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WO2017067670A1 - Nouveau procédé de préparation de tryptamines et de leurs dérivés - Google Patents

Nouveau procédé de préparation de tryptamines et de leurs dérivés Download PDF

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Publication number
WO2017067670A1
WO2017067670A1 PCT/EP2016/025121 EP2016025121W WO2017067670A1 WO 2017067670 A1 WO2017067670 A1 WO 2017067670A1 EP 2016025121 W EP2016025121 W EP 2016025121W WO 2017067670 A1 WO2017067670 A1 WO 2017067670A1
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WO
WIPO (PCT)
Prior art keywords
compound
formula
preparation
conversion
ila
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2016/025121
Other languages
English (en)
Inventor
V. Theocharis KOFTIS
Efstratios Neokosmidis
Christos RAPTIS
Sakellarios TRAKOSSAS
Thanos Andreou
Anastasia - Aikaterini VARVOGLI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmathen SA
Original Assignee
Pharmathen SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmathen SA filed Critical Pharmathen SA
Priority to CN201680061481.4A priority Critical patent/CN108271369A/zh
Publication of WO2017067670A1 publication Critical patent/WO2017067670A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Definitions

  • aryl refers to a C6-18 cyclic aromatic group, formed by one or more rings, which may optionally be substituted with one or more substituents.
  • the aromatic ring is a C6-10 ring system. Typical examples include phenyl, naphthyl and anthracenyl.
  • reducing agents are boranes, mixtures of borohydrides and boran halides, borohydrides, metal hydrides, metal catalysts, metal cations, metal amalgams, hydrazines, silanes, siloxanes, hydrosulfite, dithionite, sulfonate, phosphines, phosphites, hypophosphites, phosphorous acid, carbon, carbon monoxide, oxalic acid, formic acid, ascorbic acid, FLP reagents, hydrogen and mixtures thereof.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La présente invention concerne un nouveau procédé pour la préparation de tryptamine, de ses dérivés substitués et d'intermédiaires pour la préparation de ceux-ci.
PCT/EP2016/025121 2015-10-23 2016-10-19 Nouveau procédé de préparation de tryptamines et de leurs dérivés Ceased WO2017067670A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201680061481.4A CN108271369A (zh) 2015-10-23 2016-10-19 用于制备色胺及其衍生物的新工艺

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2015002105 2015-10-23
EPPCT/EP2015/002105 2015-10-23

Publications (1)

Publication Number Publication Date
WO2017067670A1 true WO2017067670A1 (fr) 2017-04-27

Family

ID=57209421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2016/025121 Ceased WO2017067670A1 (fr) 2015-10-23 2016-10-19 Nouveau procédé de préparation de tryptamines et de leurs dérivés

Country Status (3)

Country Link
CN (1) CN108271369A (fr)
AR (1) AR106423A1 (fr)
WO (1) WO2017067670A1 (fr)

Citations (16)

* Cited by examiner, † Cited by third party
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WO1995026723A1 (fr) 1994-04-05 1995-10-12 Interneuron Pharmaceuticals, Inc. Nouvelles phenalkylamines et tryptamines substituees, et composes apparentes
WO1997040024A1 (fr) 1996-04-23 1997-10-30 Merck & Co., Inc. Inhibiteurs de thrombine a base de pyrazinone
WO2001068648A1 (fr) 2000-03-15 2001-09-20 Aventis Pharma Deutschland Gmbh Beta-carbolines substituees ayant une activite inhibitrice de l'ikb-kinase
WO2002078693A2 (fr) 2001-03-29 2002-10-10 Eli Lilly And Company N-(2-arylethyl)benzylamines utilisees en tant qu'antagonistes du recepteur 5-ht6
WO2003014127A1 (fr) 2001-08-07 2003-02-20 Pharma Mar, S.A. Analogues antitumoraux
WO2004043967A1 (fr) 2002-11-11 2004-05-27 Grünenthal GmbH Derives de cyclohexane spirocycliques
WO2004092167A1 (fr) 2003-04-09 2004-10-28 Millennium Pharmaceuticals, Inc. Beta-carbolines utiles pour traiter une maladie inflammatoire
WO2005056554A2 (fr) 2003-12-02 2005-06-23 Exelixis, Inc. Derives d'azepinoindole en tant qu'agents pharmaceutiques
WO2005111037A1 (fr) 2004-04-09 2005-11-24 Millennium Pharmaceuticals, Inc. Utilisation de beta-carbolines pour le traitement de maladies inflammatoires
WO2008006583A1 (fr) 2006-07-14 2008-01-17 Novartis Ag Dérivés de la pyrimidine en tant qu'inhibiteurs d'alk-5
WO2009073118A1 (fr) 2007-12-04 2009-06-11 Merck & Co., Inc. Tryptamine sulfonamides en tant qu'antagonistes de 5-ht6
WO2010044054A1 (fr) 2008-10-14 2010-04-22 Actelion Pharmaceuticals Ltd Dérivés de phénéthylamide et leurs analogues hétérocycliques
WO2010080864A1 (fr) 2009-01-12 2010-07-15 Array Biopharma Inc. Composés contenant de la pipéridine et leurs utilisations
WO2010142081A1 (fr) 2009-06-12 2010-12-16 华为技术有限公司 Procédé de transmission de messages vidéo, équipement formant routeur, et système
WO2011076212A2 (fr) 2009-12-23 2011-06-30 H. Lundbeck A/S Procédés de fabrication d'un principe pharmaceutiquement actif
CN102659662A (zh) * 2012-03-28 2012-09-12 华东师范大学 3-r-3-羟基-2-氧化吲哚类化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1572647B1 (fr) * 2002-12-20 2016-09-21 Basf Se Préparation d´amines et de leurs intermédiaires
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026723A1 (fr) 1994-04-05 1995-10-12 Interneuron Pharmaceuticals, Inc. Nouvelles phenalkylamines et tryptamines substituees, et composes apparentes
WO1997040024A1 (fr) 1996-04-23 1997-10-30 Merck & Co., Inc. Inhibiteurs de thrombine a base de pyrazinone
WO2001068648A1 (fr) 2000-03-15 2001-09-20 Aventis Pharma Deutschland Gmbh Beta-carbolines substituees ayant une activite inhibitrice de l'ikb-kinase
WO2002078693A2 (fr) 2001-03-29 2002-10-10 Eli Lilly And Company N-(2-arylethyl)benzylamines utilisees en tant qu'antagonistes du recepteur 5-ht6
WO2003014127A1 (fr) 2001-08-07 2003-02-20 Pharma Mar, S.A. Analogues antitumoraux
WO2004043967A1 (fr) 2002-11-11 2004-05-27 Grünenthal GmbH Derives de cyclohexane spirocycliques
WO2004092167A1 (fr) 2003-04-09 2004-10-28 Millennium Pharmaceuticals, Inc. Beta-carbolines utiles pour traiter une maladie inflammatoire
WO2005056554A2 (fr) 2003-12-02 2005-06-23 Exelixis, Inc. Derives d'azepinoindole en tant qu'agents pharmaceutiques
WO2005111037A1 (fr) 2004-04-09 2005-11-24 Millennium Pharmaceuticals, Inc. Utilisation de beta-carbolines pour le traitement de maladies inflammatoires
WO2008006583A1 (fr) 2006-07-14 2008-01-17 Novartis Ag Dérivés de la pyrimidine en tant qu'inhibiteurs d'alk-5
WO2009073118A1 (fr) 2007-12-04 2009-06-11 Merck & Co., Inc. Tryptamine sulfonamides en tant qu'antagonistes de 5-ht6
WO2010044054A1 (fr) 2008-10-14 2010-04-22 Actelion Pharmaceuticals Ltd Dérivés de phénéthylamide et leurs analogues hétérocycliques
WO2010080864A1 (fr) 2009-01-12 2010-07-15 Array Biopharma Inc. Composés contenant de la pipéridine et leurs utilisations
WO2010142081A1 (fr) 2009-06-12 2010-12-16 华为技术有限公司 Procédé de transmission de messages vidéo, équipement formant routeur, et système
WO2011076212A2 (fr) 2009-12-23 2011-06-30 H. Lundbeck A/S Procédés de fabrication d'un principe pharmaceutiquement actif
CN102659662A (zh) * 2012-03-28 2012-09-12 华东师范大学 3-r-3-羟基-2-氧化吲哚类化合物的合成方法

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Publication number Publication date
AR106423A1 (es) 2018-01-10
CN108271369A (zh) 2018-07-10

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