más sustituyentes seleccionados independientemente entre halógeno, cicloalquilo C3-7, NR6R7, OR6, S(O)nR6 (donde n es 0, 1 ó 2); o R1 y R2 juntos pueden formar un anillo de 3-8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S, NR6 y él mismo se sustituye opcionalmente con uno o más alquilo C1-3 o halógeno; R3 representa cicloalquilo C3-7 o alquilo C1-6 el cual se puede sustituir opcionalmente por uno o más sustituyentes seleccionados independientemente entre halógeno, cicloalquilo C3-7, OR6 y NR6R7, S(O)nR6 (donde n = 0, 1 ó 2), CONR6R7, NR6COR7, SO2NR6R7 y NR6SO2R7; R4 y R5 representan independientemente hidrógeno, cicloalquilo C3-7 o alquilo C1-6, los últimos dos grupos se sustituyen opcionalmente por uno o más sustituyentes seleccionados independientemente entre halógeno, cicloalquilo C3-7, OR6 y NR76R7, S(O)nR6 (donde n = 0, 1 ó 2), CONR6R7, NR6COR7 SO2NR6R7 y NR6SO2R7; o R4 y R5 junto con el átomo de nitrógeno al cual se encuentran unidos pueden formar un anillo heterocíclico saturado de 3-8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S(O), (donde n = 0, 1 ó 2), NR8, y él mismo se sustituye opcionalmente con halógeno o alquilo C1-3; R6 y R7 representan independientemente un átomo de hidrógeno o alquilo C1-6; R8 es hidrógeno, alquilo C1-4, -COalquilo (C1-4), CO2alquilo (C1-4) o CONR6alquilo (C1-4); R9 representa arilo, heteroarilo, cicloalquilo C3-7 o alquilo c1-6, los últimos dos grupos se pueden sustituir opcionalmente por uno o más sustituyentes seleccionados independientemente entre halógeno, cicloalquilo C3-7, arilo, heteroarilo OR6 y NR6R7, S(O)nR6 (donde n = 0, 1 ó 2), CONR6R7, NR6COR7, SO2NR6R7 y NR6SO2R7; R10 y R11 representan independientemente arilo o heteroarilo, hidrógeno, cicloalquilo C3-7 o alquilo C1-6, los últimos dos grupos se sustituyen opcionalmente por uno o más sustituyentes seleccionados independientemente entre halógeno, cicloalquilo C3-7, arilo, heteroarilo, OR6 y NR6R7, S(O)nR6 (donde n = 0, 1 ó 2), CONR6R7, NR6COR7, SO2NR6R7 y NR6SO2R7; o R10 y R11 junto con el átomo de nitrógeno al cual se encuentran unidos pueden formar un anillo heterocíclico saturado de 3-8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S(O)n (donde n = 0, 1 ó 2), NR8, y él mismo se sustituye opcionalmente con halógeno o alquilo C1-3.
ARP040101180A 2003-04-07 2004-04-07 Acidos fenoxiaceticos AR043998A1 (es)

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PT1611091E (pt) 2014-12-24
IS8108A (is) 2005-10-31
CA2521425C (en) 2012-05-29
EP1611091A1 (en) 2006-01-04
NO20055219L (no) 2006-01-04
SI1611091T1 (sl) 2015-01-30
KR20050112123A (ko) 2005-11-29
MY149463A (en) 2013-08-30
NO20055219D0 (no) 2005-11-04
US20060264435A1 (en) 2006-11-23
CO5640047A2 (es) 2006-05-31
JP4898428B2 (ja) 2012-03-14
RU2372330C2 (ru) 2009-11-10
HK1085720A1 (en) 2006-09-01
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CN1791572A (zh) 2006-06-21
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US20110166117A1 (en) 2011-07-07
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CA2521425A1 (en) 2004-10-21
CY1115940T1 (el) 2017-01-25
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US8158820B2 (en) 2012-04-17
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TWI336322B (en) 2011-01-21
NZ542972A (en) 2008-07-31
WO2004089885A1 (en) 2004-10-21
KR101061339B1 (ko) 2011-08-31
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RU2005131732A (ru) 2006-05-27
JP2006522118A (ja) 2006-09-28

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