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ES2098547T3 - Benzopirano y otros antagonistas de ltb4 relacionados. - Google Patents

Benzopirano y otros antagonistas de ltb4 relacionados.

Info

Publication number
ES2098547T3
ES2098547T3 ES92921463T ES92921463T ES2098547T3 ES 2098547 T3 ES2098547 T3 ES 2098547T3 ES 92921463 T ES92921463 T ES 92921463T ES 92921463 T ES92921463 T ES 92921463T ES 2098547 T3 ES2098547 T3 ES 2098547T3
Authority
ES
Spain
Prior art keywords
benzopyran
ltb4 antagonists
antagonists
substituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921463T
Other languages
English (en)
Inventor
Kevin Koch
Lawrence S Melvin Jr
Lawrence A Reiter
Sally G Ruggeri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2098547T3 publication Critical patent/ES2098547T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)

Abstract

SE DESCRIBEN, BENZOPIRANO Y OTROS ANTAGONISTAS DE LEUCOTRIENO B4 BENZO-ENLAZADOS DE FORMULA (I) EN LA QUE A, N, R1, R2 Y R3 SE DEFINEN AQUI. LOS COMPONENTES DE FORMULA (I) EN LA QUE R1 ES UN CR4R5-COOR13 C-SUSTITUIDO PUEDEN PREPARARSE A PARTIR DEL CORRESPONDIENTE COMPUESTO CF3SO3 C-SUSTITUIDO MEDIANTE REACCION CON UN ACETAL TRIMETILSILIL CETENO.
ES92921463T 1992-01-23 1992-10-13 Benzopirano y otros antagonistas de ltb4 relacionados. Expired - Lifetime ES2098547T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467892A 1992-01-23 1992-01-23
US89005592A 1992-05-28 1992-05-28

Publications (1)

Publication Number Publication Date
ES2098547T3 true ES2098547T3 (es) 1997-05-01

Family

ID=27124835

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921463T Expired - Lifetime ES2098547T3 (es) 1992-01-23 1992-10-13 Benzopirano y otros antagonistas de ltb4 relacionados.

Country Status (27)

Country Link
US (1) US5550152A (es)
EP (1) EP0623122B1 (es)
JP (1) JP2813464B2 (es)
KR (1) KR950700274A (es)
CN (1) CN1074681A (es)
AP (1) AP385A (es)
AT (1) ATE149493T1 (es)
AU (1) AU2773392A (es)
BG (1) BG98873A (es)
BR (1) BR9207064A (es)
CA (1) CA2117349C (es)
CZ (1) CZ395492A3 (es)
DE (1) DE69217998T2 (es)
DK (1) DK0623122T3 (es)
ES (1) ES2098547T3 (es)
FI (1) FI943473L (es)
GR (1) GR3022999T3 (es)
HU (1) HUT67929A (es)
IL (1) IL104421A0 (es)
IS (1) IS3968A (es)
MX (1) MX9300313A (es)
NO (1) NO942758D0 (es)
OA (1) OA10713A (es)
PT (1) PT101182A (es)
TW (1) TW213456B (es)
UY (1) UY23537A1 (es)
WO (1) WO1993015066A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.
AU703557B2 (en) * 1994-10-13 1999-03-25 Pfizer Inc. Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4' (LTB4) antagonists
EP0785930A1 (en) * 1994-10-13 1997-07-30 Pfizer Inc. Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b 4? (ltb 4?) antagonists
US6096906A (en) * 1996-09-16 2000-08-01 Pfizer Inc. Processes for preparing substituted chromanol derivatives
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
EP0836850A3 (en) * 1996-10-17 2000-11-29 Pfizer Inc. Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
CA2427911A1 (en) 2000-11-03 2002-05-10 Bristol Myers Squibb Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
US6958156B2 (en) * 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
US6541613B2 (en) * 2000-12-15 2003-04-01 Uyrex Corporation Isoflavone derivatives
MXPA03006876A (es) * 2001-01-30 2003-11-13 Pfizer Prod Inc Intermedios y procedimientos para preparar derivados de cromanol sustituido.
AU2005266088A1 (en) * 2004-07-22 2006-02-02 Pharmacia Corporation Compositions for treatment of inflammation and pain using a combination of a COX-2 selective inhibitor and a LTB4 receptor antagonist
GEP20115239B (en) * 2006-10-31 2011-06-10 Pfizer Prod Inc Pyrazoline compounds as mineralocorticoid receptor antagonists
CN104710438B (zh) * 2013-12-11 2019-11-29 中国科学院上海药物研究所 促进iPS细胞产生的螺环类化合物及其制备方法和用途
WO2016076006A1 (ja) * 2014-11-11 2016-05-19 学校法人順天堂 加齢黄斑変性症予防又は治療剤
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
EP3383389B1 (en) 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
WO2017095724A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
WO2017095722A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
CN109289091B (zh) * 2018-10-09 2021-04-13 温州医科大学附属第一医院 一种用于装载骨髓间充质干细胞的复合支架及其制备方法
CN111647003B (zh) * 2020-06-08 2022-06-21 中国科学院昆明植物研究所 三环氧六氢色酮a及其药物组合物和其应用
CN111671745A (zh) * 2020-07-29 2020-09-18 北京大学 化合物在治疗溃疡性结肠炎药物制备中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
WO1990015801A1 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
IL104421A0 (en) 1993-05-13
OA10713A (en) 2002-12-04
JPH07503464A (ja) 1995-04-13
CA2117349A1 (en) 1993-08-05
ATE149493T1 (de) 1997-03-15
DE69217998D1 (de) 1997-04-10
AU2773392A (en) 1993-09-01
DE69217998T2 (de) 1997-06-12
CA2117349C (en) 2000-02-29
MX9300313A (es) 1994-06-30
IS3968A (is) 1993-07-24
EP0623122A1 (en) 1994-11-09
HU9402163D0 (en) 1994-09-28
DK0623122T3 (da) 1997-04-21
HUT67929A (en) 1995-05-29
CN1074681A (zh) 1993-07-28
UY23537A1 (es) 1993-06-28
FI943473A7 (fi) 1994-07-22
WO1993015066A1 (en) 1993-08-05
US5550152A (en) 1996-08-27
CZ395492A3 (en) 1994-03-16
FI943473A0 (fi) 1994-07-22
AP385A (en) 1995-05-15
JP2813464B2 (ja) 1998-10-22
FI943473L (fi) 1994-07-22
EP0623122B1 (en) 1997-03-05
TW213456B (es) 1993-09-21
GR3022999T3 (en) 1997-07-30
PT101182A (pt) 1994-03-31
AP9200441A0 (en) 1993-01-31
BR9207064A (pt) 1995-12-19
BG98873A (bg) 1995-03-31
NO942758L (no) 1994-07-22
KR950700274A (ko) 1995-01-16
NO942758D0 (no) 1994-07-22

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