[go: up one dir, main page]

NO20055766L - Positive modulatorer av nikotinacetylcholinreseptorer - Google Patents

Positive modulatorer av nikotinacetylcholinreseptorer

Info

Publication number
NO20055766L
NO20055766L NO20055766A NO20055766A NO20055766L NO 20055766 L NO20055766 L NO 20055766L NO 20055766 A NO20055766 A NO 20055766A NO 20055766 A NO20055766 A NO 20055766A NO 20055766 L NO20055766 L NO 20055766L
Authority
NO
Norway
Prior art keywords
compounds
acetylcholine receptors
positive modulators
nicotine acetylcholine
formula
Prior art date
Application number
NO20055766A
Other languages
English (en)
Inventor
James D Rosamond
Eifion Phillips
Megan Murphy
Jeanne Mary Comstock
Christopher Becker
Williarn F Michne
Thomas R Simpson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20055766L publication Critical patent/NO20055766L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Det beskrives forbindelser med Formel I eller Formel II der R1, X og Ar er som beskrevet. Det beskrives videre farmasøytisk akseptable salter derav, prosesser for fremstilling av forbindelser samt farmasøytiske preparater som inneholder forbindelsene. Forbindelsene finner særlig anvendelse i terapi, særlig for behandling av tilstander assosiert med reduksjoner i nikotintransmisjon.
NO20055766A 2003-05-06 2005-12-05 Positive modulatorer av nikotinacetylcholinreseptorer NO20055766L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0301320A SE0301320D0 (sv) 2003-05-06 2003-05-06 Positive modulators of nicotinic acetylcholine receptors
PCT/GB2004/001934 WO2004098600A1 (en) 2003-05-06 2004-05-04 Positive modulators of nicotinic acetylcholine receptors

Publications (1)

Publication Number Publication Date
NO20055766L true NO20055766L (no) 2005-12-05

Family

ID=20291221

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055766A NO20055766L (no) 2003-05-06 2005-12-05 Positive modulatorer av nikotinacetylcholinreseptorer

Country Status (13)

Country Link
US (1) US20070179172A1 (no)
EP (1) EP1631288A1 (no)
JP (1) JP2006525302A (no)
KR (1) KR20060009899A (no)
CN (1) CN1784230A (no)
AU (1) AU2004237130A1 (no)
BR (1) BRPI0410050A (no)
CA (1) CA2524019A1 (no)
MX (1) MXPA05011785A (no)
NO (1) NO20055766L (no)
SE (1) SE0301320D0 (no)
WO (1) WO2004098600A1 (no)
ZA (1) ZA200508860B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5254616B2 (ja) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
FR2884822B1 (fr) * 2005-04-22 2007-06-29 Aventis Pharma Sa Derives de triazines, leur preparation et leur application en therapeutique
DE102005027169A1 (de) * 2005-06-13 2006-12-14 Merck Patent Gmbh Tetrahydrochinolinderivate
US20080214537A1 (en) * 2007-03-02 2008-09-04 Cara Therapeutics, Inc. Bridged phenanthridines
EP2322167A1 (en) * 2007-04-02 2011-05-18 Parkinson's Institute Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
EP2729148A4 (en) 2011-07-06 2015-04-22 Parkinson S Inst COMPOSITIONS AND METHOD FOR THE TREATMENT OF SYMPTOMS IN PATIENTS WITH MORBUS PARKINSON
EP2647628A1 (en) * 2012-04-02 2013-10-09 Almirall, S.A. Substituted tricyclic compounds with activity towards ep1 receptors
WO2014017802A1 (ko) * 2012-07-23 2014-01-30 주식회사 유한양행 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물
US11299496B2 (en) 2014-07-23 2022-04-12 Northeastern University Ligands for alpha-7 nicotinic acetylcholine receptors and methods of treating neurological and inflammatory conditions
CA2974324A1 (en) 2015-01-28 2016-08-04 Zita S. Netzel Drug delivery methods and systems
US10679516B2 (en) 2015-03-12 2020-06-09 Morningside Venture Investments Limited Craving input and support system
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
CN107991409B (zh) * 2017-11-28 2020-04-24 中国医学科学院肿瘤医院 采用高效合相色谱同时测定血浆中12种磺胺类药物的方法
JP7420797B2 (ja) 2018-05-29 2024-01-23 モーニングサイド ベンチャー インベストメンツ リミテッド 薬剤送達の方法及びシステム
EP3880175A4 (en) 2018-11-16 2022-08-17 Morningside Venture Investments Limited TEMPERATURE-REGULATING TRANSDERMAL DRUG DELIVERY SYSTEM
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631050A (en) * 1968-11-13 1971-12-28 Parke Davis & Co Hexahydro-9b-methylfuro(3 2-c) quinoline compounds
JPS63225358A (ja) * 1986-10-31 1988-09-20 Sumitomo Pharmaceut Co Ltd シクロペンタ〔ｂ〕キノリン誘導体
WO1998027427A1 (en) * 1996-12-18 1998-06-25 Eli Lilly And Company Combinatorial process for preparing tetrahydroquinoline libraries
US5925527A (en) * 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
DE10137488A1 (de) * 2001-08-03 2003-02-20 Gruenenthal Gmbh Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate

Also Published As

Publication number Publication date
SE0301320D0 (sv) 2003-05-06
US20070179172A1 (en) 2007-08-02
AU2004237130A1 (en) 2004-11-18
CN1784230A (zh) 2006-06-07
JP2006525302A (ja) 2006-11-09
EP1631288A1 (en) 2006-03-08
BRPI0410050A (pt) 2006-04-25
KR20060009899A (ko) 2006-02-01
ZA200508860B (en) 2007-03-28
CA2524019A1 (en) 2004-11-18
MXPA05011785A (es) 2006-01-26
WO2004098600A1 (en) 2004-11-18

Similar Documents

Publication Publication Date Title
NO20055766L (no) Positive modulatorer av nikotinacetylcholinreseptorer
NO20061657L (no) Pyrolderivater med antibakteriell aktivitet
NO20074703L (no) Antibakterielle piperidinderivater
NO20065904L (no) Terapeutiske forbindelser
TW200615266A (en) Organic compounds
NO20064201L (no) Glukopyranosylsubstituerte benzolderivater, medikamenter inneholdende slike forbindelser, deres anvendelse og fremstilling
NO20062704L (no) Azabicykliske heterocykler som cannabinoide reseptormodulatorer
IL176110A0 (en) Azabicyclic heterocycles as cannabinoid receptor modulators
NO20062583L (no) Difenylazetidinonderivater med kolesterolabsorpsjonsinhiberende aktivitet
NO20062591L (no) Difenylazetidinonderivater med kolesterolabsorpsjonsinhiberende aktivitet
TW200716628A (en) Novel compounds
NO20061839L (no) Benzimidazolderivater, sammensetninger inneholdende dem, fremstilling derav, og anvendelse derav
NO20083250L (no) Antibakterielle pyrrolopyridiner, pyrrolopyrimidiner og pyrroloazepiner
NO20076357L (no) Azabicykliske heterocykler som cannabinoid reseptor modulatorer
DE60322417D1 (en) 4-oxo-1-(3-substituiertesphenyl)-1,4-dihydro-1,8-naphthyridin-3-carbonsäureamide alsphoshodiesterase-4-inhibitoren
NO20060147L (no) Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
NO20072089L (no) Benzimidazolderivater, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav
NO20060146L (no) Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
NO20052182L (no) Nye forbindelser
NO20063619L (no) Diarylmetylpiperazinderivater, fremstilling og anvendelse derav
MY139613A (en) Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
NO20062307L (no) Spirofuropyridinarylderivater
NO20073547L (no) Nikotinacetykolinreseptorligander
NO20064074L (no) Pyrrolokinolin- og piperidinokinolinderivater, fremstilling derav, sammensetninger inneholdende disse og anvendelse derav
NO20053805L (no) Diarylmetylindenpiperidinderivater, framgangsmate for fremstilling derav, og anvendelse derav

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application