NO20026242L - Syntesemetoder for aplidin og nye antitumorale derivater, metoder for deresfremstilling og anvendelse av disse - Google Patents

Syntesemetoder for aplidin og nye antitumorale derivater, metoder for deresfremstilling og anvendelse av disse

Info

Publication number: NO20026242L
Authority: NO; Norway
Prior art keywords: methods; aplidine; synthesis; preparation; derivatives
Prior art date: 2000-06-30

Application number

NO20026242A

Other languages

English (en)

Other versions

NO20026242D0 (no

NO334096B1 (no

Inventor

Ignacio Rodriguez

Concepcion Polanco

Felix Cuevas

Paloma Mandez

Carmen Cuevas

Pilar Gallego

Simon Munt

Ignacio Manzanares

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-30

Filing date

2002-12-27

Publication date

2003-02-27

2000-06-30 Priority claimed from GB0016148A external-priority patent/GB0016148D0/en

2001-02-15 Priority claimed from GB0103750A external-priority patent/GB0103750D0/en

2002-12-27 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2002-12-27 Publication of NO20026242D0 publication Critical patent/NO20026242D0/no

2003-02-27 Publication of NO20026242L publication Critical patent/NO20026242L/no

2013-12-09 Publication of NO334096B1 publication Critical patent/NO334096B1/no

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 2
230000000259 anti-tumor effect Effects 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
229950008499 plitidepsin Drugs 0.000 title 1
108010049948 plitidepsin Proteins 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)

NO20026242A 2000-06-30 2002-12-27 Nye antitumorale derivater avledet fra aplidin NO334096B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0016148A GB0016148D0 (en)	2000-06-30	2000-06-30	Synthetic methods for aplidine and new antitiumoral derivatives
GB0103750A GB0103750D0 (en)	2001-02-15	2001-02-15	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
PCT/GB2001/002901 WO2002002596A2 (en)	2000-06-30	2001-07-02	Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

Publications (3)

Publication Number	Publication Date
NO20026242D0 NO20026242D0 (no)	2002-12-27
NO20026242L true NO20026242L (no)	2003-02-27
NO334096B1 NO334096B1 (no)	2013-12-09

Family

ID=26244577

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20026242A NO334096B1 (no)	2000-06-30	2002-12-27	Nye antitumorale derivater avledet fra aplidin

Country Status (25)

Country	Link
US (2)	US7348310B2 (no)
EP (1)	EP1294747B1 (no)
JP (1)	JP5289662B2 (no)
KR (1)	KR100866056B1 (no)
CN (2)	CN1449408A (no)
AT (1)	ATE393775T1 (no)
AU (1)	AU6769801A (no)
BR (1)	BRPI0112375B8 (no)
CA (1)	CA2414609C (no)
CY (1)	CY1108549T1 (no)
CZ (1)	CZ304204B6 (no)
DE (1)	DE60133817T2 (no)
DK (1)	DK1294747T3 (no)
ES (1)	ES2305083T3 (no)
HK (1)	HK1052940B (no)
HU (1)	HU228998B1 (no)
IL (2)	IL153680A0 (no)
MX (1)	MXPA03000202A (no)
NO (1)	NO334096B1 (no)
NZ (1)	NZ523367A (no)
PL (1)	PL208651B1 (no)
PT (1)	PT1294747E (no)
SI (1)	SI1294747T1 (no)
UA (1)	UA76718C2 (no)
WO (1)	WO2002002596A2 (no)

Families Citing this family (23)

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US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
SK287762B6 (sk) *	1999-11-15	2011-09-05	Pharma Mar, S. A.	Použitie aplidínu na prípravu farmaceutického prostriedku na liečenie rakoviny
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
BR0109958A (pt)	2000-04-07	2003-05-27	Univ Pennsylvania	Análogos de didemnina e tamandarina e métodos de preparação e uso deles
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
HK1054191A1 (zh)	2000-10-12	2003-11-21	Pharma Mar, S.A.	施用aplidine時同時使用myoprotector的癌症治療
WO2004080477A1 (en)	2003-03-12	2004-09-23	Dana-Farber Cancer Institute, Inc.	Aplidine for multiple myeloma treatment
JP2006519848A (ja)	2003-03-12	2006-08-31	ファルマ・マール・ソシエダード・アノニマ	改良された抗腫瘍治療
US8030279B2 (en)	2003-03-21	2011-10-04	The Trustees Of The University Of Pennsylvania	Tamandarin analogs and fragments thereof and methods of making and using
EP1942944A2 (en) *	2005-10-31	2008-07-16	Genentech, Inc.	Macrocyclic depsipeptide antibody-drug conjugates and methods
KR20140101014A (ko)	2006-02-28	2014-08-18	파르마 마르 에스.에이.	개선된 항종양 치료
JP2011500650A (ja) *	2007-10-19	2011-01-06	ファルマ・マール・ソシエダード・アノニマ	改良された抗腫瘍治療
EP2262523A1 (en) *	2008-03-07	2010-12-22	Pharma Mar S.A.	Improved anticancer treatments
WO2011020913A2 (en)	2009-08-21	2011-02-24	Pharma Mar, S.A.	Cyclodepsipeptide antiviral compounds
JP2013537181A (ja) *	2010-09-10	2013-09-30	サノフイ	抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
US20230158104A1 (en)	2020-03-02	2023-05-25	Pharma Mar, S.A.	Compounds for use in autoimmune conditions
CN115243703A (zh)	2020-03-02	2022-10-25	法马马有限公司	用于组合治疗冠状病毒的pld
EP4114436A1 (en)	2020-03-02	2023-01-11	Pharma Mar S.A.	Compounds for use in the treatment of coronavirus infection
WO2021175831A2 (en)	2020-03-02	2021-09-10	Pharma Mar, S.A.	Compounds for use in viral infections
CN115594739B (zh) *	2021-06-28	2025-02-14	浙江珲达生物科技有限公司	一种dehydrodidemnin B类化合物的制备方法
WO2024165764A1 (en)	2023-02-10	2024-08-15	Pharma Mar, S.A.	Plitidepsin for use in the treatment of non-integrated dna viral infections

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US4493796A (en) *	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
DE3161556D1 (en)	1980-09-12	1984-01-05	Univ Illinois	Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4950649A (en) *	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
IT1153974B (it) *	1982-09-23	1987-01-21	Erba Farmitalia	Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en) *	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en) *	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
DE4120327A1 (de) *	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US5462726A (en) *	1993-12-17	1995-10-31	Bristol-Myers Squibb Company	Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
US5861439A (en) *	1994-11-14	1999-01-19	Alza Corporation	Method for enhanced electrotransport agent delivery
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US6156724A (en) *	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
ATE321773T1 (de) *	1996-10-24	2006-04-15	Univ Illinois	Semisynthetisches verfahren zur herstellung von didemninanalogen
EP0956033B1 (en) *	1996-10-24	2003-07-23	The Board Of Trustees Of The University Of Illinois	Total synthesis of the amino hip analogue of didemnin a
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
AU740598B2 (en) *	1997-05-07	2001-11-08	William J. Crumb	Aplidine as an L-type calcium channel enhancer
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
JP4703851B2 (ja) *	1998-07-30	2011-06-15	シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ	Ｌ−カルニチンおよびそのアルカノイル誘導体の、抗癌作用を有する医薬品の製造のための使用
US6890904B1 (en) *	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
AU781897B2 (en)	1999-05-25	2005-06-23	Point Therapeutics, Inc.	Anti-tumor comprising boroproline compounds
SK287762B6 (sk)	1999-11-15	2011-09-05	Pharma Mar, S. A.	Použitie aplidínu na prípravu farmaceutického prostriedku na liečenie rakoviny
BR0109958A (pt)	2000-04-07	2003-05-27	Univ Pennsylvania	Análogos de didemnina e tamandarina e métodos de preparação e uso deles
US6509315B1 (en) *	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
JP2004510824A (ja)	2000-10-12	2004-04-08	ファルマ・マール・ソシエダード・アノニマ	ガンの治療
AU2002336206B2 (en)	2001-10-19	2007-11-29	Pharma Mar, S.A.	Use of aplidine for the treatment of pancreatic cancer
JP2006519848A (ja)	2003-03-12	2006-08-31	ファルマ・マール・ソシエダード・アノニマ	改良された抗腫瘍治療

2001
- 2001-02-07 UA UA2003010794A patent/UA76718C2/uk unknown
- 2001-07-02 DE DE60133817T patent/DE60133817T2/de not_active Expired - Lifetime
- 2001-07-02 WO PCT/GB2001/002901 patent/WO2002002596A2/en not_active Ceased
- 2001-07-02 CZ CZ2002-4233A patent/CZ304204B6/cs not_active IP Right Cessation
- 2001-07-02 PL PL360531A patent/PL208651B1/pl unknown
- 2001-07-02 CN CN01814701A patent/CN1449408A/zh active Pending
- 2001-07-02 JP JP2002507848A patent/JP5289662B2/ja not_active Expired - Lifetime
- 2001-07-02 CA CA2414609A patent/CA2414609C/en not_active Expired - Lifetime
- 2001-07-02 KR KR1020027018030A patent/KR100866056B1/ko not_active Expired - Lifetime
- 2001-07-02 DK DK01945484T patent/DK1294747T3/da active
- 2001-07-02 PT PT01945484T patent/PT1294747E/pt unknown
- 2001-07-02 CN CN201410805461.6A patent/CN104650177A/zh active Pending
- 2001-07-02 NZ NZ52336701A patent/NZ523367A/xx not_active IP Right Cessation
- 2001-07-02 BR BR0112375A patent/BRPI0112375B8/pt not_active IP Right Cessation
- 2001-07-02 MX MXPA03000202A patent/MXPA03000202A/es active IP Right Grant
- 2001-07-02 EP EP01945484A patent/EP1294747B1/en not_active Expired - Lifetime
- 2001-07-02 HU HU0301387A patent/HU228998B1/hu unknown
- 2001-07-02 US US10/312,341 patent/US7348310B2/en not_active Expired - Lifetime
- 2001-07-02 IL IL15368001A patent/IL153680A0/xx unknown
- 2001-07-02 ES ES01945484T patent/ES2305083T3/es not_active Expired - Lifetime
- 2001-07-02 AT AT01945484T patent/ATE393775T1/de active
- 2001-07-02 SI SI200130843T patent/SI1294747T1/sl unknown
- 2001-07-02 HK HK03105236.0A patent/HK1052940B/en not_active IP Right Cessation
- 2001-07-02 AU AU6769801A patent/AU6769801A/xx active Pending
2002
- 2002-12-26 IL IL153680A patent/IL153680A/en active IP Right Grant
- 2002-12-27 NO NO20026242A patent/NO334096B1/no not_active IP Right Cessation
2007
- 2007-04-20 US US11/788,866 patent/US7678765B2/en not_active Expired - Lifetime
2008
- 2008-07-30 CY CY20081100795T patent/CY1108549T1/el unknown

Also Published As

Publication number	Publication date
HUP0301387A3 (en)	2005-04-28
HK1052940B (en)	2008-10-24
US20040097413A1 (en)	2004-05-20
EP1294747A2 (en)	2003-03-26
PL360531A1 (en)	2004-09-06
BR0112375A (pt)	2003-06-24
KR20030013477A (ko)	2003-02-14
AU6769801A (en)	2002-01-14
US7678765B2 (en)	2010-03-16
MXPA03000202A (es)	2003-10-15
BRPI0112375B1 (pt)	2020-12-01
CY1108549T1 (el)	2014-04-09
UA76718C2 (uk)	2006-09-15
WO2002002596A2 (en)	2002-01-10
IL153680A0 (en)	2003-07-06
IL153680A (en)	2012-05-31
EP1294747B1 (en)	2008-04-30
JP5289662B2 (ja)	2013-09-11
BRPI0112375B8 (pt)	2021-05-25
CA2414609C (en)	2012-04-24
PL208651B1 (pl)	2011-05-31
HK1052940A1 (en)	2003-10-03
CZ304204B6 (cs)	2014-01-02
US7348310B2 (en)	2008-03-25
DE60133817T2 (de)	2009-05-20
CZ20024233A3 (cs)	2003-06-18
CA2414609A1 (en)	2002-01-10
DK1294747T3 (da)	2008-10-27
NO20026242D0 (no)	2002-12-27
HUP0301387A2 (hu)	2003-08-28
NZ523367A (en)	2004-12-24
CN1449408A (zh)	2003-10-15
ES2305083T3 (es)	2008-11-01
US20080009435A1 (en)	2008-01-10
KR100866056B1 (ko)	2008-10-30
JP2004502702A (ja)	2004-01-29
DE60133817D1 (de)	2008-06-12
NO334096B1 (no)	2013-12-09
CN104650177A (zh)	2015-05-27
SI1294747T1 (sl)	2008-12-31
WO2002002596A3 (en)	2002-05-23
PT1294747E (pt)	2008-08-08
HU228998B1 (en)	2013-07-29
ATE393775T1 (de)	2008-05-15

Publication	Publication Date	Title
NO20026242L (no)	2003-02-27	Syntesemetoder for aplidin og nye antitumorale derivater, metoder for deresfremstilling og anvendelse av disse
PH12013500123A1 (en)	2015-10-26	Hemiasterlin derivatives and uses thereof
DK1305286T3 (da)	2005-03-14	Cyclopentanoindoler, præparater indeholdende sådanne forbindelser og fremgangsmåder til behandling
CY1108808T1 (el)	2014-04-09	Ενωσεις μοτιλιδης
NO20043016L (no)	2004-07-15	6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
NO20055741D0 (no)	2005-12-05	Nye kjemiske forbindelser
ATE311389T1 (de)	2005-12-15	Wirkstoffvorläufer von imidazopyridin-derivaten
WO2005030794A3 (en)	2005-08-18	Hemiasterlin derivatives and uses thereof
NO20054361D0 (no)	2005-09-20	Benzensylfonamidderivater, fremgangsmate for fremstilling og anvendelse derav for behandlig av smerte
ATE419242T1 (de)	2009-01-15	Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
DE60131968D1 (de)	2008-01-31	PYRANOÄ2,3-cÜIMIDAZOÄ1,2-aÜPYRIDIN-DERIVATE ZUR BEHANDLUNG VON GASTROINTESTINALEN ERKRANKUNGEN
DE602004019541D1 (de)	2009-04-02	Cycloalkyläbü kondensierte indole
CY1111290T1 (el)	2015-08-05	Παραγωγα 9-αλκυλαμινo-1-νιτρoακριδινης
ATE265418T1 (de)	2004-05-15	Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine
ATE328883T1 (de)	2006-06-15	Imidazopyridin-8-one
TW200504075A (en)	2005-02-01	Imidazopyridine intermediates
SG145574A1 (en)	2008-09-29	Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same
SE0301798D0 (sv)	2003-06-19	New use IV

Legal Events

Date	Code	Title	Description
2021-07-12	MK1K	Patent expired