[go: up one dir, main page]

ES2087854T3 - Nuevos oxatiolanos y derivados de los mismos, composiciones farmaceuticas que los contienen y el uso de los mismos como medicamentos. - Google Patents

Nuevos oxatiolanos y derivados de los mismos, composiciones farmaceuticas que los contienen y el uso de los mismos como medicamentos.

Info

Publication number
ES2087854T3
ES2087854T3 ES88310040T ES88310040T ES2087854T3 ES 2087854 T3 ES2087854 T3 ES 2087854T3 ES 88310040 T ES88310040 T ES 88310040T ES 88310040 T ES88310040 T ES 88310040T ES 2087854 T3 ES2087854 T3 ES 2087854T3
Authority
ES
Spain
Prior art keywords
same
hydrogen
group
sec
oxatiolanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88310040T
Other languages
English (en)
Inventor
Abraham Fisher
Ishai Karton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
State of Israel
Original Assignee
State of Israel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by State of Israel filed Critical State of Israel
Application granted granted Critical
Publication of ES2087854T3 publication Critical patent/ES2087854T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NUEVOS COMPUESTOS DE ESPIRO - OXATIOLANO/QUINUCLIDINA QUE CORRESPONDEN A LA FORMULA(I) Y LOS ISOMEROS GEOMETRICOS, ENANTIOMEROS, DIESTEROISOMEROS, RACEMALOS Y SALES DE ADICION ACIDAS, DONDE UNO DE Y Y Z ES O Y EL OTRO ES S(= O)N; N ES 0, 1 O 2; R''Y R" SON SLECCIONADOS DEL GRUPO CONSISTENTE EN H, ALQUILO, ALQUENILO, ALQUINILO, HIDROXUALQUILO, AMINOALQUILO, C3 - C7 CICLOALQUILO, ARILO, DIARILMETILOL Y ALQUILO SUSTITUIDO POR AL MENOS UN GRUPO ARILO, SIEMPRE QUE AL MENOS R''O R" SEAN DISTINTOSD DE H; Y X ES H, O CUANDO Y ES O Y Z ES S(= O)N SIMULTANEAMENTE, ENTONCES X PUEDE SER SELECCINADA DEL GRUPO CONSISTENTE EN DEUTERIO Y TRITIO, SIEMPRE QUE CUANDO CADA X ES H, Y ES O Y Z ES S SIMULTANEAMENTE, ENTONCES AL MENOS UNO DE R''Y R" SE SELECCIONAN DEL GRUPO ALQUENMILO, ALQUINILO, CICLOPROPILO, CICLOBUTILO, CICLOHEPTILO, HIDROXIALQUILO Y AMINOALQUILO. ESTOS COMPUESTOS SON UTILES PARA FABRICAR AGENTES TERAPEUTICOS Y DE DIAGNOSTICO APLICABLES AL SISTEMA NERVIOSO CENTRAL Y SISTEMA COLINERGICO.
ES88310040T 1987-10-28 1988-10-26 Nuevos oxatiolanos y derivados de los mismos, composiciones farmaceuticas que los contienen y el uso de los mismos como medicamentos. Expired - Lifetime ES2087854T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11447387A 1987-10-28 1987-10-28
US07/189,210 US4876260A (en) 1987-10-28 1988-05-02 Oxathiolanes

Publications (1)

Publication Number Publication Date
ES2087854T3 true ES2087854T3 (es) 1996-08-01

Family

ID=26812231

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88310040T Expired - Lifetime ES2087854T3 (es) 1987-10-28 1988-10-26 Nuevos oxatiolanos y derivados de los mismos, composiciones farmaceuticas que los contienen y el uso de los mismos como medicamentos.

Country Status (13)

Country Link
US (1) US4876260A (es)
EP (1) EP0314444B1 (es)
JP (1) JP2753280B2 (es)
KR (1) KR910007979B1 (es)
AT (1) ATE138663T1 (es)
AU (1) AU608903B2 (es)
CA (1) CA1315791C (es)
DE (1) DE3855325T2 (es)
DK (1) DK175064B1 (es)
ES (1) ES2087854T3 (es)
IL (1) IL87834A (es)
NO (1) NO167806C (es)
NZ (1) NZ226415A (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
JP2683783B2 (ja) * 1992-07-10 1997-12-03 雪印乳業株式会社 シェーグレン症候群治療剤
DE4343838C2 (de) * 1993-12-22 1998-07-09 Lohmann Therapie Syst Lts Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung
US6572880B2 (en) 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US6290986B1 (en) 1996-10-24 2001-09-18 Pharmaceutical Applications Associates, Llc Method and composition for transdermal administration of pharmacologic agents
US6479074B2 (en) 1996-10-24 2002-11-12 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
ZA984637B (en) 1997-05-30 1998-12-21 Neurosearch As Spiro-quinuclidine derivatives their preparation and use
US20040209849A1 (en) * 1998-11-27 2004-10-21 Sanochemia Pharmazeutika Aktiengesellschaft Use of effectors of the central cholinergic nervous system for treatment of delirium
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
US6433168B1 (en) 1999-07-26 2002-08-13 Sumika Fine Chemicals Co., Ltd. Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
PT2938071T (pt) 2001-11-29 2018-01-08 Godo Kaisha Ip Bridge 1 Método de remoção de distorção de codificação
BR0309875A (pt) * 2002-05-03 2007-04-10 Israel Inst For Biolog Res Isr métodos e composições para tratamento de distúrbios do sistema nervoso periférico e novos compostos úteis para isto
AR061522A1 (es) * 2006-06-20 2008-09-03 Wyeth Corp Derivados de 4-oxo-1, 3, 8-triaza[4.5]decanos como inhibidores del canal de potasio kv1.5, una composicion que los comprende y su empleo en el tratamiento de afecciones cardiacas.
US8143400B2 (en) * 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
KR20110086769A (ko) * 2008-11-23 2011-07-29 화이자 인코포레이티드 베타 세크레타제 억제제로서의 락탐
CA2750777C (en) 2009-01-26 2018-04-03 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
CN101798311A (zh) * 2010-04-07 2010-08-11 天津炜杰凯华科技有限公司 顺式西维美林的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2146962A1 (en) * 1971-07-28 1973-03-09 Yoshitomi Pharmaceutical Aza-spirodecanones - useful in treating gastric disorders
IL48453A (en) * 1975-11-11 1980-06-30 Purdue Frederick Co Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
IL48452A (en) * 1975-11-11 1979-07-25 Purdue Frederick Co Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
US4855290A (en) * 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
ZA868369B (en) * 1986-01-10 1987-11-25 Israel State Derivatives of quinuclidine
IL87234A (en) * 1987-08-13 1992-02-16 Israel Inst Biolog Res Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU2367188A (en) 1989-05-04
AU608903B2 (en) 1991-04-18
NO167806C (no) 1991-12-11
DE3855325D1 (de) 1996-07-04
CA1315791C (en) 1993-04-06
IL87834A (en) 1992-05-25
JP2753280B2 (ja) 1998-05-18
EP0314444B1 (en) 1996-05-29
DE3855325T2 (de) 1996-10-10
JPH0262883A (ja) 1990-03-02
NO884790D0 (no) 1988-10-27
NO167806B (no) 1991-09-02
EP0314444A3 (en) 1990-11-07
US4876260A (en) 1989-10-24
DK175064B1 (da) 2004-05-17
NZ226415A (en) 1990-05-28
DK598688D0 (da) 1988-10-27
DK598688A (da) 1989-04-29
EP0314444A2 (en) 1989-05-03
KR890006641A (ko) 1989-06-15
IL87834A0 (en) 1989-03-31
NO884790L (no) 1989-05-02
ATE138663T1 (de) 1996-06-15
KR910007979B1 (ko) 1991-10-05

Similar Documents

Publication Publication Date Title
ES2087854T3 (es) Nuevos oxatiolanos y derivados de los mismos, composiciones farmaceuticas que los contienen y el uso de los mismos como medicamentos.
CA2066640A1 (en) Heterocyclic compounds
ES8609303A1 (es) Un procedimiento para la preparacion de un derivado de acido6-fluor-1,4-dihidro-4-oxo-7-piperazinilquinolin sustituido-3-carboxilico
ES464324A1 (es) Un procedimiento para la preparacion de nuevos derivados de piperidina de actividad parasiticida.
NZ240676A (en) Heterocyclic compounds substituted by a (piperidin-4-yl)-1-oxoalkyl group and pharmaceutical compositions thereof
FI810250L (fi) Foerfarande foer framstaellning av nya terapeutiskt aktiva heterocykliska foereningar
GR890300125T1 (en) Billiary acid derivatives, processes for the preparation thereof and phamaceutical compositions containing them
GB1087243A (en) Improvements in or relating to naphthalene derivatives and the manufacture thereof
ATE51618T1 (de) Imidazolderivate, verfahren zu deren herstellung, deren anwendung und pharmazeutische zusammenstellungen.
ATE103921T1 (de) 1-oxa-2-oxo-8-azaspiro(4,5>decan-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen daraus.
EP0404737A3 (en) New r(-) 3-quinuclidinol derivatives
HUT75647A (en) Imidazolidinone derivatives and pharmaceutical compositions containing them, which are suitable for treament of senile dementia
ES8305359A1 (es) Un procedimiento para la preparacion de benzamitas sustituidas.
ES465322A1 (es) Un procedimiento para preparar compuestos e imericos de 4"- amino.
PT90302A (pt) Processo para a preparacao de derivados de lactamas hetero-tetraciclicas
ES2138052T3 (es) Derivados de ciclopropano y agentes antiviricos que los contienen.
SE8803765L (sv) Nya isopolypeptider samt foerfarande foer framstaellning av desamma
ATE42287T1 (de) Homocysteinthiolactonderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DK364386D0 (da) 1-alkyl-ergolinyl-thiourinstofderivater og fremgangsmaade til fremstilling deraf samt deres anvendelse
SE8406046D0 (sv) New azabiocyclic compounds and a process for the preparation thereof
ATE63550T1 (de) Neue 1-/ 3-(2-dialkylaminoaethoxy)-2-thienyl/-3phenyl-1-propanone und ihre saeureadditionssalze und verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE22683T1 (de) Substituiertes heterocyclylphenylsulphonyl und phosphonylamidine, verfahren zu deren herstellung und deren pharmazeutische anwendung.
DE3772002D1 (de) Heterocyclische herbizide.
ES2036594T3 (es) Piperidinas, o azepinas substituidas, su preparacion y su aplicacion en terapeutica.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 314444

Country of ref document: ES