PE20080835A1 - Derivados novedosos de aminopiridina que tienen accion inhibidora selectiva sobre aurora a - Google Patents
Derivados novedosos de aminopiridina que tienen accion inhibidora selectiva sobre aurora aInfo
- Publication number
- PE20080835A1 PE20080835A1 PE2007001171A PE2007001171A PE20080835A1 PE 20080835 A1 PE20080835 A1 PE 20080835A1 PE 2007001171 A PE2007001171 A PE 2007001171A PE 2007001171 A PE2007001171 A PE 2007001171A PE 20080835 A1 PE20080835 A1 PE 20080835A1
- Authority
- PE
- Peru
- Prior art keywords
- aurora
- cyclohexanocarboxyl
- thiazol
- pyridin
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
REFERIDA A UN COMPUESTO DE AMINOPIRIDINA DE FORMULA (I), DONDE R1 ES H, F, CN, NO2, ENTRE OTROS; R2 ES O, S, SO, SO2, ENTRE OTROS; R3 ES FENILO OPCIONALMENTE SUSTITUIDO; X2 ES CH, N O CX2a; X2a ES ALQUILO C1-C6, COORX1, NHCOX1, ENTRE OTROS; W ES UN RESTO DE FORMULA (a), DONDE W1 ES CH, N, O, NH O S; W2 ES CH, N, O, ENTRE OTROS; W3 ES C O N. SON COMPUESTOS PREFERIDOS: ACIDO TRANS-4-(3-CLORO-2-FLUOROFENOXI)-1-((6-(1,3-TIAZOL-2-ILAMINO)PIRIDIN-2-IL)METIL)CICLOHEXANOCARBOXILICO, ACIDO TRANS-4-(2-FLUORO-3-(TRIFLUOROMETIL)FENOXI)-1-((6-(1,3-TIAZOL-2-ILAMINO)PIRIDIN-2-IL)METIL)CICLOHEXANOCARBOXILICO, ACIDO TRANS-4-(2,3-DICLOROFENOXI-1-((6-(1,3-TIAZOL-2-ILAMINO)PIRIDIN-2-IL)METIL)CICLOHEXANOCARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS DESCRITOS SON INHIBIDORES SELECTIVOS DE LA AURORA QUINASA A Y SON UTILES PARA EL TRATAMIENTO DE TUMORES
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006236472 | 2006-08-31 | ||
| US92608607P | 2007-04-25 | 2007-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080835A1 true PE20080835A1 (es) | 2008-06-14 |
Family
ID=39136042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001171A PE20080835A1 (es) | 2006-08-31 | 2007-08-29 | Derivados novedosos de aminopiridina que tienen accion inhibidora selectiva sobre aurora a |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20100016335A1 (es) |
| EP (2) | EP2062887B1 (es) |
| JP (3) | JP2008081492A (es) |
| KR (1) | KR20090055562A (es) |
| CN (1) | CN101528731B (es) |
| AR (1) | AR062585A1 (es) |
| AU (1) | AU2007289609B2 (es) |
| CA (1) | CA2657469C (es) |
| CL (1) | CL2007002519A1 (es) |
| CO (1) | CO6190529A2 (es) |
| CR (1) | CR10553A (es) |
| EC (1) | ECSP099062A (es) |
| ES (1) | ES2389515T3 (es) |
| GT (1) | GT200900008A (es) |
| HN (1) | HN2009000113A (es) |
| IL (1) | IL196497A0 (es) |
| MA (1) | MA30719B1 (es) |
| MX (1) | MX2009000390A (es) |
| NO (1) | NO20091301L (es) |
| NZ (1) | NZ574081A (es) |
| PE (1) | PE20080835A1 (es) |
| RU (1) | RU2437880C2 (es) |
| SV (1) | SV2009003152A (es) |
| TW (1) | TW200817363A (es) |
| UA (1) | UA95972C2 (es) |
| WO (2) | WO2008026769A1 (es) |
| ZA (1) | ZA200900126B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009104802A1 (en) * | 2008-02-22 | 2009-08-27 | Banyu Pharmaceutical Co., Ltd. | Novel aminopyridine derivatives having aurora a selective inhibitory action |
| US8546572B2 (en) * | 2008-03-31 | 2013-10-01 | Sun Pharmaceutical Industries Limited | Process for the preparation of morphinane analogues |
| JP5683462B2 (ja) * | 2008-07-24 | 2015-03-11 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | オーロラキナーゼ阻害剤および抗増殖剤を含む治療用組み合わせ |
| ES2608670T3 (es) | 2009-08-17 | 2017-04-12 | Memorial Sloan-Kettering Cancer Center | Derivados de 2-(pirimidin-5-il)-tiopirimidina como moduladores de Hsp70 y Hsc70 para el tratamiento de trastornos proliferativos |
| JP5878178B2 (ja) | 2011-09-30 | 2016-03-08 | 大鵬薬品工業株式会社 | １，２，４−トリアジン−６−カルボキサミド誘導体 |
| TWI485146B (zh) * | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
| US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
| EP3143013B1 (en) | 2014-05-13 | 2019-12-18 | Memorial Sloan Kettering Cancer Center | Hsp70 modulators and methods for making and using the same |
| TWI693218B (zh) * | 2014-11-14 | 2020-05-11 | 美商美國禮來大藥廠 | 極光ａ激酶抑制劑 |
| US10866838B2 (en) * | 2015-03-25 | 2020-12-15 | Intel Corporation | Cluster computing service assurance apparatus and method |
| CN108250191B (zh) * | 2018-03-15 | 2020-10-20 | 兰州大学 | 一种3,5-二取代的2-氨基-吡嗪化合物及其制备工艺与应用 |
| WO2020049208A1 (es) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida |
| CN112898292A (zh) * | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型极光激酶抑制剂及其用途 |
| TWI785474B (zh) * | 2020-01-22 | 2022-12-01 | 大陸商北京加科思新藥研發有限公司 | 用作選擇性Aurora A抑制劑的新型雜環化合物 |
| WO2023196887A1 (en) | 2022-04-08 | 2023-10-12 | Eli Lilly And Company | Method of treatment including kras g12c inhibitors and aurora a inhibitors |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA07174A (fr) | 1981-08-24 | 1984-04-30 | May & Baker Ltd | Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent. |
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5223608A (en) | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| HUT70024A (en) | 1990-09-28 | 1995-09-28 | Smithkline Beecham Corp | Process for preparing water soluble camptothecin analogs |
| US5247089A (en) | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| US5200524A (en) | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
| US5243050A (en) | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5191082A (en) | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
| EP1238986B1 (en) | 1992-10-28 | 2008-06-25 | Genentech, Inc. | Use of Vascular endothelial cell growth factor antagonists |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| AU6267896A (en) | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| PE92198A1 (es) | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| ATE309241T1 (de) | 1999-09-10 | 2005-11-15 | Merck & Co Inc | Tyrosin kinase inhibitoren |
| AU2002213467A1 (en) | 2000-10-11 | 2002-04-22 | Chemocentryx, Inc. | Modulation of ccr4 function |
| US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| HUP0400639A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| RU2332415C2 (ru) * | 2001-04-27 | 2008-08-27 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, полезные в качестве ингибиторов протеинкиназы |
| US7144903B2 (en) | 2001-05-23 | 2006-12-05 | Amgen Inc. | CCR4 antagonists |
| EP1754706A4 (en) * | 2004-05-21 | 2010-08-18 | Banyu Pharma Co Ltd | SELECTIVE INHIBITORS FOR CDK4 AND CDK6 WITH AMINOTHIAZOLSKELETT |
| US20080027042A1 (en) * | 2004-10-29 | 2008-01-31 | Mitsuru Ohkubo | Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action |
| US7491720B2 (en) * | 2004-10-29 | 2009-02-17 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives having Aurora A selective inhibitory action |
| TW200628463A (en) | 2004-11-10 | 2006-08-16 | Synta Pharmaceuticals Corp | Heteroaryl compounds |
| GB0428082D0 (en) | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
| EP1833807A1 (en) | 2005-01-05 | 2007-09-19 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| WO2006118231A1 (ja) * | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | シアノピリジン誘導体及びその医薬としての用途 |
| WO2006124874A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibitors of b-raf kinase |
| WO2006129842A1 (ja) * | 2005-06-01 | 2006-12-07 | Banyu Pharmaceutical Co., Ltd. | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
| US7572809B2 (en) * | 2005-12-19 | 2009-08-11 | Hoffmann-La Roche Inc. | Isoquinoline aminopyrazole derivatives |
-
2007
- 2007-04-26 JP JP2007116649A patent/JP2008081492A/ja not_active Withdrawn
- 2007-08-29 US US12/310,307 patent/US20100016335A1/en not_active Abandoned
- 2007-08-29 US US11/897,272 patent/US7915263B2/en active Active
- 2007-08-29 EP EP07806706A patent/EP2062887B1/en active Active
- 2007-08-29 JP JP2008532150A patent/JP4466782B2/ja active Active
- 2007-08-29 PE PE2007001171A patent/PE20080835A1/es not_active Application Discontinuation
- 2007-08-29 ES ES07806706T patent/ES2389515T3/es active Active
- 2007-08-29 CA CA2657469A patent/CA2657469C/en not_active Expired - Fee Related
- 2007-08-29 KR KR1020097004339A patent/KR20090055562A/ko not_active Ceased
- 2007-08-29 AR ARP070103835A patent/AR062585A1/es unknown
- 2007-08-29 NZ NZ574081A patent/NZ574081A/en not_active IP Right Cessation
- 2007-08-29 CN CN200780032242.7A patent/CN101528731B/zh not_active Expired - Fee Related
- 2007-08-29 CL CL200702519A patent/CL2007002519A1/es unknown
- 2007-08-29 MX MX2009000390A patent/MX2009000390A/es active IP Right Grant
- 2007-08-29 WO PCT/JP2007/067251 patent/WO2008026769A1/ja not_active Ceased
- 2007-08-29 TW TW096132117A patent/TW200817363A/zh unknown
- 2007-08-29 WO PCT/JP2007/067250 patent/WO2008026768A1/en not_active Ceased
- 2007-08-29 RU RU2009111599/04A patent/RU2437880C2/ru not_active IP Right Cessation
- 2007-08-29 EP EP07806705A patent/EP2061782A4/en not_active Withdrawn
- 2007-08-29 UA UAA200902851A patent/UA95972C2/ru unknown
- 2007-08-29 AU AU2007289609A patent/AU2007289609B2/en not_active Ceased
-
2009
- 2009-01-07 ZA ZA200900126A patent/ZA200900126B/xx unknown
- 2009-01-13 CR CR10553A patent/CR10553A/es not_active Application Discontinuation
- 2009-01-13 GT GT200900008A patent/GT200900008A/es unknown
- 2009-01-13 EC EC2009009062A patent/ECSP099062A/es unknown
- 2009-01-13 IL IL196497A patent/IL196497A0/en unknown
- 2009-01-13 HN HN2009000113A patent/HN2009000113A/es unknown
- 2009-01-14 SV SV2009003152A patent/SV2009003152A/es unknown
- 2009-01-14 CO CO09002429A patent/CO6190529A2/es not_active Application Discontinuation
- 2009-03-20 MA MA31731A patent/MA30719B1/fr unknown
- 2009-03-30 NO NO20091301A patent/NO20091301L/no not_active Application Discontinuation
- 2009-10-29 JP JP2009248400A patent/JP5256168B2/ja active Active
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