NO20065142L - Trisubstituerte ureaer som cytokininhibitorer - Google Patents
Trisubstituerte ureaer som cytokininhibitorerInfo
- Publication number
- NO20065142L NO20065142L NO20065142A NO20065142A NO20065142L NO 20065142 L NO20065142 L NO 20065142L NO 20065142 A NO20065142 A NO 20065142A NO 20065142 A NO20065142 A NO 20065142A NO 20065142 L NO20065142 L NO 20065142L
- Authority
- NO
- Norway
- Prior art keywords
- trisubstituted ureas
- cytokine inhibitors
- inhibit
- trisubstituted
- ureas
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 4
- 108090000695 Cytokines Proteins 0.000 title abstract 4
- 235000013877 carbamide Nutrition 0.000 title abstract 3
- 150000003672 ureas Chemical class 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Den foreliggende oppfinnelse vedrører 1,1,3-trisubstituerte ureaer med formel (I): hvori R, R1 og R2 er som definert i kravene, som hemmer den ekstracellulære frigivelse av inflammatorisk cytokiner, nevnte cytokiner ansvarlige for én eller flere sykdomstilstander hos mennesker eller høyerestående pattedyr. Den foreliggende oppfinnelse vedrører ytterligere sammensetninger omfattende de 1,1,3-trisubstituerte ureaer som hemmer den ekstracellulære frigivelse av inflammatoriske cytokiner, og fremgangsmåter for å forebygge, redusere eller på annen måte kontrollere enzymer som er forstått å være de aktive komponenter ansvarlige for sykdomstilstandene beskrevet heri.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56474504P | 2004-04-22 | 2004-04-22 | |
| PCT/US2005/013869 WO2005105758A1 (en) | 2004-04-22 | 2005-04-20 | Tri-substituted ureas as cytokine inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20065142L true NO20065142L (no) | 2006-11-08 |
Family
ID=34967029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20065142A NO20065142L (no) | 2004-04-22 | 2006-11-08 | Trisubstituerte ureaer som cytokininhibitorer |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7402589B2 (no) |
| EP (2) | EP1747204B1 (no) |
| JP (2) | JP2007534688A (no) |
| KR (1) | KR100883937B1 (no) |
| CN (2) | CN1946700A (no) |
| AR (2) | AR050411A1 (no) |
| AT (1) | ATE402927T1 (no) |
| AU (1) | AU2005238484A1 (no) |
| BR (1) | BRPI0510128A (no) |
| CA (2) | CA2564589A1 (no) |
| DE (1) | DE602005008581D1 (no) |
| DK (1) | DK1747204T3 (no) |
| ES (1) | ES2311223T3 (no) |
| HR (1) | HRP20080489T3 (no) |
| IL (1) | IL178459A0 (no) |
| MA (1) | MA28638B1 (no) |
| MX (2) | MXPA06012189A (no) |
| NO (1) | NO20065142L (no) |
| PE (2) | PE20060338A1 (no) |
| PL (1) | PL1747204T3 (no) |
| PT (1) | PT1747204E (no) |
| RU (1) | RU2338739C2 (no) |
| SI (1) | SI1747204T1 (no) |
| SM (1) | SMP200600037B (no) |
| TW (2) | TW200539883A (no) |
| WO (2) | WO2005105758A1 (no) |
| ZA (1) | ZA200609326B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| CN108976172B (zh) * | 2017-05-31 | 2021-12-07 | 华东师范大学 | 一类4-嘧啶二胺类小分子有机化合物及其衍生物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
| JP2001521934A (ja) * | 1997-11-03 | 2001-11-13 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症薬としての芳香族ヘテロ環式化合物 |
| EP1163236B1 (en) * | 1999-03-12 | 2005-11-09 | Boehringer Ingelheim Pharmaceuticals Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| JO2308B1 (en) * | 1999-05-31 | 2005-09-12 | اف. هوفمان- لاروش أيه جي | Derivatives of phenylpyrmidine |
| WO2002096876A1 (en) * | 2001-05-25 | 2002-12-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Carbamate and oxamide compounds as inhibitors of cytokine production |
| ATE360417T1 (de) * | 2001-07-11 | 2007-05-15 | Boehringer Ingelheim Pharma | Methode zur behandlung von zytokinvermittelten erkrankungen |
-
2005
- 2005-04-20 CA CA002564589A patent/CA2564589A1/en not_active Abandoned
- 2005-04-20 TW TW094112581A patent/TW200539883A/zh unknown
- 2005-04-20 MX MXPA06012189A patent/MXPA06012189A/es active IP Right Grant
- 2005-04-20 WO PCT/US2005/013869 patent/WO2005105758A1/en not_active Ceased
- 2005-04-20 RU RU2006140694/04A patent/RU2338739C2/ru active
- 2005-04-20 MX MXPA06012188A patent/MXPA06012188A/es not_active Application Discontinuation
- 2005-04-20 TW TW094112578A patent/TW200538105A/zh unknown
- 2005-04-20 PL PL05740166T patent/PL1747204T3/pl unknown
- 2005-04-20 EP EP05740166A patent/EP1747204B1/en not_active Expired - Lifetime
- 2005-04-20 CA CA002564587A patent/CA2564587A1/en not_active Abandoned
- 2005-04-20 CN CNA2005800124183A patent/CN1946700A/zh active Pending
- 2005-04-20 WO PCT/US2005/013868 patent/WO2005105757A1/en not_active Ceased
- 2005-04-20 JP JP2007509682A patent/JP2007534688A/ja active Pending
- 2005-04-20 SM SM200600037T patent/SMP200600037B/it unknown
- 2005-04-20 CN CNA2005800125453A patent/CN1946701A/zh active Pending
- 2005-04-20 HR HR20080489T patent/HRP20080489T3/xx unknown
- 2005-04-20 EP EP05740317A patent/EP1737830A1/en not_active Withdrawn
- 2005-04-20 BR BRPI0510128-0A patent/BRPI0510128A/pt not_active IP Right Cessation
- 2005-04-20 AU AU2005238484A patent/AU2005238484A1/en not_active Abandoned
- 2005-04-20 KR KR1020067024157A patent/KR100883937B1/ko not_active Expired - Fee Related
- 2005-04-20 AT AT05740166T patent/ATE402927T1/de not_active IP Right Cessation
- 2005-04-20 PT PT05740166T patent/PT1747204E/pt unknown
- 2005-04-20 DK DK05740166T patent/DK1747204T3/da active
- 2005-04-20 DE DE602005008581T patent/DE602005008581D1/de not_active Expired - Fee Related
- 2005-04-20 ES ES05740166T patent/ES2311223T3/es not_active Expired - Lifetime
- 2005-04-20 SI SI200530424T patent/SI1747204T1/sl unknown
- 2005-04-20 JP JP2007509683A patent/JP2007534689A/ja active Pending
- 2005-04-21 US US11/111,612 patent/US7402589B2/en not_active Expired - Fee Related
- 2005-04-21 US US11/111,581 patent/US7449474B2/en not_active Expired - Fee Related
- 2005-04-22 PE PE2005000450A patent/PE20060338A1/es not_active Application Discontinuation
- 2005-04-22 AR ARP050101610A patent/AR050411A1/es not_active Application Discontinuation
- 2005-04-22 PE PE2005000451A patent/PE20060258A1/es not_active Application Discontinuation
- 2005-04-22 AR ARP050101611A patent/AR048874A1/es not_active Application Discontinuation
-
2006
- 2006-10-05 IL IL178459A patent/IL178459A0/en unknown
- 2006-11-08 NO NO20065142A patent/NO20065142L/no not_active Application Discontinuation
- 2006-11-09 ZA ZA200609326A patent/ZA200609326B/xx unknown
- 2006-11-21 MA MA29478A patent/MA28638B1/fr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |