OA10713A - Benzopyran and related ltb4 antagonists - Google Patents
Benzopyran and related ltb4 antagonists Download PDFInfo
- Publication number
- OA10713A OA10713A OA60544A OA60544A OA10713A OA 10713 A OA10713 A OA 10713A OA 60544 A OA60544 A OA 60544A OA 60544 A OA60544 A OA 60544A OA 10713 A OA10713 A OA 10713A
- Authority
- OA
- OAPI
- Prior art keywords
- alkyl
- hydrogen
- phenyl
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
- C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82467892A | 1992-01-23 | 1992-01-23 | |
| US89005592A | 1992-05-28 | 1992-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA10713A true OA10713A (en) | 2002-12-04 |
Family
ID=27124835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA60544A OA10713A (en) | 1992-01-23 | 1994-07-22 | Benzopyran and related ltb4 antagonists |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5550152A (fr) |
| EP (1) | EP0623122B1 (fr) |
| JP (1) | JP2813464B2 (fr) |
| KR (1) | KR950700274A (fr) |
| CN (1) | CN1074681A (fr) |
| AP (1) | AP385A (fr) |
| AT (1) | ATE149493T1 (fr) |
| AU (1) | AU2773392A (fr) |
| BG (1) | BG98873A (fr) |
| BR (1) | BR9207064A (fr) |
| CA (1) | CA2117349C (fr) |
| CZ (1) | CZ395492A3 (fr) |
| DE (1) | DE69217998T2 (fr) |
| DK (1) | DK0623122T3 (fr) |
| ES (1) | ES2098547T3 (fr) |
| FI (1) | FI943473L (fr) |
| GR (1) | GR3022999T3 (fr) |
| HU (1) | HUT67929A (fr) |
| IL (1) | IL104421A0 (fr) |
| IS (1) | IS3968A (fr) |
| MX (1) | MX9300313A (fr) |
| NO (1) | NO942758D0 (fr) |
| OA (1) | OA10713A (fr) |
| PT (1) | PT101182A (fr) |
| TW (1) | TW213456B (fr) |
| UY (1) | UY23537A1 (fr) |
| WO (1) | WO1993015066A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9300312A (es) * | 1992-01-23 | 1993-07-31 | Pfizer | Antagonistas benzopiranicos y relacionado de ltb. |
| US6051601A (en) * | 1994-10-13 | 2000-04-18 | Pfizer Inc. | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists |
| MX9702734A (es) * | 1994-10-13 | 1997-06-28 | Pfizer | Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4). |
| CA2265043C (fr) * | 1996-09-16 | 2003-01-14 | Pfizer Inc. | Procede et intermediaires pour la preparation de derives de chromanol substitues |
| US6416733B1 (en) | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
| EP0836850A3 (fr) * | 1996-10-17 | 2000-11-29 | Pfizer Inc. | Méthode pour prévenir le rejet d'allogreffes |
| EP0963755A3 (fr) * | 1998-04-16 | 2001-03-14 | Pfizer Products Inc. | Utilisation des benzopyranes pour la prévention de rejets de graiffes |
| WO2002036173A2 (fr) | 2000-11-03 | 2002-05-10 | Bristol-Myers Squibb Pharma Company | Double imagerie isotopique simultanee d'une perfusion et d'une inflammation cardiaque |
| US6541613B2 (en) * | 2000-12-15 | 2003-04-01 | Uyrex Corporation | Isoflavone derivatives |
| US6958156B2 (en) * | 2000-12-15 | 2005-10-25 | Vyrex Corporation | Isoflavone derivatives |
| BR0206771A (pt) * | 2001-01-30 | 2004-02-25 | Pfizer Prod Inc | Processos para a preparação de cidos cromanilbenzóicos |
| EP1773396A1 (fr) * | 2004-07-22 | 2007-04-18 | Pharmacia Corporation | Compositions pour le traitement anti-inflammatoire et anti-douleur au moyen d'une combinaison d'un inhibiteur selectif cox-2 et d'un antagoniste recepteur de ltb4 |
| ATE537151T1 (de) * | 2006-10-31 | 2011-12-15 | Pfizer Prod Inc | Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten |
| CN104710438B (zh) * | 2013-12-11 | 2019-11-29 | 中国科学院上海药物研究所 | 促进iPS细胞产生的螺环类化合物及其制备方法和用途 |
| JP6590224B2 (ja) * | 2014-11-11 | 2019-10-16 | 学校法人順天堂 | 加齢黄斑変性症予防又は治療剤 |
| AR105911A1 (es) | 2015-09-03 | 2017-11-22 | Forma Therapeutics Inc | Inhibidores de hdac8 bicíclicos fusionados [6,6] |
| EP3383388B1 (fr) | 2015-11-30 | 2021-04-14 | Merck Sharp & Dohme Corp. | Utilisation d'arylacylsulfonamides en tant qu'antagonistes de blt1 |
| US10450309B2 (en) | 2015-11-30 | 2019-10-22 | Merch Sharp & Dohme Corp. | Aryl sulfonamides as BLT1 antagonists |
| WO2017095723A1 (fr) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Utilisation d'arylacylsulfonamides en tant qu'antagonistes de blt1 |
| EP3383868B1 (fr) | 2015-11-30 | 2022-10-05 | Merck Sharp & Dohme LLC | Sulfonamides d'aryle utilisés en tant qu'antagonistes de blt1 |
| CN109289091B (zh) * | 2018-10-09 | 2021-04-13 | 温州医科大学附属第一医院 | 一种用于装载骨髓间充质干细胞的复合支架及其制备方法 |
| CN111647003B (zh) * | 2020-06-08 | 2022-06-21 | 中国科学院昆明植物研究所 | 三环氧六氢色酮a及其药物组合物和其应用 |
| CN111671745A (zh) * | 2020-07-29 | 2020-09-18 | 北京大学 | 化合物在治疗溃疡性结肠炎药物制备中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| CA1320490C (fr) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Agents antiinflammatoires |
| US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
| US5059609A (en) * | 1987-10-19 | 1991-10-22 | Pfizer Inc. | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases |
| WO1990015801A1 (fr) * | 1989-06-22 | 1990-12-27 | Pfizer Inc. | Sulfamides substitues et composes apparentes dans le traitement de l'asthme, de l'arthrite et des maladies apparentees |
-
1992
- 1992-10-13 CA CA002117349A patent/CA2117349C/fr not_active Expired - Lifetime
- 1992-10-13 AU AU27733/92A patent/AU2773392A/en not_active Abandoned
- 1992-10-13 WO PCT/US1992/008555 patent/WO1993015066A1/fr not_active Ceased
- 1992-10-13 DK DK92921463.3T patent/DK0623122T3/da active
- 1992-10-13 DE DE69217998T patent/DE69217998T2/de not_active Expired - Lifetime
- 1992-10-13 AT AT92921463T patent/ATE149493T1/de not_active IP Right Cessation
- 1992-10-13 US US08/256,809 patent/US5550152A/en not_active Expired - Lifetime
- 1992-10-13 JP JP5513182A patent/JP2813464B2/ja not_active Expired - Fee Related
- 1992-10-13 CZ CS923954A patent/CZ395492A3/cs unknown
- 1992-10-13 BR BR9207064A patent/BR9207064A/pt not_active Application Discontinuation
- 1992-10-13 ES ES92921463T patent/ES2098547T3/es not_active Expired - Lifetime
- 1992-10-13 EP EP92921463A patent/EP0623122B1/fr not_active Expired - Lifetime
- 1992-10-13 HU HU9402163A patent/HUT67929A/hu unknown
- 1992-10-13 FI FI943473A patent/FI943473L/fi unknown
- 1992-10-17 TW TW081108272A patent/TW213456B/zh active
- 1992-11-10 AP APAP/P/1992/000441A patent/AP385A/en active
-
1993
- 1993-01-18 IL IL104421A patent/IL104421A0/xx unknown
- 1993-01-18 UY UY23537A patent/UY23537A1/es unknown
- 1993-01-19 IS IS3968A patent/IS3968A/is unknown
- 1993-01-20 CN CN93100695A patent/CN1074681A/zh active Pending
- 1993-01-22 MX MX9300313A patent/MX9300313A/es unknown
- 1993-01-22 PT PT101182A patent/PT101182A/pt not_active Application Discontinuation
-
1994
- 1994-06-24 BG BG98873A patent/BG98873A/xx unknown
- 1994-07-22 OA OA60544A patent/OA10713A/en unknown
- 1994-07-22 NO NO942758A patent/NO942758D0/no unknown
- 1994-07-23 KR KR1019940702540A patent/KR950700274A/ko not_active Ceased
-
1997
- 1997-04-01 GR GR970400673T patent/GR3022999T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO942758L (no) | 1994-07-22 |
| CZ395492A3 (en) | 1994-03-16 |
| AP9200441A0 (en) | 1993-01-31 |
| CN1074681A (zh) | 1993-07-28 |
| MX9300313A (es) | 1994-06-30 |
| WO1993015066A1 (fr) | 1993-08-05 |
| DE69217998T2 (de) | 1997-06-12 |
| ES2098547T3 (es) | 1997-05-01 |
| FI943473A0 (fi) | 1994-07-22 |
| EP0623122A1 (fr) | 1994-11-09 |
| KR950700274A (ko) | 1995-01-16 |
| DE69217998D1 (de) | 1997-04-10 |
| CA2117349C (fr) | 2000-02-29 |
| GR3022999T3 (en) | 1997-07-30 |
| UY23537A1 (es) | 1993-06-28 |
| TW213456B (fr) | 1993-09-21 |
| EP0623122B1 (fr) | 1997-03-05 |
| DK0623122T3 (da) | 1997-04-21 |
| IL104421A0 (en) | 1993-05-13 |
| NO942758D0 (no) | 1994-07-22 |
| CA2117349A1 (fr) | 1993-08-05 |
| IS3968A (is) | 1993-07-24 |
| JP2813464B2 (ja) | 1998-10-22 |
| ATE149493T1 (de) | 1997-03-15 |
| PT101182A (pt) | 1994-03-31 |
| JPH07503464A (ja) | 1995-04-13 |
| BG98873A (bg) | 1995-03-31 |
| HUT67929A (en) | 1995-05-29 |
| AP385A (en) | 1995-05-15 |
| AU2773392A (en) | 1993-09-01 |
| US5550152A (en) | 1996-08-27 |
| FI943473A7 (fi) | 1994-07-22 |
| FI943473L (fi) | 1994-07-22 |
| BR9207064A (pt) | 1995-12-19 |
| HU9402163D0 (en) | 1994-09-28 |
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