NO20054710L - Immunmodulerende heterosykliske forbindelser - Google Patents
Immunmodulerende heterosykliske forbindelserInfo
- Publication number
- NO20054710L NO20054710L NO20054710A NO20054710A NO20054710L NO 20054710 L NO20054710 L NO 20054710L NO 20054710 A NO20054710 A NO 20054710A NO 20054710 A NO20054710 A NO 20054710A NO 20054710 L NO20054710 L NO 20054710L
- Authority
- NO
- Norway
- Prior art keywords
- heterocyclic compounds
- immunomodulating
- immunomodulating heterocyclic
- solvate
- hydrate
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 abstract 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Forbindelser med formel (I) er inhibitorer for CD80 og anvendbare i immunomodulasjonsterapi: hvor Ri og R3 uavhengig av hverandre er H, F, Cl, Br, -NO2, -CN, C1-C6 alkyl eventuelt substituert med F eller Cl, eller C1-C6 alkoksy eventuelt substituert med F; R4 er en karboksylsyregruppe (-COOH) eller en ester derav, eller -C(=O)NR6R7, -NR7C(=O)R6, -NR7C(=O)OR6, -NHC(=O)NR7R6 eller -NHC(=S)NR7R6 hvor Re er H, eller et radikal med formel -(Alk)m-Q hvor m is 0 or 1, Alk er et eventuelt substituert, toverdig, rettkjedet eller forgrenet C1-C12 alkylen-, C2-C12 alkenylen-, C2-C12 alkynylenradikal eller et toverdig C3-C12 karbosyklisk radikal, hvor alle radikalene kan inneholde en eller flere -O-, -S- eller -N(R8)-linkere hvor R8 er H eller d-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl eller C3-C6 sykloalkyl, og Q er H, -NRgRiohvor R9 og Rio uavhengig av hverandre er H, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C6 sykloalkyl, en estergruppe, en eventuelt substituert karbosyklisk eller heterosyklisk gruppe, eller R9 og Rio danner en ring sammen med nitrogenet som de er
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0305876A GB0305876D0 (en) | 2003-03-14 | 2003-03-14 | Immuno inhibitory heterocyclic compounds |
| GB0319429A GB0319429D0 (en) | 2003-08-19 | 2003-08-19 | Immuno Inhibitory Heterocyclic compounds |
| PCT/GB2004/001008 WO2004081011A1 (en) | 2003-03-14 | 2004-03-10 | Immunomodulating heterocyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20054710D0 NO20054710D0 (no) | 2005-10-13 |
| NO20054710L true NO20054710L (no) | 2005-12-13 |
| NO332136B1 NO332136B1 (no) | 2012-07-02 |
Family
ID=32992598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054710A NO332136B1 (no) | 2003-03-14 | 2005-10-13 | Immunomodulerende heterosyklisk forbindelse, anvendelse derav for fremstilling av et medikament, og farmasoytisk eller veterinaermedisinsk preparat omfattende forbindelsen |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7276505B2 (no) |
| EP (2) | EP2284172A1 (no) |
| JP (1) | JP4892338B2 (no) |
| KR (1) | KR101133959B1 (no) |
| AT (1) | ATE489388T1 (no) |
| BR (1) | BRPI0408365B8 (no) |
| CA (1) | CA2519063C (no) |
| DE (1) | DE602004030225D1 (no) |
| DK (1) | DK1603917T3 (no) |
| EA (2) | EA014080B1 (no) |
| EC (1) | ECSP056104A (no) |
| IL (1) | IL170389A (no) |
| MX (1) | MXPA05009667A (no) |
| NO (1) | NO332136B1 (no) |
| NZ (1) | NZ541973A (no) |
| PL (2) | PL383655A1 (no) |
| PT (1) | PT1603917E (no) |
| SI (1) | SI1603917T1 (no) |
| WO (1) | WO2004081011A1 (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1603917T3 (da) | 2003-03-14 | 2011-02-28 | Medigene Ag | Immunmodulerende heterocycliske forbindelser |
| GB0325644D0 (en) | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
| GB0411770D0 (en) * | 2004-05-26 | 2004-06-30 | Avidex Ltd | Immuno inhibitory heterocyclic compouds |
| US7932253B2 (en) | 2004-08-09 | 2011-04-26 | Medigene Ag | Immunomodulating oxopyrrazolocinnolines as CD80 inhibitors |
| JP2009504597A (ja) * | 2005-08-10 | 2009-02-05 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | アシルトリプトファノール |
| GB0603522D0 (en) * | 2006-02-22 | 2006-04-05 | Avidex Ltd | Kinase inhibition |
| MX2008011791A (es) | 2006-03-15 | 2008-09-25 | Wyeth Corp | Azaciclilaminas-n-sustituidas como antagonistas de histamina-3. |
| MX2008014743A (es) | 2006-05-19 | 2008-12-01 | Wyeth Corp | N-benzoil- y n-bencilpirrolidin-3-ilaminas como antagonistas de histamina-3. |
| JPWO2008004610A1 (ja) * | 2006-07-05 | 2009-12-03 | 国立大学法人 東京大学 | ナンセンス変異型遺伝性疾患の治療方法 |
| PE20081152A1 (es) | 2006-10-06 | 2008-08-10 | Wyeth Corp | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 |
| PE20090812A1 (es) | 2007-07-16 | 2009-06-14 | Wyeth Corp | Derivados de aminoalquilazol como antagonistas de histamina-3 |
| EP2020404A1 (en) * | 2007-08-01 | 2009-02-04 | Bayer Schering Pharma Aktiengesellschaft | Cyanomethyl substituted N-Acyl Tryptamines |
| WO2009043784A1 (en) | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
| GB201021104D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| EP2676666A1 (en) | 2012-06-20 | 2013-12-25 | Eidgenössische Technische Hochschule Zürich (ETH) | Compounds for use in diagnosis or therapy of vulnerable atherosclerotic plaques |
| EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
| US20170247326A1 (en) * | 2014-09-10 | 2017-08-31 | Epizyme, Inc. | Substituted Pyrrolidine Carboxamide Compounds |
| US11046683B2 (en) | 2016-12-15 | 2021-06-29 | Ono Pharmaceutical Co., Ltd. | Activator of TREK (TWIK RElated K+ channels) channels |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB629412A (en) | 1946-12-24 | 1949-09-20 | Geigy Ag J R | Manufacture of metallisable monoazo dyestuffs of the pyrazolone series |
| US3576637A (en) | 1967-04-20 | 1971-04-27 | Konishiroku Photo Ind | Lith-type of emulsion containing pyrozolone |
| JPS61161285A (ja) * | 1984-12-28 | 1986-07-21 | ルセル−ユクラフ | ピラゾロ〔４，３−ｃ〕シンノリン−３−オンの誘導体、それらの塩類、これらの製造法、薬剤としての使用、これらを含有する組成物及び中間体生成物 |
| US4591589A (en) * | 1985-01-16 | 1986-05-27 | Roussel Uclaf | 2-aryl pyrazolo[4,3-c]cinnolin-3-ones |
| DE3626221A1 (de) | 1986-08-02 | 1988-02-04 | Agfa Gevaert Ag | Farbfotografisches aufzeichnungsmaterial zur herstellung farbiger aufsichtsbilder |
| US4906644A (en) | 1986-11-20 | 1990-03-06 | Mitsubishi Kasei Corporation | Lipid-peroxide formation inhibiting composition and novel compounds useful therefor |
| DE3903993A1 (de) | 1989-02-10 | 1990-08-16 | Basf Ag | Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus |
| AR006520A1 (es) * | 1996-03-20 | 1999-09-08 | Astra Pharma Prod | Derivados de 2-arilpirazolisoquinolina y cinolinona y procedimiento para su preparacion. |
| GB9713707D0 (en) | 1997-06-27 | 1997-09-03 | Merck Sharp & Dohme | Therapeutic agents |
| SE0102404D0 (sv) | 2001-07-04 | 2001-07-04 | Active Biotech Ab | Novel immunomodulating compounds |
| CA2452596C (en) | 2001-07-05 | 2010-12-21 | Takeda Chemical Industries, Ltd. | Benzo-fused 5-membered heterocyclic compounds, their production and use |
| US7566711B2 (en) * | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| ATE353898T1 (de) | 2002-11-22 | 2007-03-15 | Active Biotech Ab | Pyrazolochinoline mit immunmodulierenderwirkung |
| ATE425164T1 (de) | 2002-12-16 | 2009-03-15 | Active Biotech Ab | Tetrazyklische immunmodulierende verbindungen |
| DK1603917T3 (da) | 2003-03-14 | 2011-02-28 | Medigene Ag | Immunmodulerende heterocycliske forbindelser |
| GB0325644D0 (en) | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
| GB0411770D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Immuno inhibitory heterocyclic compouds |
| US7932253B2 (en) | 2004-08-09 | 2011-04-26 | Medigene Ag | Immunomodulating oxopyrrazolocinnolines as CD80 inhibitors |
| US20060221590A1 (en) * | 2005-03-31 | 2006-10-05 | Edoardo Campini | System and method for Advanced Mezzanine Card connection |
| GB0603522D0 (en) | 2006-02-22 | 2006-04-05 | Avidex Ltd | Kinase inhibition |
-
2004
- 2004-03-10 DK DK04719006.1T patent/DK1603917T3/da active
- 2004-03-10 BR BRPI0408365A patent/BRPI0408365B8/pt not_active IP Right Cessation
- 2004-03-10 SI SI200431606T patent/SI1603917T1/sl unknown
- 2004-03-10 EP EP10014524A patent/EP2284172A1/en not_active Withdrawn
- 2004-03-10 DE DE602004030225T patent/DE602004030225D1/de not_active Expired - Lifetime
- 2004-03-10 NZ NZ541973A patent/NZ541973A/en not_active IP Right Cessation
- 2004-03-10 JP JP2006505937A patent/JP4892338B2/ja not_active Expired - Lifetime
- 2004-03-10 EA EA200702435A patent/EA014080B1/ru not_active IP Right Cessation
- 2004-03-10 KR KR1020057017070A patent/KR101133959B1/ko not_active Expired - Lifetime
- 2004-03-10 AT AT04719006T patent/ATE489388T1/de active
- 2004-03-10 WO PCT/GB2004/001008 patent/WO2004081011A1/en not_active Ceased
- 2004-03-10 MX MXPA05009667A patent/MXPA05009667A/es active IP Right Grant
- 2004-03-10 CA CA2519063A patent/CA2519063C/en not_active Expired - Lifetime
- 2004-03-10 PL PL383655A patent/PL383655A1/pl unknown
- 2004-03-10 PL PL04719006T patent/PL1603917T3/pl unknown
- 2004-03-10 EP EP04719006A patent/EP1603917B1/en not_active Expired - Lifetime
- 2004-03-10 PT PT04719006T patent/PT1603917E/pt unknown
- 2004-03-10 US US10/547,448 patent/US7276505B2/en not_active Expired - Lifetime
- 2004-03-10 EA EA200501370A patent/EA009680B1/ru not_active IP Right Cessation
-
2005
- 2005-08-18 IL IL170389A patent/IL170389A/en active IP Right Grant
- 2005-10-13 NO NO20054710A patent/NO332136B1/no unknown
- 2005-10-14 EC EC2005006104A patent/ECSP056104A/es unknown
-
2007
- 2007-08-28 US US11/845,837 patent/US7598247B2/en not_active Expired - Lifetime
-
2009
- 2009-08-24 US US12/545,902 patent/US8309552B2/en not_active Expired - Fee Related
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