AR008721A1 - Nueva composicion medicamentosa acuosa y su utilizacion para la produccion de aerosoles libres de gas propulsor - Google Patents
Nueva composicion medicamentosa acuosa y su utilizacion para la produccion de aerosoles libres de gas propulsorInfo
- Publication number
- AR008721A1 AR008721A1 ARP970106019A ARP970106019A AR008721A1 AR 008721 A1 AR008721 A1 AR 008721A1 AR P970106019 A ARP970106019 A AR P970106019A AR P970106019 A ARP970106019 A AR P970106019A AR 008721 A1 AR008721 A1 AR 008721A1
- Authority
- AR
- Argentina
- Prior art keywords
- production
- atrovent
- drug composition
- aqueous drug
- new aqueous
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000007921 spray Substances 0.000 title 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 abstract 3
- 229940098165 atrovent Drugs 0.000 abstract 3
- KEWHKYJURDBRMN-XSAPEOHZSA-M chembl2134724 Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-XSAPEOHZSA-M 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- LSLYOANBFKQKPT-UHFFFAOYSA-N fenoterol Chemical compound C=1C(O)=CC(O)=CC=1C(O)CNC(C)CC1=CC=C(O)C=C1 LSLYOANBFKQKPT-UHFFFAOYSA-N 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 229960002052 salbutamol Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 Ba 679 Br Chemical compound 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 229940097478 combivent Drugs 0.000 abstract 1
- 229960001361 ipratropium bromide Drugs 0.000 abstract 1
- LHLMOSXCXGLMMN-VVQPYUEFSA-M ipratropium bromide Chemical compound [Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 LHLMOSXCXGLMMN-VVQPYUEFSA-M 0.000 abstract 1
- RGHXWDVNBYKJQH-UHFFFAOYSA-N nitroacetic acid Chemical compound OC(=O)C[N+]([O-])=O RGHXWDVNBYKJQH-UHFFFAOYSA-N 0.000 abstract 1
- LCELQERNWLBPSY-YAYGZGPXSA-M oxivent Chemical compound [Br-].C1([C@@H](CO)C(=O)OC2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CC)=CC=CC=C1 LCELQERNWLBPSY-YAYGZGPXSA-M 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
Composicion medicamentosa acuosa en forma de solucion y su utilizacion para la produccion de aerosoles libres de gas propulsor, para inhalacion. Lascomposiciones contienen un principio activo farmacologicamente eficaz seleccionado a partirdel grupo de los bemiméticos, anticolinérgicos,antialérgicos y/o antihistamínicos, un formador de complejos, un conservante, sustancias auxiliares, saborizantes y etanol. El principio activo estádestinado para la administracion inhalativa, especialmente para el tratamiento de las vías respiratorias. Tal principio activo se selecciona entre: fenotrol,bromuro de ipratropio, berotec, atrovent, berodual, atrovent, berotec, salbutamol, combivent, atrovent, salbutamol, Ba 679 Br, BEA 2108Br y oxivent.El formador de complejos se selecciona entre: ácido nitroacético, ácido cítrico, ácido ascorbico, o sus sales y EDTA o sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19653969A DE19653969A1 (de) | 1996-12-20 | 1996-12-20 | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008721A1 true AR008721A1 (es) | 2000-02-09 |
Family
ID=7815979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970106019A AR008721A1 (es) | 1996-12-20 | 1997-12-19 | Nueva composicion medicamentosa acuosa y su utilizacion para la produccion de aerosoles libres de gas propulsor |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US20010008632A1 (es) |
| EP (2) | EP0946146B1 (es) |
| JP (1) | JP4659160B2 (es) |
| KR (1) | KR100496723B1 (es) |
| CN (1) | CN1097455C (es) |
| AR (1) | AR008721A1 (es) |
| AT (1) | ATE235887T1 (es) |
| AU (1) | AU740543B2 (es) |
| BG (1) | BG64433B1 (es) |
| BR (1) | BRPI9713596C1 (es) |
| CA (1) | CA2275392C (es) |
| CO (1) | CO4920211A1 (es) |
| DE (2) | DE19653969A1 (es) |
| DK (1) | DK0946146T3 (es) |
| EE (1) | EE03949B1 (es) |
| EG (1) | EG23981A (es) |
| ES (1) | ES2196388T3 (es) |
| HR (1) | HRP970694B1 (es) |
| HU (2) | HU228494B1 (es) |
| ID (1) | ID22481A (es) |
| IL (1) | IL130464A (es) |
| MY (1) | MY124547A (es) |
| NO (1) | NO320652B1 (es) |
| NZ (1) | NZ336825A (es) |
| PE (1) | PE32899A1 (es) |
| PL (1) | PL189511B1 (es) |
| PT (1) | PT946146E (es) |
| RS (1) | RS49803B (es) |
| RU (1) | RU2219906C2 (es) |
| SA (1) | SA97180756B1 (es) |
| SI (1) | SI0946146T1 (es) |
| SK (1) | SK282910B6 (es) |
| TR (1) | TR199901408T2 (es) |
| TW (1) | TW438605B (es) |
| UA (1) | UA64736C2 (es) |
| UY (1) | UY24813A1 (es) |
| WO (1) | WO1998027959A2 (es) |
| ZA (1) | ZA9711370B (es) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19615422A1 (de) | 1996-04-19 | 1997-11-20 | Boehringer Ingelheim Kg | Zweikammer-Kartusche für treibgasfreie Dosieraerosole |
| DE19733651A1 (de) * | 1997-08-04 | 1999-02-18 | Boehringer Ingelheim Pharma | Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole |
| DE19808295A1 (de) | 1998-02-27 | 1999-11-11 | Boehringer Ingelheim Int | Behälter für eine medizinische Flüssigkeit |
| DE19847968A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
| SE9803770D0 (sv) * | 1998-11-05 | 1998-11-05 | Astra Ab | Dry powder pharmaceutical formulation |
| DE19940713A1 (de) | 1999-02-23 | 2001-03-01 | Boehringer Ingelheim Int | Kartusche für eine Flüssigkeit |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| US20100197719A1 (en) * | 1999-05-12 | 2010-08-05 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
| US20040002548A1 (en) * | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
| DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
| WO2002026223A2 (en) * | 2000-09-29 | 2002-04-04 | Board Of Trustees Operating Michigan State University | Catecholamine pharmaceutical compositions and methods |
| RS50859B (sr) * | 2000-10-31 | 2010-08-31 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg. | Formulacija rastvora za inhalaciju sa soli tiotropijuma |
| DE10062712A1 (de) * | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
| SK288031B6 (sk) * | 2000-10-31 | 2012-12-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Propellant-free liquid inhalation formulation |
| US20020137764A1 (en) | 2000-10-31 | 2002-09-26 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
| US20020193392A1 (en) * | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
| DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
| GB2375958B (en) * | 2001-04-09 | 2005-03-02 | George Margetts | The use of steroids to lower the levels of cortisol |
| DE10136555A1 (de) | 2001-07-27 | 2003-02-13 | Boehringer Ingelheim Int | Optimierte Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung derartiger Verfahren |
| DK1446119T3 (da) * | 2001-09-18 | 2006-07-10 | Nycomed Danmark Aps | Præparater omfattende Ipratropium og xylometazolin til behandling af almindelig forkölelse |
| CA2464660C (en) * | 2001-10-26 | 2011-12-20 | Dey, L.P. | Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma |
| AU3297402A (en) * | 2001-10-26 | 2003-10-30 | Dey, L.P. | An albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease |
| JP2010184937A (ja) * | 2001-10-26 | 2010-08-26 | Dey Lp | 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、キット、吸入溶液を中に有する１容器を作成する方法、および、吸入溶液を作成する方法 |
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| EP1531866A1 (en) * | 2002-08-29 | 2005-05-25 | Cipla Ltd. | Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids |
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| US9808471B2 (en) * | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| GB2400554B (en) * | 2003-04-16 | 2007-04-18 | George Margetts | Treatment of angiotensin II-induced cardiovascular disease |
| US8912174B2 (en) | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
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| US20050203088A1 (en) * | 2004-01-09 | 2005-09-15 | Boehringer Ingelheim International Gmbh | Medicament combinations based on scopine- or tropene acid esters with EGFR-kinase inhibitors |
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| US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
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| JP5658268B2 (ja) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
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| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| RU2479304C1 (ru) * | 2012-05-29 | 2013-04-20 | Шолекс Девелопмент Гмбх, | Стабильный раствор фенотерола гидробромида |
| RU2493827C1 (ru) * | 2012-10-03 | 2013-09-27 | Шолекс Девелопмент Гмбх | Стабильный комбинированный раствор фенотерола гидробромида и ипратропия бромида |
| MX2015013845A (es) | 2013-04-01 | 2016-05-09 | Pulmatrix Inc | Polvos secos de tiotropio. |
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| WO2015065223A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Стабильный раствор фенотерола гидробромида |
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-
1996
- 1996-12-20 DE DE19653969A patent/DE19653969A1/de not_active Ceased
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1997
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- 1997-12-16 JP JP52833698A patent/JP4659160B2/ja not_active Expired - Lifetime
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- 1997-12-16 DK DK97952949T patent/DK0946146T3/da active
- 1997-12-16 SI SI9730537T patent/SI0946146T1/xx unknown
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- 1997-12-16 WO PCT/EP1997/007062 patent/WO1998027959A2/de not_active Ceased
- 1997-12-16 BR BRPI9713596A patent/BRPI9713596C1/pt not_active IP Right Cessation
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- 1997-12-16 EP EP97952949A patent/EP0946146B1/de not_active Expired - Lifetime
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- 1997-12-16 HU HU0600044A patent/HU228494B1/hu unknown
- 1997-12-16 NZ NZ336825A patent/NZ336825A/en not_active IP Right Cessation
- 1997-12-16 EP EP02010785A patent/EP1230916A3/de not_active Withdrawn
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- 1997-12-16 AU AU56636/98A patent/AU740543B2/en not_active Expired
- 1997-12-16 US US09/331,023 patent/US20010008632A1/en not_active Abandoned
- 1997-12-16 AT AT97952949T patent/ATE235887T1/de active
- 1997-12-16 RU RU99116025/15A patent/RU2219906C2/ru active
- 1997-12-16 SK SK814-99A patent/SK282910B6/sk not_active IP Right Cessation
- 1997-12-16 CN CN97180735A patent/CN1097455C/zh not_active Expired - Lifetime
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