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AP2009004763A0 - Pyrazole derivatives as cytochrome P450 inhibitors - Google Patents

Pyrazole derivatives as cytochrome P450 inhibitors

Info

Publication number
AP2009004763A0
AP2009004763A0 AP2009004763A AP2009004763A AP2009004763A0 AP 2009004763 A0 AP2009004763 A0 AP 2009004763A0 AP 2009004763 A AP2009004763 A AP 2009004763A AP 2009004763 A AP2009004763 A AP 2009004763A AP 2009004763 A0 AP2009004763 A0 AP 2009004763A0
Authority
AP
ARIPO
Prior art keywords
cytochrome
inhibitors
pyrazole derivatives
pyrazole
derivatives
Prior art date
Application number
AP2009004763A
Other languages
English (en)
Inventor
Rongliang Chen
Simon Paul Planken
Scott Channing Sutton
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2009004763A0 publication Critical patent/AP2009004763A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AP2009004763A 2006-07-05 2007-06-25 Pyrazole derivatives as cytochrome P450 inhibitors AP2009004763A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80659606P 2006-07-05 2006-07-05
US91098807P 2007-04-10 2007-04-10
US94180807P 2007-06-04 2007-06-04
PCT/IB2007/001878 WO2008004096A1 (fr) 2006-07-05 2007-06-25 Dérivés de pyrazole utilisés en tant qu'inhibiteurs du cytochrome p450

Publications (1)

Publication Number Publication Date
AP2009004763A0 true AP2009004763A0 (en) 2009-02-28

Family

ID=38515807

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2009004763A AP2009004763A0 (en) 2006-07-05 2007-06-25 Pyrazole derivatives as cytochrome P450 inhibitors

Country Status (24)

Country Link
US (1) US7919488B2 (fr)
EP (1) EP2046774A1 (fr)
KR (1) KR20090034958A (fr)
CN (1) CN101511812A (fr)
AP (1) AP2009004763A0 (fr)
AR (1) AR062154A1 (fr)
AU (1) AU2007270814B2 (fr)
CA (1) CA2660031A1 (fr)
CO (1) CO6150178A2 (fr)
CR (1) CR10573A (fr)
EA (1) EA200900135A1 (fr)
GT (1) GT200700053A (fr)
IL (1) IL196490A0 (fr)
MA (1) MA30629B1 (fr)
MX (1) MX2009000482A (fr)
NO (1) NO20090346L (fr)
NZ (1) NZ574207A (fr)
PE (1) PE20080998A1 (fr)
RS (1) RS20090036A (fr)
TN (1) TN2009000033A1 (fr)
TW (1) TWI334867B (fr)
UY (1) UY30460A1 (fr)
WO (1) WO2008004096A1 (fr)
ZA (1) ZA200900478B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101534824A (zh) * 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷
CN101679258A (zh) * 2007-03-13 2010-03-24 亚瑞特医疗公司 作为可溶性环氧化合物水解酶抑制剂的4-哌啶基脲化合物
JP2011512359A (ja) 2008-02-14 2011-04-21 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のアンタゴニストとしての環式ジアリールエーテル化合物
JP2011518130A (ja) 2008-04-02 2011-06-23 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のアミノアルキルフェニルアンタゴニスト
DE102008057364A1 (de) 2008-11-14 2010-05-20 Bayer Schering Pharma Aktiengesellschaft Substituierte Aryl-Verbindungen und ihre Verwendung
DE102008057344A1 (de) 2008-11-14 2010-05-20 Bayer Schering Pharma Aktiengesellschaft Aminoalkyl-substituierte Aryl-Verbindungen und ihre Verwendung
DE102009041242A1 (de) 2009-09-11 2011-12-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung
DE102008057343A1 (de) 2008-11-14 2010-05-20 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung
DE102009041241A1 (de) 2009-09-11 2011-08-04 Bayer Schering Pharma Aktiengesellschaft, 13353 Substituierte Aryl-Verbindungen und ihre Verwendung
US8383654B2 (en) 2008-11-17 2013-02-26 Panmira Pharmaceuticals, Llc Heterocyclic antagonists of prostaglandin D2 receptors
JP5860459B2 (ja) 2010-06-30 2016-02-16 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激薬
ES2572803T3 (es) 2010-11-09 2016-06-02 Ironwood Pharmaceuticals, Inc. Estimuladores de GCs
US9139564B2 (en) 2011-12-27 2015-09-22 Ironwood Pharmaceuticals, Inc. 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators
WO2014000178A1 (fr) * 2012-06-27 2014-01-03 Merck Sharp & Dohme Corp. Dérivés de sulfamide et leurs méthodes d'utilisation permettant d'améliorer la pharmacocinétique d'un médicament
CN104540813A (zh) * 2012-06-27 2015-04-22 默沙东公司 磺酰胺衍生物以及使用它们用于改善药物的药物动力学的方法
WO2014194519A1 (fr) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Dérivés imidazole et leurs procédés d'utilisation pour l'amélioration des propriétés pharmacocinétiques d'un médicament
WO2015070366A1 (fr) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Dérivés d'imidazole et de triazole liés à aryle et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament
WO2015070367A1 (fr) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Dérivés d'imidazole et de triazole liés à la pipéridine ou la pipérazine et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0024795D0 (en) 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases
SI1373263T1 (en) * 2001-04-05 2005-04-30 Torrent Pharmaceuticals Ltd Heterocyclic compounds for aging-related and diabetic vascular complications
US7008953B2 (en) * 2003-07-30 2006-03-07 Agouron Pharmaceuticals, Inc. 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
US7662844B2 (en) * 2004-07-12 2010-02-16 Osi Pharmaceuticals, Inc. Naphthylene derivatives as cytochrome P450 inhibitors
DE602006012713D1 (de) * 2005-09-23 2010-04-15 Pfizer Prod Inc Pyridinaminosulfonylsubstituierte benzamide als inhibitoren von cytochrom p450 3a4 (cyp3a4)

Also Published As

Publication number Publication date
AU2007270814B2 (en) 2011-07-14
IL196490A0 (en) 2011-07-31
MA30629B1 (fr) 2009-08-03
TW200811159A (en) 2008-03-01
NO20090346L (no) 2009-02-19
MX2009000482A (es) 2009-01-27
UY30460A1 (es) 2008-02-29
NZ574207A (en) 2010-10-29
CA2660031A1 (fr) 2008-01-10
KR20090034958A (ko) 2009-04-08
US20080021011A1 (en) 2008-01-24
GT200700053A (es) 2009-08-03
CO6150178A2 (es) 2010-04-20
AU2007270814A1 (en) 2008-01-10
TN2009000033A1 (fr) 2010-08-19
CR10573A (es) 2009-02-12
WO2008004096A1 (fr) 2008-01-10
RS20090036A (sr) 2010-06-30
CN101511812A (zh) 2009-08-19
US7919488B2 (en) 2011-04-05
ZA200900478B (en) 2010-04-28
AR062154A1 (es) 2008-10-22
EA200900135A1 (ru) 2009-06-30
PE20080998A1 (es) 2008-08-15
EP2046774A1 (fr) 2009-04-15
TWI334867B (en) 2010-12-21

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