NO20080187L - Aspartylproteaseinhibitorer - Google Patents
AspartylproteaseinhibitorerInfo
- Publication number
- NO20080187L NO20080187L NO20080187A NO20080187A NO20080187L NO 20080187 L NO20080187 L NO 20080187L NO 20080187 A NO20080187 A NO 20080187A NO 20080187 A NO20080187 A NO 20080187A NO 20080187 L NO20080187 L NO 20080187L
- Authority
- NO
- Norway
- Prior art keywords
- cognitive
- compounds
- formula
- disclosed
- neurodegenerative diseases
- Prior art date
Links
- 208000010877 cognitive disease Diseases 0.000 abstract 2
- 230000001149 cognitive effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004770 neurodegeneration Effects 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 102000004580 Aspartic Acid Proteases Human genes 0.000 abstract 1
- 108010017640 Aspartic Acid Proteases Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 229940122041 Cholinesterase inhibitor Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003551 muscarinic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69053705P | 2005-06-14 | 2005-06-14 | |
| PCT/US2006/022918 WO2006138264A2 (fr) | 2005-06-14 | 2006-06-12 | Inhibiteurs d'aspartyl protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080187L true NO20080187L (no) | 2008-03-14 |
Family
ID=37114557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080187A NO20080187L (no) | 2005-06-14 | 2008-01-11 | Aspartylproteaseinhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7868000B2 (fr) |
| EP (1) | EP1896478B1 (fr) |
| JP (2) | JP2008543849A (fr) |
| KR (1) | KR20080029965A (fr) |
| CN (1) | CN101228163A (fr) |
| AR (1) | AR054617A1 (fr) |
| AU (1) | AU2006259572A1 (fr) |
| BR (1) | BRPI0612072A2 (fr) |
| CA (1) | CA2609582A1 (fr) |
| EC (1) | ECSP078003A (fr) |
| IL (1) | IL187814A0 (fr) |
| MX (1) | MX2007016180A (fr) |
| NO (1) | NO20080187L (fr) |
| PE (1) | PE20070135A1 (fr) |
| RU (1) | RU2008100165A (fr) |
| SG (1) | SG162790A1 (fr) |
| TW (2) | TWI332005B (fr) |
| WO (1) | WO2006138264A2 (fr) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| AR049401A1 (es) * | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) * | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| CN101228163A (zh) | 2005-06-14 | 2008-07-23 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
| RU2008100164A (ru) | 2005-06-14 | 2009-07-20 | Шеринг Корпорейшн (US) | Получение и применение соединений в качестве ингибиторов протеаз |
| AU2006259675A1 (en) * | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
| GB0521508D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| US7763606B2 (en) | 2005-10-27 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| GB0525673D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| AU2007258435A1 (en) * | 2006-06-12 | 2007-12-21 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| WO2008073370A1 (fr) * | 2006-12-12 | 2008-06-19 | Schering Corporation | Inhibiteurs de la protéase aspartyle contenant un système de noyau tricyclique |
| EP2064191B1 (fr) * | 2006-12-12 | 2014-06-25 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase d'aspartyle |
| TW200902499A (en) | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
| MX2010002674A (es) | 2007-09-06 | 2010-03-25 | Schering Corp | Moduladores de gamma secretasa. |
| WO2009061699A1 (fr) | 2007-11-05 | 2009-05-14 | Schering Corporation | Modulateurs de gamma-secrétase |
| EP2227471A1 (fr) * | 2007-12-11 | 2010-09-15 | Schering Corporation | Modulateurs de gamma sécrétase |
| CL2009000954A1 (es) * | 2008-04-22 | 2010-12-31 | Schering Corp | Compuestos derivados de 2-imino-3-metil pirrolo pirimidinona,inhibidores de bace-1; composicion farmaceutica; y su uso para tratar, prevenir y/o retardar el inicio de una patologia de beta-amiloide seleccionada de enfermedad de alzheimer, enfermedad de parkinson, perdida de la memoria, sindrome de down, entre otras. |
| WO2010056849A1 (fr) | 2008-11-13 | 2010-05-20 | Schering Corporation | Modulateurs de gamma sécrétase |
| TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
| TW201034666A (en) | 2008-12-22 | 2010-10-01 | Schering Corp | Gamma secretase modulators |
| EP2379566A2 (fr) | 2008-12-22 | 2011-10-26 | Schering Corporation | Modulateurs de gamma secretase |
| FR2944011B1 (fr) * | 2009-04-03 | 2011-05-20 | Pf Medicament | Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. |
| WO2010147975A1 (fr) | 2009-06-16 | 2010-12-23 | Schering Corporation | Modulateurs de gamma sécrétase |
| EP2443121A2 (fr) | 2009-06-16 | 2012-04-25 | Schering Corporation | Modulateurs de gamma sécrétase |
| WO2010147973A1 (fr) | 2009-06-16 | 2010-12-23 | Schering Corporation | Modulateurs de gamma sécrétase |
| GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| GB0912777D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
| EP2281824A1 (fr) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Dérivés de furan-imidazolone pour le traitement de maladies ou de troubles cognitifs, neurodégénératifs ou neuronaux |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| WO2011044184A1 (fr) | 2009-10-08 | 2011-04-14 | Schering Corporation | Composés hétérocycliques de type imino-pentafluorosulfure utilisés en tant qu'inhibiteurs de bace1, compositions en contenant et leur utilisation |
| US8563543B2 (en) | 2009-10-08 | 2013-10-22 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| US8569310B2 (en) | 2009-10-08 | 2013-10-29 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use |
| JPWO2011071109A1 (ja) * | 2009-12-11 | 2013-04-22 | 塩野義製薬株式会社 | アミノ基を有する縮合ヘテロ環化合物 |
| WO2012069428A1 (fr) | 2010-11-22 | 2012-05-31 | Noscira, S.A. | Dérivés de bipyridine-sulfonamide pour le traitement de maladies et d'affections neurodégénératives |
| US8415483B2 (en) | 2010-12-22 | 2013-04-09 | Astrazeneca Ab | Compounds and their use as BACE inhibitors |
| GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| EP2665716B1 (fr) | 2011-01-21 | 2017-03-08 | Eisai R&D Management Co., Ltd. | Procédés et composés utiles dans la synthèse de dérivés fusionnés d'aminodihydrothiazine |
| GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| EP2694489B1 (fr) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | Composés de dioxyde de thiadiazine condensés avec des dérivés oxacycliques en c5-c6 comme inhibiteurs de bace, compositions, et utilisation use |
| WO2012138590A1 (fr) * | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Composés de dioxyde de thiadiazine fusionnée à la pyrrolidine en tant qu'inhibiteurs de bace, compositions et leur utilisation |
| US9181236B2 (en) | 2011-08-22 | 2015-11-10 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use |
| US9650336B2 (en) | 2011-10-10 | 2017-05-16 | Astrazeneca Ab | Mono-fluoro beta-secretase inhibitors |
| WO2013142370A1 (fr) | 2012-03-19 | 2013-09-26 | Varghese John | Inhibiteurs de bace spécifiques de l'app (asbi) et leurs utilisations |
| JO3143B1 (ar) * | 2012-04-03 | 2017-09-20 | Lilly Co Eli | مركبات تتراهيدرو بيرولو ثيازين |
| BR112014029705A2 (pt) | 2012-06-01 | 2017-06-27 | Takeda Pharmaceuticals Co | composto ou sal, medicamento, métodos para inibir quinase de janus em um mamífero, e para a profilaxia ou tratamento de doenças autoimunes, e, uso de um composto ou sal |
| US9000185B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cycloalkyl ether compounds and their use as BACE inhibitors |
| US9000183B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors |
| US9000182B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | 2H-imidazol-4-amine compounds and their use as BACE inhibitors |
| US9000184B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors |
| US10548882B2 (en) | 2012-06-21 | 2020-02-04 | Astrazeneca Ab | Camsylate salt |
| WO2014062549A1 (fr) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Composés de dioxyde de thiadiazine substitués tricycliques en tant qu'inhibiteurs de bace, compositions et leur utilisation |
| US9416129B2 (en) | 2012-10-17 | 2016-08-16 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use |
| US9328124B2 (en) * | 2012-10-26 | 2016-05-03 | Eli Lilly And Company | BACE inhibitors |
| US9580396B2 (en) | 2012-12-21 | 2017-02-28 | Merck Sharp & Dohme Corp. | C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and their use |
| DK2956443T3 (da) | 2013-02-12 | 2020-01-20 | Buck Inst Res Aging | Hydantoiner som modulatorer af BACE-medieret APP-forarbejdning |
| TWI593692B (zh) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
| TWI639607B (zh) | 2013-06-18 | 2018-11-01 | 美國禮來大藥廠 | Ｂａｃｅ抑制劑 |
| US9745324B2 (en) | 2013-12-18 | 2017-08-29 | Merck Sharp & Dohme Corp. | Iminothiadiazepane dioxide compounds as BACE inhibitors, compositions, and their use |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| CN104761557B (zh) * | 2015-04-08 | 2017-02-22 | 河南师范大学 | 六氢‑1H‑吡咯并[3,4‑d]嘧啶类化合物及其制备方法 |
| AR104241A1 (es) | 2015-04-29 | 2017-07-05 | Lilly Co Eli | Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos |
| EP3414253B1 (fr) * | 2016-02-11 | 2021-07-21 | Merck Sharp & Dohme Corp. | Composés de dioxyde d'iminothiazine condensé oxacylique en c5 a c6 portant un lieur éther en tant qu'inhibiteurs de bace, compositions et leur utilisation |
| CN107892697B (zh) * | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| RU2020131405A (ru) | 2018-02-28 | 2022-03-24 | Джапан Тобакко Инк. | Сконденсированные с насыщенным кольцом дигидропиримидиноновые или дигидротриазиноновые соединения и их применение в фармацевтике |
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-
2006
- 2006-06-12 CN CNA2006800215030A patent/CN101228163A/zh active Pending
- 2006-06-12 WO PCT/US2006/022918 patent/WO2006138264A2/fr not_active Ceased
- 2006-06-12 TW TW095120854A patent/TWI332005B/zh active
- 2006-06-12 MX MX2007016180A patent/MX2007016180A/es active IP Right Grant
- 2006-06-12 BR BRPI0612072-5A patent/BRPI0612072A2/pt not_active IP Right Cessation
- 2006-06-12 AR ARP060102461A patent/AR054617A1/es not_active Application Discontinuation
- 2006-06-12 PE PE2006000655A patent/PE20070135A1/es not_active Application Discontinuation
- 2006-06-12 TW TW098137006A patent/TW201004961A/zh unknown
- 2006-06-12 KR KR1020077029300A patent/KR20080029965A/ko not_active Withdrawn
- 2006-06-12 EP EP06784807.7A patent/EP1896478B1/fr active Active
- 2006-06-12 SG SG201004170-5A patent/SG162790A1/en unknown
- 2006-06-12 US US11/451,541 patent/US7868000B2/en active Active
- 2006-06-12 JP JP2008516997A patent/JP2008543849A/ja active Pending
- 2006-06-12 AU AU2006259572A patent/AU2006259572A1/en not_active Abandoned
- 2006-06-12 RU RU2008100165/04A patent/RU2008100165A/ru not_active Application Discontinuation
- 2006-06-12 CA CA002609582A patent/CA2609582A1/fr not_active Abandoned
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- 2007-12-02 IL IL187814A patent/IL187814A0/en unknown
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- 2008-01-11 NO NO20080187A patent/NO20080187L/no not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101228163A (zh) | 2008-07-23 |
| JP2008543849A (ja) | 2008-12-04 |
| MX2007016180A (es) | 2008-03-07 |
| SG162790A1 (en) | 2010-07-29 |
| RU2008100165A (ru) | 2009-07-20 |
| CA2609582A1 (fr) | 2006-12-28 |
| TW201004961A (en) | 2010-02-01 |
| TWI332005B (en) | 2010-10-21 |
| US20070060575A1 (en) | 2007-03-15 |
| IL187814A0 (en) | 2008-08-07 |
| TW200716642A (en) | 2007-05-01 |
| WO2006138264A3 (fr) | 2007-03-01 |
| ECSP078003A (es) | 2008-01-23 |
| PE20070135A1 (es) | 2007-03-09 |
| AR054617A1 (es) | 2007-07-04 |
| AU2006259572A1 (en) | 2006-12-28 |
| KR20080029965A (ko) | 2008-04-03 |
| US7868000B2 (en) | 2011-01-11 |
| JP2008201784A (ja) | 2008-09-04 |
| EP1896478A2 (fr) | 2008-03-12 |
| WO2006138264A2 (fr) | 2006-12-28 |
| BRPI0612072A2 (pt) | 2010-10-19 |
| EP1896478B1 (fr) | 2014-05-21 |
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