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NO20084516L - Terfenylderivater for behandling av alzheimers sykdom - Google Patents

Terfenylderivater for behandling av alzheimers sykdom

Info

Publication number
NO20084516L
NO20084516L NO20084516A NO20084516A NO20084516L NO 20084516 L NO20084516 L NO 20084516L NO 20084516 A NO20084516 A NO 20084516A NO 20084516 A NO20084516 A NO 20084516A NO 20084516 L NO20084516 L NO 20084516L
Authority
NO
Norway
Prior art keywords
alzheimer
disease
treatment
terfenyl
derivatives
Prior art date
Application number
NO20084516A
Other languages
English (en)
Norwegian (no)
Inventor
Chih Yung Ho
Alison Reid
Kathryn Smelt
Valerie Reader
Mihiro Sunose
Svenja Burckhardt
Jeremy Major
Francis Wilson
Richard John Harrison
Remedios Hernandez-Perni
Cyrille Boussard
Jess Taylor
Adeline Leformal
Andrew Cansfield
Yan Zhang
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20084516(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of NO20084516L publication Critical patent/NO20084516L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20084516A 2006-04-21 2008-10-27 Terfenylderivater for behandling av alzheimers sykdom NO20084516L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (en) 2006-04-21 2006-04-21 Terphenyl derivatives for treatment of Alzheimer's disease
PCT/US2007/066951 WO2007124351A1 (en) 2006-04-21 2007-04-19 Terphenyl derivatives for treatment of alzheimer' s disease

Publications (1)

Publication Number Publication Date
NO20084516L true NO20084516L (no) 2009-01-13

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084516A NO20084516L (no) 2006-04-21 2008-10-27 Terfenylderivater for behandling av alzheimers sykdom

Country Status (34)

Country Link
US (1) US8106236B2 (es)
EP (2) EP1847524B1 (es)
JP (1) JP5422827B2 (es)
KR (1) KR101494906B1 (es)
CN (1) CN101484410B (es)
AR (1) AR060621A1 (es)
AT (1) ATE445586T1 (es)
AU (1) AU2007240382B2 (es)
BR (1) BRPI0710632A2 (es)
CA (1) CA2649845C (es)
CR (2) CR10376A (es)
CY (1) CY1109729T1 (es)
DE (1) DE602006009764D1 (es)
DK (1) DK1847524T3 (es)
EA (1) EA016908B1 (es)
ES (2) ES2333539T3 (es)
GE (1) GEP20115211B (es)
IL (2) IL194853A0 (es)
MA (1) MA30420B1 (es)
MX (1) MX2008013447A (es)
MY (1) MY148988A (es)
NO (1) NO20084516L (es)
NZ (1) NZ572999A (es)
PE (1) PE20080267A1 (es)
PL (1) PL1847524T3 (es)
PT (1) PT1847524E (es)
SI (1) SI1847524T1 (es)
SM (1) SMP200800062B (es)
TN (1) TNSN08414A1 (es)
TW (1) TWI435720B (es)
UA (1) UA95766C2 (es)
UY (1) UY30300A1 (es)
WO (1) WO2007124351A1 (es)
ZA (1) ZA200809857B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1847524T3 (da) 2006-04-21 2010-01-11 Cellzome Ltd Terphenylderivater til behandling af Alzheimers sygdom
WO2009052350A1 (en) 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
BRPI0817433A2 (pt) 2007-10-19 2015-06-16 Janssen Pharmaceutica Nv Moduladores de gama-secretase piperidinila e piperazinila
MX2010004311A (es) * 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Productos intermedios de moduladores de gamma-secretasa.
CA2702959C (en) 2007-10-19 2016-07-26 Janssen Pharmaceutica Nv Carbon linked modulators of .gamma.-secretase
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CN101896461A (zh) * 2007-12-13 2010-11-24 安姆根有限公司 γ分泌酶调节剂
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
BRPI0908837A2 (pt) * 2008-03-11 2015-07-21 Neurosearch As Derivado de triarila, composição farmacêutica, uso de um derivado de triarila, e, método para tratar, prevenir ou para o alívio de uma doença, um distúrbio ou uma condição de um corpo de animal vivo
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
CA2828748C (en) * 2011-03-03 2019-06-25 Denovamed Inc. Antimicrobial / adjuvant compounds and methods
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
MA55974A (fr) * 2019-05-15 2022-03-23 Chemocentryx Inc Composés triaryles pour le traitement de maladies pd-l1
KR20230113770A9 (ko) * 2020-11-27 2024-03-25 미라이랩 바이오사이언스 인코퍼레이티드 고순도 β 니코틴아미드 모노뉴클레오티드(NMN) 및 그 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
AU4537400A (en) 1999-05-12 2000-12-05 Neurosearch A/S Ion channel modulating agents
AU5702201A (en) 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
WO2001081312A2 (en) 2000-04-24 2001-11-01 Merck Frosst Canada & Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
CN1277872C (zh) * 2001-02-20 2006-10-04 安德鲁斯街大学管理处 含金属的树状物
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
AU2003298740A1 (en) * 2002-12-05 2004-06-30 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
CA2523336A1 (en) * 2003-04-30 2004-11-11 Merck Frosst Canada Ltd. 8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors
WO2005110963A1 (en) 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
WO2007020194A1 (en) * 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Piperidine and piperazine derivatives as p2x3 antagonists
JP5155171B2 (ja) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物
DK1847524T3 (da) 2006-04-21 2010-01-11 Cellzome Ltd Terphenylderivater til behandling af Alzheimers sygdom

Also Published As

Publication number Publication date
CA2649845C (en) 2014-09-16
US20070254957A1 (en) 2007-11-01
PL1847524T3 (pl) 2010-03-31
JP2009538275A (ja) 2009-11-05
AR060621A1 (es) 2008-07-02
WO2007124351A1 (en) 2007-11-01
IL194853A0 (en) 2009-08-03
KR101494906B1 (ko) 2015-02-24
CR10376A (es) 2009-02-26
SI1847524T1 (sl) 2010-01-29
EA016908B1 (ru) 2012-08-30
EP2016039B1 (en) 2012-08-01
CY1109729T1 (el) 2014-09-10
PE20080267A1 (es) 2008-05-16
EP2016039A1 (en) 2009-01-21
SMAP200800062A (it) 2008-11-19
JP5422827B2 (ja) 2014-02-19
NZ572999A (en) 2012-06-29
UA95766C2 (ru) 2011-08-25
KR20090024678A (ko) 2009-03-09
ATE445586T1 (de) 2009-10-15
MY148988A (en) 2013-06-28
UY30300A1 (es) 2007-08-31
AU2007240382A1 (en) 2007-11-01
DE602006009764D1 (de) 2009-11-26
TW200810746A (en) 2008-03-01
EP1847524A1 (en) 2007-10-24
ZA200809857B (en) 2009-08-26
EA200802173A1 (ru) 2009-06-30
CA2649845A1 (en) 2007-11-01
CN101484410A (zh) 2009-07-15
MA30420B1 (fr) 2009-05-04
DK1847524T3 (da) 2010-01-11
MX2008013447A (es) 2009-03-10
IL194789A0 (en) 2009-08-03
ES2333539T3 (es) 2010-02-23
SMP200800062B (it) 2009-07-14
CN101484410B (zh) 2013-08-21
EP1847524B1 (en) 2009-10-14
TNSN08414A1 (en) 2010-04-14
BRPI0710632A2 (pt) 2011-08-23
HK1134923A1 (en) 2010-05-20
PT1847524E (pt) 2009-12-18
AU2007240382B2 (en) 2013-05-02
GEP20115211B (en) 2011-04-26
TWI435720B (zh) 2014-05-01
CR10452A (es) 2009-02-23
ES2392352T3 (es) 2012-12-10
US8106236B2 (en) 2012-01-31

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application