OA11648A - 4,4-Biarylpiperidine derivatives with opioid receptor activity. - Google Patents

4,4-Biarylpiperidine derivatives with opioid receptor activity. Download PDF

Info

Publication number: OA11648A
Authority: OA; OAPI
Prior art keywords: comp; phenyl; alkyl; formula; piperidin
Prior art date: 1998-09-09

Application number

OA1200100057A

Other languages

English (en)

Inventor

Spiros Liras

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-09

Filing date

1999-09-06

Publication date

2004-12-08

1999-09-06 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-12-08 Publication of OA11648A publication Critical patent/OA11648A/en

Links

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101150051314 tin-10 gene Proteins 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229940045860 white wax Drugs 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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Organic Chemistry (AREA)
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Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
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Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)
Nutrition Science (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

OA1200100057A 1998-09-09 1999-09-06 4,4-Biarylpiperidine derivatives with opioid receptor activity. OA11648A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9956598P	1998-09-09	1998-09-09

Publications (1)

Publication Number	Publication Date
OA11648A true OA11648A (en)	2004-12-08

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ID=22275622

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Application Number	Title	Priority Date	Filing Date
OA1200100057A OA11648A (en)	1998-09-09	1999-09-06	4,4-Biarylpiperidine derivatives with opioid receptor activity.

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US (2)	US6720336B2 (sk)
EP (1)	EP1112255B1 (sk)
JP (1)	JP2002524445A (sk)
KR (1)	KR20010075024A (sk)
CN (1)	CN1316993A (sk)
AP (1)	AP2001002088A0 (sk)
AR (1)	AR022376A1 (sk)
AT (1)	ATE312819T1 (sk)
AU (1)	AU749096B2 (sk)
BG (1)	BG105411A (sk)
BR (1)	BR9913512A (sk)
CA (1)	CA2343236C (sk)
CO (1)	CO5170416A1 (sk)
CZ (1)	CZ2001850A3 (sk)
DE (1)	DE69928945T2 (sk)
EA (1)	EA200100203A1 (sk)
EE (1)	EE200100145A (sk)
ES (1)	ES2252960T3 (sk)
GE (1)	GEP20033025B (sk)
GT (1)	GT199900146A (sk)
HK (1)	HK1040396A1 (sk)
HN (1)	HN1999000149A (sk)
HR (1)	HRP20010167A2 (sk)
HU (1)	HUP0103542A3 (sk)
ID (1)	ID29129A (sk)
IL (1)	IL141506A0 (sk)
IS (1)	IS5860A (sk)
MA (1)	MA26686A1 (sk)
NO (1)	NO20011183L (sk)
NZ (1)	NZ509841A (sk)
OA (1)	OA11648A (sk)
PA (1)	PA8481301A1 (sk)
PE (1)	PE20001053A1 (sk)
PL (1)	PL346648A1 (sk)
SK (1)	SK3032001A3 (sk)
SV (1)	SV1999000147A (sk)
TN (1)	TNSN99169A1 (sk)
TR (1)	TR200100694T2 (sk)
WO (1)	WO2000014066A1 (sk)
YU (1)	YU11501A (sk)
ZA (1)	ZA200101744B (sk)

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AU727972B2 (en)	1996-05-16	2001-01-04	H. Lundbeck A/S	Dihydropyrimidines and uses thereof
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1999
- 1999-09-01 HN HN1999000149A patent/HN1999000149A/es unknown
- 1999-09-03 GT GT199900146A patent/GT199900146A/es unknown
- 1999-09-06 EP EP99939576A patent/EP1112255B1/en not_active Expired - Lifetime
- 1999-09-06 OA OA1200100057A patent/OA11648A/en unknown
- 1999-09-06 AP APAP/P/2001/002088A patent/AP2001002088A0/en unknown
- 1999-09-06 HK HK02101744.5A patent/HK1040396A1/zh unknown
- 1999-09-06 CN CN99810757A patent/CN1316993A/zh active Pending
- 1999-09-06 WO PCT/IB1999/001512 patent/WO2000014066A1/en not_active Ceased
- 1999-09-06 JP JP2000568825A patent/JP2002524445A/ja active Pending
- 1999-09-06 EA EA200100203A patent/EA200100203A1/ru unknown
- 1999-09-06 EE EEP200100145A patent/EE200100145A/xx unknown
- 1999-09-06 GE GEAP19995785A patent/GEP20033025B/en unknown
- 1999-09-06 BR BR9913512-4A patent/BR9913512A/pt not_active IP Right Cessation
- 1999-09-06 TR TR2001/00694T patent/TR200100694T2/xx unknown
- 1999-09-06 ID IDW20010549A patent/ID29129A/id unknown
- 1999-09-06 CZ CZ2001850A patent/CZ2001850A3/cs unknown
- 1999-09-06 KR KR1020017003088A patent/KR20010075024A/ko not_active Ceased
- 1999-09-06 CA CA002343236A patent/CA2343236C/en not_active Expired - Fee Related
- 1999-09-06 IL IL14150699A patent/IL141506A0/xx unknown
- 1999-09-06 AT AT99939576T patent/ATE312819T1/de not_active IP Right Cessation
- 1999-09-06 PL PL99346648A patent/PL346648A1/xx not_active Application Discontinuation
- 1999-09-06 AU AU53837/99A patent/AU749096B2/en not_active Ceased
- 1999-09-06 SK SK303-2001A patent/SK3032001A3/sk unknown
- 1999-09-06 ES ES99939576T patent/ES2252960T3/es not_active Expired - Lifetime
- 1999-09-06 NZ NZ509841A patent/NZ509841A/en unknown
- 1999-09-06 HU HU0103542A patent/HUP0103542A3/hu unknown
- 1999-09-06 DE DE69928945T patent/DE69928945T2/de not_active Expired - Fee Related
- 1999-09-06 HR HR20010167A patent/HRP20010167A2/hr not_active Application Discontinuation
- 1999-09-07 PE PE1999000898A patent/PE20001053A1/es not_active Application Discontinuation
- 1999-09-07 AR ARP990104494A patent/AR022376A1/es not_active Application Discontinuation
- 1999-09-08 SV SV1999000147A patent/SV1999000147A/es not_active Application Discontinuation
- 1999-09-08 MA MA25759A patent/MA26686A1/fr unknown
- 1999-09-08 PA PA19998481301A patent/PA8481301A1/es unknown
- 1999-09-08 TN TNTNSN99169A patent/TNSN99169A1/fr unknown
- 1999-09-09 CO CO99057228A patent/CO5170416A1/es not_active Application Discontinuation
- 1999-09-16 YU YU11501A patent/YU11501A/sh unknown
2001
- 2001-02-23 IS IS5860A patent/IS5860A/is unknown
- 2001-03-01 ZA ZA200101744A patent/ZA200101744B/en unknown
- 2001-03-08 NO NO20011183A patent/NO20011183L/no not_active Application Discontinuation
- 2001-04-04 BG BG105411A patent/BG105411A/bg unknown
- 2001-07-10 US US09/901,825 patent/US6720336B2/en not_active Expired - Fee Related
2003
- 2003-12-23 US US10/744,735 patent/US20040138220A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AR022376A1 (es)	2002-09-04
IS5860A (is)	2001-02-23
IL141506A0 (en)	2002-03-10
ZA200101744B (en)	2002-06-03
AP2001002088A0 (en)	2001-03-31
KR20010075024A (ko)	2001-08-09
MA26686A1 (fr)	2004-12-20
HK1040396A1 (zh)	2002-06-07
CA2343236A1 (en)	2000-03-16
SK3032001A3 (en)	2002-04-04
HUP0103542A3 (en)	2002-11-28
EA200100203A1 (ru)	2001-08-27
US20020013321A1 (en)	2002-01-31
CO5170416A1 (es)	2002-06-27
ID29129A (id)	2001-08-02
CZ2001850A3 (cs)	2001-12-12
DE69928945D1 (de)	2006-01-19
ATE312819T1 (de)	2005-12-15
HN1999000149A (es)	2000-01-12
NO20011183L (no)	2001-05-04
SV1999000147A (es)	2000-09-06
EP1112255B1 (en)	2005-12-14
HRP20010167A2 (en)	2002-02-28
EP1112255A1 (en)	2001-07-04
US20040138220A1 (en)	2004-07-15
TR200100694T2 (tr)	2001-10-22
AU5383799A (en)	2000-03-27
CA2343236C (en)	2006-01-03
BG105411A (bg)	2001-12-29
BR9913512A (pt)	2001-06-05
PE20001053A1 (es)	2000-10-14
ES2252960T3 (es)	2006-05-16
EE200100145A (et)	2002-06-17
US6720336B2 (en)	2004-04-13
GEP20033025B (en)	2003-07-25
HUP0103542A2 (hu)	2002-01-28
DE69928945T2 (de)	2006-07-27
GT199900146A (es)	2001-02-24
TNSN99169A1 (fr)	2005-11-10
NZ509841A (en)	2003-08-29
CN1316993A (zh)	2001-10-10
WO2000014066A1 (en)	2000-03-16
YU11501A (sh)	2003-10-31
PL346648A1 (en)	2002-02-25
NO20011183D0 (no)	2001-03-08
AU749096B2 (en)	2002-06-20
JP2002524445A (ja)	2002-08-06
PA8481301A1 (es)	2000-09-29

Publication	Publication Date	Title
OA11648A (en)	2004-12-08	4,4-Biarylpiperidine derivatives with opioid receptor activity.
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US20040254190A1 (en)	2004-12-16	3-Benzhydrylidene-8-aza-bicyclo[3.2.1]octane derivatives with opioid receptor activity
CA2299036C (en)	2005-06-07	4-phenyl-4-heteroarylpiperidine derivatives
MXPA02007175A (es)	2003-01-31	Derivados 1-difenilmetilpirazolicos como ligandos de receptores de opioides.
MXPA01002485A (en)	2001-11-21	4,4-biarylpiperidine derivatives with opioid receptor activity
MXPA00001828A (en)	2001-06-26	4-phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands
MXPA01006789A (en)	2002-03-26	3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives