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AR011660A1 - Uso de un compuesto neurotrofico de sulfonamida para efectuar una actividad neuronal en un animal - Google Patents

Uso de un compuesto neurotrofico de sulfonamida para efectuar una actividad neuronal en un animal

Info

Publication number
AR011660A1
AR011660A1 ARP980100597A ARP980100597A AR011660A1 AR 011660 A1 AR011660 A1 AR 011660A1 AR P980100597 A ARP980100597 A AR P980100597A AR P980100597 A ARP980100597 A AR P980100597A AR 011660 A1 AR011660 A1 AR 011660A1
Authority
AR
Argentina
Prior art keywords
branched
straight
alkyl
alkenyl
substituted
Prior art date
Application number
ARP980100597A
Other languages
English (en)
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25175836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR011660(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of AR011660A1 publication Critical patent/AR011660A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Uso de compuestos de sulfonamidas neurotroficas, de bajo peso molecular y de molécula pequena, que tienen afinidad por las inmunofilinas del tipo FKBPpara inhibir la actividad enzimática relacionada con las proteínas inmunofilínicas, particularmente con la actividad enzimática de la isomerasade peptidilpropilo o rotamasa. Los compuestos preferidos son los de la formula (I), o sales aceptables farmacéuticamente de las mismas, en las cuales: A esCH2, oxígeno, NH o N-(alquilo C1-C4); B y D son, independientemente, Ar, H, alquilo de cadena recta o ramificada (C1-C6), alquenilo de cadena recta oramificada (C1-C6), alquilo o alquenilo de cadena recta o ramificada (C1-C6) sustituido o no, o alquilo o alquenilo (C1-C6) de cadena recta o ramificadasustituido o no,o formula (II)donde Q es H,alquilo de cadena recta o ramificada (C1-C6) o alquenilo de cadena recta o ramificada (C1-C6) y T es Ar ocicloalquilo sustituido de cinco a siete miembros; E es alquilo (C1-C6) decadena recta o ramificada, alquenilo (C1-C6) de cadena recta o ramificada,cicloalquilo (C5-C7), cicloalquenilo (C5-C7) sustituidos por alquilo recto o ramificado (C1-C4) o alquenilo (C1-C4) recto o ramificado, [alquilo (C2-C4)o alquenilo (C2-C4)]-Ar o Ar; J es hidrogeno, alquilo C1 o C2 o bencilo; K es alquilo, bencilo o ciclohexilmetilo (C1-C4) recto o ramificado; o en donde sepueden formar J y K juntos para formar un anillo heterocíclico de 5 a 7 miembros, que puede contener unsustituyente O, S, SO o SO2.
ARP980100597A 1997-02-12 1998-02-11 Uso de un compuesto neurotrofico de sulfonamida para efectuar una actividad neuronal en un animal AR011660A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/799,407 US5721256A (en) 1997-02-12 1997-02-12 Method of using neurotrophic sulfonamide compounds

Publications (1)

Publication Number Publication Date
AR011660A1 true AR011660A1 (es) 2000-08-30

Family

ID=25175836

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980100597A AR011660A1 (es) 1997-02-12 1998-02-11 Uso de un compuesto neurotrofico de sulfonamida para efectuar una actividad neuronal en un animal

Country Status (12)

Country Link
US (4) US5721256A (es)
EP (1) EP1014978A4 (es)
JP (1) JP2001511806A (es)
AR (1) AR011660A1 (es)
AU (1) AU6268898A (es)
CA (1) CA2280742A1 (es)
CR (1) CR5720A (es)
GT (1) GT199800024A (es)
PA (1) PA8446601A1 (es)
PE (1) PE52399A1 (es)
WO (1) WO1998035675A1 (es)
ZA (1) ZA98824B (es)

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AU5606400A (en) 1999-07-09 2001-01-30 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
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US6495549B1 (en) * 1999-07-15 2002-12-17 Pfizer Inc FKBP inhibitors
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Also Published As

Publication number Publication date
US5721256A (en) 1998-02-24
AU6268898A (en) 1998-09-08
EP1014978A1 (en) 2000-07-05
US5968957A (en) 1999-10-19
JP2001511806A (ja) 2001-08-14
CR5720A (es) 2001-01-25
US6245783B1 (en) 2001-06-12
EP1014978A4 (en) 2003-05-28
CA2280742A1 (en) 1998-08-20
WO1998035675A1 (en) 1998-08-20
PA8446601A1 (es) 2000-05-24
US20030114492A1 (en) 2003-06-19
ZA98824B (en) 1998-10-30
PE52399A1 (es) 1999-05-27
GT199800024A (es) 1999-07-23

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