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NO20081838L - 5-lipoksygenaseaktiverende protein-(FLAP)-inhibitorer - Google Patents

5-lipoksygenaseaktiverende protein-(FLAP)-inhibitorer

Info

Publication number
NO20081838L
NO20081838L NO20081838A NO20081838A NO20081838L NO 20081838 L NO20081838 L NO 20081838L NO 20081838 A NO20081838 A NO 20081838A NO 20081838 A NO20081838 A NO 20081838A NO 20081838 L NO20081838 L NO 20081838L
Authority
NO
Norway
Prior art keywords
flap
activating protein
inhibitors
lipoxygenase activating
compounds
Prior art date
Application number
NO20081838A
Other languages
English (en)
Other versions
NO342361B1 (no
Inventor
John H Hutchinson
Petpiboon Peppi Prasit
Mark Moran
Jillian F Evans
Brian Andrew Stearns
Jeffrey Roger Roppe
Yiwei Li
Jasmine Eleanor Zunic
Jeannie M Arruda
Nicholas Simon Stock
Mustapha Haddach
Original Assignee
Amira Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amira Pharmaceuticals Inc filed Critical Amira Pharmaceuticals Inc
Publication of NO20081838L publication Critical patent/NO20081838L/no
Publication of NO342361B1 publication Critical patent/NO342361B1/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)

Abstract

Det er her beskrevet er forbindelser og farmasøytiske preparater som inneholder slike forbindelser, som modulerer aktiviteten til 5-lipoksygenase-aktiverende protein (FLAP). Her er det også beskrevet metoder for anvendelse av slike FLAP-modulatorer, alene og i kombinasjon med andre forbindelser, for behandling av luftveissykdommer, kardiovaskulære sykdommer og andre leukotrien-avhengige eller leukotrien-medierte tilstander eller sykdommer.
NO20081838A 2005-11-04 2008-04-16 3-[3-tert-butylsulfanyl-1-[4-(6-etoksy-pyridin-3-yl)-benzyl]-5-(5-metyl-pyridin-2-ylmetoksy)-1H-indol-2-yl]-2,2-dimetyl-propionsyre, farmasøytisk preparat omfattende slike, kombinasjoner omfattende slike, anvendelse av slike som medikament og anvendelse av slike for behandling av sykdom NO342361B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73403005P 2005-11-04 2005-11-04
US74717406P 2006-05-12 2006-05-12
US82334406P 2006-08-23 2006-08-23
US11/553,946 US7977359B2 (en) 2005-11-04 2006-10-27 5-lipdxygenase-activating protein (FLAP) inhibitors
PCT/US2006/042690 WO2007056021A2 (en) 2005-11-04 2006-10-30 5-lipoxygenase-activating protein (flap) inhibitors

Publications (2)

Publication Number Publication Date
NO20081838L true NO20081838L (no) 2008-07-29
NO342361B1 NO342361B1 (no) 2018-05-14

Family

ID=38004604

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081838A NO342361B1 (no) 2005-11-04 2008-04-16 3-[3-tert-butylsulfanyl-1-[4-(6-etoksy-pyridin-3-yl)-benzyl]-5-(5-metyl-pyridin-2-ylmetoksy)-1H-indol-2-yl]-2,2-dimetyl-propionsyre, farmasøytisk preparat omfattende slike, kombinasjoner omfattende slike, anvendelse av slike som medikament og anvendelse av slike for behandling av sykdom

Country Status (26)

Country Link
US (3) US7977359B2 (no)
EP (2) EP1943219B8 (no)
JP (3) JP4705986B2 (no)
KR (1) KR101031766B1 (no)
CN (1) CN102295637A (no)
AT (1) ATE530521T1 (no)
AU (2) AU2006311973B9 (no)
BR (1) BRPI0618046A2 (no)
CA (1) CA2628490C (no)
CR (1) CR9942A (no)
CY (1) CY1112383T1 (no)
DK (1) DK1943219T3 (no)
EA (2) EA018616B1 (no)
ES (1) ES2373977T3 (no)
HR (1) HRP20120033T1 (no)
IL (2) IL190873A0 (no)
MA (1) MA29931B1 (no)
MY (1) MY151159A (no)
NO (1) NO342361B1 (no)
NZ (2) NZ592541A (no)
PL (1) PL1943219T3 (no)
PT (1) PT1943219E (no)
RS (1) RS52189B (no)
SG (1) SG166813A1 (no)
SI (1) SI1943219T1 (no)
WO (1) WO2007056021A2 (no)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070225285A1 (en) * 2005-11-04 2007-09-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US20070244128A1 (en) * 2005-11-04 2007-10-18 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US20070219206A1 (en) * 2005-11-04 2007-09-20 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US20100068301A1 (en) 2006-11-30 2010-03-18 Hutchinson John H Compositions and treatments comprising 5-lipoxygenase-activating protein inhibitors and nitric oxide modulators
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
US20110160249A1 (en) * 2008-05-23 2011-06-30 Schaab Kevin Murray 5-lipoxygenase-activating protein inhibitor
EP2331541B1 (en) * 2008-09-04 2015-04-22 Boehringer Ingelheim International GmbH Indolizine inhibitors of leukotriene production
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
JP2012513406A (ja) * 2008-12-23 2012-06-14 パンミラ ファーマシューティカルズ，エルエルシー． 皮膚科学の疾病の処置のためのｆｌａｐ阻害剤の局所製剤
CA2744898A1 (en) * 2008-12-23 2010-07-01 Amira Pharmaceuticals, Inc. Topical formulations of flap inhibitors for administration to an eye
EP4008327A1 (en) 2009-04-29 2022-06-08 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
CN102574822A (zh) 2009-08-04 2012-07-11 阿米拉制药公司 作为溶血磷脂酸受体拮抗剂的化合物
EP2480547A4 (en) * 2009-09-23 2013-02-20 Panmira Pharmaceuticals Llc INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE
JP2013506624A (ja) * 2009-09-23 2013-02-28 アミラ ファーマシューティカルズ，インク． ５−リポキシゲナーゼのインドリジンインヒビター
GB2474120B (en) 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
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