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NO20084530L - Substituerte prolinamider, deres produksjon og anvendelse som medikament - Google Patents

Substituerte prolinamider, deres produksjon og anvendelse som medikament

Info

Publication number
NO20084530L
NO20084530L NO20084530A NO20084530A NO20084530L NO 20084530 L NO20084530 L NO 20084530L NO 20084530 A NO20084530 A NO 20084530A NO 20084530 A NO20084530 A NO 20084530A NO 20084530 L NO20084530 L NO 20084530L
Authority
NO
Norway
Prior art keywords
drug
production
prolinamides
substituted prolinamides
substituted
Prior art date
Application number
NO20084530A
Other languages
English (en)
Inventor
Wolfgang Wienen
Henning Priepke
Roland Pfau
Annette Maria Schuler-Metz
Georg Dahmann
Herbert Nar
Kai Gerlach
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO20084530L publication Critical patent/NO20084530L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Det beskrives nye substituerte prolinamider med den generelle formel (I) hvor D, L, E, G, J, M, R3, R4, R5 og R13 er som definert i beskrivelsen, deres tautomerer, deres enantiomerer, deres diastereomerer, deres blandinger og deres salter, særlig deres fysiologisk akseptable salter, med uorganiske eller organiske syrer eller baser, som oppviser verdifulle egenskaper.
NO20084530A 2006-05-16 2008-10-28 Substituerte prolinamider, deres produksjon og anvendelse som medikament NO20084530L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06113977 2006-05-16
EP07102566 2007-02-16
PCT/EP2007/054631 WO2007131982A2 (de) 2006-05-16 2007-05-14 Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
NO20084530L true NO20084530L (no) 2008-12-12

Family

ID=38646563

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084530A NO20084530L (no) 2006-05-16 2008-10-28 Substituerte prolinamider, deres produksjon og anvendelse som medikament

Country Status (23)

Country Link
US (1) US7807693B2 (no)
EP (1) EP2051975B1 (no)
JP (1) JP5263686B2 (no)
KR (1) KR101422456B1 (no)
AR (1) AR060945A1 (no)
AU (1) AU2007251614B2 (no)
BR (1) BRPI0711648A2 (no)
CA (1) CA2653753C (no)
CL (1) CL2007001391A1 (no)
DK (1) DK2051975T3 (no)
EA (1) EA200802210A1 (no)
EC (1) ECSP088824A (no)
ES (1) ES2395538T3 (no)
IL (1) IL195245A (no)
MX (1) MX2008014499A (no)
MY (1) MY146623A (no)
NO (1) NO20084530L (no)
NZ (1) NZ573573A (no)
PE (1) PE20080702A1 (no)
PL (1) PL2051975T3 (no)
TW (1) TW200813047A (no)
UY (1) UY30352A1 (no)
WO (1) WO2007131982A2 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1975165A1 (de) 2007-03-27 2008-10-01 Boehringer Ingelheim Pharma GmbH & Co. KG Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel
JP5524852B2 (ja) 2007-11-15 2014-06-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換アミド、それらの製造及び医薬品としての使用
JP2011518127A (ja) * 2008-03-31 2011-06-23 エヴォテック・アクチエンゲゼルシャフト ヒスタミンｈ３受容体アンタゴニストとしてのテトラヒドロナフチリジンおよびそれらのアザ誘導体
GB201209138D0 (en) 2012-05-24 2012-07-04 Ono Pharmaceutical Co Compounds
WO2014127815A1 (en) 2013-02-21 2014-08-28 Boehringer Ingelheim International Gmbh Dihydropteridinones i
JP6337750B2 (ja) * 2013-11-22 2018-06-06 小野薬品工業株式会社 化合物
KR102408261B1 (ko) 2014-02-03 2022-06-10 비타이 파마슈티컬즈, 엘엘씨 Ror-감마의 디하이드로피롤로피리딘 저해제
DK3113772T3 (da) * 2014-03-07 2020-12-07 Biocryst Pharm Inc Trifluormethylsubstituerede pyrazoler som inhibitorer af kallikrein fra humant plasma
DK3207043T6 (da) 2014-10-14 2020-01-20 Vitae Pharmaceuticals Llc Dihydropyrrolopyridin-inhibitorer af ror-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
EP3078378B1 (en) 2015-04-08 2020-06-24 Vaiomer Use of factor xa inhibitors for regulating glycemia
US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
EP3868750A1 (en) 2015-11-20 2021-08-25 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
CN111225914B (zh) 2017-07-24 2022-10-11 生命医药有限责任公司 RORγ的抑制剂
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN114646701B (zh) * 2022-03-01 2023-09-29 浙江国邦药业有限公司 一种l-脯氨酰胺中有关物质的hplc测试方法
WO2024214038A1 (en) * 2023-04-14 2024-10-17 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
JP3975254B2 (ja) * 2002-07-25 2007-09-12 日野自動車株式会社 チャイルドシート用アンカの取付構造
DE10329457A1 (de) 2003-04-03 2005-01-20 Merck Patent Gmbh Ethinylprolinderivate
DE502004009440D1 (de) 2003-04-03 2009-06-10 Merck Patent Gmbh Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-(4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen
CN1809346A (zh) * 2003-06-18 2006-07-26 默克专利股份公司 作为凝血因子xa和viia的抑制剂用于治疗形成血栓的1－[(4－乙炔基苯基) ]－2－[(苯基)]－吡咯烷－1,2－二酰胺衍生物
ES2223277B1 (es) 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
DE10358814A1 (de) * 2003-12-16 2005-07-21 Merck Patent Gmbh Prolinylarylacetamide
DE102004014945A1 (de) 2004-03-26 2005-10-13 Merck Patent Gmbh Prolinylderivate
US7453002B2 (en) * 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
DE102004045796A1 (de) 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
JP2008535887A (ja) 2005-04-11 2008-09-04 グラクソ グループ リミテッド 第Ｘａ因子阻害剤としての３−スルホニルアミノ−ピロリジン−２−オン誘導体
WO2007009883A1 (en) 2005-07-15 2007-01-25 F. Hoffmann-La Roche Ag Novel heteroaryl fused cyclic amines

Also Published As

Publication number Publication date
AU2007251614B2 (en) 2013-01-17
AU2007251614A1 (en) 2007-11-22
EA200802210A1 (ru) 2009-06-30
ES2395538T3 (es) 2013-02-13
KR101422456B1 (ko) 2014-07-23
MX2008014499A (es) 2008-11-27
EP2051975B1 (de) 2012-09-12
JP2009537483A (ja) 2009-10-29
IL195245A (en) 2012-09-24
JP5263686B2 (ja) 2013-08-14
MY146623A (en) 2012-09-14
BRPI0711648A2 (pt) 2011-11-29
CA2653753A1 (en) 2007-11-22
IL195245A0 (en) 2009-09-22
PL2051975T3 (pl) 2013-01-31
UY30352A1 (es) 2008-01-02
ECSP088824A (es) 2008-11-27
PE20080702A1 (es) 2008-07-10
NZ573573A (en) 2011-10-28
DK2051975T3 (da) 2012-10-15
CA2653753C (en) 2013-09-24
US20080139605A1 (en) 2008-06-12
AR060945A1 (es) 2008-07-23
KR20090017523A (ko) 2009-02-18
WO2007131982A3 (de) 2008-01-10
CL2007001391A1 (es) 2008-01-18
WO2007131982A2 (de) 2007-11-22
EP2051975A2 (de) 2009-04-29
TW200813047A (en) 2008-03-16
HK1131140A1 (en) 2010-01-15
US7807693B2 (en) 2010-10-05

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application