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NO20083726L - Spiroindolinon derivater - Google Patents

Spiroindolinon derivater

Info

Publication number
NO20083726L
NO20083726L NO20083726A NO20083726A NO20083726L NO 20083726 L NO20083726 L NO 20083726L NO 20083726 A NO20083726 A NO 20083726A NO 20083726 A NO20083726 A NO 20083726A NO 20083726 L NO20083726 L NO 20083726L
Authority
NO
Norway
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
enantiomers
esters
Prior art date
Application number
NO20083726A
Other languages
English (en)
Norwegian (no)
Inventor
Jin-Jun Liu
Zhuming Zhang
Qingjie Ding
Li Chen
Song Yang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20083726L publication Critical patent/NO20083726L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20083726A 2006-03-13 2008-08-29 Spiroindolinon derivater NO20083726L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78195806P 2006-03-13 2006-03-13
US88175607P 2007-01-22 2007-01-22
PCT/EP2007/052038 WO2007104664A1 (fr) 2006-03-13 2007-03-05 Dérivés de spiroindolinone

Publications (1)

Publication Number Publication Date
NO20083726L true NO20083726L (no) 2008-11-25

Family

ID=38179455

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083726A NO20083726L (no) 2006-03-13 2008-08-29 Spiroindolinon derivater

Country Status (15)

Country Link
US (1) US20070213341A1 (fr)
EP (1) EP1996590B1 (fr)
JP (1) JP5038337B2 (fr)
KR (1) KR101131031B1 (fr)
AR (1) AR059957A1 (fr)
AT (1) ATE483711T1 (fr)
AU (1) AU2007224505B2 (fr)
BR (1) BRPI0709605A2 (fr)
CA (1) CA2645062A1 (fr)
DE (1) DE602007009650D1 (fr)
IL (1) IL193641A0 (fr)
NO (1) NO20083726L (fr)
RU (1) RU2435771C2 (fr)
TW (1) TW200801000A (fr)
WO (1) WO2007104664A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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ES2320955B1 (es) * 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
US7553833B2 (en) * 2007-05-17 2009-06-30 Hoffmann-La Roche Inc. 3,3-spiroindolinone derivatives
US8134001B2 (en) * 2007-12-14 2012-03-13 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) * 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
EP2108641A1 (fr) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. Nouveaux dérivés substitués de spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one et leur utilisation comme ihibiteurs de p38 mitogen-activated kinase
EP2113503A1 (fr) * 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. Nouveaux dérivés d'indolin-2-one substitués et leur utilisation comme inhibiteurs de p38 mitogen-activated kinase
KR100915320B1 (ko) 2008-09-29 2009-09-03 (주)메디룬 생리통완화를 위한 휴대용 조합자극기
US20100190814A1 (en) * 2009-01-26 2010-07-29 Li Chen Spiroindolinone derivative prodrugs
US7928233B2 (en) 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
CN102741259B (zh) 2009-07-31 2016-04-13 全球结核病药物研发联盟 硝基咪唑并噁嗪和硝基咪唑并噁唑的类似物及其用途
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US9962459B2 (en) * 2010-07-02 2018-05-08 Basf Se Ultrathin fluid-absorbent cores
CA2829188C (fr) * 2011-03-10 2016-10-18 Daiichi Sankyo Company, Limited Derive de dispiropyrrolidine
US9376425B2 (en) 2011-09-27 2016-06-28 Amgen, Inc. Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
WO2014100065A1 (fr) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Imidazopyridines substituées en tant qu'inhibiteurs de hdm2
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
AU2014223547B2 (en) 2013-02-28 2017-11-16 Amgen Inc. A benzoic acid derivative MDM2 inhibitor for the treatment of cancer
US9758495B2 (en) 2013-03-14 2017-09-12 Amgen Inc. Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
EP3164401B1 (fr) 2014-07-03 2018-12-26 Boehringer Ingelheim International GmbH Nouvelles spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one composés et leur dérivés comme inhibiteurs de mdm2-p53
DK3183254T3 (da) 2014-08-21 2019-08-19 Boehringer Ingelheim Int Nye spiro[3h-indol-3,2 ?-pyrrolidin]-2(1h)-one forbindelser og derivater som mdm2-p53 inhibitorer
TWI711452B (zh) 2015-02-20 2020-12-01 日商第一三共股份有限公司 癌症的倂用治療法
US10485794B2 (en) 2015-04-13 2019-11-26 Daiichi Sankyo Company, Limited Treatment method by combined use of MDM2 inhibitor and BTK inhibitor
WO2017060431A1 (fr) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Composés de spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one et leurs dérivés à titre d'inhibiteurs de mdm2-p53
EP3458101B1 (fr) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Conjugués anticorps-protac et procédés d'utilisation
CN109843329A (zh) 2016-10-17 2019-06-04 第一三共株式会社 使用mdm2抑制剂和dna甲基转移酶抑制剂的组合治疗方法
EP3511334A1 (fr) * 2018-01-16 2019-07-17 Adamed sp. z o.o. Composés de 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole] -2,3'-dione comme agents thérapeutiques activant le tp53
CN117462324A (zh) 2018-03-07 2024-01-30 Soovu实验室公司 用于通过刺激热觉纤维改善疼痛缓解的系统和方法
WO2023056069A1 (fr) 2021-09-30 2023-04-06 Angiex, Inc. Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation
WO2024240858A1 (fr) 2023-05-23 2024-11-28 Valerio Therapeutics Molécules protac dirigées contre un système de réparation de dommages à l'adn et leurs utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ151495A3 (en) * 1992-12-11 1995-12-13 Merck & Co Inc Spiropiperidine derivatives, process of their preparation and a pharmaceutical composition containing thereof
CN1361779A (zh) * 1999-07-21 2002-07-31 阿斯特拉曾尼卡有限公司 新化合物
JP2009530236A (ja) * 2006-03-13 2009-08-27 エフ．ホフマン−ラ ロシュ アーゲー スピロインドリノン誘導体

Also Published As

Publication number Publication date
BRPI0709605A2 (pt) 2011-07-19
AU2007224505A1 (en) 2007-09-20
RU2008140386A (ru) 2010-04-20
RU2435771C2 (ru) 2011-12-10
EP1996590A1 (fr) 2008-12-03
WO2007104664A1 (fr) 2007-09-20
US20070213341A1 (en) 2007-09-13
JP2009529566A (ja) 2009-08-20
JP5038337B2 (ja) 2012-10-03
AU2007224505B2 (en) 2012-05-03
ATE483711T1 (de) 2010-10-15
CA2645062A1 (fr) 2007-09-20
EP1996590B1 (fr) 2010-10-06
DE602007009650D1 (de) 2010-11-18
TW200801000A (en) 2008-01-01
KR20080095279A (ko) 2008-10-28
AR059957A1 (es) 2008-05-14
KR101131031B1 (ko) 2012-04-12
IL193641A0 (en) 2009-05-04

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