AR042273A1 - Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen - Google Patents
Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR042273A1 AR042273A1 ARP030104441A ARP030104441A AR042273A1 AR 042273 A1 AR042273 A1 AR 042273A1 AR P030104441 A ARP030104441 A AR P030104441A AR P030104441 A ARP030104441 A AR P030104441A AR 042273 A1 AR042273 A1 AR 042273A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- optionally substituted
- hydroxy
- alkyl
- alkoxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
- -1 amino, carbamoylamino Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 4
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000676 alkoxyimino group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
- C07D231/24—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms having sulfone or sulfonic acid radicals in the molecule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de pirazol de la fórmula (1), en donde R1 es hidrógeno o alquilo inferior; R2 es alquilo inferior opcionalmente sustituido con halógeno, hidroxi, alcoxiimino inferior o alcoxi inferior; alquenilo inferior; cicloalquilo; ciano; alcanoilo inferior; cicloalquilcarbonilo; N,N-di-alquilcarbamoilo (inferior); carbamoilo; N-alcoxi inferior-N-alquilcarbamoilo inferior; amino; dialquilamino (inferior); alcoxicarbonilamino inferior; N,N-dialquilcarbamoilamino (inferior); N-(N,N-dialquilcarbamoilo (inferior)-N-alquilamino inferior; halógeno; hidroxi; carboxi; alcoxicarbonilo inferior; aroilo, heterociclicarbonilo; grupo heterocíclico; alquilsulfonilo inferior; alcoxi inferior opcionalmente sustituido con alcoxi inferior, N-N-dialquilcarbamoilo (inferior) o halógeno; cicloalquiloxi; alquiltio inferior; o alquilsulfinilo inferior; R3 es alquilo inferior opcionalmente sustituido con amino, carbamoilamino o alquilsulfonilamino inferior, halógeno; ciano; hidroxi; alcanoiloxi inferior; alquilendioxi inferior; alcoxi inferior opcionalmente sustituido con arilo, hidroxi, ciano, amino, alcoxicarbonilamino inferior, alquilsulfonilamino inferior o carbamoilamino; nitro; amino, grupo heterocíclico; alquiltio inferior; alquilsulfinilo inferior; o alquilsulfonilo inferior; R4 es hidrógeno; ciano; amino opcionalmente sustituido con ftaloílo o alquilo inferior; arilo; grupo heterocíclico; alcoxi inferior; hidroxi; alquilsulfoniloxi inferior; alcanoiloxi inferior; alquilo inferior sustituido con tritilamino y alcoxicarbonilo inferior, amino y alcoxicarbonilo inferior, amino y carboxi, amino y carbamoilo, o amino e hidroxi; N-alcoxicarbonilo inferior-N-alquilamino inferior; alcanoilo inferior opcionalmente sustituido con halógeno; carboxi; alquilsulfonilo inferior; sulfo; alquilsililoxi inferior; alcoxicarbonilo inferior; sulfamoilo opcionalmente sustituido con alquilo inferior; carbamoilo opcionalmente sustituido con alquilo inferior; alquiltio inferior; alquilsulfinilo inferior; carbamoiloxi; tioureido; o un grupo de la fórmula R5-G-J-, en la cual G es -CO- o -SO2-; j es -N(R6)- (donde R6 es hidrógeno o alquilo inferior); y R5 es amino opcionalmente sustituido con alcoxicarbonilo inferior o alquilo inferior; alquilo inferior opcionalmente sustituido con hidroxi, alcoxicarbonilamino inferior, alcanoiloxi inferior; amino o halógeno; alcoxi inferior; hidrógeno; grupo heterocíclico; o arilo; X es O, S, SO o SO2; Y es CH o N; Z es alquileno inferior o alquenileno inferior; y m es 0 ó 1; siempre que cuando R4 es hidrógeno; entonces R3 es alquilo inferior sustituido con amino, carbamoilamino o alquilsulfonilamino inferior; o alcoxi inferior sustituido con arilo, hidroxi, ciano, amino, alcoxicarbonilamino inferior, alquilsulfonilamino inferior o carbamoilamino; o sales de los mismos. El proceso para preparar dichos compuestos de fórmula (1), y las composiciones farmacéuticas que los contienen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002953019A AU2002953019A0 (en) | 2002-12-02 | 2002-12-02 | Azole derivatives |
| AU2002953602A AU2002953602A0 (en) | 2002-12-30 | 2002-12-30 | New compounds |
| AU2003902015A AU2003902015A0 (en) | 2003-04-29 | 2003-04-29 | Azole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042273A1 true AR042273A1 (es) | 2005-06-15 |
Family
ID=32474716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104441A AR042273A1 (es) | 2002-12-02 | 2003-12-02 | Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7183306B2 (es) |
| EP (1) | EP1567503B1 (es) |
| JP (1) | JP4419078B2 (es) |
| KR (1) | KR20050083761A (es) |
| AR (1) | AR042273A1 (es) |
| AT (1) | ATE538097T1 (es) |
| BR (1) | BR0316332A (es) |
| CA (1) | CA2505945A1 (es) |
| ES (1) | ES2379076T3 (es) |
| MX (1) | MXPA05005742A (es) |
| NO (1) | NO20053215L (es) |
| NZ (1) | NZ540515A (es) |
| PL (1) | PL377778A1 (es) |
| TW (1) | TW200410942A (es) |
| WO (1) | WO2004050632A1 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1355885A1 (en) * | 2001-01-02 | 2003-10-29 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine derivatives useful as cyclooxygenase inhibitor |
| CA2505945A1 (en) | 2002-12-02 | 2004-06-17 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives useful as cox-i inhibitors |
| US7622471B2 (en) | 2003-02-07 | 2009-11-24 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives having a pyridazine and pyridine functionality |
| US20050075323A1 (en) * | 2003-03-05 | 2005-04-07 | Pfizer Inc | Beta3 adrenergic receptor agonists and uses thereof |
| US20060079566A1 (en) * | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
| US20090149463A1 (en) * | 2004-02-20 | 2009-06-11 | Leifeng Cheng | Therapeutic agents |
| US20080064682A1 (en) * | 2004-07-01 | 2008-03-13 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole Derivatives |
| KR20070046099A (ko) * | 2004-08-06 | 2007-05-02 | 다이이찌 세이야꾸 가부시기가이샤 | 항혈소판약 및 그의 제조방법 |
| JP2008526887A (ja) * | 2005-01-10 | 2008-07-24 | ユニバーシティ オブ コネチカット | カンナビノイド受容体に作用する新規なヘテロピロール類似体 |
| FR2882365B1 (fr) * | 2005-02-21 | 2007-09-07 | Sanofi Aventis Sa | Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutique |
| GB0514739D0 (en) * | 2005-07-19 | 2005-08-24 | Astrazeneca Ab | Therapeutic agents |
| GB0516661D0 (en) * | 2005-08-13 | 2005-09-21 | Astrazeneca Ab | Therapeutic agents |
| WO2007111323A1 (ja) | 2006-03-27 | 2007-10-04 | Toray Industries, Inc. | ウレイド誘導体およびその医薬用途 |
| JPWO2008029912A1 (ja) | 2006-09-07 | 2010-01-21 | 国立大学法人 岡山大学 | シクロオキシゲナーゼ１（ｃｏｘ−１）選択的阻害活性を有するベンズアミドを骨格とする化合物 |
| JP5222855B2 (ja) * | 2006-12-18 | 2013-06-26 | ７ティーエム ファーマ エイ／エス | Ｃｂ１受容体のモジュレーター |
| GB0702862D0 (en) * | 2007-02-14 | 2007-03-28 | Univ Aberdeen | Therapeutic compounds |
| WO2008105383A1 (ja) * | 2007-02-26 | 2008-09-04 | Toray Industries, Inc. | ピラゾール誘導体およびその医薬用途 |
| WO2008114859A1 (ja) * | 2007-03-22 | 2008-09-25 | Astellas Pharma Inc. | ピラゾール誘導体を含有する医薬組成物 |
| US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
| JP5704925B2 (ja) | 2008-02-08 | 2015-04-22 | ウェルズ ファーゴ バンク ナショナル アソシエイション | オリゴマー−カンナビノイドコンジュゲート |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| KR20110027657A (ko) | 2008-06-25 | 2011-03-16 | 다이이찌 산쿄 가부시키가이샤 | 카르복실산 화합물 |
| WO2010038029A1 (en) * | 2008-10-02 | 2010-04-08 | Cambrex Karlskoga Ab | New process for preparing diketones and medicaments |
| TWI435874B (zh) | 2008-10-31 | 2014-05-01 | Toray Industries | 環己烷衍生物及其醫藥用途 |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| US20120108823A1 (en) | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
| DE102009036604A1 (de) | 2009-07-30 | 2011-02-03 | Aicuris Gmbh & Co. Kg | Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung |
| DE102011055815A1 (de) * | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| DE102012016908A1 (de) | 2012-08-17 | 2014-02-20 | Aicuris Gmbh & Co. Kg | Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung |
| MX382630B (es) | 2016-04-29 | 2025-03-13 | Fgh Biotech Inc | Compuestos de pirazol disustituidos para el tratamiento de enfermedades. |
| BR112019003139B1 (pt) | 2016-08-15 | 2022-11-01 | Bayer Cropscience Aktiengesellschaft | Processo para preparação de 3-amino-1-((2,6-dissubstituído)fenil)pirazóis |
| CN110072861B (zh) | 2016-09-07 | 2022-11-11 | Fgh生物科技公司 | 用于治疗疾病的二取代吡唑类化合物 |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN115611790A (zh) * | 2022-10-31 | 2023-01-17 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一种甲硫基甲基苯基醚的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164381A (en) | 1986-05-29 | 1992-11-17 | Ortho Pharmaceutical Corporation | Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same |
| US4826868A (en) | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
| US5051518A (en) | 1987-05-29 | 1991-09-24 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides |
| PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| US5550147A (en) | 1992-02-05 | 1996-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
| US5298521A (en) | 1993-08-30 | 1994-03-29 | Ortho Pharmaceutical Corporation | 1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use |
| JPH10509140A (ja) | 1994-11-08 | 1998-09-08 | エーザイ株式会社 | ピラゾール誘導体 |
| ES2136018B1 (es) | 1997-06-17 | 2000-07-01 | Menarini Lab | Compuestos inhibidores selectivos de la ciclooxigenasa-i y su utilizacion como analgesicos, antiinflamatorios y antiartriticos. |
| WO1999062885A1 (en) | 1998-06-05 | 1999-12-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents |
| WO2000018741A2 (en) * | 1998-09-30 | 2000-04-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole compounds as cox-2 inhibitors |
| AU4308300A (en) * | 1999-05-03 | 2000-11-17 | Dr. Reddy's Research Foundation | Pyrazoles having antiinflammatory activity |
| ATE252576T1 (de) | 1999-12-03 | 2003-11-15 | Pfizer Prod Inc | Heteroarylphenylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel |
| AU2001253749A1 (en) * | 2000-04-25 | 2001-11-07 | Pharmacia Corporation | 2-fluorobenzenesulfonyl compounds for the treatment of inflammation |
| EP1355885A1 (en) | 2001-01-02 | 2003-10-29 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine derivatives useful as cyclooxygenase inhibitor |
| AUPR878201A0 (en) | 2001-11-09 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | New compounds |
| US20030162824A1 (en) | 2001-11-12 | 2003-08-28 | Krul Elaine S. | Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor |
| ATE422201T1 (de) | 2002-04-05 | 2009-02-15 | Cadila Healthcare Ltd | 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen |
| CA2505945A1 (en) | 2002-12-02 | 2004-06-17 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives useful as cox-i inhibitors |
| CN100421632C (zh) | 2005-02-01 | 2008-10-01 | 金磊 | 人工心脏瓣膜成形环 |
-
2003
- 2003-11-14 CA CA002505945A patent/CA2505945A1/en not_active Abandoned
- 2003-11-14 EP EP03812289A patent/EP1567503B1/en not_active Expired - Lifetime
- 2003-11-14 WO PCT/JP2003/014489 patent/WO2004050632A1/en not_active Ceased
- 2003-11-14 US US10/706,999 patent/US7183306B2/en not_active Expired - Fee Related
- 2003-11-14 MX MXPA05005742A patent/MXPA05005742A/es active IP Right Grant
- 2003-11-14 NZ NZ540515A patent/NZ540515A/en unknown
- 2003-11-14 PL PL377778A patent/PL377778A1/pl unknown
- 2003-11-14 AT AT03812289T patent/ATE538097T1/de active
- 2003-11-14 BR BR0316332-6A patent/BR0316332A/pt not_active IP Right Cessation
- 2003-11-14 KR KR1020057006436A patent/KR20050083761A/ko not_active Abandoned
- 2003-11-14 JP JP2004570721A patent/JP4419078B2/ja not_active Expired - Fee Related
- 2003-11-14 ES ES03812289T patent/ES2379076T3/es not_active Expired - Lifetime
- 2003-12-01 TW TW092133632A patent/TW200410942A/zh unknown
- 2003-12-02 AR ARP030104441A patent/AR042273A1/es unknown
-
2005
- 2005-06-30 NO NO20053215A patent/NO20053215L/no not_active Application Discontinuation
-
2006
- 2006-12-13 US US11/610,230 patent/US20070112037A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20053215L (no) | 2005-09-01 |
| TW200410942A (en) | 2004-07-01 |
| US20040116475A1 (en) | 2004-06-17 |
| CA2505945A1 (en) | 2004-06-17 |
| NO20053215D0 (no) | 2005-06-30 |
| PL377778A1 (pl) | 2006-02-20 |
| HK1087102A1 (zh) | 2006-10-06 |
| MXPA05005742A (es) | 2005-08-16 |
| US7183306B2 (en) | 2007-02-27 |
| JP4419078B2 (ja) | 2010-02-24 |
| EP1567503B1 (en) | 2011-12-21 |
| ATE538097T1 (de) | 2012-01-15 |
| WO2004050632A1 (en) | 2004-06-17 |
| EP1567503A1 (en) | 2005-08-31 |
| BR0316332A (pt) | 2005-09-27 |
| JP2006514095A (ja) | 2006-04-27 |
| KR20050083761A (ko) | 2005-08-26 |
| NZ540515A (en) | 2008-01-31 |
| US20070112037A1 (en) | 2007-05-17 |
| ES2379076T3 (es) | 2012-04-20 |
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