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NO20082354L - Nye sykliske forbindelser - Google Patents

Nye sykliske forbindelser

Info

Publication number
NO20082354L
NO20082354L NO20082354A NO20082354A NO20082354L NO 20082354 L NO20082354 L NO 20082354L NO 20082354 A NO20082354 A NO 20082354A NO 20082354 A NO20082354 A NO 20082354A NO 20082354 L NO20082354 L NO 20082354L
Authority
NO
Norway
Prior art keywords
hepatitis
cyclic compounds
new cyclic
virus
replication
Prior art date
Application number
NO20082354A
Other languages
English (en)
Inventor
Masahiro Neya
Seiji Yoshimura
Kazunori Kamijyo
Takuya Makino
Minoru Yasuda
Toshio Yamanaka
Eisaku Tsujii
Yukiko Yamagishi
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of NO20082354L publication Critical patent/NO20082354L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende oppfinnelse angår en ny, syklisk peptidforbindelse eller et salt derav, som har antihepatitt C-virusaktivitet basert på inhiberende aktivitet mot RNA replikasjon av hepatitt Cvirusreplikon, fremgangsmåte for fremstilling derav omfattende en omleiringsreaksjon under en mild, sur betingelse og de etterfølgende aminosyreforandringsreaksjoner, etc., et farmasøytisk preparat omfattende den samme, og en metode for profylaktisk og/eller terapeutisk behandling av hepatitt C i et menneske eller et dyr.
NO20082354A 2005-10-26 2008-05-23 Nye sykliske forbindelser NO20082354L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73001105P 2005-10-26 2005-10-26
US75120405P 2005-12-19 2005-12-19
PCT/JP2006/321924 WO2007049803A1 (en) 2005-10-26 2006-10-26 New cyclic peptide compounds

Publications (1)

Publication Number Publication Date
NO20082354L true NO20082354L (no) 2008-07-01

Family

ID=37847219

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082354A NO20082354L (no) 2005-10-26 2008-05-23 Nye sykliske forbindelser

Country Status (17)

Country Link
US (2) US7872097B2 (no)
EP (1) EP1957518B1 (no)
JP (1) JP5218051B2 (no)
KR (1) KR101273681B1 (no)
CN (1) CN101305019B (no)
AU (1) AU2006306974B2 (no)
BR (1) BRPI0617781A2 (no)
CA (1) CA2623898C (no)
ES (1) ES2557477T3 (no)
IL (1) IL190286A0 (no)
NO (1) NO20082354L (no)
PL (1) PL1957518T3 (no)
PT (1) PT1957518E (no)
RU (1) RU2423377C2 (no)
TW (1) TWI391403B (no)
WO (1) WO2007049803A1 (no)
ZA (1) ZA200803525B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101687012A (zh) 2007-05-02 2010-03-31 安斯泰来制药有限公司 新的环肽化合物
WO2010035722A1 (ja) * 2008-09-24 2010-04-01 アステラス製薬株式会社 ペプチド化合物およびその製造方法
WO2010088573A1 (en) * 2009-01-30 2010-08-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
WO2010131962A2 (en) * 2009-05-15 2010-11-18 Stichting Het Nederlands Kanker Instituut Lysine compounds and their use in site- and chemoselective modification of peptides and proteins
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
JP2013516424A (ja) * 2009-12-30 2013-05-13 サイネクシス，インコーポレーテッド シクロスポリン類似体
WO2014035707A1 (en) * 2012-08-25 2014-03-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
CN104603146B (zh) 2012-09-29 2018-01-02 诺华股份有限公司 环肽类化合物及其作为药物的用途
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
WO2015031381A1 (en) * 2013-08-26 2015-03-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271267A (ja) * 1991-04-23 1993-10-19 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１４５９物質、その製法及び用途
DE69928938T2 (de) * 1998-07-01 2006-08-17 Debiopharm S.A. Neues cyclosporin mit verbesserter wirkung
JP4232866B2 (ja) * 2000-10-19 2009-03-04 有限会社 ケアティス 細胞障害抑制剤
JP2005511538A (ja) * 2001-10-19 2005-04-28 アイソテクニカ インコーポレーテッド シクロスポリン類似体混合物及びそれらの免疫調節剤としての使用
GB0320638D0 (en) * 2003-09-03 2003-10-01 Novartis Ag Organic compounds
JP2007015926A (ja) * 2003-10-06 2007-01-25 Fujisawa Pharmaceut Co Ltd Ｃ型肝炎治療剤
CA2580448C (en) 2004-10-01 2012-09-18 Debiopharm Sa Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection and pharmaceutical composition comprising said [d-meala]3-[etval]4-cyclosporin
NZ554514A (en) 2004-10-01 2010-10-29 Scynexis Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7696167B2 (en) 2004-11-22 2010-04-13 Astellas Pharma Inc. Cyclic peptide compound

Also Published As

Publication number Publication date
US8252895B2 (en) 2012-08-28
KR20080065297A (ko) 2008-07-11
KR101273681B1 (ko) 2013-06-25
AU2006306974B2 (en) 2011-09-22
IL190286A0 (en) 2011-08-01
US7872097B2 (en) 2011-01-18
CN101305019B (zh) 2012-12-12
PL1957518T3 (pl) 2016-07-29
US20100286033A1 (en) 2010-11-11
ZA200803525B (en) 2009-08-26
BRPI0617781A2 (pt) 2011-08-09
PT1957518E (pt) 2016-02-26
TWI391403B (zh) 2013-04-01
CA2623898A1 (en) 2007-05-03
CN101305019A (zh) 2008-11-12
EP1957518B1 (en) 2015-12-09
RU2423377C2 (ru) 2011-07-10
AU2006306974A1 (en) 2007-05-03
JP2009513562A (ja) 2009-04-02
JP5218051B2 (ja) 2013-06-26
EP1957518A1 (en) 2008-08-20
US20090170755A1 (en) 2009-07-02
CA2623898C (en) 2013-12-24
RU2008116674A (ru) 2009-10-27
TW200732351A (en) 2007-09-01
ES2557477T3 (es) 2016-01-26
WO2007049803A1 (en) 2007-05-03

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application