AR021542A1 - Un compuesto de sulfonamida y las composiciones y preparaciones farmaceuticas que lo contienen - Google Patents
Un compuesto de sulfonamida y las composiciones y preparaciones farmaceuticas que lo contienenInfo
- Publication number
- AR021542A1 AR021542A1 ARP990106177A ARP990106177A AR021542A1 AR 021542 A1 AR021542 A1 AR 021542A1 AR P990106177 A ARP990106177 A AR P990106177A AR P990106177 A ARP990106177 A AR P990106177A AR 021542 A1 AR021542 A1 AR 021542A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- aryl
- action
- lower alkyl
- heterocyclic group
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- -1 Sulfonamide compounds Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 239000000050 smooth muscle relaxant Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se revelan compuestos de sulfonamida de la formula (1), en la cual: R1 es un grupo arilo o heterocíclico sustituido por lo menos por un sustituyenteseleccionado del grupo consistente en: (a) arilo, (b) un grupo heterocíclico sustituido por oxo o halogeno, (c) halogeno, (d) haloalquilo inferior, (e) alcoxiinferior opcionalmente sustituido por cicloalquilo inferior, (f) amino opcionalmente sustituido por lo menos por un sustituyente seleccionado del grupo queconsiste en alquilo inferior, opcionalmente sustituido por cicloalquilo inferior, carboxi protegido, acilo, alquil-carbamoilo inferior y alcan-sulfoniloinferior, (g) nitro, y (h) alquilo inferior opcionalmente sustituido por arilo; R2 es un alquilo inferior o alcoxi inferior; R3 es un hidrogeno o alquiloinferior; R4 es un alquenilo inferior opcionalmente sustituido por arilo o un grupo heterocíclico, arilo opcionalmente sustituido por carboxi o carboxiprotegido, alquilo inferior opcionalmente sustituido por aciloxi, amino opcionalmente sustituido por alquilo inferior, o grupo heterocíclico opcionalmentesustituido por halogeno; y A es un alquileno inferior o una sal del mismo. Estos compuestos son utiles para la profilaxis y el tratamiento de enfermedadescurables sobre la base deuna accion hipoglucémica y de aquellas enfermedades curables sobre la base de una accion inhibitoria de cGMP-PDE, una accionrelajante de los musculos lisos, una accion broncodilatadora, una accion vasodilatadora, una accion inhibitoria de las células de los musculos lisos y unaaccion inhibitoria de la alergia. También se revelan las composiciones y preparaciones farmacéuticas que contienen dichos compuestos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34617598 | 1998-12-04 | ||
| JP36754098 | 1998-12-24 | ||
| JP25928399 | 1999-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021542A1 true AR021542A1 (es) | 2002-07-24 |
Family
ID=27334802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106177A AR021542A1 (es) | 1998-12-04 | 1999-12-03 | Un compuesto de sulfonamida y las composiciones y preparaciones farmaceuticas que lo contienen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6573274B1 (es) |
| EP (1) | EP1136492A4 (es) |
| KR (1) | KR20010086593A (es) |
| CN (1) | CN1335847A (es) |
| AR (1) | AR021542A1 (es) |
| AU (1) | AU769890B2 (es) |
| BR (1) | BR9916919A (es) |
| CA (1) | CA2352871A1 (es) |
| CZ (1) | CZ20011981A3 (es) |
| HK (1) | HK1044154A1 (es) |
| HU (1) | HUP0104549A3 (es) |
| IL (1) | IL143439A0 (es) |
| TR (1) | TR200101568T2 (es) |
| TW (1) | TW577889B (es) |
| WO (1) | WO2000034277A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0995742A4 (en) * | 1997-06-27 | 2004-08-25 | Fujisawa Pharmaceutical Co | SULPHONAMIDE COMPOUNDS AND THEIR MEDICAL USE |
| KR20030023747A (ko) * | 2000-08-11 | 2003-03-19 | 화이자 인코포레이티드 | 인슐린 저항성 증후군의 치료 |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| WO2005082414A2 (en) * | 2004-03-02 | 2005-09-09 | Astellas Pharma Inc. | Concomitant drugs of a sulfonamide and another therapeutic agent |
| KR20090115151A (ko) * | 2007-02-06 | 2009-11-04 | 씨아이피엘에이 엘티디. | 에틸-ｎ-(2,3-디클로로-6-니트로벤질)글라이신 염산염의 제조방법 |
| JPWO2014123203A1 (ja) * | 2013-02-06 | 2017-02-02 | 京都薬品工業株式会社 | 糖尿病治療薬 |
| GB201321741D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| US9067914B1 (en) * | 2013-12-10 | 2015-06-30 | Genzyme Corporation | Tropomyosin-related kinase (TRK) inhibitors |
| CN112074505B (zh) | 2018-03-08 | 2024-04-05 | 因赛特公司 | 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215994A (en) * | 1990-09-25 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic derivatives |
| EP0503838A3 (en) | 1991-03-08 | 1992-10-07 | Merck & Co. Inc. | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| US5128327A (en) * | 1991-03-25 | 1992-07-07 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle |
| WO1993019067A1 (en) | 1991-09-12 | 1993-09-30 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine derivatives as angiotensin ii antagonists |
| WO1997024334A1 (en) | 1995-12-28 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| DE69826286T2 (de) | 1997-06-27 | 2005-11-24 | Fujisawa Pharmaceutical Co., Ltd. | Derivate mit einem aromatischen ring |
| EP0995742A4 (en) * | 1997-06-27 | 2004-08-25 | Fujisawa Pharmaceutical Co | SULPHONAMIDE COMPOUNDS AND THEIR MEDICAL USE |
-
1999
- 1999-12-01 WO PCT/JP1999/006748 patent/WO2000034277A1/ja not_active Ceased
- 1999-12-01 CA CA002352871A patent/CA2352871A1/en not_active Abandoned
- 1999-12-01 TR TR2001/01568T patent/TR200101568T2/xx unknown
- 1999-12-01 HU HU0104549A patent/HUP0104549A3/hu unknown
- 1999-12-01 AU AU14141/00A patent/AU769890B2/en not_active Ceased
- 1999-12-01 IL IL14343999A patent/IL143439A0/xx unknown
- 1999-12-01 CN CN99816022A patent/CN1335847A/zh active Pending
- 1999-12-01 HK HK02105752.5A patent/HK1044154A1/zh unknown
- 1999-12-01 KR KR1020017006948A patent/KR20010086593A/ko not_active Ceased
- 1999-12-01 EP EP99973290A patent/EP1136492A4/en not_active Withdrawn
- 1999-12-01 BR BR9916919-3A patent/BR9916919A/pt not_active IP Right Cessation
- 1999-12-01 US US09/856,172 patent/US6573274B1/en not_active Expired - Fee Related
- 1999-12-01 CZ CZ20011981A patent/CZ20011981A3/cs unknown
- 1999-12-02 TW TW088121089A patent/TW577889B/zh not_active IP Right Cessation
- 1999-12-03 AR ARP990106177A patent/AR021542A1/es not_active Application Discontinuation
-
2003
- 2003-02-10 US US10/360,806 patent/US6890934B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW577889B (en) | 2004-03-01 |
| HUP0104549A3 (en) | 2002-12-28 |
| KR20010086593A (ko) | 2001-09-13 |
| AU769890B2 (en) | 2004-02-05 |
| WO2000034277A1 (en) | 2000-06-15 |
| EP1136492A1 (en) | 2001-09-26 |
| US6573274B1 (en) | 2003-06-03 |
| BR9916919A (pt) | 2002-01-15 |
| CA2352871A1 (en) | 2000-06-15 |
| HK1044154A1 (zh) | 2002-10-11 |
| IL143439A0 (en) | 2002-04-21 |
| CN1335847A (zh) | 2002-02-13 |
| EP1136492A4 (en) | 2002-03-27 |
| HUP0104549A2 (hu) | 2002-04-29 |
| US20030171396A1 (en) | 2003-09-11 |
| US6890934B2 (en) | 2005-05-10 |
| TR200101568T2 (tr) | 2001-10-22 |
| CZ20011981A3 (cs) | 2002-01-16 |
| AU1414100A (en) | 2000-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |