AR035930A1 - Derivados de la piperazina disustituida 1,4-utiles como bloqueadores de adrenoceptores uro-selectivos alfa sub-uno - Google Patents
Derivados de la piperazina disustituida 1,4-utiles como bloqueadores de adrenoceptores uro-selectivos alfa sub-unoInfo
- Publication number
- AR035930A1 AR035930A1 ARP010105588A ARP010105588A AR035930A1 AR 035930 A1 AR035930 A1 AR 035930A1 AR P010105588 A ARP010105588 A AR P010105588A AR P010105588 A ARP010105588 A AR P010105588A AR 035930 A1 AR035930 A1 AR 035930A1
- Authority
- AR
- Argentina
- Prior art keywords
- sub
- useful
- compounds
- piperazine
- uro
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 108060003345 Adrenergic Receptor Proteins 0.000 title 1
- 102000017910 Adrenergic receptor Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La presente se relaciona con un derivado nuevo de la piperazina disustituida-1,4 de la fórmula (1) y sus sales aditivas de ácido farmacéuticamente aceptables que tienen actividad de antagonista adrenoceptor-alfa-sub-uno uroselectiva. Los compuestos son útiles en el tratamiento de los síntomas de hiperplasia prostática benigna (BPH). También se relaciona con los métodos para realizar los compuestos y el método para tratar los síntomas de la hiperplasia prostática benigna utilizando los compuestos. Reivindicación 1: Un compuesto caracterizado por tener la estructura de la fórmula (1) sus sales, amidas, enantiómeros, diastereómeros, oxidos-n, prodrogas, metabolitos o sus polimorfos farmacéuticamente aceptables, donde A es una cadena alquilo recta o ramificada C1-4 y R es cinnamil, benzil, benzil sustituido, fenil, mono- o grupo fenil disustituido sustituido con los sustitutos seleccionados independientemente del grupo que consiste en halógeno, hidroxi, alquilo C1-6, alcoxi C1-6, grupo trifluorometil, nitro, trifluoroalcoxi o (dihalodifenil)metil.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1097DE2000 | 2000-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035930A1 true AR035930A1 (es) | 2004-07-28 |
Family
ID=11097130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105588A AR035930A1 (es) | 2000-11-30 | 2001-11-30 | Derivados de la piperazina disustituida 1,4-utiles como bloqueadores de adrenoceptores uro-selectivos alfa sub-uno |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6914064B2 (es) |
| EP (1) | EP1339682A1 (es) |
| JP (1) | JP2004514711A (es) |
| KR (1) | KR20030068164A (es) |
| CN (1) | CN1230423C (es) |
| AP (1) | AP2003002810A0 (es) |
| AR (1) | AR035930A1 (es) |
| AU (2) | AU2231502A (es) |
| BG (1) | BG107943A (es) |
| BR (1) | BR0115865A (es) |
| CA (1) | CA2430343A1 (es) |
| CZ (1) | CZ20031698A3 (es) |
| DO (1) | DOP2001000296A (es) |
| EA (1) | EA006941B1 (es) |
| EE (1) | EE200300250A (es) |
| HU (1) | HUP0400545A3 (es) |
| MA (1) | MA26064A1 (es) |
| MX (1) | MXPA03004850A (es) |
| NZ (1) | NZ526226A (es) |
| OA (1) | OA12537A (es) |
| PA (1) | PA8534001A1 (es) |
| PL (1) | PL362210A1 (es) |
| SK (1) | SK8052003A3 (es) |
| WO (1) | WO2002044151A1 (es) |
| ZA (1) | ZA200304242B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1787995A (zh) * | 2002-04-08 | 2006-06-14 | 兰贝克赛实验室有限公司 | 用作尿－选择性α－1A肾上腺素受体阻滞剂的α,w－二羧酰亚胺衍生物 |
| WO2005037281A1 (en) * | 2003-10-15 | 2005-04-28 | Ranbaxy Laboratories Limited | 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist |
| EP1746998A1 (en) * | 2004-03-22 | 2007-01-31 | Ranbaxy Laboratories, Ltd. | Combination therapy for lower urinary tract symptoms |
| WO2005113498A1 (en) * | 2004-05-19 | 2005-12-01 | Ranbaxy Laboratories Limited | Adrenergic receptor antagonists |
| EP1758583A2 (en) * | 2004-05-31 | 2007-03-07 | Ranbaxy Laboratories Limited | Arylpiperazine derivatives useful as adrenergic receptor antagonists |
| WO2006018815A1 (en) * | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Piperazine derivatives as adrenergic receptor antagonists |
| WO2006051399A1 (en) * | 2004-11-11 | 2006-05-18 | Ranbaxy Laboratories Limited | Piperazine derivatives useful as adrenergic receptor antagonists |
| WO2006051374A2 (en) * | 2004-11-11 | 2006-05-18 | Ranbaxy Laboratories Limited | Arylpiperazines useful as adrenergic receptor antagonists |
| WO2006092710A1 (en) * | 2005-03-02 | 2006-09-08 | Ranbaxy Laboratories Limited | Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione |
| WO2006117760A1 (en) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | Adrenergic receptor antagonists |
| WO2007029156A2 (en) * | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Isoindoledione derivatives as adrenergic receptor antagonists |
| WO2007039809A1 (en) * | 2005-10-05 | 2007-04-12 | Ranbaxy Laboratories Limited | Metabolites of 2- {3-[4-(5-fluoro-2-isopropoxy-phenyl)-piperazin-1-yl]-propyl} -5,6-dihydroxy-hexahydro-isoindole-1,3-dione |
| WO2010040274A1 (zh) | 2008-10-10 | 2010-04-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| KR102229618B1 (ko) | 2009-05-05 | 2021-03-18 | 알닐람 파마슈티칼스 인코포레이티드 | 지질 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57197265A (en) * | 1981-05-29 | 1982-12-03 | Eisai Co Ltd | Carboxylic acid imide derivative, its preparation and medicament containing the same |
| JPS5936661A (ja) * | 1982-08-26 | 1984-02-28 | Eisai Co Ltd | カルボン酸イミド誘導体およびその製造方法ならびにそれを含有する医薬 |
| JPS5976059A (ja) * | 1982-10-21 | 1984-04-28 | Sumitomo Chem Co Ltd | 環状イミド誘導体及びその酸付加塩 |
| JPS5995267A (ja) * | 1982-11-25 | 1984-06-01 | Eisai Co Ltd | カルボン酸イミド誘導体およびその製造方法 |
| US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
| AT387773B (de) * | 1983-09-12 | 1989-03-10 | Bristol Myers Co | Verfahren zur herstellung von 1-heteroaryl-4-((2,5-pyrrolidindion-1-yl)aklyl) iperazin-derivaten |
| JPS60204784A (ja) | 1984-03-29 | 1985-10-16 | Eisai Co Ltd | カルボン酸イミド誘導体 |
| JP2918899B2 (ja) | 1989-03-09 | 1999-07-12 | 住友製薬株式会社 | 環状イミド誘導体の製造方法 |
| US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
| DK0748800T3 (da) * | 1995-06-09 | 2001-08-27 | Hoffmann La Roche | Pyrimidindion-, pyrimidintrion- og triazindionderivater som alfa-1-adrenergiske receptorantagonister |
| WO1998037893A1 (en) | 1997-02-26 | 1998-09-03 | Sumitomo Pharmaceuticals Co., Ltd. | Dopamine d4 receptor antagonist |
| TR199902971T2 (xx) * | 1997-05-12 | 2001-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | Selim prostat hiperplazisinin tedavisinde yararl� aril ikameli piperazinler. |
| US6083950A (en) * | 1997-11-13 | 2000-07-04 | Ranbaxy Laboratories Limited | 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers |
-
2001
- 2001-11-29 MX MXPA03004850A patent/MXPA03004850A/es unknown
- 2001-11-29 PL PL01362210A patent/PL362210A1/xx not_active Application Discontinuation
- 2001-11-29 AU AU2231502A patent/AU2231502A/xx active Pending
- 2001-11-29 EE EEP200300250A patent/EE200300250A/xx unknown
- 2001-11-29 AP APAP/P/2003/002810A patent/AP2003002810A0/en unknown
- 2001-11-29 WO PCT/IB2001/002261 patent/WO2002044151A1/en not_active Ceased
- 2001-11-29 EA EA200300620A patent/EA006941B1/ru not_active IP Right Cessation
- 2001-11-29 EP EP01998540A patent/EP1339682A1/en not_active Withdrawn
- 2001-11-29 CZ CZ20031698A patent/CZ20031698A3/cs unknown
- 2001-11-29 BR BR0115865-1A patent/BR0115865A/pt not_active IP Right Cessation
- 2001-11-29 PA PA20018534001A patent/PA8534001A1/es unknown
- 2001-11-29 KR KR10-2003-7007305A patent/KR20030068164A/ko not_active Withdrawn
- 2001-11-29 NZ NZ526226A patent/NZ526226A/en unknown
- 2001-11-29 JP JP2002546521A patent/JP2004514711A/ja not_active Withdrawn
- 2001-11-29 OA OA1200300149A patent/OA12537A/en unknown
- 2001-11-29 CA CA002430343A patent/CA2430343A1/en not_active Abandoned
- 2001-11-29 CN CNB018220460A patent/CN1230423C/zh not_active Expired - Fee Related
- 2001-11-29 AU AU2002222315A patent/AU2002222315B2/en not_active Ceased
- 2001-11-29 HU HU0400545A patent/HUP0400545A3/hu unknown
- 2001-11-29 SK SK805-2003A patent/SK8052003A3/sk not_active Application Discontinuation
- 2001-11-30 US US09/998,115 patent/US6914064B2/en not_active Expired - Fee Related
- 2001-11-30 AR ARP010105588A patent/AR035930A1/es not_active Application Discontinuation
- 2001-11-30 DO DO2001000296A patent/DOP2001000296A/es unknown
-
2003
- 2003-05-30 ZA ZA200304242A patent/ZA200304242B/en unknown
- 2003-05-30 MA MA27188A patent/MA26064A1/fr unknown
- 2003-06-25 BG BG107943A patent/BG107943A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002222315B2 (en) | 2007-06-21 |
| HUP0400545A3 (en) | 2007-05-02 |
| CN1486300A (zh) | 2004-03-31 |
| EE200300250A (et) | 2003-10-15 |
| AU2231502A (en) | 2002-06-11 |
| ZA200304242B (en) | 2004-03-02 |
| OA12537A (en) | 2006-06-05 |
| US6914064B2 (en) | 2005-07-05 |
| WO2002044151A1 (en) | 2002-06-06 |
| KR20030068164A (ko) | 2003-08-19 |
| HUP0400545A2 (hu) | 2004-07-28 |
| CZ20031698A3 (cs) | 2003-11-12 |
| NZ526226A (en) | 2004-05-28 |
| JP2004514711A (ja) | 2004-05-20 |
| BG107943A (bg) | 2004-08-31 |
| SK8052003A3 (en) | 2003-12-02 |
| MA26064A1 (fr) | 2004-04-01 |
| MXPA03004850A (es) | 2004-01-26 |
| EA006941B1 (ru) | 2006-06-30 |
| EP1339682A1 (en) | 2003-09-03 |
| EA200300620A1 (ru) | 2003-12-25 |
| AP2003002810A0 (en) | 2003-06-30 |
| PL362210A1 (en) | 2004-10-18 |
| CA2430343A1 (en) | 2002-06-06 |
| DOP2001000296A (es) | 2003-03-15 |
| BR0115865A (pt) | 2003-12-23 |
| PA8534001A1 (es) | 2002-12-11 |
| US20020156085A1 (en) | 2002-10-24 |
| CN1230423C (zh) | 2005-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |