NO20080110L - Benzimidazolderivativer som 5-HT6,5-HT24 - Google Patents
Benzimidazolderivativer som 5-HT6,5-HT24Info
- Publication number
- NO20080110L NO20080110L NO20080110A NO20080110A NO20080110L NO 20080110 L NO20080110 L NO 20080110L NO 20080110 A NO20080110 A NO 20080110A NO 20080110 A NO20080110 A NO 20080110A NO 20080110 L NO20080110 L NO 20080110L
- Authority
- NO
- Norway
- Prior art keywords
- benzimidazole derivatives
- compounds
- formula
- methods
- compositions
- Prior art date
Links
- -1 5-HT6 Chemical class 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69943505P | 2005-07-13 | 2005-07-13 | |
| PCT/EP2006/063788 WO2007006677A1 (en) | 2005-07-13 | 2006-07-03 | Benzimidazole derivatives as 5-ht6,5-ht24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080110L true NO20080110L (no) | 2008-04-11 |
Family
ID=37054633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080110A NO20080110L (no) | 2005-07-13 | 2008-01-08 | Benzimidazolderivativer som 5-HT6,5-HT24 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7582760B2 (ru) |
| EP (1) | EP1904483A1 (ru) |
| JP (1) | JP2009501184A (ru) |
| KR (1) | KR100983752B1 (ru) |
| CN (1) | CN101263136A (ru) |
| AR (1) | AR056418A1 (ru) |
| AU (1) | AU2006268713A1 (ru) |
| BR (1) | BRPI0613430A2 (ru) |
| CA (1) | CA2615007A1 (ru) |
| IL (1) | IL188486A0 (ru) |
| MX (1) | MX2008000411A (ru) |
| NO (1) | NO20080110L (ru) |
| RU (1) | RU2415138C2 (ru) |
| TW (1) | TW200738697A (ru) |
| WO (1) | WO2007006677A1 (ru) |
| ZA (1) | ZA200800213B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006037482A2 (en) * | 2004-09-30 | 2006-04-13 | F. Hoffmann-La Roche Ag | Compositions and methods for treating cognitive disorders |
| TWI417099B (zh) * | 2007-03-23 | 2013-12-01 | Neuraxon Inc | 具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物 |
| CN101679381A (zh) | 2007-03-23 | 2010-03-24 | 艾博特股份有限两合公司 | 适用于治疗对5-羟色胺5-ht6受体调节有反应的疾病的氮杂环丁烷类化合物 |
| CN102153538B (zh) * | 2010-02-11 | 2013-12-11 | 山东轩竹医药科技有限公司 | 苯并环衍生物 |
| JP6515175B2 (ja) | 2014-07-08 | 2019-05-15 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 芳香族ヘテロ環誘導体及びその医薬的適用 |
| CR20180255A (es) | 2015-11-06 | 2018-06-22 | Hoffmann La Roche | Derivados de indolin-2-ona |
| CN107118161B (zh) * | 2017-05-05 | 2019-12-31 | 湖北工业大学 | 2-正丙基-4-甲基苯并咪唑-6-羧酸的合成方法 |
| EP3530651A1 (en) * | 2018-02-21 | 2019-08-28 | Adamed sp. z o.o. | Indole and benzimidazole derivatives as dual 5-ht2a and 5-ht6 receptor antagonists |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2510111A1 (fr) * | 1981-07-24 | 1983-01-28 | Roussel Uclaf | Nouveaux derives du piperidin-3-yl indole, leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| FR2510112A1 (fr) * | 1981-07-24 | 1983-01-28 | Roussel Uclaf | Nouveaux derives du 2-oxo-pyrid-3-yl ou piperidin-3-yl indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
| FR2621586B1 (fr) | 1987-10-08 | 1990-02-02 | Roussel Uclaf | Nouveaux derives de l'azapirodecane, leur procede de preparation et leur application comme medicaments |
| TW203049B (ru) | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| FR2667068B1 (fr) * | 1990-09-26 | 1994-09-09 | Adir | Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
| US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| US5834587A (en) | 1996-10-08 | 1998-11-10 | Smithkline Beecham Corporation | G-protein coupled receptor, HLTEX 11 |
| WO1999037643A1 (en) | 1998-01-26 | 1999-07-29 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
| EP1076647A2 (en) | 1998-04-29 | 2001-02-21 | American Home Products Corporation | Antipsychotic indolyl derivatives |
| US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
| EP1263754A1 (en) | 2000-02-01 | 2002-12-11 | Millennium Pharmaceuticals, Inc. | INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa |
| AU2001249397A1 (en) | 2000-03-24 | 2001-10-08 | Cor Therapeutics, Inc. | Oxindole inhibitors of factor xa |
| CA2405565A1 (en) | 2000-04-21 | 2001-11-01 | Pharmacia & Upjohn Company | Compounds for treating fibromyalgia and chronic fatigue syndrome |
| AR033520A1 (es) | 2000-04-27 | 2003-12-26 | Upjohn Co | (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona |
| US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| AR031152A1 (es) | 2000-10-31 | 2003-09-10 | Upjohn Co | Tratamientos nuevos para el sindrome de piernas inquietas |
| EP1585731A2 (en) | 2002-09-18 | 2005-10-19 | Eli Lilly And Company | Histamine h3 receptor antagonists, preparaton and therapeutic uses |
| AU2003267769A1 (en) | 2002-10-25 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Use of heterocyclic amine-type compounds as neuroprotective agents |
| JP4401297B2 (ja) | 2002-11-08 | 2010-01-20 | エフ．ホフマン−ラ ロシュ アーゲー | 置換ベンゾオキサジノン及びその使用 |
| MXPA06000701A (es) | 2003-07-23 | 2006-04-11 | Wyeth Corp | Compuestos de sulfonildihidrobencimidazolona como ligandos de 5-hidroxitriptamina-6. |
| BRPI0412868A (pt) | 2003-07-23 | 2006-10-03 | Wyeth Corp | compostos de sulfonildihidroimidazopiridinona como ligantes da 5-hidroxitriptamina-6 |
| RU2006129464A (ru) * | 2004-01-16 | 2008-02-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные 1-бензил-5-пиперазин-1-ил-3, 4-дигидро-1н-хиназолин-2-она и соответствующие производные 1н-бензо (1, 2, 6) тиадиазин-2, 2-диоксида и 1, 4-дигидробензо (1, 3)оксазин-2-она в качестве модуляторов рецептора 5-гидрокситриптамина (5нт) для лечения заболевания центральной нервной системы |
| WO2006037482A2 (en) * | 2004-09-30 | 2006-04-13 | F. Hoffmann-La Roche Ag | Compositions and methods for treating cognitive disorders |
| WO2006066133A2 (en) * | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
-
2006
- 2006-07-03 CN CNA2006800333249A patent/CN101263136A/zh active Pending
- 2006-07-03 BR BRPI0613430-0A patent/BRPI0613430A2/pt not_active IP Right Cessation
- 2006-07-03 EP EP06777544A patent/EP1904483A1/en not_active Withdrawn
- 2006-07-03 RU RU2008100081/04A patent/RU2415138C2/ru not_active IP Right Cessation
- 2006-07-03 CA CA002615007A patent/CA2615007A1/en not_active Abandoned
- 2006-07-03 JP JP2008520840A patent/JP2009501184A/ja active Pending
- 2006-07-03 AU AU2006268713A patent/AU2006268713A1/en not_active Abandoned
- 2006-07-03 KR KR1020087000750A patent/KR100983752B1/ko not_active Expired - Fee Related
- 2006-07-03 MX MX2008000411A patent/MX2008000411A/es not_active Application Discontinuation
- 2006-07-03 WO PCT/EP2006/063788 patent/WO2007006677A1/en not_active Ceased
- 2006-07-10 TW TW095125005A patent/TW200738697A/zh unknown
- 2006-07-11 AR ARP060102971A patent/AR056418A1/es not_active Application Discontinuation
- 2006-07-12 US US11/485,911 patent/US7582760B2/en not_active Expired - Fee Related
-
2007
- 2007-12-27 IL IL188486A patent/IL188486A0/en unknown
-
2008
- 2008-01-08 NO NO20080110A patent/NO20080110L/no not_active Application Discontinuation
- 2008-01-08 ZA ZA200800213A patent/ZA200800213B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007006677A1 (en) | 2007-01-18 |
| AR056418A1 (es) | 2007-10-10 |
| CN101263136A (zh) | 2008-09-10 |
| TW200738697A (en) | 2007-10-16 |
| KR100983752B1 (ko) | 2010-09-24 |
| ZA200800213B (en) | 2008-12-31 |
| RU2008100081A (ru) | 2009-08-20 |
| CA2615007A1 (en) | 2007-01-18 |
| MX2008000411A (es) | 2008-03-10 |
| AU2006268713A1 (en) | 2007-01-18 |
| US7582760B2 (en) | 2009-09-01 |
| RU2415138C2 (ru) | 2011-03-27 |
| KR20080019286A (ko) | 2008-03-03 |
| IL188486A0 (en) | 2008-04-13 |
| US20070015744A1 (en) | 2007-01-18 |
| EP1904483A1 (en) | 2008-04-02 |
| BRPI0613430A2 (pt) | 2011-01-11 |
| JP2009501184A (ja) | 2009-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |