NO984928L - Pyrazinontrombininhibitorer - Google Patents
PyrazinontrombininhibitorerInfo
- Publication number
- NO984928L NO984928L NO984928A NO984928A NO984928L NO 984928 L NO984928 L NO 984928L NO 984928 A NO984928 A NO 984928A NO 984928 A NO984928 A NO 984928A NO 984928 L NO984928 L NO 984928L
- Authority
- NO
- Norway
- Prior art keywords
- pyrazinontrombininhibitorer
- compounds
- useful
- inhibiting thrombin
- thrombotic occlusions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1604196P | 1996-04-23 | 1996-04-23 | |
| GBGB9609714.2A GB9609714D0 (en) | 1996-05-09 | 1996-05-09 | Pyridinone thrombin inhibitors |
| US4300997P | 1997-04-14 | 1997-04-14 | |
| PCT/US1997/006744 WO1997040024A1 (fr) | 1996-04-23 | 1997-04-18 | Inhibiteurs de thrombine a base de pyrazinone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO984928D0 NO984928D0 (no) | 1998-10-22 |
| NO984928L true NO984928L (no) | 1998-12-22 |
Family
ID=27268274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO984928A NO984928L (no) | 1996-04-23 | 1998-10-22 | Pyrazinontrombininhibitorer |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0900207B1 (fr) |
| JP (1) | JP3140790B2 (fr) |
| KR (1) | KR20000010650A (fr) |
| AT (1) | ATE209191T1 (fr) |
| AU (1) | AU714985B2 (fr) |
| BG (1) | BG102948A (fr) |
| BR (1) | BR9708859A (fr) |
| CA (1) | CA2252964A1 (fr) |
| CZ (1) | CZ340898A3 (fr) |
| DE (1) | DE69709727T2 (fr) |
| EE (1) | EE9800353A (fr) |
| HR (1) | HRP970211A2 (fr) |
| IL (1) | IL126404A0 (fr) |
| IS (1) | IS4853A (fr) |
| NO (1) | NO984928L (fr) |
| NZ (1) | NZ331993A (fr) |
| PE (1) | PE13399A1 (fr) |
| PL (1) | PL329441A1 (fr) |
| SK (1) | SK145398A3 (fr) |
| TR (1) | TR199802133T2 (fr) |
| WO (1) | WO1997040024A1 (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU746024B2 (en) * | 1996-04-23 | 2002-04-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| EP0927171B1 (fr) * | 1996-09-16 | 2002-02-20 | Du Pont Pharmaceuticals Company | Pyrazinones et triazinones ainsi que leurs derives |
| JP2001518932A (ja) * | 1997-03-24 | 2001-10-16 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害薬 |
| US6011038A (en) * | 1997-09-05 | 2000-01-04 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| AU753479B2 (en) * | 1998-05-19 | 2002-10-17 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| US6147078A (en) * | 1998-05-19 | 2000-11-14 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| JP2002516326A (ja) * | 1998-05-26 | 2002-06-04 | メルク エンド カムパニー インコーポレーテッド | イミダゾピリジン系トロンビン阻害薬 |
| EP1589029B1 (fr) | 1998-06-11 | 2010-03-17 | Ortho-McNeil Pharmaceuticals, Inc. | Inhibiteurs de protéase à base de pyrazine |
| DK0997474T3 (da) * | 1998-08-14 | 2004-02-09 | Pfizer | Antithrombotiske midler |
| CA2343109A1 (fr) * | 1998-09-28 | 2000-04-06 | Merck & Co., Inc. | Inhibiteurs de la thrombine |
| JP2002528542A (ja) | 1998-10-30 | 2002-09-03 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害剤 |
| AU747776B2 (en) | 1998-10-30 | 2002-05-23 | Merck & Co., Inc. | Thrombin inhibitors |
| WO2000038683A1 (fr) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | INHIBITEURS DU FACTEUR Xa OU DE LA THROMBINE |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| EP1202975B1 (fr) * | 1999-05-19 | 2005-04-06 | Pharmacia Corporation | Pyrazinones d'heteroaryle et d'aryle polycyclique substituees utiles a l'inhibition selective de la coagulation en cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| EP1586565A1 (fr) * | 1999-05-19 | 2005-10-19 | Pharmacia Corporation | Pyrazinones d'hétéroaryle et d'aryle polycyclique substituées utiles à l'inhibition selective de la coagulation en cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6664255B1 (en) * | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| UA58636C2 (uk) * | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
| JP4749640B2 (ja) | 1999-07-19 | 2011-08-17 | メルク フロスト カナダ リミテツド | ピラジノン、このような化合物を含む組成物 |
| CA2391012A1 (fr) * | 1999-11-23 | 2001-05-31 | Merck & Co., Inc. | Inhibiteurs de thrombine a base de pyrazinone |
| AU2001243598A1 (en) | 2000-03-13 | 2001-09-24 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| AU2001245856A1 (en) | 2000-03-23 | 2001-10-03 | Merck & Co., Inc. | Thrombin inhibitors |
| CA2405306A1 (fr) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Pyridones polycycliques 4-aryl et heteroaryl substituees utiles pour l'inhibition selective de la cascade de coagulation |
| AU2001249870A1 (en) | 2000-04-05 | 2001-10-23 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| US6506761B1 (en) | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| AU2001255410A1 (en) * | 2000-04-14 | 2001-10-30 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| US6506760B1 (en) | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| US6686484B2 (en) | 2000-04-17 | 2004-02-03 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| CA2415932A1 (fr) | 2000-07-17 | 2002-01-24 | 3-Dimensional Pharmaceuticals, Inc. | Pyrazinones oxyguanidines cycliques comme inhibiteurs de protease |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| EP1351686A2 (fr) | 2000-11-20 | 2003-10-15 | Pharmacia Corporation | Aryl-et-heteroaryl-pyridines polycycliques substituees utiles dans l'inhibition selective de la cascade de la coagulation |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| CA2462305A1 (fr) | 2001-10-03 | 2003-04-10 | Michael S. South | Composes heterocycliques a 6 chainons utiles dans l'inhibition selective de la cascade de la coagulation |
| BR0213099A (pt) | 2001-10-03 | 2004-10-19 | Pharmacia Corp | Compostos policìclicos de 5 membros substituìdos úteis para inibição seletiva da cascata de coagulação |
| AP1822A (en) | 2002-02-14 | 2008-01-30 | Pharmacia Corp | Substituted pyridinones as modulators of P38 MAP kinase. |
| GB0306615D0 (en) * | 2003-03-22 | 2003-04-30 | Astrazeneca Ab | New use |
| EP1526131A1 (fr) * | 2003-10-22 | 2005-04-27 | Graffinity Pharmaceuticals Aktiengesellschaft | Aminoalkyl-pyrazinones et -pyridones et leur utilisation comme inhibiteurs de la thrombine |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| JP2008546684A (ja) * | 2005-06-17 | 2008-12-25 | アストラゼネカ アクチボラグ | トロンビン阻害性２−オキソ−１，２，５，６−テトラヒドロピリジン誘導体 |
| WO2017067670A1 (fr) | 2015-10-23 | 2017-04-27 | Pharmathen S.A. | Nouveau procédé de préparation de tryptamines et de leurs dérivés |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0262096B1 (fr) * | 1986-09-26 | 1992-01-02 | Ciba-Geigy Ag | Aminopyrazinones et aminotriazinones |
-
1997
- 1997-04-18 EE EE9800353A patent/EE9800353A/xx unknown
- 1997-04-18 SK SK1453-98A patent/SK145398A3/sk unknown
- 1997-04-18 EP EP97918780A patent/EP0900207B1/fr not_active Expired - Lifetime
- 1997-04-18 CZ CZ983408A patent/CZ340898A3/cs unknown
- 1997-04-18 TR TR1998/02133T patent/TR199802133T2/xx unknown
- 1997-04-18 BR BR9708859A patent/BR9708859A/pt not_active Application Discontinuation
- 1997-04-18 JP JP09538296A patent/JP3140790B2/ja not_active Expired - Fee Related
- 1997-04-18 IL IL12640497A patent/IL126404A0/xx unknown
- 1997-04-18 PL PL97329441A patent/PL329441A1/xx unknown
- 1997-04-18 NZ NZ331993A patent/NZ331993A/xx unknown
- 1997-04-18 DE DE69709727T patent/DE69709727T2/de not_active Expired - Fee Related
- 1997-04-18 AU AU26799/97A patent/AU714985B2/en not_active Ceased
- 1997-04-18 AT AT97918780T patent/ATE209191T1/de active
- 1997-04-18 CA CA002252964A patent/CA2252964A1/fr not_active Abandoned
- 1997-04-18 KR KR1019980708609A patent/KR20000010650A/ko not_active Withdrawn
- 1997-04-18 WO PCT/US1997/006744 patent/WO1997040024A1/fr not_active Ceased
- 1997-04-21 HR HR60/043,009A patent/HRP970211A2/xx not_active Application Discontinuation
- 1997-04-23 PE PE1997000308A patent/PE13399A1/es not_active Application Discontinuation
-
1998
- 1998-09-25 IS IS4853A patent/IS4853A/is unknown
- 1998-10-22 NO NO984928A patent/NO984928L/no unknown
- 1998-11-23 BG BG102948A patent/BG102948A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9708859A (pt) | 1999-08-03 |
| EP0900207B1 (fr) | 2001-11-21 |
| EP0900207A1 (fr) | 1999-03-10 |
| BG102948A (bg) | 1999-11-30 |
| DE69709727D1 (de) | 2002-02-21 |
| JP3140790B2 (ja) | 2001-03-05 |
| AU714985B2 (en) | 2000-01-13 |
| HRP970211A2 (en) | 1998-06-30 |
| IS4853A (is) | 1998-09-25 |
| NZ331993A (en) | 2000-04-28 |
| WO1997040024A1 (fr) | 1997-10-30 |
| SK145398A3 (en) | 1999-05-07 |
| PL329441A1 (en) | 1999-03-29 |
| CA2252964A1 (fr) | 1997-10-30 |
| AU2679997A (en) | 1997-11-12 |
| ATE209191T1 (de) | 2001-12-15 |
| DE69709727T2 (de) | 2002-08-08 |
| CZ340898A3 (cs) | 1999-02-17 |
| EE9800353A (et) | 1999-04-15 |
| TR199802133T2 (xx) | 2000-09-21 |
| IL126404A0 (en) | 1999-05-09 |
| KR20000010650A (ko) | 2000-02-25 |
| JP2000508334A (ja) | 2000-07-04 |
| NO984928D0 (no) | 1998-10-22 |
| PE13399A1 (es) | 1999-02-11 |
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