AR084948A1 - Agente antifungico topico - Google Patents
Agente antifungico topicoInfo
- Publication number
- AR084948A1 AR084948A1 ARP120100287A ARP120100287A AR084948A1 AR 084948 A1 AR084948 A1 AR 084948A1 AR P120100287 A ARP120100287 A AR P120100287A AR P120100287 A ARP120100287 A AR P120100287A AR 084948 A1 AR084948 A1 AR 084948A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen atom
- amino
- halogen
- trifluoromethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se proporciona un agente anti-Trichopitona que comprende como ingrediente activo un compuesto que tiene el esqueleto de 2-(1H-pirazol-l-il)fenol.Reivindicación 1: Un compuesto representado por la fórmula (1), en donde: R1 representa un átomo de hidrógeno, alquilo C1-6 o trifluorometilo; R2 representa un átomo de hidrógeno, alquilo C1-6, halógeno, -COO(alquilo C1-6) o -(CH2)1-3COOR (R representa un átomo de hidrógeno o alquilo C1-6); R3 representa un átomo de hidrógeno, alquilo C1-6, amino, trifluorometilo u -OR (R representa un átomo de hidrógeno o alquilo C1-6); R4 representa un grupo hidroxilo; R5 representa un átomo de hidrógeno, alquilo C1-6, un grupo hidroxilo o halógeno; R6 representa un alquilo C1-6, trifluorometilo, halógeno, amino, -NRaRb, nitro, hidroxi alquilo C1-6, -CONRaRb, -COO(alquilo C1-6), -COOH, -(CH2)1-3COOR u -ORa (R representa un átomo de hidrógeno o alquilo C1-6 y Ra y Rb pueden ser iguales o diferentes entre sí y representan un átomo de hidrógeno, alquilo C1-6 o acilo C1-6); R7 representa un átomo de hidrógeno, alquilo C1-6, -OR (R representa un átomo de hidrógeno o alquilo C1-6) o halógeno; y R8 representa un átomo de hidrógeno, alquilo C1-6, un grupo hidroxilo, amino o nitro, siempre que, cuando R1 es un átomo de hidrógeno, R3 no sea un átomo de hidrógeno y se excluya el compuesto en donde R1 es ter-butilo, R3 es amino, R4 es un grupo hidroxilo y R6 es metilo; o una de sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011017347 | 2011-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084948A1 true AR084948A1 (es) | 2013-07-10 |
Family
ID=46580967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100287A AR084948A1 (es) | 2011-01-30 | 2012-01-30 | Agente antifungico topico |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8889727B2 (es) |
| EP (1) | EP2669274B1 (es) |
| JP (1) | JP5362128B2 (es) |
| KR (1) | KR101463707B1 (es) |
| CN (1) | CN103339112B (es) |
| AR (1) | AR084948A1 (es) |
| AU (1) | AU2012209696B2 (es) |
| BR (1) | BR112013018938B1 (es) |
| CA (1) | CA2825889C (es) |
| CL (1) | CL2013001995A1 (es) |
| CO (1) | CO6741178A2 (es) |
| DK (1) | DK2669274T3 (es) |
| ES (1) | ES2560930T3 (es) |
| IL (1) | IL227705A (es) |
| MX (1) | MX2013008777A (es) |
| MY (1) | MY161280A (es) |
| PH (1) | PH12013501606A1 (es) |
| RU (1) | RU2593990C2 (es) |
| SG (1) | SG192582A1 (es) |
| TW (1) | TWI491593B (es) |
| UA (1) | UA110816C2 (es) |
| WO (1) | WO2012102404A1 (es) |
| ZA (1) | ZA201305718B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015001235A2 (pt) * | 2012-07-30 | 2017-07-04 | Meiji Seika Pharma Co Ltd | agente líquido tópico para o tratamento de dermatofitose |
| AR091934A1 (es) | 2012-07-30 | 2015-03-11 | Meiji Seika Pharma Co Ltd | Parche para antidermatofitosis |
| US8805865B2 (en) | 2012-10-15 | 2014-08-12 | Juked, Inc. | Efficient matching of data |
| WO2014111871A1 (en) | 2013-01-17 | 2014-07-24 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
| KR102137861B1 (ko) * | 2014-08-13 | 2020-07-24 | 메이지 세이카 파루마 가부시키가이샤 | 결정성 항백선균약 및 그 제조 방법 |
| ES2894370T3 (es) | 2016-03-15 | 2022-02-14 | Igor Polyakov | Composiciones para el tratamiento y prevención de enfermedades podales y de las pezuñas |
| JP6582158B1 (ja) | 2017-10-30 | 2019-09-25 | 科研製薬株式会社 | 爪白癬治療用の外用製剤 |
| CN110862349B (zh) * | 2019-11-11 | 2023-05-05 | 南京医科大学 | 依达拉奉类似物及其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3628892A1 (de) | 1986-08-26 | 1988-03-10 | Bayer Ag | Substituierte 1-aryl-3-tert.-butyl-pyrazole |
| ES2015648A6 (es) | 1989-05-05 | 1990-09-01 | Consejo Superior Investigacion | Procedeimiento de sintesis de mono y bis (3-r3-4-r4-5-r5-pirazol-1-il)1,4-dihidroxibencenos. |
| TW297813B (es) * | 1993-09-24 | 1997-02-11 | Takeda Pharm Industry Co Ltd | |
| DE4414897A1 (de) | 1994-04-28 | 1995-11-02 | Hoechst Ag | Aromatische Diazoniumsalze und deren Verwendung in strahlungsempfindlichen Gemischen |
| JP3729884B2 (ja) | 1995-01-05 | 2005-12-21 | 関東電化工業株式会社 | フルオロフェノール類の製造方法 |
| JPH1160528A (ja) | 1997-08-12 | 1999-03-02 | Ube Ind Ltd | ４−クロロ−３−トリフルオロメチルフェノールの製法 |
| DE60011420T2 (de) | 2000-03-03 | 2005-06-09 | Sumitomo Chemical Co. Ltd. | Verfahren zur herstellung von phenylhydrazinen |
| ATE360417T1 (de) | 2001-07-11 | 2007-05-15 | Boehringer Ingelheim Pharma | Methode zur behandlung von zytokinvermittelten erkrankungen |
| JP4537855B2 (ja) * | 2002-10-09 | 2010-09-08 | 久光製薬株式会社 | 抗真菌活性を有する新規ピラゾール化合物 |
| KR100509603B1 (ko) | 2002-12-28 | 2005-08-22 | 삼성에스디아이 주식회사 | 적색 발광 화합물 및 이를 채용한 유기 전계 발광 소자 |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| WO2007083320A2 (en) | 2006-01-19 | 2007-07-26 | Matrix Laboratories Ltd | Conversion of aromatic diazonium salt to aryl hydrazine |
| WO2008024978A2 (en) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Tetrahydroindolone and tetrahydroindazolone derivatives |
-
2012
- 2012-01-30 CA CA2825889A patent/CA2825889C/en not_active Expired - Fee Related
- 2012-01-30 ES ES12739689.3T patent/ES2560930T3/es active Active
- 2012-01-30 WO PCT/JP2012/051991 patent/WO2012102404A1/ja not_active Ceased
- 2012-01-30 AR ARP120100287A patent/AR084948A1/es unknown
- 2012-01-30 RU RU2013140163/04A patent/RU2593990C2/ru not_active IP Right Cessation
- 2012-01-30 SG SG2013057690A patent/SG192582A1/en unknown
- 2012-01-30 KR KR1020137022868A patent/KR101463707B1/ko not_active Expired - Fee Related
- 2012-01-30 BR BR112013018938-0A patent/BR112013018938B1/pt not_active IP Right Cessation
- 2012-01-30 MY MYPI2013701321A patent/MY161280A/en unknown
- 2012-01-30 JP JP2012554877A patent/JP5362128B2/ja not_active Expired - Fee Related
- 2012-01-30 EP EP12739689.3A patent/EP2669274B1/en not_active Not-in-force
- 2012-01-30 CN CN201280006728.4A patent/CN103339112B/zh not_active Expired - Fee Related
- 2012-01-30 UA UAA201310519A patent/UA110816C2/uk unknown
- 2012-01-30 DK DK12739689.3T patent/DK2669274T3/en active
- 2012-01-30 US US13/982,734 patent/US8889727B2/en not_active Expired - Fee Related
- 2012-01-30 MX MX2013008777A patent/MX2013008777A/es active IP Right Grant
- 2012-01-30 TW TW101102991A patent/TWI491593B/zh not_active IP Right Cessation
- 2012-01-30 PH PH1/2013/501606A patent/PH12013501606A1/en unknown
- 2012-01-30 AU AU2012209696A patent/AU2012209696B2/en not_active Ceased
-
2013
- 2013-06-21 CO CO13148029A patent/CO6741178A2/es unknown
- 2013-07-08 CL CL2013001995A patent/CL2013001995A1/es unknown
- 2013-07-29 IL IL227705A patent/IL227705A/en active IP Right Grant
- 2013-07-29 ZA ZA2013/05718A patent/ZA201305718B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |