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WO2008135525A3 - Substituted azetidines, manufacturing and use thereof as medicaments - Google Patents

Substituted azetidines, manufacturing and use thereof as medicaments Download PDF

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Publication number
WO2008135525A3
WO2008135525A3 PCT/EP2008/055411 EP2008055411W WO2008135525A3 WO 2008135525 A3 WO2008135525 A3 WO 2008135525A3 EP 2008055411 W EP2008055411 W EP 2008055411W WO 2008135525 A3 WO2008135525 A3 WO 2008135525A3
Authority
WO
WIPO (PCT)
Prior art keywords
medicaments
manufacturing
substituted azetidines
azetidines
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/055411
Other languages
French (fr)
Other versions
WO2008135525A2 (en
Inventor
Kai Gerlach
Henning Priepke
Wolfgang Wienen
Annette Schuler-Metz
Herbert Nar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of WO2008135525A2 publication Critical patent/WO2008135525A2/en
Publication of WO2008135525A3 publication Critical patent/WO2008135525A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to new substituted carboxylic acid amides of general formula (I), wherein D, L, E, G, M, R3, R4, R5 et R13 are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
PCT/EP2008/055411 2007-05-02 2008-05-02 Substituted azetidines, manufacturing and use thereof as medicaments Ceased WO2008135525A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107341 2007-05-02
EP07107341.5 2007-05-02

Publications (2)

Publication Number Publication Date
WO2008135525A2 WO2008135525A2 (en) 2008-11-13
WO2008135525A3 true WO2008135525A3 (en) 2008-12-31

Family

ID=39810221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/055411 Ceased WO2008135525A2 (en) 2007-05-02 2008-05-02 Substituted azetidines, manufacturing and use thereof as medicaments

Country Status (1)

Country Link
WO (1) WO2008135525A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2220079A2 (en) 2007-11-15 2010-08-25 Boehringer Ingelheim International GmbH Substituted amides, manufacturing and use thereof as medicaments
RU2013138372A (en) * 2011-01-19 2015-02-27 Галапаго Нв ASETIDINE DERIVATIVES USED FOR TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES
JP6052527B2 (en) 2013-02-21 2016-12-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Dihydropteridinone I
EP3078378B1 (en) 2015-04-08 2020-06-24 Vaiomer Use of factor xa inhibitors for regulating glycemia
CR20180413A (en) 2016-02-05 2018-12-04 Denali Therapeutics Inc INHIBITORS OF PROTEIN QUINASA 1 THAT INTERACT WITH THE RECEIVER
JP7208137B2 (en) 2016-12-09 2023-01-18 デナリ セラピューティクス インコーポレイテッド Compounds, compositions and methods
IL314082A (en) 2022-01-12 2024-09-01 Denali Therapeutics Inc Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004091A1 (en) * 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
WO2003018551A1 (en) * 2001-08-30 2003-03-06 Astrazeneca Ab New mandelic acid derivatives and their use as thrombin inhibitors
US20030134801A1 (en) * 1998-12-29 2003-07-17 Lg Life Sciences, Ltd. Thrombin inhibitors
US20040147502A1 (en) * 2002-12-17 2004-07-29 Bisacchi Gregory S. Beta lactam compounds and their use as inhibitors of tryptase
WO2006108039A2 (en) * 2005-04-04 2006-10-12 Daiamed, Inc. Substituted azetidinones

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030134801A1 (en) * 1998-12-29 2003-07-17 Lg Life Sciences, Ltd. Thrombin inhibitors
WO2001004091A1 (en) * 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
WO2003018551A1 (en) * 2001-08-30 2003-03-06 Astrazeneca Ab New mandelic acid derivatives and their use as thrombin inhibitors
US20040147502A1 (en) * 2002-12-17 2004-07-29 Bisacchi Gregory S. Beta lactam compounds and their use as inhibitors of tryptase
WO2006108039A2 (en) * 2005-04-04 2006-10-12 Daiamed, Inc. Substituted azetidinones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAN W T ET AL: "AZETIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 3, no. 8, 1 January 1995 (1995-01-01), pages 1123 - 1143, XP000612953, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
WO2008135525A2 (en) 2008-11-13

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