AR015515A1 - Compuestos de triazol-[4,5-d]pirimidina, composiciones farmaceuticas que los contienen y proceso para la preparacion de dichos compuestos - Google Patents
Compuestos de triazol-[4,5-d]pirimidina, composiciones farmaceuticas que los contienen y proceso para la preparacion de dichos compuestosInfo
- Publication number
- AR015515A1 AR015515A1 ARP990100529A ARP990100529A AR015515A1 AR 015515 A1 AR015515 A1 AR 015515A1 AR P990100529 A ARP990100529 A AR P990100529A AR P990100529 A ARP990100529 A AR P990100529A AR 015515 A1 AR015515 A1 AR 015515A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- halogen
- cycloalkyl
- compounds
- Prior art date
Links
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical class C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 title 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- -1 methylenedioxy Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Compuestos de triazol[4,5-d]pirimidina de formula (I) en donde: R1 es un grupo alquilo C1-6, alquenilo C2-6 alquinilo C2-6, cicloalquilo C3-8, arilo otienilo, estando cada grupo opcionalmente sustituido con uno o más sustituyentes seleccionados apar tir de halogeno, OR8, NR9R10, SR11 o alquilo C1-6 (estandoel mismo opcionalmente sustituido con uno o más átomos de halogeno); R2 es alquilo C1-8, alquenilo C2-8 o cicloalquilo C3-8 cada uno de los cuales puede estaropcionalmente sustituido conuno o más sustituyentes seleccionados a partir de halogeno, OR8, NR9R10, SR11, alquilo C1-6, cicloalquilo C3-8, piridilo o arilo(pudiendo los dos ultimos estar opcionalmente sustituidos con uno o más sustituyentes seleccionados a partir de halogeno,OR20, C(O)R11, NR14C(O)R15,NR16SO2R17, SO2NR18R19, nitro, NR12R13, SR11, metilendioxi o alquilo C1-6 que está opcionalmente sustituido con uno o más átomos de halogeno); R3 y R4 sonambos de hidroxi, R5 es hidrogeno o alquilo C1-6, R6 es alquilo C1-6opcio nalmente sustituido con uno o más grupos seleccionados a partir de alquilo C1-6,alquenilo C2-6, alquinilo C2-6, halogeno, OR21, cicloalquilo C3-6, o R6 es cicloalquilo C3-6, o R6 es -A-fenilo o -A-piridilo pudiendo estar cada uno deellosopcionalment e sustituido con uno o más grupos seleccionados a partir de alquilo C1-6, alquenilo C2-6, alquinilo C2-6, halogeno, OC1-6 alquilo, cicloalquiloC3-6, o metilendioxi, o R5 y R6 junto con el átomo de nitrogeno al cual están unidosforman un anillo satur ado de 5 a 7-miebros opcionalmente sustituido conalquilo C1-6; A es un enlace o alquilo C1-6; R8 es hidrogeno, alquilo C1-6 (el cual puede estar opcionalmente sustituido con uno o más átomos de halogeno) oarilo (el cual puedeestar opcionalmente sust ituido con uno o más sustituyentes seleccionados a partir de halogeno, nitro, C(O)R11, OR20, SR11, NR12R13,NR14C(O)R15, NR16SO2R17, SO2NR18R19; R9 es H, alquilo C1-6(el cual puede estar opcionalmente sustituido con uno o másátomos de halogeno) o ari lo (el cualpuede estar opcionalmente sustituido con uno o más sustituyentes seleccionados a partir de halogeno, nitro, C(O)R20, OR20, SR11, NR12R13, NR14C(O)R15,
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9800458A SE9800458D0 (sv) | 1998-02-17 | 1998-02-17 | Novel compounds |
| SE9803669A SE9803669D0 (sv) | 1998-10-26 | 1998-10-26 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015515A1 true AR015515A1 (es) | 2001-05-02 |
Family
ID=26663214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100529A AR015515A1 (es) | 1998-02-17 | 1999-02-08 | Compuestos de triazol-[4,5-d]pirimidina, composiciones farmaceuticas que los contienen y proceso para la preparacion de dichos compuestos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6369064B1 (es) |
| EP (1) | EP1056749B1 (es) |
| JP (1) | JP2002503663A (es) |
| KR (1) | KR20010078696A (es) |
| CN (1) | CN1291193A (es) |
| AR (1) | AR015515A1 (es) |
| AT (1) | ATE232866T1 (es) |
| AU (1) | AU2650099A (es) |
| BR (1) | BR9907934A (es) |
| CA (1) | CA2316264A1 (es) |
| DE (1) | DE69905451T2 (es) |
| HU (1) | HUP0100328A3 (es) |
| ID (1) | ID27127A (es) |
| IL (1) | IL137812A0 (es) |
| MX (1) | MXPA00007634A (es) |
| NO (1) | NO20004089L (es) |
| NZ (1) | NZ505250A (es) |
| PL (1) | PL342430A1 (es) |
| SK (1) | SK12242000A3 (es) |
| TR (1) | TR200002380T2 (es) |
| WO (1) | WO1999041254A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702773D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| SE9904129D0 (sv) | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| AR028110A1 (es) * | 2000-06-02 | 2003-04-23 | Astrazeneca Ab | Nuevo proceso |
| GB0013488D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| US7086397B2 (en) * | 2002-02-16 | 2006-08-08 | Graham Lindley Spruiell | Patient usable emergency medical kit |
| GB0219746D0 (en) * | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
| US7504497B2 (en) * | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
| US7749981B2 (en) | 2003-10-21 | 2010-07-06 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound |
| US7335648B2 (en) | 2003-10-21 | 2008-02-26 | Inspire Pharmaceuticals, Inc. | Non-nucleotide composition and method for inhibiting platelet aggregation |
| EP1685135B1 (en) * | 2003-10-21 | 2010-05-26 | Inspire Pharmaceuticals, Inc. | TETRAHYDRO-FURO[3,4-d]DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION |
| US7932376B2 (en) | 2005-05-05 | 2011-04-26 | Inspire Pharmaceuticals, Inc. | Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation |
| JPWO2007020935A1 (ja) * | 2005-08-17 | 2009-02-26 | 小野薬品工業株式会社 | Ｐ２ｙ１２受容体および／またはｐ２ｙ１４受容体ブロッカーを含有してなる疼痛治療剤 |
| US7566722B2 (en) | 2006-10-31 | 2009-07-28 | Janssen Pharmaceutica, N.V. | Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists |
| BRPI0918038B1 (pt) * | 2008-09-09 | 2021-07-13 | Astrazeneca Ab | Processo para preparar um composto |
| WO2015027431A1 (en) * | 2013-08-29 | 2015-03-05 | Merck Sharp & Dohme Corp. | 2,2-difluorodioxolo a2a receptor antagonists |
| WO2015162630A1 (en) * | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
| DK3433234T3 (da) | 2016-03-22 | 2022-01-03 | Merck Sharp & Dohme | Allosteriske modulatorer af nicotinacetylcholinreceptorer |
| CN111116592A (zh) * | 2019-11-27 | 2020-05-08 | 杭州沧海帆医药科技有限公司 | 嘧啶并三氮唑类化合物及其医药用途 |
| CN112876485A (zh) * | 2021-01-25 | 2021-06-01 | 郭丽伟 | 一种用于治疗子宫平滑肌高频率强直性收缩相关疾病的化合物 |
| US20250017936A1 (en) * | 2021-11-22 | 2025-01-16 | Purdue Research Foundation | Cell-potent bisubstrate inhibitors for nicotinamide n-methyltransferase (nnmt) and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4742064A (en) | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
| GB8826205D0 (en) | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
| TW427996B (en) | 1995-07-11 | 2001-04-01 | Astra Pharma Prod | Novel triazolopyrimidines and their use as medicaments |
| WO1998028300A1 (en) | 1996-12-20 | 1998-07-02 | Astra Pharmaceuticals Ltd. | Triazolo[4,5-d]pyrimidinyl derivatives and their use as medicaments |
| SE9702772D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| SE9702774D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
-
1999
- 1999-02-05 BR BR9907934-8A patent/BR9907934A/pt not_active IP Right Cessation
- 1999-02-05 WO PCT/SE1999/000154 patent/WO1999041254A1/en not_active Ceased
- 1999-02-05 ID IDW20001348A patent/ID27127A/id unknown
- 1999-02-05 DE DE69905451T patent/DE69905451T2/de not_active Expired - Fee Related
- 1999-02-05 IL IL13781299A patent/IL137812A0/xx unknown
- 1999-02-05 TR TR2000/02380T patent/TR200002380T2/xx unknown
- 1999-02-05 US US09/269,330 patent/US6369064B1/en not_active Expired - Fee Related
- 1999-02-05 AT AT99906644T patent/ATE232866T1/de not_active IP Right Cessation
- 1999-02-05 JP JP2000531447A patent/JP2002503663A/ja active Pending
- 1999-02-05 SK SK1224-2000A patent/SK12242000A3/sk unknown
- 1999-02-05 PL PL99342430A patent/PL342430A1/xx not_active Application Discontinuation
- 1999-02-05 AU AU26500/99A patent/AU2650099A/en not_active Abandoned
- 1999-02-05 NZ NZ505250A patent/NZ505250A/xx unknown
- 1999-02-05 EP EP99906644A patent/EP1056749B1/en not_active Expired - Lifetime
- 1999-02-05 MX MXPA00007634A patent/MXPA00007634A/es unknown
- 1999-02-05 CA CA002316264A patent/CA2316264A1/en not_active Abandoned
- 1999-02-05 HU HU0100328A patent/HUP0100328A3/hu unknown
- 1999-02-05 KR KR1020007008936A patent/KR20010078696A/ko not_active Withdrawn
- 1999-02-05 CN CN99802951A patent/CN1291193A/zh active Pending
- 1999-02-08 AR ARP990100529A patent/AR015515A1/es unknown
-
2000
- 2000-08-16 NO NO20004089A patent/NO20004089L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2316264A1 (en) | 1999-08-19 |
| EP1056749A1 (en) | 2000-12-06 |
| HUP0100328A3 (en) | 2003-04-28 |
| CN1291193A (zh) | 2001-04-11 |
| MXPA00007634A (es) | 2003-09-10 |
| IL137812A0 (en) | 2001-10-31 |
| JP2002503663A (ja) | 2002-02-05 |
| KR20010078696A (ko) | 2001-08-21 |
| AU2650099A (en) | 1999-08-30 |
| ID27127A (id) | 2001-03-01 |
| US6369064B1 (en) | 2002-04-09 |
| TR200002380T2 (tr) | 2001-03-21 |
| HUP0100328A2 (hu) | 2001-09-28 |
| DE69905451D1 (de) | 2003-03-27 |
| NO20004089L (no) | 2000-10-16 |
| BR9907934A (pt) | 2000-10-24 |
| PL342430A1 (en) | 2001-06-04 |
| NZ505250A (en) | 2002-10-25 |
| WO1999041254A1 (en) | 1999-08-19 |
| EP1056749B1 (en) | 2003-02-19 |
| NO20004089D0 (no) | 2000-08-16 |
| SK12242000A3 (sk) | 2001-03-12 |
| DE69905451T2 (de) | 2003-11-20 |
| ATE232866T1 (de) | 2003-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |